Thomas Schalch
@schalchlab.bsky.social
Structural and molecular biologists with a fascination for chromatin and gene silencing. University of Leicester.
Reposted by Thomas Schalch
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
January 23, 2025 at 1:47 PM
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Reposted by Thomas Schalch
🧬 1/ Heterochromatin protein 1 (HP1) still surprises us after all these years: It simply sticks to chromatin when pericentric heterochromatin domains – the chromocenters – are activated in mouse fibroblasts and acts as a local rather than global repressor. New preprint: doi.org/10.1101/2024...
December 13, 2024 at 1:47 PM
🧬 1/ Heterochromatin protein 1 (HP1) still surprises us after all these years: It simply sticks to chromatin when pericentric heterochromatin domains – the chromocenters – are activated in mouse fibroblasts and acts as a local rather than global repressor. New preprint: doi.org/10.1101/2024...
Reposted by Thomas Schalch
I am recruiting a postdoc with experience in Protein Biochemistry, Structural Biology & Chromatin Biology. If you are passionate about the complex world of chromatin modifications, please contact me for more details 🙏.
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
December 10, 2024 at 5:12 AM
I am recruiting a postdoc with experience in Protein Biochemistry, Structural Biology & Chromatin Biology. If you are passionate about the complex world of chromatin modifications, please contact me for more details 🙏.
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
Location: SAiGENCI, Adelaide, Australia
🦘🍷🏄🏖️🇦🇺
📢 #PhD Position 🎓 @leicstructbio.bsky.social @mcbleicester.bsky.social. Developing protein-based therapies for mesothelioma. Work with experts in epigenetics & cancer biology. Apply by Jan 10, 2025. #PhDSky #AcademicSky
Details: www.schalchlab.org/mesoinject
Details: www.schalchlab.org/mesoinject
PhD opening: Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies – Schalch Lab
www.schalchlab.org
December 4, 2024 at 3:43 PM
📢 #PhD Position 🎓 @leicstructbio.bsky.social @mcbleicester.bsky.social. Developing protein-based therapies for mesothelioma. Work with experts in epigenetics & cancer biology. Apply by Jan 10, 2025. #PhDSky #AcademicSky
Details: www.schalchlab.org/mesoinject
Details: www.schalchlab.org/mesoinject
Reposted by Thomas Schalch
We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression.
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester on FindAPhD.com
PhD Project - Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester, listed on FindAPhD.com
www.findaphd.com
November 21, 2024 at 5:25 PM
We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression.
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky
#AcademicSky Details: tinyurl.com/4fhavzxh
#AcademicSky Details: tinyurl.com/4fhavzxh
Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester on FindAPhD.com
PhD Project - Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester, listed on FindAPhD.com
tinyurl.com
November 21, 2024 at 9:59 AM
🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky
#AcademicSky Details: tinyurl.com/4fhavzxh
#AcademicSky Details: tinyurl.com/4fhavzxh
Gutting when you find your dream project done and dusted on bioRxiv. Du et al. performed an impressive tour-de-force to solve the Clr4-H3K14ub structure. Great to see that the ubiquitin-binding region we found by XDS-MS matches the crystal structure perfectly! www.biorxiv.org/content/10.1...
Mechanistic Insights into the Stimulation of the Histone H3K9 Methyltransferase Clr4 by Proximal H3K14 Ubiquitination
H3K9 methylation is an evolutionarily conserved hallmark of heterochromatin and plays crucial roles in chromosome segregation, genome stability, and gene expression regulation. Clr4 is the sole histon...
www.biorxiv.org
November 18, 2024 at 4:41 PM
Gutting when you find your dream project done and dusted on bioRxiv. Du et al. performed an impressive tour-de-force to solve the Clr4-H3K14ub structure. Great to see that the ubiquitin-binding region we found by XDS-MS matches the crystal structure perfectly! www.biorxiv.org/content/10.1...
Reposted by Thomas Schalch
Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg
November 10, 2024 at 9:43 PM
Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg
Reposted by Thomas Schalch
In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography https://www.biorxiv.org/content/10.1101/2024.02.21.581285v1
In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography https://www.biorxiv.org/content/10.1101/2024.02.21.581285v1
Long terminal repeat (LTR) retrotransposons belong to the transposable elements (TE), autonomously r
www.biorxiv.org
February 23, 2024 at 3:51 AM
In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography https://www.biorxiv.org/content/10.1101/2024.02.21.581285v1