David Calderwood
@calderwoodlab.bsky.social
The Calderwood Lab (Yale University, USA) uses biochemistry, cell biology and structural biology to study cell adhesion, signaling and the cytoskeleton.
Reposted by David Calderwood
New preprint alert! biorxiv.org/content/10.1...
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Nerve growth factor (NGF) binding to the receptor tyrosine kinase, TrkA, drives neurotrophic signaling essential for neuronal development and survival. This interaction simultaneously drives periphera...
biorxiv.org
November 18, 2025 at 11:28 PM
New preprint alert! biorxiv.org/content/10.1...
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
Nerve growth factor binding to TrkA helps neuronal growth and survival, but also triggers pain. This dual role has long complicated therapeutic targeting of this highly sought-after pathway in #Clinicaltrials for #chronicPain and #neurodegeneration.
Reposted by David Calderwood
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels - Nature Biotechnology
Epithelial organoids are grown without Matrigel using a single-chain antibody.
www.nature.com
November 3, 2025 at 11:15 AM
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Calderwood
Join us in welcoming our 2025-2026 Alan C. Sartorelli Lectureship speaker, Dr. Tobias Meyer. He will be presenting his work at 4 pm on Thursday, October 16th in The Anlyan Center.
October 13, 2025 at 9:33 PM
Join us in welcoming our 2025-2026 Alan C. Sartorelli Lectureship speaker, Dr. Tobias Meyer. He will be presenting his work at 4 pm on Thursday, October 16th in The Anlyan Center.
Reposted by David Calderwood
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
www.rockefeller.edu/news/38446-h...
How cells move and change shape—and why it matters for our health - News
Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...
www.rockefeller.edu
October 9, 2025 at 11:54 AM
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
www.rockefeller.edu/news/38446-h...
Reposted by David Calderwood
Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social
Mechanochemical waves in focal adhesions during cell migration
Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.
www.science.org
October 6, 2025 at 3:13 PM
Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social
Reposted by David Calderwood
The integrin odyssey - a journey full of fundamental discoveries.
pubmed.ncbi.nlm.nih.gov/40988584/
pubmed.ncbi.nlm.nih.gov/40988584/
The integrin odyssey - a journey full of fundamental discoveries - PubMed
Integrins are widely expressed cell adhesion receptors that link extracellular matrix proteins to the cytoskeleton. Most integrins connect to the actin cytoskeleton through different types of adhesion...
pubmed.ncbi.nlm.nih.gov
September 24, 2025 at 12:05 PM
The integrin odyssey - a journey full of fundamental discoveries.
pubmed.ncbi.nlm.nih.gov/40988584/
pubmed.ncbi.nlm.nih.gov/40988584/
Reposted by David Calderwood
So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work
Molecular exaptation by the integrin αI domain
An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.
www.science.org
September 10, 2025 at 7:34 PM
So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work
Reposted by David Calderwood
📢 Attention #undergraduates, #gradstudents, and early-career #postdocs! Apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards ✈️ that support your attendance at #CellBio2025 (Dec. 6-10) in Philadelphia! Apply by October 17 👉 rupress.org/jcb/pages/al...
@ascbiology.bsky.social
@ascbiology.bsky.social
September 10, 2025 at 3:02 PM
📢 Attention #undergraduates, #gradstudents, and early-career #postdocs! Apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards ✈️ that support your attendance at #CellBio2025 (Dec. 6-10) in Philadelphia! Apply by October 17 👉 rupress.org/jcb/pages/al...
@ascbiology.bsky.social
@ascbiology.bsky.social
Reposted by David Calderwood
Excellent talk from Yossi Schlessinger at the ASBMB Meeting. He gave the Herbert Tabor Research Award Lecture to a capacity crowd.
April 15, 2025 at 7:03 PM
Excellent talk from Yossi Schlessinger at the ASBMB Meeting. He gave the Herbert Tabor Research Award Lecture to a capacity crowd.
Reposted by David Calderwood
Join us in welcoming our next 2025 Pharmacology Seminar Series speaker, Jim Collins. He will be presenting his work at 12 pm on Thursday, April 17th in the Brady Auditorium.
April 14, 2025 at 4:47 PM
Join us in welcoming our next 2025 Pharmacology Seminar Series speaker, Jim Collins. He will be presenting his work at 12 pm on Thursday, April 17th in the Brady Auditorium.
congratulations Moi and team!
Thank you @hypothesisfund.bsky.social and @krishnanyamuna.bsky.social for this opportunity to shed ‘light’ on membrane contacts! Honored to be part of this and congratulations to my fellow awardees. Can’t wait to start this scientific adventure @yalepharm.bsky.social @yaleschoolofmed.bsky.social!
4/ With a 'molecular scalpel'🔪 to 'biopsy' membrane sites where cells/organoids make contact, Awardee @moitrayee-lab.bsky.social's research may reveal new insights into cellular processes & disease development (e.g. ALS).
🎉Congrats Dr. Bhattacharyya! @yale.edu
🙏#HFScout @krishnanyamuna.bsky.social
🎉Congrats Dr. Bhattacharyya! @yale.edu
🙏#HFScout @krishnanyamuna.bsky.social
April 3, 2025 at 4:45 PM
congratulations Moi and team!
Congratulations Yansheng and colleagues!
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: Cell www.cell.com/cell/fulltex...
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: Cell www.cell.com/cell/fulltex...
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions
This study presents a comprehensive atlas of protein and phosphoprotein turnover across
16 mouse tissues and brain regions using advanced proteomics and isotope labeling.
It reveals tissue-specific pr...
www.cell.com
March 26, 2025 at 2:25 PM
Congratulations Yansheng and colleagues!
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: Cell www.cell.com/cell/fulltex...
Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: Cell www.cell.com/cell/fulltex...
Very sorry to hear about Mike's passing
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:40 PM
Very sorry to hear about Mike's passing
Congrats to the Gupta lab and collaborators in the @moitrayee-lab.bsky.social, Yansheng Liu and Jim Rothman labs. bit.ly/proteinlibrary
‘Molecular library’ opens up new frontier of biological space-time
A new platform from the Yale Nanobiology Institute provides access to numerous membrane proteins – key targets in the fight against resistant disease
bit.ly
March 20, 2025 at 1:51 PM
Congrats to the Gupta lab and collaborators in the @moitrayee-lab.bsky.social, Yansheng Liu and Jim Rothman labs. bit.ly/proteinlibrary
Reposted by David Calderwood
It’s an honor to host Dario Alessi for our Department of Cell Biology seminar series tomorrow! #parkinsonsresearch
March 17, 2025 at 2:42 PM
It’s an honor to host Dario Alessi for our Department of Cell Biology seminar series tomorrow! #parkinsonsresearch
Reposted by David Calderwood
Today marks the beginning of OpenRxiv, which replaces bioRxiv and medRxiv, the world's largest preprint platform for life and medical science
openrxiv.org/introducing-...
@openrxiv.bsky.social
openrxiv.org/introducing-...
@openrxiv.bsky.social
March 11, 2025 at 2:55 PM
Today marks the beginning of OpenRxiv, which replaces bioRxiv and medRxiv, the world's largest preprint platform for life and medical science
openrxiv.org/introducing-...
@openrxiv.bsky.social
openrxiv.org/introducing-...
@openrxiv.bsky.social
Reposted by David Calderwood
BBS-Wide Joint Cultural Foods Social Hour! This Friday :)
February 5, 2025 at 7:20 PM
BBS-Wide Joint Cultural Foods Social Hour! This Friday :)
@fda.govFDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain www.fda.gov/news-events/...
FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain
The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.
www.fda.gov
January 31, 2025 at 12:34 AM
@fda.govFDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain www.fda.gov/news-events/...
Reposted by David Calderwood
Titus Boggon will be speaking at the next seminar in our 2025 Pharmacology Seminar Series. Join us at 12 pm on Thursday, January 23 in the Brady Auditorium to hear about his exciting work.
January 22, 2025 at 6:18 AM
Titus Boggon will be speaking at the next seminar in our 2025 Pharmacology Seminar Series. Join us at 12 pm on Thursday, January 23 in the Brady Auditorium to hear about his exciting work.
Looking forward to Tim's Tai-Shun Lin Memorial lecture this afternoon
January 16, 2025 at 3:05 PM
Looking forward to Tim's Tai-Shun Lin Memorial lecture this afternoon
Reposted by David Calderwood
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
January 14, 2025 at 4:03 PM
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
Reposted by David Calderwood
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!
November 21, 2024 at 6:33 AM
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!