Chris Shore
@christophershore.bsky.social
Postdoc researcher at KCL interested in ageing, genetics, epigenetics, and transcriptomics.
Reposted by Chris Shore
📣New from Park & Xing!
📄Origins and implications of intron retention quantitative trait loci in human tissues
📄Origins and implications of intron retention quantitative trait loci in human tissues
Origins and implications of intron retention quantitative trait loci in human tissues
Intron retention is an important form of RNA variation. We mapped intron retention
quantitative trait loci (irQTLs) in human tissues. irQTLs can generate expression
quantitative trait loci (eQTLs) thr...
www.cell.com
November 4, 2025 at 4:04 PM
📣New from Park & Xing!
📄Origins and implications of intron retention quantitative trait loci in human tissues
📄Origins and implications of intron retention quantitative trait loci in human tissues
Reposted by Chris Shore
In this study, Gallicchio et al. describe how cleavage factor II (CFII) components serve as a mechanistic switch that controls alternative mRNA cleavage and polyadenylation during spermatogenic differentiation.
Learn more here:
➡️ tinyurl.com/gd351649
Learn more here:
➡️ tinyurl.com/gd351649
September 13, 2024 at 3:02 PM
In this study, Gallicchio et al. describe how cleavage factor II (CFII) components serve as a mechanistic switch that controls alternative mRNA cleavage and polyadenylation during spermatogenic differentiation.
Learn more here:
➡️ tinyurl.com/gd351649
Learn more here:
➡️ tinyurl.com/gd351649
Reposted by Chris Shore
Big news! My 1st first-author paper (2 years in making!) reveals adipose tissue gene expression and clinical traits predict future lipid drug use years ahead. Our model hit an impressive AUC of 0.919, dramatically outperforming traditional risk scores (0.722) for prediction! Link below rdcu.be/eDrKr
Adipose tissue gene expression and longitudinal clinical phenotypes are early biomarkers of lipid-regulating drug usage
Scientific Reports - Adipose tissue gene expression and longitudinal clinical phenotypes are early biomarkers of lipid-regulating drug usage
rdcu.be
September 1, 2025 at 2:35 PM
Big news! My 1st first-author paper (2 years in making!) reveals adipose tissue gene expression and clinical traits predict future lipid drug use years ahead. Our model hit an impressive AUC of 0.919, dramatically outperforming traditional risk scores (0.722) for prediction! Link below rdcu.be/eDrKr
Reposted by Chris Shore
Nice to see recent author Christopher Shore featured in the @geneticssociety.bsky.social Trainee Excellence Spotlight!
Trainee Excellence Spotlight: Christopher Shore
Trainee Excellence Spotlight, TES, Trainee, Spotlight, ASHG, American Society for Human Genetics, Genetics
www.ashg.org
April 7, 2025 at 8:43 PM
Nice to see recent author Christopher Shore featured in the @geneticssociety.bsky.social Trainee Excellence Spotlight!
Reposted by Chris Shore
Reposted by Chris Shore
I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know
November 14, 2024 at 8:48 AM
I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know
Reposted by Chris Shore
Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics
DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
Liu et al. report that DNMT1 inhibition causes transient accumulation of hemi-methylated
DNA at CpG islands, which stimulates UHRF1-mediated H3K18ub. This enhances SUV39H1/H2
activity, nucleates new H...
www.cell.com
December 4, 2024 at 3:02 AM
Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics
Reposted by Chris Shore
If you're working with Nightingale Health metabolomics data from UK Biobank, be sure to check out the excellent (and important) work @sritchie73.bsky.social and colleagues have done on its QC and normalisation: www.nature.com/articles/s41...
ukbnmr on CRAN: cran.r-project.org/web/packages...
ukbnmr on CRAN: cran.r-project.org/web/packages...
Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants - Scientific Data
Scientific Data - Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants
www.nature.com
December 1, 2024 at 8:01 PM
If you're working with Nightingale Health metabolomics data from UK Biobank, be sure to check out the excellent (and important) work @sritchie73.bsky.social and colleagues have done on its QC and normalisation: www.nature.com/articles/s41...
ukbnmr on CRAN: cran.r-project.org/web/packages...
ukbnmr on CRAN: cran.r-project.org/web/packages...
Reposted by Chris Shore
🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky
#AcademicSky Details: tinyurl.com/4fhavzxh
#AcademicSky Details: tinyurl.com/4fhavzxh
Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester on FindAPhD.com
PhD Project - Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester, listed on FindAPhD.com
tinyurl.com
November 21, 2024 at 9:59 AM
🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky
#AcademicSky Details: tinyurl.com/4fhavzxh
#AcademicSky Details: tinyurl.com/4fhavzxh
Reposted by Chris Shore
Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...
Single-molecule states link transcription factor binding to gene expression - Nature
A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...
www.nature.com
November 20, 2024 at 8:34 PM
Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...
Interesting to see the discrepancy between different countries here, especially regarding the 'protests about scientific topics' section.
New #preprint! We surveyed 71,922 people in 68 countries to find out: Where do they come across information about #science? How do they #communicate about it? We also tested country factors like #AcademicFreedom and #PressFreedom and identified interesting patterns 🔎
➡️ osf.io/preprints/os...
🧵 1/10
➡️ osf.io/preprints/os...
🧵 1/10
November 19, 2024 at 8:35 AM
Interesting to see the discrepancy between different countries here, especially regarding the 'protests about scientific topics' section.
Reposted by Chris Shore
I know I have been hammering down how bad sleep deprivation is for the brain transcriptome, but how much can you undo with a subsequent nap and how fast? Read our preprint and find out www.biorxiv.org/content/10.1...
Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex
Sleep is an essential, tightly regulated biological function. Sleep is also a homeostatic process, with the need to sleep increasing as a function of being awake. Acute sleep deprivation (SD) increase...
www.biorxiv.org
November 19, 2024 at 6:02 AM
I know I have been hammering down how bad sleep deprivation is for the brain transcriptome, but how much can you undo with a subsequent nap and how fast? Read our preprint and find out www.biorxiv.org/content/10.1...
Reposted by Chris Shore
New preprint on our method aa-tRNA-seq: chemically capturing aminoacylated tRNA molecules & pulling them through nanopores. It’s been a blast working with my collaborator Aleks Radakovic to take this from idea to promising pilot data to some looking exciting biology to chase down in future work.
Here for my first post. Our new approach to study tRNA aminoacylation by nanopore sequencing. Started as a napkin sketch ~1 year ago! This was a fun one, congrats to @laurakwhite.bsky.social and Aleks.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nanopore sequencing of intact aminoacylated tRNAs
Transfer RNAs (tRNA) are decorated during biogenesis with a variety of modifications that modulate their stability, aminoacylation, and decoding potential during translation. The complex landscape of ...
www.biorxiv.org
November 19, 2024 at 3:17 AM
New preprint on our method aa-tRNA-seq: chemically capturing aminoacylated tRNA molecules & pulling them through nanopores. It’s been a blast working with my collaborator Aleks Radakovic to take this from idea to promising pilot data to some looking exciting biology to chase down in future work.