Chloe Slaney
@chloeslaney.bsky.social
Senior Research Associate in genetic epidemiology in the MRC IEU, Bristol University. Inflammation in neurological/psychiatric conditions and cognition using population-based cohort and genetics data.
Pinned
Chloe Slaney
@chloeslaney.bsky.social
· Jun 10
Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
Reposted by Chloe Slaney
Honoured to receive the 25th Anniversary MRC Millenium Medal. My mid-1980s epidemiological apprenticeship was at the MRC Epidemiology Unit in Cardiff in the mid-1980s, and my senescence with the MRC IEU, closing in March 2028
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
November 14, 2025 at 5:02 PM
Honoured to receive the 25th Anniversary MRC Millenium Medal. My mid-1980s epidemiological apprenticeship was at the MRC Epidemiology Unit in Cardiff in the mid-1980s, and my senescence with the MRC IEU, closing in March 2028
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...
Reposted by Chloe Slaney
A special collection of 6 papers on cohort studies in China is just out in @bmj.com www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
Enhancing cohort studies in China and internationally
*/
www.bmj.com
October 28, 2025 at 9:51 AM
A special collection of 6 papers on cohort studies in China is just out in @bmj.com www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...
Reposted by Chloe Slaney
Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity
Associate Director, Equity Lab
Salary: £120,800 Closing date: 9th November Contract type: Permanent Interview dates: 24th and 28th November The Wellcome Trust is a global charitable foundation. We improve health for everyone by fun...
wellcome.wd3.myworkdayjobs.com
October 23, 2025 at 11:12 PM
Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity
Reposted by Chloe Slaney
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Reposted by Chloe Slaney
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
September 26, 2025 at 5:10 PM
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
Reposted by Chloe Slaney
Reposted by Chloe Slaney
Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!
Shining a light on the un-common to identify novel health risk-factors - GW4 BioMed MRC DTP
Project Code MRCPHS26Br Nivard Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary Complex traits such as body mass index and height are influenced by a mixt...
gw4biomed.ac.uk
September 19, 2025 at 7:46 AM
Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!
Reposted by Chloe Slaney
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Reposted by Chloe Slaney
In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...
Being Too Helpful At Work Can Hurt Your Career—Here’s How To Say No
Women are more likely to take on behind-the-scenes duties at work—extra tasks like onboarding or event planning—and it's hurting their careers. Here's how to say no.
www.forbes.com
July 7, 2025 at 8:03 PM
In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...
Reposted by Chloe Slaney
Really enjoying Prof Emma Robinson’s accessibly-delivered talk on behavioural markers of mood/antidepressant effects! Really clear justification for focus on behavioural readouts of mood - and v thought provoking notes on welfare. #BAP2025
June 30, 2025 at 9:02 AM
Really enjoying Prof Emma Robinson’s accessibly-delivered talk on behavioural markers of mood/antidepressant effects! Really clear justification for focus on behavioural readouts of mood - and v thought provoking notes on welfare. #BAP2025
Reposted by Chloe Slaney
Studying the genetics of intelligence measures can help us understand the neurobiology of cognition and neurodevelopmental conditions 🧬🧠
We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.
Preprint: www.medrxiv.org/content/10.1...
Thread 👇
We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.
Preprint: www.medrxiv.org/content/10.1...
Thread 👇
June 21, 2025 at 4:08 AM
Studying the genetics of intelligence measures can help us understand the neurobiology of cognition and neurodevelopmental conditions 🧬🧠
We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.
Preprint: www.medrxiv.org/content/10.1...
Thread 👇
We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.
Preprint: www.medrxiv.org/content/10.1...
Thread 👇
Reposted by Chloe Slaney
Netherlands study of 55,000 adults found higher inflammation (CRP) linked to more negative mood, anxiety, and slower thinking.
Genetic data also suggest CRP and GlycA may play a causal role in negative affect.
www.nature.com/articles/s41...
Genetic data also suggest CRP and GlycA may play a causal role in negative affect.
www.nature.com/articles/s41...
Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study - Translational Psychiatry
Translational Psychiatry - Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study
www.nature.com
May 10, 2025 at 6:40 PM
Netherlands study of 55,000 adults found higher inflammation (CRP) linked to more negative mood, anxiety, and slower thinking.
Genetic data also suggest CRP and GlycA may play a causal role in negative affect.
www.nature.com/articles/s41...
Genetic data also suggest CRP and GlycA may play a causal role in negative affect.
www.nature.com/articles/s41...
Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
June 10, 2025 at 9:00 AM
Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
▶️ onlinelibrary.wiley.com/doi/10.1111/...
@uob-ieu.bsky.social @bristoluni.bsky.social
Reposted by Chloe Slaney
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
May 13, 2025 at 1:25 PM
Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.
Open access: www.nature.com/articles/s41...
Reposted by Chloe Slaney
This is huge! Honestly can't wait to dive into this dataset.
Big news for health data research and population diversity: The Mexico City Prospective Study data are now available securely to approved researchers worldwide. www.ndph.ox.ac.uk/news/latin-a...
Cohort description: www.ctsu.ox.ac.uk/research/pro...
Cohort description: www.ctsu.ox.ac.uk/research/pro...
Latin-American genetic data available securely to approved researchers worldwide/Datos genéticos latinoamericanos disponibles para investigadores de todo el mundo
www.ndph.ox.ac.uk
May 2, 2025 at 5:43 PM
This is huge! Honestly can't wait to dive into this dataset.
Reposted by Chloe Slaney
Last few days left to apply! Come and work with us!
🚨job alert!
Fancy working on mental health electronic health records #EHR?
Working across the Uni of Cambridge and industry, alongside Akrivia Health?
We are looking for an experienced postdoctoral researcher or engineer to help develop common data models for EHR.
www.jobs.cam.ac.uk/job/50667/
1/3
Fancy working on mental health electronic health records #EHR?
Working across the Uni of Cambridge and industry, alongside Akrivia Health?
We are looking for an experienced postdoctoral researcher or engineer to help develop common data models for EHR.
www.jobs.cam.ac.uk/job/50667/
1/3
April 9, 2025 at 8:05 AM
Last few days left to apply! Come and work with us!
Reposted by Chloe Slaney
Final version published so time to talk about it: doi.org/10.1093/aje/...
When using multiple imputation to account for missing data we often use auxiliary variables (variables included in the imputation model but not the analysis model) to 1) reduce bias and 2) improve statistical efficiency.
When using multiple imputation to account for missing data we often use auxiliary variables (variables included in the imputation model but not the analysis model) to 1) reduce bias and 2) improve statistical efficiency.
Analyses using multiple imputation need to consider missing data in auxiliary variables
Abstract. Auxiliary variables are used in multiple imputation (MI) to reduce bias and increase efficiency. These variables may often themselves be incomple
doi.org
February 19, 2025 at 10:25 AM
Final version published so time to talk about it: doi.org/10.1093/aje/...
When using multiple imputation to account for missing data we often use auxiliary variables (variables included in the imputation model but not the analysis model) to 1) reduce bias and 2) improve statistical efficiency.
When using multiple imputation to account for missing data we often use auxiliary variables (variables included in the imputation model but not the analysis model) to 1) reduce bias and 2) improve statistical efficiency.
Reposted by Chloe Slaney
Hello hello, I am trying to find even more postdoc positions to apply for in psychiatric genetics - please let me know if you are hiring or your lab is!
March 9, 2025 at 1:22 AM
Hello hello, I am trying to find even more postdoc positions to apply for in psychiatric genetics - please let me know if you are hiring or your lab is!
Reposted by Chloe Slaney
Eager to learn more about the latest immunopsychiatry research? 🔎
Be sure to come along to the @pixielabkcl.bsky.social Immunopsychiatry Meeting next week where I'll be presenting some of my PhD work! @uob-ieu.bsky.social
Link below 👇
Be sure to come along to the @pixielabkcl.bsky.social Immunopsychiatry Meeting next week where I'll be presenting some of my PhD work! @uob-ieu.bsky.social
Link below 👇
After a short hiatus, we're back again with our next Immunopsychaitry Meeting! Join us next week for talks by a brilliant pair of speakers Enzo Cipriani and @eimearfoley.bsky.social🥼
@kingsioppn.bsky.social @valeriamondelli.bsky.social
🕓Monday 24th Feb @ 4pm (GMT)
🔗Join online: bit.ly/40tX9DB
@kingsioppn.bsky.social @valeriamondelli.bsky.social
🕓Monday 24th Feb @ 4pm (GMT)
🔗Join online: bit.ly/40tX9DB
February 20, 2025 at 9:16 AM
Eager to learn more about the latest immunopsychiatry research? 🔎
Be sure to come along to the @pixielabkcl.bsky.social Immunopsychiatry Meeting next week where I'll be presenting some of my PhD work! @uob-ieu.bsky.social
Link below 👇
Be sure to come along to the @pixielabkcl.bsky.social Immunopsychiatry Meeting next week where I'll be presenting some of my PhD work! @uob-ieu.bsky.social
Link below 👇
Reposted by Chloe Slaney
You might forget how much you drink… but your body remembers.
Prediction of alcohol consumption using blood-based DNA methylation (correlates better with brain health self report!)
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
Prediction of alcohol consumption using blood-based DNA methylation (correlates better with brain health self report!)
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
Blood-based epigenome-wide association study and prediction of alcohol consumption - Clinical Epigenetics
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as...
clinicalepigeneticsjournal.biomedcentral.com
January 27, 2025 at 2:48 PM
You might forget how much you drink… but your body remembers.
Prediction of alcohol consumption using blood-based DNA methylation (correlates better with brain health self report!)
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
Prediction of alcohol consumption using blood-based DNA methylation (correlates better with brain health self report!)
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
Reposted by Chloe Slaney
Scientific discovery and advance is not, and never has been, “efficient”.
January 25, 2025 at 6:11 PM
Scientific discovery and advance is not, and never has been, “efficient”.
Reposted by Chloe Slaney
🚨PLEASE SHARE: Senior reseach post: come and work at the IEU with Gib Hemani and @mendelrandom.bsky.social on Mendelian randomization, become my co-worker :) – research posts with closing date 5th February 2025.
Details | Working at Bristol | University of Bristol
University of Bristol Beacon House Queens Road Bristol, BS8 1QU, UK Tel: +44 (0)117 928 9000 Contact us
bristol.ac.uk
January 13, 2025 at 3:07 PM
🚨PLEASE SHARE: Senior reseach post: come and work at the IEU with Gib Hemani and @mendelrandom.bsky.social on Mendelian randomization, become my co-worker :) – research posts with closing date 5th February 2025.
Lovely evening celebrating the end of 2024 in the Immunopsychiatry Group!
December 13, 2024 at 9:58 AM
Lovely evening celebrating the end of 2024 in the Immunopsychiatry Group!