ちけらぼ Chike Lab.
@chike-lab.bsky.social
Takako S. Chikenji & Yuki Saito, Senescence, Chronic inflammation, Fibrosis, Regeneration, Regenerative therapy
https://www.chikenjisaitolab.org/
https://www.chikenjisaitolab.org/
Reposted by ちけらぼ Chike Lab.
Systematic profiling reveals betaine as an exercise mimetic for geroprotection: Cell www.cell.com/cell/fulltex...
Systematic profiling reveals betaine as an exercise mimetic for geroprotection
Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived
betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and
geroprotective activit...
www.cell.com
June 25, 2025 at 5:28 PM
Systematic profiling reveals betaine as an exercise mimetic for geroprotection: Cell www.cell.com/cell/fulltex...
Reposted by ちけらぼ Chike Lab.
✨July Issue✨| Immunometabolism in systemic lupus erythematosus
SLE is characterized by altered metabolic profiles and changes in immune cell metabolism. The authors discuss how interventions that target metabolic processes might provide treatment options for SLE.
bit.ly/4kTL0Ru
#Rheumsky #Medsky
SLE is characterized by altered metabolic profiles and changes in immune cell metabolism. The authors discuss how interventions that target metabolic processes might provide treatment options for SLE.
bit.ly/4kTL0Ru
#Rheumsky #Medsky
Immunometabolism in systemic lupus erythematosus - Nature Reviews Rheumatology
Systemic lupus erythematosus is characterized by altered metabolic profiles and changes in immune cell metabolism. The authors review these changes and discuss how interventions that target metab...
bit.ly
June 26, 2025 at 8:42 AM
✨July Issue✨| Immunometabolism in systemic lupus erythematosus
SLE is characterized by altered metabolic profiles and changes in immune cell metabolism. The authors discuss how interventions that target metabolic processes might provide treatment options for SLE.
bit.ly/4kTL0Ru
#Rheumsky #Medsky
SLE is characterized by altered metabolic profiles and changes in immune cell metabolism. The authors discuss how interventions that target metabolic processes might provide treatment options for SLE.
bit.ly/4kTL0Ru
#Rheumsky #Medsky
Reposted by ちけらぼ Chike Lab.
Prospective cohort study in the UK Biobank investigated assoc. between the EAT-Lancet diet and rheumatoid arthritis. Greater adherence to the EAT-Lancet diet was linked to reduced risk of RA, with significant mediation by the metabolomic signature
Arthritis & Rheumatology
doi.org/10.1002/art....
Arthritis & Rheumatology
doi.org/10.1002/art....
June 26, 2025 at 1:05 PM
Prospective cohort study in the UK Biobank investigated assoc. between the EAT-Lancet diet and rheumatoid arthritis. Greater adherence to the EAT-Lancet diet was linked to reduced risk of RA, with significant mediation by the metabolomic signature
Arthritis & Rheumatology
doi.org/10.1002/art....
Arthritis & Rheumatology
doi.org/10.1002/art....
Reposted by ちけらぼ Chike Lab.
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science www.science.org/doi/10.1126/...
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...
www.science.org
June 26, 2025 at 6:26 PM
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science www.science.org/doi/10.1126/...
Reposted by ちけらぼ Chike Lab.
Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
www.science.org
June 20, 2025 at 6:34 PM
Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!
Reposted by ちけらぼ Chike Lab.
👋Our June issue's out!
Cover: #Ferroptosis hotspots
👉🏼Editorial on #microscopy reporting
👉🏼Review on #mitochondria membrane
🔬 #cholesterol transport #neutrophils #exosomes #CellDeath #RNA #DNArepair #BreastCancer #ExtracellularVesicles #peroxisome proteins & more!
www.nature.com/ncb/volumes/...
Cover: #Ferroptosis hotspots
👉🏼Editorial on #microscopy reporting
👉🏼Review on #mitochondria membrane
🔬 #cholesterol transport #neutrophils #exosomes #CellDeath #RNA #DNArepair #BreastCancer #ExtracellularVesicles #peroxisome proteins & more!
www.nature.com/ncb/volumes/...
June 20, 2025 at 2:19 PM
👋Our June issue's out!
Cover: #Ferroptosis hotspots
👉🏼Editorial on #microscopy reporting
👉🏼Review on #mitochondria membrane
🔬 #cholesterol transport #neutrophils #exosomes #CellDeath #RNA #DNArepair #BreastCancer #ExtracellularVesicles #peroxisome proteins & more!
www.nature.com/ncb/volumes/...
Cover: #Ferroptosis hotspots
👉🏼Editorial on #microscopy reporting
👉🏼Review on #mitochondria membrane
🔬 #cholesterol transport #neutrophils #exosomes #CellDeath #RNA #DNArepair #BreastCancer #ExtracellularVesicles #peroxisome proteins & more!
www.nature.com/ncb/volumes/...
Reposted by ちけらぼ Chike Lab.
How do shortened telomeres affect organismal health-/lifespan?
Using a zebrafish model, Miguel Godinho Ferreira @miguelgf.bsky.social and coworkers show that premature aging symptoms depend on cGAS-STING signaling
www.embopress.org/doi/full/10....
Using a zebrafish model, Miguel Godinho Ferreira @miguelgf.bsky.social and coworkers show that premature aging symptoms depend on cGAS-STING signaling
www.embopress.org/doi/full/10....
June 10, 2025 at 7:32 AM
How do shortened telomeres affect organismal health-/lifespan?
Using a zebrafish model, Miguel Godinho Ferreira @miguelgf.bsky.social and coworkers show that premature aging symptoms depend on cGAS-STING signaling
www.embopress.org/doi/full/10....
Using a zebrafish model, Miguel Godinho Ferreira @miguelgf.bsky.social and coworkers show that premature aging symptoms depend on cGAS-STING signaling
www.embopress.org/doi/full/10....
Reposted by ちけらぼ Chike Lab.
Really interesting study...still reading it but really enjoying it.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Ecological Realism Accelerates Epigenetic Aging in Mice
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory-reared and....
onlinelibrary.wiley.com
May 24, 2025 at 2:12 AM
Really interesting study...still reading it but really enjoying it.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by ちけらぼ Chike Lab.
Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species.
Learn more in a new #SciencePerspective: scim.ag/43iprSX
Learn more in a new #SciencePerspective: scim.ag/43iprSX
Astrocytes, hidden puppet masters of the brain
Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators
scim.ag
May 16, 2025 at 3:10 PM
Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species.
Learn more in a new #SciencePerspective: scim.ag/43iprSX
Learn more in a new #SciencePerspective: scim.ag/43iprSX
Reposted by ちけらぼ Chike Lab.
🚨 Calling senescence researchers!
Applications are open for the #ICSARome2025
@icsasenescence.bsky.social & @yicsac.bsky.social
Travel Fellowships 🌍✈️
Need-based & merit-based awards available!
🗓️ Deadline: May 15
Applications are open for the #ICSARome2025
@icsasenescence.bsky.social & @yicsac.bsky.social
Travel Fellowships 🌍✈️
Need-based & merit-based awards available!
🗓️ Deadline: May 15
April 10, 2025 at 7:01 PM
🚨 Calling senescence researchers!
Applications are open for the #ICSARome2025
@icsasenescence.bsky.social & @yicsac.bsky.social
Travel Fellowships 🌍✈️
Need-based & merit-based awards available!
🗓️ Deadline: May 15
Applications are open for the #ICSARome2025
@icsasenescence.bsky.social & @yicsac.bsky.social
Travel Fellowships 🌍✈️
Need-based & merit-based awards available!
🗓️ Deadline: May 15
Reposted by ちけらぼ Chike Lab.
Psychedelics reduce fear by targeting immune cells that modulate brain cells
This Nature paper uses a combination of genomic & behavioural screens to show that astrocytes in the amygdala limit stress-induced fear behaviour through epidermal growth factor receptor
🧪
www.nature.com/articles/s41...
This Nature paper uses a combination of genomic & behavioural screens to show that astrocytes in the amygdala limit stress-induced fear behaviour through epidermal growth factor receptor
🧪
www.nature.com/articles/s41...
Psychedelic control of neuroimmune interactions governing fear - Nature
Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.
www.nature.com
April 27, 2025 at 5:45 AM
Psychedelics reduce fear by targeting immune cells that modulate brain cells
This Nature paper uses a combination of genomic & behavioural screens to show that astrocytes in the amygdala limit stress-induced fear behaviour through epidermal growth factor receptor
🧪
www.nature.com/articles/s41...
This Nature paper uses a combination of genomic & behavioural screens to show that astrocytes in the amygdala limit stress-induced fear behaviour through epidermal growth factor receptor
🧪
www.nature.com/articles/s41...
ちけらぼ 山本花練さん(M2) Best Presentation Awardを受賞
www.chikenjisaitolab.org/post/%E5%B1%...
www.chikenjisaitolab.org/post/%E5%B1%...
山本花練さん(M2) Best Presentation Awardを受賞
令和６年度北海道大学大学院保健科学院修士課程研究発表賞(Best Presentation Award)を山本花練さんが受賞しました！おめでとうございます！
https://www.chikenjisaitolab.org/post/山本花練さん-m2-best-presentation-awardを受賞
March 31, 2025 at 12:48 PM
ちけらぼ 山本花練さん(M2) Best Presentation Awardを受賞
www.chikenjisaitolab.org/post/%E5%B1%...
www.chikenjisaitolab.org/post/%E5%B1%...
Reposted by ちけらぼ Chike Lab.
The #tidyplots paper is now published in iMeta 🎉🥳🔥
Whenever you use tidyplots in your published work, consider citing doi.org/10.1002/imt2... 🙏
#rstats #dataviz #phd
Whenever you use tidyplots in your published work, consider citing doi.org/10.1002/imt2... 🙏
#rstats #dataviz #phd
March 19, 2025 at 5:41 PM
The #tidyplots paper is now published in iMeta 🎉🥳🔥
Whenever you use tidyplots in your published work, consider citing doi.org/10.1002/imt2... 🙏
#rstats #dataviz #phd
Whenever you use tidyplots in your published work, consider citing doi.org/10.1002/imt2... 🙏
#rstats #dataviz #phd
Reposted by ちけらぼ Chike Lab.
Reposted by ちけらぼ Chike Lab.
Research Highlight ✨|TASL has a key role in SLE
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
March 12, 2025 at 10:19 AM
Research Highlight ✨|TASL has a key role in SLE
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖
@rebsamenlab.bsky.social
@dib-unil.bsky.social
Reposted by ちけらぼ Chike Lab.
見逃されてきた「ダークプロテイン」(News記事)
ゲノム上でタンパク質をコードすると考えられていなかった領域から、多数の「ダークプロテイン」が発現することが明らかになっている。遺伝子調節やがんにおいて重要な役割を果たす可能性があり、 治療標的としても重要かも。
まだまだ謎は多い、、
ゲノム上でタンパク質をコードすると考えられていなかった領域から、多数の「ダークプロテイン」が発現することが明らかになっている。遺伝子調節やがんにおいて重要な役割を果たす可能性があり、 治療標的としても重要かも。
まだまだ謎は多い、、
‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.
www.nature.com
February 8, 2025 at 10:00 AM
見逃されてきた「ダークプロテイン」(News記事)
ゲノム上でタンパク質をコードすると考えられていなかった領域から、多数の「ダークプロテイン」が発現することが明らかになっている。遺伝子調節やがんにおいて重要な役割を果たす可能性があり、 治療標的としても重要かも。
まだまだ謎は多い、、
ゲノム上でタンパク質をコードすると考えられていなかった領域から、多数の「ダークプロテイン」が発現することが明らかになっている。遺伝子調節やがんにおいて重要な役割を果たす可能性があり、 治療標的としても重要かも。
まだまだ謎は多い、、
Reposted by ちけらぼ Chike Lab.
ggalign: Bridging the Grammar of Graphics and Biological Multilayered Complexity 🧬🖥️🧪
Paper: https://www.biorxiv.org/content/10.1101/2025.02.06.636847v1
#Rstats Code: https://github.com/Yunuuuu/ggalign
Docs: https://yunuuuu.github.io/ggalign/
Book (Quarto): https://yunuuuu.github.io/ggalign-book/
Paper: https://www.biorxiv.org/content/10.1101/2025.02.06.636847v1
#Rstats Code: https://github.com/Yunuuuu/ggalign
Docs: https://yunuuuu.github.io/ggalign/
Book (Quarto): https://yunuuuu.github.io/ggalign-book/
February 8, 2025 at 12:14 PM
ggalign: Bridging the Grammar of Graphics and Biological Multilayered Complexity 🧬🖥️🧪
Paper: https://www.biorxiv.org/content/10.1101/2025.02.06.636847v1
#Rstats Code: https://github.com/Yunuuuu/ggalign
Docs: https://yunuuuu.github.io/ggalign/
Book (Quarto): https://yunuuuu.github.io/ggalign-book/
Paper: https://www.biorxiv.org/content/10.1101/2025.02.06.636847v1
#Rstats Code: https://github.com/Yunuuuu/ggalign
Docs: https://yunuuuu.github.io/ggalign/
Book (Quarto): https://yunuuuu.github.io/ggalign-book/
Reposted by ちけらぼ Chike Lab.
In this review, Narain et al. discuss the contribution of mechanical force, at both the cellular and tissue levels, to cancer development, metastasis, and treatment response.
Learn more here:
➡️ tinyurl.com/gd352110
Learn more here:
➡️ tinyurl.com/gd352110
January 29, 2025 at 6:43 PM
In this review, Narain et al. discuss the contribution of mechanical force, at both the cellular and tissue levels, to cancer development, metastasis, and treatment response.
Learn more here:
➡️ tinyurl.com/gd352110
Learn more here:
➡️ tinyurl.com/gd352110
Reposted by ちけらぼ Chike Lab.
タンパク質凝集体と細胞の休止状態
細菌においてタンパク質凝集がエネルギー産生に関与するタンパク質を隔離しATP枯渇を引き起こすことで休眠状態を誘導するらしい。さらに凝集体が固化することで休眠からの成長再開が阻害されるらしい
物性変化で運命が変わるのは面白い
細菌においてタンパク質凝集がエネルギー産生に関与するタンパク質を隔離しATP枯渇を引き起こすことで休眠状態を誘導するらしい。さらに凝集体が固化することで休眠からの成長再開が阻害されるらしい
物性変化で運命が変わるのは面白い
Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery - Nature Communications
Recalcitrant infections are often caused by dormant bacteria, including persisters and viable but nonculturable cells. Here, the authors explore how composition and structure of protein aggregates…
www.nature.com
January 27, 2025 at 10:00 AM
タンパク質凝集体と細胞の休止状態
細菌においてタンパク質凝集がエネルギー産生に関与するタンパク質を隔離しATP枯渇を引き起こすことで休眠状態を誘導するらしい。さらに凝集体が固化することで休眠からの成長再開が阻害されるらしい
物性変化で運命が変わるのは面白い
細菌においてタンパク質凝集がエネルギー産生に関与するタンパク質を隔離しATP枯渇を引き起こすことで休眠状態を誘導するらしい。さらに凝集体が固化することで休眠からの成長再開が阻害されるらしい
物性変化で運命が変わるのは面白い
Reposted by ちけらぼ Chike Lab.
New #JCI_insight paper: Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair. #MyoBlue tinyurl.com/52xznpcx
JCI Insight -
Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair
tinyurl.com
January 28, 2025 at 5:25 PM
New #JCI_insight paper: Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair. #MyoBlue tinyurl.com/52xznpcx
Reposted by ちけらぼ Chike Lab.
January 24, 2025 at 9:00 PM
Reposted by ちけらぼ Chike Lab.
#tidyplots offers a variety of discrete color schemes 🌈
The default scheme `colors_discrete_friendly` is inspired by Okabe and Ito (2008) and was designed to maximize accessibility for individuals with color vision deficiencies.
#rstats #dataviz #phd
The default scheme `colors_discrete_friendly` is inspired by Okabe and Ito (2008) and was designed to maximize accessibility for individuals with color vision deficiencies.
#rstats #dataviz #phd
January 18, 2025 at 12:42 AM
#tidyplots offers a variety of discrete color schemes 🌈
The default scheme `colors_discrete_friendly` is inspired by Okabe and Ito (2008) and was designed to maximize accessibility for individuals with color vision deficiencies.
#rstats #dataviz #phd
The default scheme `colors_discrete_friendly` is inspired by Okabe and Ito (2008) and was designed to maximize accessibility for individuals with color vision deficiencies.
#rstats #dataviz #phd
Reposted by ちけらぼ Chike Lab.
New website for #tidyplots use cases, complete with data and code 🤩
tidyplots.org/use-cases/
#rstats #dataviz #phd
tidyplots.org/use-cases/
#rstats #dataviz #phd
January 13, 2025 at 3:32 PM
New website for #tidyplots use cases, complete with data and code 🤩
tidyplots.org/use-cases/
#rstats #dataviz #phd
tidyplots.org/use-cases/
#rstats #dataviz #phd
Reposted by ちけらぼ Chike Lab.
Stanford has launched a beta version of an incredible research #AI tool.
It’s called #STORM, and basically you enter a topic and it will search hundreds of websites to write an article about its major findings.
Available to everyone for free!
storm.genie.stanford.edu
It’s called #STORM, and basically you enter a topic and it will search hundreds of websites to write an article about its major findings.
Available to everyone for free!
storm.genie.stanford.edu
I agree to the terms of service.
storm.genie.stanford.edu
January 1, 2025 at 8:47 AM
Stanford has launched a beta version of an incredible research #AI tool.
It’s called #STORM, and basically you enter a topic and it will search hundreds of websites to write an article about its major findings.
Available to everyone for free!
storm.genie.stanford.edu
It’s called #STORM, and basically you enter a topic and it will search hundreds of websites to write an article about its major findings.
Available to everyone for free!
storm.genie.stanford.edu
Reposted by ちけらぼ Chike Lab.
2. Sousa et al., Cell Rep. The immune landscape of murine skeletal muscle regeneration and aging. tinyurl.com/ucmj2s87
The immune landscape of murine skeletal muscle regeneration and aging
Sousa et al. characterized, with time and single-cell resolution, the immune environment of the regenerating skeletal muscle, revealing a profound remodeling of myeloid and lymphoid compartments in aging. This knowledge anticipates the potential of immune cells as targets to improve regenerative capacity in aging.
tinyurl.com
December 30, 2024 at 1:58 PM
2. Sousa et al., Cell Rep. The immune landscape of murine skeletal muscle regeneration and aging. tinyurl.com/ucmj2s87