Alan Chiu
@chiuonscience.bsky.social
Scientist interested in diabetes (especially Type 1), organoids, islets, oncology, and tissue engineering … also unhealthy devoted to the Oscar campaigns of actresses
Views are my own and do not represent BreakthroughT1D
Views are my own and do not represent BreakthroughT1D
Several BreakthroughT1D funding opportunities available
1) Advancing GRS, especially in non-European backgrounds
2) Early detection in adult-onset T1D
3) Tech for scaling manufactured islets
Feel free to reach out with questions. Open to industry and academia
#funding #grants #T1D
1) Advancing GRS, especially in non-European backgrounds
2) Early detection in adult-onset T1D
3) Tech for scaling manufactured islets
Feel free to reach out with questions. Open to industry and academia
#funding #grants #T1D
Type 1 Diabetes Funding Opportunities - Breakthrough T1D
Explore Breakthrough T1D’s funding opportunities for type 1 diabetes research. Learn how we support innovative projects driving breakthroughs in T1D treatment, prevention, and cures.
www.breakthrought1d.org
May 6, 2025 at 8:19 PM
Reposted by Alan Chiu
Are you interested in developing a research programme in cell biology of diabetes? Do you work in pancreatic islets and/or other metabolically relevant cells? We have a Lectureship post opening in our Section @imperialcollegeldn.bsky.social
Apply by 25th March:
www.imperial.ac.uk/jobs/search-...
Apply by 25th March:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
February 15, 2025 at 10:00 AM
Are you interested in developing a research programme in cell biology of diabetes? Do you work in pancreatic islets and/or other metabolically relevant cells? We have a Lectureship post opening in our Section @imperialcollegeldn.bsky.social
Apply by 25th March:
www.imperial.ac.uk/jobs/search-...
Apply by 25th March:
www.imperial.ac.uk/jobs/search-...
Listening to my academic friends tell me all about their plans to write and be productive during their sabbaticals knowing full well that if I was ever given one I’d used it to binge watch all 47 seasons of survivor chronologically
December 15, 2024 at 11:55 PM
Listening to my academic friends tell me all about their plans to write and be productive during their sabbaticals knowing full well that if I was ever given one I’d used it to binge watch all 47 seasons of survivor chronologically
Cool advancements! The biggest obstacle for use is still how long it takes to image these things, even using an Operetta it would take me more than a full day to image 96 well plates before with how many stacks were needed for sufficient resolution.
December 5, 2024 at 7:11 PM
Cool advancements! The biggest obstacle for use is still how long it takes to image these things, even using an Operetta it would take me more than a full day to image 96 well plates before with how many stacks were needed for sufficient resolution.
How cool, the Clevers lab able to generate fetal pancreatic organoids with all 3 lineages including insulin+ endocrine cells. Will be a really powerful tool for understanding and modeling pancreatic development and dysfunction.
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the
human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term
expansion in vitro and genera...
www.cell.com
December 3, 2024 at 3:51 PM
How cool, the Clevers lab able to generate fetal pancreatic organoids with all 3 lineages including insulin+ endocrine cells. Will be a really powerful tool for understanding and modeling pancreatic development and dysfunction.
Really encouraging results! T1D patients on tirzepatide lost an average of 10% of their bw without an increase in DKA or severe hypoglycemic events … looking forward to future studies with readouts on its effect on CVD
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Effect of Tirzepatide on Body Weight and Diabetes Control in Adults With Type 1 Diabetes and Overweight or Obesity
To determine the effect of tirzepatide on weight, diabetes control, and insulin requirements, and its safety profile in adults with type 1 diabetes (T…
www.sciencedirect.com
November 29, 2024 at 1:22 PM
Really encouraging results! T1D patients on tirzepatide lost an average of 10% of their bw without an increase in DKA or severe hypoglycemic events … looking forward to future studies with readouts on its effect on CVD
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Really interesting read! To me, vascularization of grafts is the least developed aspect of islet transplantation and studies like this are helpful for understanding what exactly is it we're trying to build
Check out our review led by the amazing @rlhull-meichle.bsky.social on the role of pancreatic microvascualture in health and disease and beta cell replacement therapies: journals.sagepub.com/doi/full/10....
November 27, 2024 at 6:26 PM
Really interesting read! To me, vascularization of grafts is the least developed aspect of islet transplantation and studies like this are helpful for understanding what exactly is it we're trying to build
Reposted by Alan Chiu
Stem cell-derived islets engineered to express EGFRt were targeted by CAR-Treg cells to suppress innate and adaptive immune responses, which may prevent immune rejection for #T1D cell therapy. Congrats to the Ferreira and Russ teams! www.cell.com/cell-reports... #regenerativemedicine
November 25, 2024 at 9:01 PM
Stem cell-derived islets engineered to express EGFRt were targeted by CAR-Treg cells to suppress innate and adaptive immune responses, which may prevent immune rejection for #T1D cell therapy. Congrats to the Ferreira and Russ teams! www.cell.com/cell-reports... #regenerativemedicine
Really interesting ... maybe it will help with the shaming (often from medical professionals) of women who struggle to produce enough if there is an additional alternative to formula
Meet the biotech startups brewing milk in bioreactors to improve on baby formula
Lab-grown breast milk - Nature Biotechnology
Meet the biotech startups brewing milk in bioreactors to improve on baby formula.
www.nature.com
November 25, 2024 at 5:38 PM
Really interesting ... maybe it will help with the shaming (often from medical professionals) of women who struggle to produce enough if there is an additional alternative to formula
Reposted by Alan Chiu
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
November 25, 2024 at 11:16 AM
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Reposted by Alan Chiu
Check out this fantastic work by our lab alumnus Kai Wang: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Now out in Cell Stem Cell
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
Pan et al. generate lineage-specific venous endothelial cells with a heterozygous
TIE2-mutation from human iPSCs to recapitulate venous malformations in vitro and in vivo.
Deep learning combined with ...
www.cell.com
November 24, 2024 at 4:20 AM
Check out this fantastic work by our lab alumnus Kai Wang: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Now out in Cell Stem Cell
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Alan Chiu
Great to see this update by Kidney Research UK on all things #Diabetic #Kidneydisease in 2024. Special thanks for highlighting the work of our #PhD student Paige on targetting cell senescence in diabetic nephropathy 👩🔬🥼🧪..Full details 👇👇 #NephSky #diabetes
www.kidneyresearchuk.org/2024/10/24/d...
www.kidneyresearchuk.org/2024/10/24/d...
Diabetes and kidney disease: progress in 2024 - Kidney Research UK
From research to workshops with the diabetes community, progress is being made to prevent the progress of diabetes to kidney disease
www.kidneyresearchuk.org
November 21, 2024 at 7:09 PM
Great to see this update by Kidney Research UK on all things #Diabetic #Kidneydisease in 2024. Special thanks for highlighting the work of our #PhD student Paige on targetting cell senescence in diabetic nephropathy 👩🔬🥼🧪..Full details 👇👇 #NephSky #diabetes
www.kidneyresearchuk.org/2024/10/24/d...
www.kidneyresearchuk.org/2024/10/24/d...
Wow not sure if it was just the gays behind us yas-ing every 15 seconds but the Wicked movie was kind of … incredible?
Also no one sang along!!! I’m sorry I doubted you Times Square AMC, it just felt like you’d be likely to attract people who wouldn’t be able to contain themselves
Also no one sang along!!! I’m sorry I doubted you Times Square AMC, it just felt like you’d be likely to attract people who wouldn’t be able to contain themselves
November 23, 2024 at 12:27 AM
Wow not sure if it was just the gays behind us yas-ing every 15 seconds but the Wicked movie was kind of … incredible?
Also no one sang along!!! I’m sorry I doubted you Times Square AMC, it just felt like you’d be likely to attract people who wouldn’t be able to contain themselves
Also no one sang along!!! I’m sorry I doubted you Times Square AMC, it just felt like you’d be likely to attract people who wouldn’t be able to contain themselves
Actually maybe the sign of mainstreaming is when Greys Anatomy does a CAR T centric episode
November 21, 2024 at 12:09 AM
Actually maybe the sign of mainstreaming is when Greys Anatomy does a CAR T centric episode
Cell therapy manufacturing hubs like the one being built on Long Island are going to be huge for access (and economically) as CAR-T and other treatments expand beyond oncology and become more mainstream, especially as the hypoimmune CAR-T efforts seem to be struggling
The counterattack
An immune cell treatment that fights cancer is now taking aim at autoimmune disease
🔗https://www.science.org/content/article/breakthrough-cancer-immunotherapy-now-taking-aim-autoimmune-disease
h/t @kellyservick.bsky.social & Jennifer Couzin-Frankel👨🔬
An immune cell treatment that fights cancer is now taking aim at autoimmune disease
🔗https://www.science.org/content/article/breakthrough-cancer-immunotherapy-now-taking-aim-autoimmune-disease
h/t @kellyservick.bsky.social & Jennifer Couzin-Frankel👨🔬
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease
CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand
www.science.org
November 20, 2024 at 10:32 PM
Cell therapy manufacturing hubs like the one being built on Long Island are going to be huge for access (and economically) as CAR-T and other treatments expand beyond oncology and become more mainstream, especially as the hypoimmune CAR-T efforts seem to be struggling
Reposted by Alan Chiu
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
November 20, 2024 at 9:55 AM
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
⭐💸 Funding Opps 💸⭐
Two new calls from BreakthroughT1D
The first is for advancing technologies that support engraftment of transplants
The second looks at common mechanisms for autoimmune disease
Feel free to reach out with questions
#funding #t1d #grants
www.breakthrought1d.org/explore-rese...
Two new calls from BreakthroughT1D
The first is for advancing technologies that support engraftment of transplants
The second looks at common mechanisms for autoimmune disease
Feel free to reach out with questions
#funding #t1d #grants
www.breakthrought1d.org/explore-rese...
Funding Opportunities - Breakthrough T1D
Grant handbook A comprehensive collection of Breakthrough T1D’s grant mechanisms and descriptions; application guidelines and checklists; administrative resources; terms and conditions (updated July 2...
www.breakthrought1d.org
November 19, 2024 at 9:35 PM
⭐💸 Funding Opps 💸⭐
Two new calls from BreakthroughT1D
The first is for advancing technologies that support engraftment of transplants
The second looks at common mechanisms for autoimmune disease
Feel free to reach out with questions
#funding #t1d #grants
www.breakthrought1d.org/explore-rese...
Two new calls from BreakthroughT1D
The first is for advancing technologies that support engraftment of transplants
The second looks at common mechanisms for autoimmune disease
Feel free to reach out with questions
#funding #t1d #grants
www.breakthrought1d.org/explore-rese...
Reposted by Alan Chiu
Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
DEFINE_ME
www.ajkd.org
November 17, 2024 at 11:09 AM
Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide
www.ajkd.org/article/S027...
www.ajkd.org/article/S027...
One of my favorite things about these early BlueSky days is getting recommended posts like this and discovering entire fields of science I didn’t even know existed/had a name
Started up a bioarch starter pack 🤩
Let me know if you want to be added or have suggestions 😊
#archaeology #bioarchaeology
go.bsky.app/N5yfURb
Let me know if you want to be added or have suggestions 😊
#archaeology #bioarchaeology
go.bsky.app/N5yfURb
November 18, 2024 at 12:01 AM
One of my favorite things about these early BlueSky days is getting recommended posts like this and discovering entire fields of science I didn’t even know existed/had a name
I set up a calendar reminder to buy I’m Still Here tickets weeks ago but then was too distracted by talks at AHA and forgot to buy them and now they’re sold out 😭😭😭😭
November 17, 2024 at 11:57 PM
I set up a calendar reminder to buy I’m Still Here tickets weeks ago but then was too distracted by talks at AHA and forgot to buy them and now they’re sold out 😭😭😭😭
Another exciting trial result for GLP-1s (tirzepatide), this time for HFpEF
Add that to the growing list of secondary benefits it could have for T1D patients as an adjuvant to insulin
www.nejm.org/doi/full/10....
Add that to the growing list of secondary benefits it could have for T1D patients as an adjuvant to insulin
www.nejm.org/doi/full/10....
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide,
a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like
peptide-1 receptor...
www.nejm.org
November 17, 2024 at 9:28 PM
Another exciting trial result for GLP-1s (tirzepatide), this time for HFpEF
Add that to the growing list of secondary benefits it could have for T1D patients as an adjuvant to insulin
www.nejm.org/doi/full/10....
Add that to the growing list of secondary benefits it could have for T1D patients as an adjuvant to insulin
www.nejm.org/doi/full/10....
Looking forward to reconnecting with the science community (and the nice sections of the film community :p ) on this app
I'm also here at #AHA2024 exploring therapies for the T1D community if anyone has insights they'd like to share!
I'm also here at #AHA2024 exploring therapies for the T1D community if anyone has insights they'd like to share!
November 17, 2024 at 12:54 AM
Looking forward to reconnecting with the science community (and the nice sections of the film community :p ) on this app
I'm also here at #AHA2024 exploring therapies for the T1D community if anyone has insights they'd like to share!
I'm also here at #AHA2024 exploring therapies for the T1D community if anyone has insights they'd like to share!