We need goat yoga for after the #kidneywk run next year

as far as I know the fish oil craze started with bad math over an Icelandic or Greenland study, and has been a cesspit of bad science since then and this finding reminds me of what my mom said:

if it is to good to be true, it is

Agreed - already have some proactive DMI folks on Finerenone - has been safe and lowers proteinuria in my hands

Agreed - seems a little “fishy”

This is like the Rockies winning the World Series….

For finerenone in type 1 DKD I think albuminuria is OK

For Atacicept - this is preliminary data which gets them accelerated FDA approval and a few months of making 💰until the GFR slope analysis comes through?

#KidneyWk

While I agree, here in Australia the drugs will not get funded by the govt without the harder endpoints unless of course the price is okay which of course is not going to happen. It’s exciting to see all these new therapeutics but unless the cost comes down I doubt we will see them in Australia soon

Finerenone has already shown benefit in type 2 DM and the benefit was primarily driven by albuminuria reduction. To me the type 1 diabetes trial was simply a safety trial since there’s no reason to believe the mechanism would be any different so I’m fine with the albuminuria surrogate

Move on - once it became approved as a surrogate endpoint there is zero incentive for trials to use hard endpoints as primary outcomes. Trials are shorter and more importantly cheaper.

All of them

I would accept a UNa

Good luck getting an accurate weight. Plus are you going to wait 24 hours before dose escalation? And then there’s 👇🏾

pubmed.ncbi.nlm.nih.gov/25595470/