Juan Melero-Martin
@meleromartinlab.bsky.social
Associate Professor | Bioengineering, Vascular Biology, Regenerative Medicine lab | @BostonChildrens, @harvardmed & @harvardstemcell
The new @stemcellpodcast.com episode is out! It was a real pleasure to speak with Drs. Daylon James & Arun Sharma about vascular organoids, stem cell engraftment, and our lab’s work. Thanks for the thoughtful questions and for spotlighting our research!
📢 A new episode is out!
We chat with Dr. Juan Melero-Martin (@meleromartinlab.bsky.social about how #VascularNetworks are formed and the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells.
🔊 Listen now: https://bit.ly/4qwoGke
We chat with Dr. Juan Melero-Martin (@meleromartinlab.bsky.social about how #VascularNetworks are formed and the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells.
🔊 Listen now: https://bit.ly/4qwoGke
October 31, 2025 at 12:10 AM
The new @stemcellpodcast.com episode is out! It was a real pleasure to speak with Drs. Daylon James & Arun Sharma about vascular organoids, stem cell engraftment, and our lab’s work. Thanks for the thoughtful questions and for spotlighting our research!
Our new Advanced Science paper is out! We show that human bone-derived endothelial cells drive bone regeneration via KIT ligand expression, revealing a vascular niche role in skeletal repair.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#BoneRegeneration #KITLG #EndothelialCells
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#BoneRegeneration #KITLG #EndothelialCells
Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand
Bone-specific endothelial cells (b-ECs) uniquely express KITLG, which recruits c-Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the os...
advanced.onlinelibrary.wiley.com
June 24, 2025 at 11:57 AM
Our new Advanced Science paper is out! We show that human bone-derived endothelial cells drive bone regeneration via KIT ligand expression, revealing a vascular niche role in skeletal repair.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#BoneRegeneration #KITLG #EndothelialCells
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#BoneRegeneration #KITLG #EndothelialCells
Reposted by Juan Melero-Martin
Member publication alert:
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
www.sciencedirect.com/science/arti...
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
www.sciencedirect.com/science/arti...
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
Vascular organoids (VOs) are valuable tools for studying vascular development, disease, and regenerative medicine. However, controlling endothelial an…
www.sciencedirect.com
June 17, 2025 at 9:35 PM
Member publication alert:
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
www.sciencedirect.com/science/arti...
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
www.sciencedirect.com/science/arti...
Reposted by Juan Melero-Martin
Member publication alert:
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment
www.nature.com/articles/s44...
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment
www.nature.com/articles/s44...
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment - Nature Cardiovascular Research
Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while simultaneously preventing iPS cell-...
www.nature.com
June 17, 2025 at 9:37 PM
Member publication alert:
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment
www.nature.com/articles/s44...
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment
www.nature.com/articles/s44...
Reposted by Juan Melero-Martin
Vascular organoids promote revascularization of ischemic muscle and pancreatic islet transplantation in mice www.cell.com/cell-stem-ce... #NBThighlight
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
Melero-Martin and colleagues developed a rapid method to generate vascular organoids
from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1.
This strategy enabled contro...
www.cell.com
June 17, 2025 at 7:49 AM
Vascular organoids promote revascularization of ischemic muscle and pancreatic islet transplantation in mice www.cell.com/cell-stem-ce... #NBThighlight
Our latest paper is out in Cell Stem Cell! We show how co-activation of ETV2 and NKX3.1 in iPSCs generates vascular organoids with functional microvasculature. A powerful platform for vascular therapies. @bostonchildrens.bsky.social @cellpress.bsky.social ss.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
Melero-Martin and colleagues developed a rapid method to generate vascular organoids
from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1.
This strategy enabled contro...
www.cell.com
June 13, 2025 at 3:55 PM
Our latest paper is out in Cell Stem Cell! We show how co-activation of ETV2 and NKX3.1 in iPSCs generates vascular organoids with functional microvasculature. A powerful platform for vascular therapies. @bostonchildrens.bsky.social @cellpress.bsky.social ss.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
New in @natcardiovascres.nature.com. ETV2 guides endothelial cell fate by recruiting REST to repress alternative lineages. This paper offers new insights into EC specification using single-cell multi-omics. Glad to have contributed!
#ETV2 #endothelialcells #stemcells
www.nature.com/articles/s44...
#ETV2 #endothelialcells #stemcells
www.nature.com/articles/s44...
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment - Nature Cardiovascular Research
Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while simultaneously preventing iPS cell-...
www.nature.com
June 10, 2025 at 2:02 PM
New in @natcardiovascres.nature.com. ETV2 guides endothelial cell fate by recruiting REST to repress alternative lineages. This paper offers new insights into EC specification using single-cell multi-omics. Glad to have contributed!
#ETV2 #endothelialcells #stemcells
www.nature.com/articles/s44...
#ETV2 #endothelialcells #stemcells
www.nature.com/articles/s44...
Excited to share our new review, now online at Trends in Cell Biology! We discuss mitochondrial transfer in endothelial cells and its role in vascular health. Big shoutout to first author Gwang-Bum Im for putting this together! @cellpress.bsky.social
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Mitochondrial transfer in endothelial cells and vascular health
Mitochondria play a vital role in cellular energy metabolism and vascular health,
with their function directly influencing endothelial cell (EC) bioenergetics and integrity.
Mitochondrial transfer has...
www.cell.com
May 15, 2025 at 7:37 PM
Excited to share our new review, now online at Trends in Cell Biology! We discuss mitochondrial transfer in endothelial cells and its role in vascular health. Big shoutout to first author Gwang-Bum Im for putting this together! @cellpress.bsky.social
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Exciting new work from the Bischoff Lab just out in @jclinical-invest.bsky.social - They reveal how the endothelial SOX18–mevalonate pathway axis opens the door to repurposing statins for treating infantile hemangioma.
www.jci.org/articles/vie...
Editor’s Note: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Editor’s Note: www.jci.org/articles/vie...
April 2, 2025 at 9:11 PM
Exciting new work from the Bischoff Lab just out in @jclinical-invest.bsky.social - They reveal how the endothelial SOX18–mevalonate pathway axis opens the door to repurposing statins for treating infantile hemangioma.
www.jci.org/articles/vie...
Editor’s Note: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Editor’s Note: www.jci.org/articles/vie...
Reposted by Juan Melero-Martin
Time flies! This week, we say goodbye to Hyunjung (Emily) Kim, a visiting graduate student from Seoul National University. Emily, it’s been fantastic having you @bostonchildrens.bsky.social @harvardmed.bsky.social —your energy and hard work will be missed. Wishing you all the best back in Korea!
February 11, 2025 at 2:24 AM
Time flies! This week, we say goodbye to Hyunjung (Emily) Kim, a visiting graduate student from Seoul National University. Emily, it’s been fantastic having you @bostonchildrens.bsky.social @harvardmed.bsky.social —your energy and hard work will be missed. Wishing you all the best back in Korea!
Reposted by Juan Melero-Martin
Although it's only January, slots are filling up quickly for #GRC_Angiogenesis! If you love blood vessels and wanna dig into their interactions with their neighbors, Newport is the place to be this summer! We will soon start selecting abstracts for short talks! Don't wait, apply today. Link 👇
January 24, 2025 at 12:13 PM
Although it's only January, slots are filling up quickly for #GRC_Angiogenesis! If you love blood vessels and wanna dig into their interactions with their neighbors, Newport is the place to be this summer! We will soon start selecting abstracts for short talks! Don't wait, apply today. Link 👇
Excited to speak at the @medicinebydesign.bsky.social Global Speaker Series on Jan 21! I'll be sharing recent work from @bostonchildrens.bsky.social & @harvardmed.bsky.social. Looking forward to great discussions & meeting amazing faculty!
mbd.utoronto.ca/event/global...
January 13, 2025 at 1:48 PM
Excited to speak at the @medicinebydesign.bsky.social Global Speaker Series on Jan 21! I'll be sharing recent work from @bostonchildrens.bsky.social & @harvardmed.bsky.social. Looking forward to great discussions & meeting amazing faculty!
mbd.utoronto.ca/event/global...
Reposted by Juan Melero-Martin
NEW: GutID, the first commercial human gut health test powered by HiFi sequencing, sets a new benchmark in gut microbiome testing. Learn how this transformative tool leverages #PacBio tech to open new frontiers in #healthcare by providing deeper insights into the human #microbiome. bit.ly/3CfmGIF
January 10, 2025 at 4:01 PM
NEW: GutID, the first commercial human gut health test powered by HiFi sequencing, sets a new benchmark in gut microbiome testing. Learn how this transformative tool leverages #PacBio tech to open new frontiers in #healthcare by providing deeper insights into the human #microbiome. bit.ly/3CfmGIF
Yesterday, we celebrated the holidays at our annual Department of Cardiac Surgery party! The Melero-Martin Lab enjoyed great food, a few drinks, and even better company. Grateful for such an amazing team. Wishing all a joyful holiday season! 🎊🎄 @bostonchildrens.bsky.social @harvardmed.bsky.social
December 18, 2024 at 2:17 PM
Yesterday, we celebrated the holidays at our annual Department of Cardiac Surgery party! The Melero-Martin Lab enjoyed great food, a few drinks, and even better company. Grateful for such an amazing team. Wishing all a joyful holiday season! 🎊🎄 @bostonchildrens.bsky.social @harvardmed.bsky.social
Check out this fantastic work by our lab alumnus Kai Wang: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Now out in Cell Stem Cell
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
Pan et al. generate lineage-specific venous endothelial cells with a heterozygous
TIE2-mutation from human iPSCs to recapitulate venous malformations in vitro and in vivo.
Deep learning combined with ...
www.cell.com
November 24, 2024 at 4:20 AM
Check out this fantastic work by our lab alumnus Kai Wang: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Now out in Cell Stem Cell
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Our lab just got bigger! This fall, we welcomed three new postdocs—Dr. Shih-Yen Wei (Taiwan), Dr. JinJu Kim (Korea), and Dr. Youlu Chen (China)—and visiting student Hyunjung Kim (Korea) to our team at @bostonchildrens.bsky.social and @harvardmed.bsky.social. Welcome aboard!
meleromartinlab.com
meleromartinlab.com
November 22, 2024 at 1:16 PM
Our lab just got bigger! This fall, we welcomed three new postdocs—Dr. Shih-Yen Wei (Taiwan), Dr. JinJu Kim (Korea), and Dr. Youlu Chen (China)—and visiting student Hyunjung Kim (Korea) to our team at @bostonchildrens.bsky.social and @harvardmed.bsky.social. Welcome aboard!
meleromartinlab.com
meleromartinlab.com