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@mzloteanu.bsky.social

#statstab #452 Assumption Checking Prevents Assumption Hacking in Multiverse Meta-Analyses

Thoughts: Heterogeneity, publication bias, multiverse analysis, z-curve and more.

#zcurve #multiverse #heterogeneity #metaanalysis #bias #publicationbias

replicationindex.com/2025/06/13/a...

Assumption Checking Prevents Assumption Hacking in Multiverse Meta-Analyses - Replicability-Index

In a nutshell Statistical methods for meta-analyses make different assumptions. For this reason, different methods can produce different results with the same data. Meta-analysts often struggle to mak...

replicationindex.com

November 4, 2025 at 6:16 PM

Per Engzell

@pengzell.bsky.social

Amazing. Someone points out that the results of nudge metaanalysis are actually all publication bias. Original authors then brush it off with ”[being] a relatively young field … comes with some methodological growing pains.”

Catherine Frieman @cjfrieman.bsky.social · 14d

there have been big questions raised about the quality and reliability of the research suggesting that small nudges (like moving an entry field or asking people to tick a box) meaningfully affect behaviour

No evidence for nudging after adjusting for publication bias | PNAS

No evidence for nudging after adjusting for publication bias

www.pnas.org

November 2, 2025 at 11:26 AM

Cardiovascular Diseases Research Institute

@tumscvdri.bsky.social

Higher Systemic Immune-Inflammation Index is associated with non-alcoholic fatty liver disease; Hedge’s g = 0.11 and odds ratio (OR) = 1.45. Further longitudinal studies are needed. #NAFLD #SII #SystemicInflammation #Biomarker #MetaAnalysis journals.lww.com/annals-of-me...

October 30, 2025 at 5:19 AM

CardioOB

@cardioob.bsky.social

Oral antihypertensive Rx during pregnancy:
systematic review & network #metaanalysis

❓methyldopa vs labetalol vs nifedipine vs placebo/no Rx

@acog.org @drklindley.bsky.social @minnowwalsh.bsky.social @abraguo.bsky.social
#CardioObstetrics #ACCRepOB #ACCCardioOB
www.ajog.org/article/S000...

October 27, 2025 at 5:02 PM

Cochrane Denmark & CEBMO

@cochranedkcebmo.bsky.social

What: Webinar on trial sequential analysis (TSA) in meta-analyses
When: 28 Oct 2025 13:00 to 13:45 (CEST)
Where: syddanskuni.zoom.us/j/61110310530

Christian Gunge Riberholt, associate professor at the University of Copenhagen, will talk about TSA and the potential errors of using it.

#MetaAnalysis

Example of a trial sequential analysis plot. From: https://ctu.dk/tsa/

October 20, 2025 at 11:40 AM

Sebastian Gechert

@sgechert.bsky.social

Looking forward to this great event, participating in the #replication games and presenting our #metaanalysis on #energy price elasticities www.tu-chemnitz.de/wirtschaft/v.... Thanks to @i4replication.bsky.social , Abel and the MAERnet team for making this happen in such a great place!

October 15, 2025 at 1:15 PM

Cardiovascular Diseases Research Institute

@tumscvdri.bsky.social

GLP-1 receptor agonists (GLP-1RAs) boost weight loss and help fight #WeightRegain after #BariatricSurgery, according to the latest #MetaAnalysis. Early treatment shows greater effects. Most side effects are mild and gastrointestinal. More long-term data needed! link.springer.com/article/10.1...

The role of glucagon-like peptide-1 receptor agonists in weight regain treatment or prevention after bariatric surgery: a systematic review and meta-analysis - Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity

Background Weight regain (WR) and insufficient weight loss (WL) occur in 20–25% of patients after bariatric surgery due to various factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown promise in promoting WL; however, evidence regarding their effectiveness in managing WL and preventing WR post-bariatric surgery remains limited. Objective This study aims to evaluate the role of GLP-1RAs in treating and preventing WR following bariatric surgery. Methods A systematic search was conducted across PubMed, Scopus, and Web of Science for studies assessing the impact of GLP-1RAs on WR after bariatric surgery. Results Our search identified 27 original studies, with 10 included in the meta-analysis involving 769 participants (392 treated with GLP-1RAs). The mean age was 44.05 years, with 30.47% male. The time interval from surgery to the initiation of GLP-1RAs treatment ranged from 1.5 to 86.7 months, with treatment durations between 4 and 12 months. The analysis showed significantly greater WL in the GLP-1RAs group compared to placebo (SMD = 0.82, 95% CI 0.23 to 1.42). Subgroup analysis for treatment durations ≤ 6 months indicated a higher WL in the GLP-1RAs group (SMD = 0.79, 95% CI 0.25 to 1.34). Adverse events were primarily gastrointestinal, with nausea significantly more frequently in the GLP-1RAs group (OR = 2.01, 95% CI 1.24 to 3.27). Conclusion GLP-1RAs effectively promote WL among participants experiencing WR after bariatric surgery. Initiating GLP-1RAs therapy shortly after surgery may help prevent WR. Further research is warranted to explore long-term outcomes and optimize treatment protocols for this patient population. Graphical Abstract

link.springer.com

October 8, 2025 at 5:21 AM

Adam Lendvai

@lendvaiaz.bsky.social

Evolutionary theory meets ballistics: longevity researchers pondering how cannons shaped extrinsic mortality patterns back in the day. @englishse.bsky.social has a model in mind, @eivimeycook.bsky.social prefers a metaanalysis, @kokkonut.bsky.social maybe thinking if they could shoot kokkonuts...? 🙂

October 2, 2025 at 9:31 PM

Alexander J. Stein

@ajstein.bsky.social

#MetaAnalysis with a total of 1.2 m participants finds adherence to #plantbased dietary patterns, esp. those rich in healthy plant foods—like fruits, #vegetables, whole grains, #legumes & nuts—may be beneficial for reducing the risk of colorectal cancer: doi.org/10.1016/j.ga... #cancer #health

Redirecting

doi.org

September 30, 2025 at 7:21 PM

zellerlab.bsky.social

@zellerlab.bsky.social

Meta-analyses, CRC, and microbes in Heidelberg!

@selinpekel.bsky.social presented a poster at #EESMicrobiome
2025, showing how a universal microbiome signature for CRC emerges across cohorts, ages of onset , and sequencing methods.

#Microbiome #ColorectalCancer #EMBL #MetaAnalysis #LUMC

September 19, 2025 at 9:29 AM

Fae | spoiler tag: #hz2

@unholyangeldust.bsky.social

s2’s may have flaws in delivery, or a premise that people disagree with (like the “worth of a human soul is innate” premise of s1). but exploring themes of misinformation in metaanalysis in conversations is in and of itself going to do a lot of good! whether or not we agree with the story’s message!

September 17, 2025 at 1:31 AM

Allen Tien, MD, MHS mdlogix.com 94,698 田一彦

@allentien.bsky.social

https://www.cambridge.org/core/journals/psychological-medicine/article/affective-problems-and-decline-in-cognitive-state-in-older-adults-a-systematic-review-and-metaanalysis/5D529D177B003920ECC3A7280BAB7318?utm_campaign=meetedgar&utm_medium=social&utm_source=meetedgar.com #Mood...

Affective problems and decline in cognitive state in olde...

www.cambridge.org

February 6, 2025 at 7:06 AM

Allen Tien, MD, MHS mdlogix.com 94,698 田一彦

@allentien.bsky.social

https://www.cambridge.org/core/journals/psychological-medicine/article/affective-problems-and-decline-in-cognitive-state-in-older-adults-a-systematic-review-and-metaanalysis/5D529D177B003920ECC3A7280BAB7318?utm_campaign=meetedgar&utm_medium=social&utm_source=meetedgar.com...

Affective problems and decline in cognitive state in olde...

www.cambridge.org

January 21, 2025 at 4:56 PM

Oikos

@oikosjournal.bsky.social

Ignite: Europe's Nature Restoration Law has now been adopted. What comes next?

https://doi.org/10.1111/oik.11209

#MetaAnalysis #NaturalRegeneration #EcologicalRestoration #Succession #Vegetation

March 17, 2025 at 5:06 PM

Jan R. Boehnke

@jrboehnke.bsky.social

...into the wider picture shown by #MetaAnalysis projects focusing on this area such as ES=0.04
(n=133 effect sizes in educationendowmentfoundation.org.uk/projects-and...) or
ES=0.06 (n=267 in papers.ssrn.com/sol3/papers....).

And there are good discussions for reasons for the small effect sizes.