Christian Burns
@burnsbioimaging.bsky.social
UC Merced, PostDoc
PhD
Focused on the Hematopoietic System, Biomedical Imaging and Intravital Microscopy of the Thymus
PhD
Focused on the Hematopoietic System, Biomedical Imaging and Intravital Microscopy of the Thymus
Pinned
Intravital two-photon microscopy of the native mouse thymus
The thymus, a key organ in the adaptive immune system, is sensitive to a variety of insults including cytotoxic preconditioning, which leads to atrophy, compression of the blood vascular system, and a...
journals.plos.org
Our paper "Intravital Two-Photon Microscopy of the Native Thymus" demonstrating in vivo imaging of the native thymus for the first time is finally out.
You can read it here: journals.plos.org/plosone/arti...
You can read it here: journals.plos.org/plosone/arti...
Reposted by Christian Burns
I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬
You can read the paper here: rdcu.be/eOKdU
You can read the paper here: rdcu.be/eOKdU
November 17, 2025 at 9:35 AM
I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬
You can read the paper here: rdcu.be/eOKdU
You can read the paper here: rdcu.be/eOKdU
Reposted by Christian Burns
The culmination of years of hard work by Anna Maria Reuss & Co: aDISCO - a protocol for clearing & antibody-staining human formalin-fixed paraffin-embedded (FFPE) tissue! With lots of @mesospim.bsky.social #lightsheet #Microscopy @ptrrupprecht.bsky.social & many more!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 27, 2025 at 7:30 AM
The culmination of years of hard work by Anna Maria Reuss & Co: aDISCO - a protocol for clearing & antibody-staining human formalin-fixed paraffin-embedded (FFPE) tissue! With lots of @mesospim.bsky.social #lightsheet #Microscopy @ptrrupprecht.bsky.social & many more!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Christian Burns
Lymphatic vessels traced to their origins from a specialised pool of cells called angioblasts
📷: Irina Lupu @degrainger.bsky.social Nils Kirschnick et al @oliverastone.bsky.social Friedemann Kiefer
@ox.ac.uk @uni-muenster.de @naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
📷: Irina Lupu @degrainger.bsky.social Nils Kirschnick et al @oliverastone.bsky.social Friedemann Kiefer
@ox.ac.uk @uni-muenster.de @naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
March 20, 2025 at 8:42 AM
Lymphatic vessels traced to their origins from a specialised pool of cells called angioblasts
📷: Irina Lupu @degrainger.bsky.social Nils Kirschnick et al @oliverastone.bsky.social Friedemann Kiefer
@ox.ac.uk @uni-muenster.de @naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
📷: Irina Lupu @degrainger.bsky.social Nils Kirschnick et al @oliverastone.bsky.social Friedemann Kiefer
@ox.ac.uk @uni-muenster.de @naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
Reposted by Christian Burns
Reducing Neutrophil Extracellular Traps cuts risks (stroke, bleeds & neurological problems) in tumour-like brain vascular lesion cerebral cavernous malformation
Image with @leicamicrosystems.bsky.social
📷: Favour Onyeogaziri et al @uu.se
@naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
Image with @leicamicrosystems.bsky.social
📷: Favour Onyeogaziri et al @uu.se
@naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
March 18, 2025 at 8:32 AM
Reducing Neutrophil Extracellular Traps cuts risks (stroke, bleeds & neurological problems) in tumour-like brain vascular lesion cerebral cavernous malformation
Image with @leicamicrosystems.bsky.social
📷: Favour Onyeogaziri et al @uu.se
@naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
Image with @leicamicrosystems.bsky.social
📷: Favour Onyeogaziri et al @uu.se
@naturecvr.bsky.social
➡️: bpod.org.uk/archive/2025...
Reposted by Christian Burns
3D reconstruction of a 3-day-old #zebrafish heart beating. Credit to Michael Weber (prev. @mpi-cbg.de). #ZebrafishZunday 🧪
March 16, 2025 at 9:50 AM
3D reconstruction of a 3-day-old #zebrafish heart beating. Credit to Michael Weber (prev. @mpi-cbg.de). #ZebrafishZunday 🧪
Reposted by Christian Burns
An earthworm-inspired robot could make undergrounding of power lines cheaper and safer, reducing the risk of future wildfire outbreaks.
A Groundbreaking Way to Break Ground
An earthworm-inspired robot could make undergrounding of power lines cheaper and safer, reducing the risk of future wildfire outbreaks.
www.hackster.io
March 14, 2025 at 4:34 PM
An earthworm-inspired robot could make undergrounding of power lines cheaper and safer, reducing the risk of future wildfire outbreaks.
Reposted by Christian Burns
3D ultrastructure of blood stages of the #malaria parasite reveals organelle details as potential treatment targets
📹: Felix Evers et al Taco Kooij lab Radboud University Medical Center, Nijmegen in @naturecomms.bsky.social
➡️: bpod.org.uk/archive/2025... with
John Ankers
📹: Felix Evers et al Taco Kooij lab Radboud University Medical Center, Nijmegen in @naturecomms.bsky.social
➡️: bpod.org.uk/archive/2025... with
John Ankers
March 13, 2025 at 8:48 AM
3D ultrastructure of blood stages of the #malaria parasite reveals organelle details as potential treatment targets
📹: Felix Evers et al Taco Kooij lab Radboud University Medical Center, Nijmegen in @naturecomms.bsky.social
➡️: bpod.org.uk/archive/2025... with
John Ankers
📹: Felix Evers et al Taco Kooij lab Radboud University Medical Center, Nijmegen in @naturecomms.bsky.social
➡️: bpod.org.uk/archive/2025... with
John Ankers
Reposted by Christian Burns
This is our best in vivo AP propagation movie so far. Recorded at 1k Hz from the axonal branches of a fly CNS neuron, using voltage indicator pAce.
March 5, 2025 at 4:45 PM
This is our best in vivo AP propagation movie so far. Recorded at 1k Hz from the axonal branches of a fly CNS neuron, using voltage indicator pAce.
Reposted by Christian Burns
Scientists have designed an “ingenious” side-view device that lets them observe the structural changes of 3D tumour spheroids more comprehensively.
https://elifesciences.org/articles/101886?utm_source=bluesky&utm_medium=social&utm_campaign=organic
https://elifesciences.org/articles/101886?utm_source=bluesky&utm_medium=social&utm_campaign=organic
February 25, 2025 at 9:21 AM
Scientists have designed an “ingenious” side-view device that lets them observe the structural changes of 3D tumour spheroids more comprehensively.
https://elifesciences.org/articles/101886?utm_source=bluesky&utm_medium=social&utm_campaign=organic
https://elifesciences.org/articles/101886?utm_source=bluesky&utm_medium=social&utm_campaign=organic
Reposted by Christian Burns
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
February 12, 2025 at 1:59 AM
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
Reposted by Christian Burns
Previously undescribed role found in zebrafish for transcription factor Sox10 in initiating skeletal mineralization
📷: Stefani Gjorcheska et al Barske lab
@cincyresearch.bsky.social in @dev-journal.bsky.social
➡️: bpod.org.uk/archive/2025...
📷: Stefani Gjorcheska et al Barske lab
@cincyresearch.bsky.social in @dev-journal.bsky.social
➡️: bpod.org.uk/archive/2025...
February 5, 2025 at 10:43 AM
Previously undescribed role found in zebrafish for transcription factor Sox10 in initiating skeletal mineralization
📷: Stefani Gjorcheska et al Barske lab
@cincyresearch.bsky.social in @dev-journal.bsky.social
➡️: bpod.org.uk/archive/2025...
📷: Stefani Gjorcheska et al Barske lab
@cincyresearch.bsky.social in @dev-journal.bsky.social
➡️: bpod.org.uk/archive/2025...
Reposted by Christian Burns
#Pericyte - #EndothelialCell interplay in 3D Microvessel (160-μmφ hBMMSC HUVEC) in tunable Collagen Hydrogel
Low-temp 4°C polymerized gel➡️stiff-bundled collagen fibers➡️
⏬Pericytic differentiation (⏫NOTCH3 TGFβ1)
⏫Sprouting
⏫Permeability
⏫#Pericrine IL-8
#SciAdv 2025
www.science.org/doi/full/10....
Low-temp 4°C polymerized gel➡️stiff-bundled collagen fibers➡️
⏬Pericytic differentiation (⏫NOTCH3 TGFβ1)
⏫Sprouting
⏫Permeability
⏫#Pericrine IL-8
#SciAdv 2025
www.science.org/doi/full/10....
February 4, 2025 at 1:10 PM
#Pericyte - #EndothelialCell interplay in 3D Microvessel (160-μmφ hBMMSC HUVEC) in tunable Collagen Hydrogel
Low-temp 4°C polymerized gel➡️stiff-bundled collagen fibers➡️
⏬Pericytic differentiation (⏫NOTCH3 TGFβ1)
⏫Sprouting
⏫Permeability
⏫#Pericrine IL-8
#SciAdv 2025
www.science.org/doi/full/10....
Low-temp 4°C polymerized gel➡️stiff-bundled collagen fibers➡️
⏬Pericytic differentiation (⏫NOTCH3 TGFβ1)
⏫Sprouting
⏫Permeability
⏫#Pericrine IL-8
#SciAdv 2025
www.science.org/doi/full/10....
Reposted by Christian Burns
A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo. It works well with wide-field imaging, two-photon microscopy, and fiber photometry biorxiv.org/content/10.1...
February 4, 2025 at 3:49 AM
A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo. It works well with wide-field imaging, two-photon microscopy, and fiber photometry biorxiv.org/content/10.1...
Reposted by Christian Burns
This video shows a subset of ribosomes inside a cancer cell actively translating mRNA molecules.
Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.
Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.
February 4, 2025 at 12:59 AM
This video shows a subset of ribosomes inside a cancer cell actively translating mRNA molecules.
Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.
Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.
Reposted by Christian Burns
Details protocols for
1) Micro-ultrasound imaging of 🐭 #SuperiorMesentericArtery Vevo 2100 @VisualSonics
2) Isolation of 🐭Abdominal aorta with ALL major branches😍
#STARProtocols 2025
www.sciencedirect.com/science/arti...
1) Micro-ultrasound imaging of 🐭 #SuperiorMesentericArtery Vevo 2100 @VisualSonics
2) Isolation of 🐭Abdominal aorta with ALL major branches😍
#STARProtocols 2025
www.sciencedirect.com/science/arti...
February 3, 2025 at 1:12 PM
Details protocols for
1) Micro-ultrasound imaging of 🐭 #SuperiorMesentericArtery Vevo 2100 @VisualSonics
2) Isolation of 🐭Abdominal aorta with ALL major branches😍
#STARProtocols 2025
www.sciencedirect.com/science/arti...
1) Micro-ultrasound imaging of 🐭 #SuperiorMesentericArtery Vevo 2100 @VisualSonics
2) Isolation of 🐭Abdominal aorta with ALL major branches😍
#STARProtocols 2025
www.sciencedirect.com/science/arti...
Reposted by Christian Burns
Identifying Higd1b as unique specific marker of pericytes enables subtypes & their roles to be distinguished in detail
📷: Timothy Klouda, Yunhye Kim & Seung-Han Baek et al
@bostonchildrens.bsky.social in
@embojournal.org
➡️: bpod.org.uk/archive/2025...
📷: Timothy Klouda, Yunhye Kim & Seung-Han Baek et al
@bostonchildrens.bsky.social in
@embojournal.org
➡️: bpod.org.uk/archive/2025...
February 3, 2025 at 3:51 PM
Identifying Higd1b as unique specific marker of pericytes enables subtypes & their roles to be distinguished in detail
📷: Timothy Klouda, Yunhye Kim & Seung-Han Baek et al
@bostonchildrens.bsky.social in
@embojournal.org
➡️: bpod.org.uk/archive/2025...
📷: Timothy Klouda, Yunhye Kim & Seung-Han Baek et al
@bostonchildrens.bsky.social in
@embojournal.org
➡️: bpod.org.uk/archive/2025...
Reposted by Christian Burns
We just released and uploaded a new version of *Mastodon*, the large-scale tracking and track-editing framework for large, multi-view images.
Mastodon is available via Fiji, via a dedicated update site.
mastodon.readthedocs.io/en/latest/do...
Below is a thread that survey some of the novelties ⏬️
Mastodon is available via Fiji, via a dedicated update site.
mastodon.readthedocs.io/en/latest/do...
Below is a thread that survey some of the novelties ⏬️
January 30, 2025 at 4:44 PM
We just released and uploaded a new version of *Mastodon*, the large-scale tracking and track-editing framework for large, multi-view images.
Mastodon is available via Fiji, via a dedicated update site.
mastodon.readthedocs.io/en/latest/do...
Below is a thread that survey some of the novelties ⏬️
Mastodon is available via Fiji, via a dedicated update site.
mastodon.readthedocs.io/en/latest/do...
Below is a thread that survey some of the novelties ⏬️
Reposted by Christian Burns
Researchers have broadened the spectrum of available bioluminescence colors.
The new method allowed the team to captured a single image of 20 different bioluminescence color samples with an ordinary smartphone camera.
Read the OPN story: bit.ly/3WFO5KR
#color #light #bioluminescence #imaging
The new method allowed the team to captured a single image of 20 different bioluminescence color samples with an ordinary smartphone camera.
Read the OPN story: bit.ly/3WFO5KR
#color #light #bioluminescence #imaging
January 29, 2025 at 8:14 PM
Researchers have broadened the spectrum of available bioluminescence colors.
The new method allowed the team to captured a single image of 20 different bioluminescence color samples with an ordinary smartphone camera.
Read the OPN story: bit.ly/3WFO5KR
#color #light #bioluminescence #imaging
The new method allowed the team to captured a single image of 20 different bioluminescence color samples with an ordinary smartphone camera.
Read the OPN story: bit.ly/3WFO5KR
#color #light #bioluminescence #imaging
Reposted by Christian Burns
January 28, 2025 at 10:36 PM
Reposted by Christian Burns
Organ-on-a-chip model of changes in collagen stiffness around capillaries reveals role of perivascular cells in vascular response in health & disease
📷: Cristiane M. Franca et al Luiz E. Bertassoni lab
@ohsunews.bsky.social in Science Advances @science.org
➡️: bpod.org.uk/archive/2025...
📷: Cristiane M. Franca et al Luiz E. Bertassoni lab
@ohsunews.bsky.social in Science Advances @science.org
➡️: bpod.org.uk/archive/2025...
January 27, 2025 at 9:13 AM
Organ-on-a-chip model of changes in collagen stiffness around capillaries reveals role of perivascular cells in vascular response in health & disease
📷: Cristiane M. Franca et al Luiz E. Bertassoni lab
@ohsunews.bsky.social in Science Advances @science.org
➡️: bpod.org.uk/archive/2025...
📷: Cristiane M. Franca et al Luiz E. Bertassoni lab
@ohsunews.bsky.social in Science Advances @science.org
➡️: bpod.org.uk/archive/2025...
Reposted by Christian Burns
CellAge
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
January 20, 2025 at 1:26 PM
CellAge
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
Reposted by Christian Burns
France-BioImaging open-desks in #bioimage-analysis!
Are you an imaging scientist working with a core-facility of @france-bioimaging.bsky.social ?
We organize bi-monthly consultation sessions for researchers working in a lab in France, supporting their project with bioimage analysis
Are you an imaging scientist working with a core-facility of @france-bioimaging.bsky.social ?
We organize bi-monthly consultation sessions for researchers working in a lab in France, supporting their project with bioimage analysis
January 20, 2025 at 12:06 PM
France-BioImaging open-desks in #bioimage-analysis!
Are you an imaging scientist working with a core-facility of @france-bioimaging.bsky.social ?
We organize bi-monthly consultation sessions for researchers working in a lab in France, supporting their project with bioimage analysis
Are you an imaging scientist working with a core-facility of @france-bioimaging.bsky.social ?
We organize bi-monthly consultation sessions for researchers working in a lab in France, supporting their project with bioimage analysis
Reposted by Christian Burns
Our fully 3D-printed microscope is featured in @newscientist.bsky.social www.newscientist.com/article/2462...
World’s first fully 3D-printed microscope made in under 3 hours
The microscope cost less than £50 to build using an open-source design and a common 3D printer
www.newscientist.com
January 10, 2025 at 9:44 PM
Our fully 3D-printed microscope is featured in @newscientist.bsky.social www.newscientist.com/article/2462...
Reposted by Christian Burns
We built on the @openflexure.bsky.social platform to combine a 3D printed microscope chassis with both a 3D printed condenser and objective lens.
Now we have the entire microscope, including the optics, printed for less than £7.00… and it works!
(2/N)
Now we have the entire microscope, including the optics, printed for less than £7.00… and it works!
(2/N)
December 21, 2024 at 4:01 PM
We built on the @openflexure.bsky.social platform to combine a 3D printed microscope chassis with both a 3D printed condenser and objective lens.
Now we have the entire microscope, including the optics, printed for less than £7.00… and it works!
(2/N)
Now we have the entire microscope, including the optics, printed for less than £7.00… and it works!
(2/N)
Reposted by Christian Burns
1/6 🧵 I'm building what might be the smallest #opensource #spectrometer with an easy to use UI! I call it a pocket spectrometer. Combining #M5StickC (~$20) with AS7341 sensor (~$16). My goal? A complete spectrometer that is barely larger than a sample cuvette itself.
November 25, 2024 at 11:36 PM
1/6 🧵 I'm building what might be the smallest #opensource #spectrometer with an easy to use UI! I call it a pocket spectrometer. Combining #M5StickC (~$20) with AS7341 sensor (~$16). My goal? A complete spectrometer that is barely larger than a sample cuvette itself.