Christian Seitz
@chemchristian.bsky.social
Viruses, vaccines, and some big big computers at the University of Chicago | Argonne National Laboratory with @ramanathanlab.bsky.social and Jim Davis. he/him ✞⚽🎾
Paper was rejected today! Scanning through the reviews, there were some factual/scientific errors that need to be corrected before it can be published 😱 Happy that peer review caught this, would much rather publish a better paper later than rush one out with errors
November 24, 2025 at 10:10 PM
Paper was rejected today! Scanning through the reviews, there were some factual/scientific errors that need to be corrected before it can be published 😱 Happy that peer review caught this, would much rather publish a better paper later than rush one out with errors
Reposted by Christian Seitz
Reviving this account to say that the last paper from my PhD is out in final form!
Here, we look at how the timing of artificial tactile sensations (delivered via intracortical microstimulation/ICMS) is perceived relative to visual cues in two participants with spinal cord injuries. 🧠✋👀
Here, we look at how the timing of artificial tactile sensations (delivered via intracortical microstimulation/ICMS) is perceived relative to visual cues in two participants with spinal cord injuries. 🧠✋👀
Visual context affects the perceived timing of tactile sensations elicited through intracortical microstimulation: a case study of two participants | Journal of Neurophysiology | American Physiologica...
Intracortical microstimulation (ICMS) is a technique to provide tactile sensations for a somatosensory brain-machine interface (BMI). A viable BMI must function within the rich, multisensory environme...
journals.physiology.org
November 24, 2025 at 8:21 PM
Reviving this account to say that the last paper from my PhD is out in final form!
Here, we look at how the timing of artificial tactile sensations (delivered via intracortical microstimulation/ICMS) is perceived relative to visual cues in two participants with spinal cord injuries. 🧠✋👀
Here, we look at how the timing of artificial tactile sensations (delivered via intracortical microstimulation/ICMS) is perceived relative to visual cues in two participants with spinal cord injuries. 🧠✋👀
Reposted by Christian Seitz
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
May 28, 2025 at 10:18 AM
The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.
Reposted by Christian Seitz
Are you a grad student or postdoc at the bench in the UC system? If so, please DM.
(for the record, this is a question about laboratory procedure, not any individual PI)
#chemsky ⚗️
(for the record, this is a question about laboratory procedure, not any individual PI)
#chemsky ⚗️
May 22, 2025 at 6:38 PM
Are you a grad student or postdoc at the bench in the UC system? If so, please DM.
(for the record, this is a question about laboratory procedure, not any individual PI)
#chemsky ⚗️
(for the record, this is a question about laboratory procedure, not any individual PI)
#chemsky ⚗️
Here at the BV-BRC workshop - refreshing to be at a workshop without a set problem to solve. Learning just for the sake of learning 😉
May 5, 2025 at 9:53 PM
Here at the BV-BRC workshop - refreshing to be at a workshop without a set problem to solve. Learning just for the sake of learning 😉
Reposted by Christian Seitz
Some crystal structures show evidence of multiple stable conformations, such as loops or side chains with two distinct regions of density. These can be correctly modeled by MD, but not modern protein ensemble prediction tools like AlphaFlow or DiG (BioEmu not tested)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 23, 2025 at 2:32 PM
Some crystal structures show evidence of multiple stable conformations, such as loops or side chains with two distinct regions of density. These can be correctly modeled by MD, but not modern protein ensemble prediction tools like AlphaFlow or DiG (BioEmu not tested)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This is a cool program I've worked with for a few years matching STEM professionals and students as pen pals; if you're a 5th-8th grade teacher interested in pen pals for the fall, check out prescientist.org/for-teachers/
For Teachers - Letters to a Pre-Scientist
Overview Are you a 5-8th grade STEM teacher in the US who wants to bring Letters to a Pre-Scientist into your classroom? We would love to hear from you! Teacher ...
prescientist.org
April 16, 2025 at 9:26 PM
This is a cool program I've worked with for a few years matching STEM professionals and students as pen pals; if you're a 5th-8th grade teacher interested in pen pals for the fall, check out prescientist.org/for-teachers/
every time I'm off blue sky for more than a day or two and return, my feed (I only follow scientists) morphs into a tsunami of political clickbait, worse than twitter. Blocking left and right but it never gets any better. Spending less and less time here because of all the political junk smh
April 11, 2025 at 9:02 PM
every time I'm off blue sky for more than a day or two and return, my feed (I only follow scientists) morphs into a tsunami of political clickbait, worse than twitter. Blocking left and right but it never gets any better. Spending less and less time here because of all the political junk smh
not attending but met up with @leftymiller.bsky.social at #ACSSpring2025! I feel people are always excited about the science at conferences but I'm always excited about the connections and the people behind the science
March 25, 2025 at 10:51 PM
not attending but met up with @leftymiller.bsky.social at #ACSSpring2025! I feel people are always excited about the science at conferences but I'm always excited about the connections and the people behind the science
Reposted by Christian Seitz
happy to say it - our projects are hiring again!
Job Board
All OMSF positions are currently remote, and we generally accept applications worldwide. Some positions may be restricted to the United States. All positions require a valid work permit - OMSF has lim...
omsf.io
February 20, 2025 at 9:57 PM
happy to say it - our projects are hiring again!
Reposted by Christian Seitz
Water-mediated interactions between glycans are weakly repulsive and unexpectedly long-ranged https://www.biorxiv.org/content/10.1101/2025.02.16.638483v1
February 21, 2025 at 1:48 AM
Water-mediated interactions between glycans are weakly repulsive and unexpectedly long-ranged https://www.biorxiv.org/content/10.1101/2025.02.16.638483v1
Reposted by Christian Seitz
Everything is chaos, but I wanted to share some awesome recent science from the lab that hints at where the future of biomolecular simulation is headed:
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
February 19, 2025 at 7:30 PM
Everything is chaos, but I wanted to share some awesome recent science from the lab that hints at where the future of biomolecular simulation is headed:
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
Foundation simulation models that can be fine-tuned to experimental free energy data to produce systematically more accurate predictions.
exciting times! Will definitely be trying this out
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
February 17, 2025 at 7:06 PM
exciting times! Will definitely be trying this out
Reposted by Christian Seitz
#compchem Good read: Markov State Models with Weighted Ensemble Simulation: How to Eliminate the Trajectory Merging Bias #compchemsky #biosky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Markov State Models with Weighted Ensemble Simulation: How to Eliminate the Trajectory Merging Bias
The weighted ensemble (WE) algorithm is gaining popularity as a rare event method for studying long timescale processes with molecular dynamics. WE is particularly useful for determining kinetic prope...
pubs.acs.org
February 14, 2025 at 12:10 PM
#compchem Good read: Markov State Models with Weighted Ensemble Simulation: How to Eliminate the Trajectory Merging Bias #compchemsky #biosky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Christian Seitz
🚨Preprint Alert!🚨
#ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔
Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️
biorxiv.org/content/10.1...
1/🧵
#ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔
Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️
biorxiv.org/content/10.1...
1/🧵
February 12, 2025 at 7:01 PM
🚨Preprint Alert!🚨
#ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔
Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️
biorxiv.org/content/10.1...
1/🧵
#ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔
Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️
biorxiv.org/content/10.1...
1/🧵
Reposted by Christian Seitz
We’re thrilled to announce the launch of Bind Research, the UK’s first not-for-profit Focused Research Organisation, with long-term support from the Department for Science, Innovation and Technology’s Research Ventures Catalyst Programme, industry, and charities.
February 11, 2025 at 9:24 AM
We’re thrilled to announce the launch of Bind Research, the UK’s first not-for-profit Focused Research Organisation, with long-term support from the Department for Science, Innovation and Technology’s Research Ventures Catalyst Programme, industry, and charities.
Reposted by Christian Seitz
We developed a computationally efficient method to predict hot spots driving conformational changes in small molecule sensing proteins. It can easily be generalized to explore allosteric couplings in a wide range of proteins. Code available in the preprint, check it out ! #compchem #compbio
Can we determine the positions whose simulataneous perturbation would lead to maximum overlap between two conformers? We solve this problem and demonstrate its utility on sensor design -- by @mberksoz.bsky.social, @ara-17.bsky.social, Burak Kocuk and @cananatlgn.bsky.social
February 11, 2025 at 7:12 PM
Reposted by Christian Seitz
CDR3 loop conformation, specifically whether the C-terminus is kinked or not, is a major determinants of whether a nanobody-antigen complex is correctly predicted using SOTA protein structure prediction software doi.org/10.1021/acs....
February 13, 2025 at 7:06 AM
CDR3 loop conformation, specifically whether the C-terminus is kinked or not, is a major determinants of whether a nanobody-antigen complex is correctly predicted using SOTA protein structure prediction software doi.org/10.1021/acs....
Reposted by Christian Seitz
First new work from @moldynfr.bsky.social and me in collaboration with Sebastian Milster and Joe Dzubiella herein Freiburg: coarse-graining the transport dynamics of particles through responsive media via Langevin equation models. #Chemsky #compchem #softmatter arxiv.org/abs/2501.18484
Nonequilibrium friction and free energy estimates for kinetic coarse-graining -- Driven particles in responsive media
Predicting the molecular friction and energy landscapes under nonequilibrium conditions is key to coarse-graining the dynamics of selective solute transport through complex, fluctuating and responsive...
arxiv.org
January 31, 2025 at 9:38 AM
First new work from @moldynfr.bsky.social and me in collaboration with Sebastian Milster and Joe Dzubiella herein Freiburg: coarse-graining the transport dynamics of particles through responsive media via Langevin equation models. #Chemsky #compchem #softmatter arxiv.org/abs/2501.18484
Reposted by Christian Seitz
Our colleagues in Prague have released a database for molecular biophysics data - mbdb-data.org! 🌍📊 A great step forwards FAIR data in biophysics. 🙌✨ @mosbri.bsky.social
Molecular Biophysics Database
mbdb-data.org
January 31, 2025 at 10:24 AM
Our colleagues in Prague have released a database for molecular biophysics data - mbdb-data.org! 🌍📊 A great step forwards FAIR data in biophysics. 🙌✨ @mosbri.bsky.social
Reposted by Christian Seitz
MSKCC is looking for an AI Drug Discovery Lead to drive collaborations between researchers and pharma/biotech within the Office of Technology Development to accelerate the discovery and development of new therapeutics:
www.linkedin.com/jobs/view/41...
www.linkedin.com/jobs/view/41...
Memorial Sloan Kettering Cancer Center hiring AI Drug Discovery Lead in New York, NY | LinkedIn
Posted 4:46:37 PM. $118,800.00-$196,200.00Company Overview The people of Memorial Sloan Kettering Cancer Center (MSK)…See this and similar jobs on LinkedIn.
www.linkedin.com
January 31, 2025 at 3:52 PM
MSKCC is looking for an AI Drug Discovery Lead to drive collaborations between researchers and pharma/biotech within the Office of Technology Development to accelerate the discovery and development of new therapeutics:
www.linkedin.com/jobs/view/41...
www.linkedin.com/jobs/view/41...
Reposted by Christian Seitz
There's just one week until the application period ends for the Frontera Fellowship! Collaborate with experts at the Texas Advanced Computing Center and use the powerful Frontera supercomputer to aid your research. Applications close February 7.
Learn more: bit.ly/425QQc7
Learn more: bit.ly/425QQc7
January 31, 2025 at 9:26 PM
There's just one week until the application period ends for the Frontera Fellowship! Collaborate with experts at the Texas Advanced Computing Center and use the powerful Frontera supercomputer to aid your research. Applications close February 7.
Learn more: bit.ly/425QQc7
Learn more: bit.ly/425QQc7
Reposted by Christian Seitz
The Living Journal of Computational Molecular Science (LiveCoMS) is on BlueSky! Check out our recent blog post on why @livecomsjournal.bsky.social matters to find out more about us: livecomsjournal.org/index.php/li... #compchem #chemsky
Why LiveCoMS matters
| Living Journal of Computational Molecular Science
livecomsjournal.org
January 30, 2025 at 9:11 PM
The Living Journal of Computational Molecular Science (LiveCoMS) is on BlueSky! Check out our recent blog post on why @livecomsjournal.bsky.social matters to find out more about us: livecomsjournal.org/index.php/li... #compchem #chemsky
Reposted by Christian Seitz
Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.
More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers
https://go.nature.com/3Ej9RxA
https://go.nature.com/3Ej9RxA
More than 40% of postdocs leave academia, study reveals
Nature - Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
go.nature.com
January 26, 2025 at 11:03 AM
Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.
Reposted by Christian Seitz
Our newest preprint is out. A PyMOL plugin giving access to a broad suite of high-performance, fast, and easy to use methods for virtual screening (50K molecules/h), docking, analysis of molecular interactions, dynamics, engineering permitting complex workflows.
NRGSuite-Qt: A PyMOL plugin for high-throughput virtual screening, molecular docking, normal-mode analysis, the study of molecular interactions and the detection of binding-site similarities https://www.biorxiv.org/content/10.1101/2025.01.23.634566v1
January 24, 2025 at 2:38 PM
Our newest preprint is out. A PyMOL plugin giving access to a broad suite of high-performance, fast, and easy to use methods for virtual screening (50K molecules/h), docking, analysis of molecular interactions, dynamics, engineering permitting complex workflows.