Carmen.Gilgas
@carmengilgas.bsky.social
Biology Teacher|PhD Cell Biology| Focus on cell organization and dynamics| Proud owner of a wannabe white direwolf|
@carmen.gilgas(XTw)
@carmen.gilgas(XTw)
Reposted by Carmen.Gilgas
Is cortical actin the sole driver of cellular membrane bleb expansion?
Junichi Ikenouchi and colleagues implicate also calcium-dependent CaMKII supercomplex reorganization, generating local osmotic pressure to cause water influx for bleb growth
link.springer.com/article/10.1...
Junichi Ikenouchi and colleagues implicate also calcium-dependent CaMKII supercomplex reorganization, generating local osmotic pressure to cause water influx for bleb growth
link.springer.com/article/10.1...
CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion - The EMBO Journal
Blebs are membrane protrusions formed when localized regions of the plasma membrane detach from the actin cortex, enabling outward expansion driven by intracellular pressure. These structures play cri...
link.springer.com
February 5, 2026 at 9:38 AM
Is cortical actin the sole driver of cellular membrane bleb expansion?
Junichi Ikenouchi and colleagues implicate also calcium-dependent CaMKII supercomplex reorganization, generating local osmotic pressure to cause water influx for bleb growth
link.springer.com/article/10.1...
Junichi Ikenouchi and colleagues implicate also calcium-dependent CaMKII supercomplex reorganization, generating local osmotic pressure to cause water influx for bleb growth
link.springer.com/article/10.1...
Reposted by Carmen.Gilgas
For those interested in topological analysis of biomolecular condensates!
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
May 25, 2025 at 10:49 AM
For those interested in topological analysis of biomolecular condensates!
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
Hay quienes, como los agujeros negros, carecen de luz propia. Paradójicamente, son los objetos más brillantes del universo.
February 5, 2026 at 6:57 AM
Hay quienes, como los agujeros negros, carecen de luz propia. Paradójicamente, son los objetos más brillantes del universo.
La manipulación es la herramienta de quien carece de virtudes.
Quien posee integridad, honestidad o carisma genuino, persuade mediante la confianza y la evidencia.
Quien posee integridad, honestidad o carisma genuino, persuade mediante la confianza y la evidencia.
February 5, 2026 at 6:55 AM
La manipulación es la herramienta de quien carece de virtudes.
Quien posee integridad, honestidad o carisma genuino, persuade mediante la confianza y la evidencia.
Quien posee integridad, honestidad o carisma genuino, persuade mediante la confianza y la evidencia.
Reposted by Carmen.Gilgas
For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began
go.nature.com/3JyRV4S
go.nature.com/3JyRV4S
How did life get multicellular? Five simple organisms could have the answer
Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.
go.nature.com
August 27, 2025 at 10:19 AM
For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began
go.nature.com/3JyRV4S
go.nature.com/3JyRV4S
Could mitosis clear misfolded proteins?
June 14, 2025 at 10:35 PM
Could mitosis clear misfolded proteins?
Just some thoughts spiraling today...We have long regarded the cell as a discrete system — and rightly so, but what if that assumption is limiting? more akin to a Möbius strip of membranes and coexisting liquid phases?
June 12, 2025 at 11:39 AM
Just some thoughts spiraling today...We have long regarded the cell as a discrete system — and rightly so, but what if that assumption is limiting? more akin to a Möbius strip of membranes and coexisting liquid phases?
De novo lipid synthesis and polarized prenylation drive cell invasion through basement membrane
pubmed.ncbi.nlm.nih.gov/39007804/
pubmed.ncbi.nlm.nih.gov/39007804/
April 28, 2025 at 7:43 PM
De novo lipid synthesis and polarized prenylation drive cell invasion through basement membrane
pubmed.ncbi.nlm.nih.gov/39007804/
pubmed.ncbi.nlm.nih.gov/39007804/
Reposted by Carmen.Gilgas
"these approaches estimate the number of ribosomes on a transcript, the translation initiation rate, and the overall number of translation events before its decay, all in a genome-wide manner" #rnasky #ribosome www.nature.com/articles/s41...
Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts - Nature Communications
Ribosome profiling faces issues with rRNA contamination and measurements of ribosome numbers on transcripts. Here, the authors develop Ribo-FilterOut and Ribo-Calibration, methods which can be used to...
www.nature.com
March 15, 2025 at 7:53 AM
"these approaches estimate the number of ribosomes on a transcript, the translation initiation rate, and the overall number of translation events before its decay, all in a genome-wide manner" #rnasky #ribosome www.nature.com/articles/s41...
Reposted by Carmen.Gilgas
So... Can be animals without #scutoids?
This a difficult question to answer, you cannot get mutants without scutoids.
So we designed a computational model to demonstrated that it is not possible to form epithelial tubes without apico-basal intercalations.
www.csbj.org/article/S200...
This a difficult question to answer, you cannot get mutants without scutoids.
So we designed a computational model to demonstrated that it is not possible to form epithelial tubes without apico-basal intercalations.
www.csbj.org/article/S200...
March 24, 2025 at 9:17 AM
So... Can be animals without #scutoids?
This a difficult question to answer, you cannot get mutants without scutoids.
So we designed a computational model to demonstrated that it is not possible to form epithelial tubes without apico-basal intercalations.
www.csbj.org/article/S200...
This a difficult question to answer, you cannot get mutants without scutoids.
So we designed a computational model to demonstrated that it is not possible to form epithelial tubes without apico-basal intercalations.
www.csbj.org/article/S200...
Reposted by Carmen.Gilgas
Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW
plos.io/3DRtAEW
March 19, 2025 at 9:13 AM
Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW
plos.io/3DRtAEW
Reposted by Carmen.Gilgas
Study maps RNA polymerase II across 10 cancers, unveiling hypertranscription and its link to poor outcomes. Key: HER2 amplification! #CancerResearch PMID:39946483, Science 2025, @ScienceMagazine https://doi.org/10.1126/science.ads2169 #Medsky #Pharmsky #RNA 🧪
https://doi.org/10.1126/science.ads2169
No description available
doi.org
March 17, 2025 at 10:10 AM
Study maps RNA polymerase II across 10 cancers, unveiling hypertranscription and its link to poor outcomes. Key: HER2 amplification! #CancerResearch PMID:39946483, Science 2025, @ScienceMagazine https://doi.org/10.1126/science.ads2169 #Medsky #Pharmsky #RNA 🧪
Reposted by Carmen.Gilgas
The Translation Termination Factor eRF3 Interacts Sequentially with eRF1 and ABCE1 on the Ribosome https://www.biorxiv.org/content/10.1101/2025.02.05.636767v1
February 8, 2025 at 10:32 PM
The Translation Termination Factor eRF3 Interacts Sequentially with eRF1 and ABCE1 on the Ribosome https://www.biorxiv.org/content/10.1101/2025.02.05.636767v1
Beyond known protein-coding genes, ribosomes are actively translating thousands of previously unrecognized dark proteins 🦹♀️🦹♂️🧟
👇👇👇👇
👇👇👇👇
"Dark proteins." Also known as microproteins. There are thousands of them in our cells and we're still struggling to define their function. Succinctly reviewed @nature.com www.nature.com/articles/d41...
‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases
The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.
www.nature.com
February 3, 2025 at 12:07 AM
Beyond known protein-coding genes, ribosomes are actively translating thousands of previously unrecognized dark proteins 🦹♀️🦹♂️🧟
👇👇👇👇
👇👇👇👇
Reposted by Carmen.Gilgas
Highly recommend Sipser's @mitofficial.bsky.social Theory of Computation course to anyone interested in computation. Thorough and clear introduction. Plus, it’s FREE and available online! 🌐📚
ocw.mit.edu/courses/18-4...
#ComputerScience #TheoryOfComputation #OnlineLearning
ocw.mit.edu/courses/18-4...
#ComputerScience #TheoryOfComputation #OnlineLearning
Theory of Computation | Mathematics | MIT OpenCourseWare
This course emphasizes computability and computational complexity theory. Topics include regular and context-free languages, decidable and undecidable problems, reducibility, recursive function theory...
ocw.mit.edu
January 27, 2025 at 8:49 AM
Highly recommend Sipser's @mitofficial.bsky.social Theory of Computation course to anyone interested in computation. Thorough and clear introduction. Plus, it’s FREE and available online! 🌐📚
ocw.mit.edu/courses/18-4...
#ComputerScience #TheoryOfComputation #OnlineLearning
ocw.mit.edu/courses/18-4...
#ComputerScience #TheoryOfComputation #OnlineLearning
Reposted by Carmen.Gilgas
#NCB2024
In September, @maitrejl.bsky.social, Schliffka, Mukherjee & co showed that in the early mouse #embryo inverse blebs grow into cells at cell–cell adhesion sites in response to luminal fluid accumulation and pressure build-up.
rdcu.be/d4uCu
www.nature.com/articles/s41...
In September, @maitrejl.bsky.social, Schliffka, Mukherjee & co showed that in the early mouse #embryo inverse blebs grow into cells at cell–cell adhesion sites in response to luminal fluid accumulation and pressure build-up.
rdcu.be/d4uCu
www.nature.com/articles/s41...
Inverse blebs operate as hydraulic pumps during mouse blastocyst formation
Nature Cell Biology - Schliffka et al. show that in the early mouse embryo, hemispherical intrusions, or inverse blebs, grow into cells at cell–cell adhesion sites in response to luminal...
rdcu.be
December 22, 2024 at 4:28 PM
#NCB2024
In September, @maitrejl.bsky.social, Schliffka, Mukherjee & co showed that in the early mouse #embryo inverse blebs grow into cells at cell–cell adhesion sites in response to luminal fluid accumulation and pressure build-up.
rdcu.be/d4uCu
www.nature.com/articles/s41...
In September, @maitrejl.bsky.social, Schliffka, Mukherjee & co showed that in the early mouse #embryo inverse blebs grow into cells at cell–cell adhesion sites in response to luminal fluid accumulation and pressure build-up.
rdcu.be/d4uCu
www.nature.com/articles/s41...
There is something that has been weighing on my mind lately:
Are scientists the new toxic influencers?
🐛🐛🐛🐛
Let's open an unnecessary can of worms
👇👇👇
Are scientists the new toxic influencers?
🐛🐛🐛🐛
Let's open an unnecessary can of worms
👇👇👇
January 17, 2025 at 6:37 PM
There is something that has been weighing on my mind lately:
Are scientists the new toxic influencers?
🐛🐛🐛🐛
Let's open an unnecessary can of worms
👇👇👇
Are scientists the new toxic influencers?
🐛🐛🐛🐛
Let's open an unnecessary can of worms
👇👇👇
Single-cell lipid biology, (Crotta Asis et al., Trends in Cell Biology).
🐛🐛🐛
www.cell.com/trends/cell-...
🐛🐛🐛
www.cell.com/trends/cell-...
January 16, 2025 at 12:21 AM
Single-cell lipid biology, (Crotta Asis et al., Trends in Cell Biology).
🐛🐛🐛
www.cell.com/trends/cell-...
🐛🐛🐛
www.cell.com/trends/cell-...
Reposted by Carmen.Gilgas
How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division?
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
January 15, 2025 at 4:04 PM
How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division?
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
Reposted by Carmen.Gilgas
Golgi-associated nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection https://www.biorxiv.org/content/10.1101/2025.01.08.631933v1
January 13, 2025 at 9:30 AM
Golgi-associated nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection https://www.biorxiv.org/content/10.1101/2025.01.08.631933v1
Reposted by Carmen.Gilgas
PPIFold: A Tool for Analysis of Protein-Protein Interaction from AlphaPullDown https://www.biorxiv.org/content/10.1101/2025.01.08.631489v1
January 13, 2025 at 9:47 AM
PPIFold: A Tool for Analysis of Protein-Protein Interaction from AlphaPullDown https://www.biorxiv.org/content/10.1101/2025.01.08.631489v1
Reposted by Carmen.Gilgas
Monte Carlo simulations predict distinct real EEG patterns in individuals with high and low IQs https://www.biorxiv.org/content/10.1101/2025.01.07.631738v1
January 13, 2025 at 10:15 AM
Monte Carlo simulations predict distinct real EEG patterns in individuals with high and low IQs https://www.biorxiv.org/content/10.1101/2025.01.07.631738v1