Brian Sheridan Lab
@bsheridanlab.bsky.social
T Cells and Mucosal Immunology
Assoc. Professor at Stony Brook University
Assoc. Professor at Stony Brook University
Reposted by Brian Sheridan Lab
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
October 29, 2025 at 12:11 PM
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
Enjoyed sharing my home brew 'Cyto-hops-ic IE-ale' with everyone at our departmental Oktoberfest. Unfortunately, only my lab and a select few understood the reference.
October 21, 2025 at 6:12 PM
Enjoyed sharing my home brew 'Cyto-hops-ic IE-ale' with everyone at our departmental Oktoberfest. Unfortunately, only my lab and a select few understood the reference.
www.nejm.org/doi/10.1056/...
Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels
Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 18, 2025 at 10:31 PM
www.nejm.org/doi/10.1056/...
Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels
Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels
I'll take #gdTcells for $500
Things got competitive with immunology jeopardy (slight bias towards certain topics 😉) at our @bsheridanlab.bsky.social @priyadevarajan.bsky.social joint lab meeting this week!
July 30, 2025 at 9:23 PM
I'll take #gdTcells for $500
Reposted by Brian Sheridan Lab
A key US Senate committee has indicated that it will reject the huge budget cuts that President Donald Trump proposed for some science agencies, including the US National Science Foundation and NASA.
go.nature.com/40H0XST
go.nature.com/40H0XST
US senators poised to reject Trump’s proposed massive science cuts
Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.
go.nature.com
July 10, 2025 at 10:31 PM
A key US Senate committee has indicated that it will reject the huge budget cuts that President Donald Trump proposed for some science agencies, including the US National Science Foundation and NASA.
go.nature.com/40H0XST
go.nature.com/40H0XST
Reposted by Brian Sheridan Lab
As NIH budget deliberations continue, prepare to hear Bhattacharya deflect substantial questions about the negative effects of his funding policies with “I’m an economist.”
He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.
He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.
BHATTACHARYA'S "FORWARD FUNDING" SCHEME
In last week's Senate Appropriations hearing with the NIH Director, Bhattacharya and Sen. Baldwin clashed over the proposed scheme. Baldwin said it was "funny math," to which Bhattacharya responded, "I'm an economist."
www.politico.com/newsletters/...
In last week's Senate Appropriations hearing with the NIH Director, Bhattacharya and Sen. Baldwin clashed over the proposed scheme. Baldwin said it was "funny math," to which Bhattacharya responded, "I'm an economist."
www.politico.com/newsletters/...
NIH’s ‘forward-funding scheme’
NIH Director Jay Bhattacharya and Sen. Tammy Baldwin (D-Wis.) sparred over a proposal in the White House budget plan to give more grant recipients their money up front during a Senate Appropriations p...
www.politico.com
June 16, 2025 at 10:26 AM
As NIH budget deliberations continue, prepare to hear Bhattacharya deflect substantial questions about the negative effects of his funding policies with “I’m an economist.”
He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.
He’s not a very good one if he’s unable to assess the impact of funding decisions at the agency he directs.
Reposted by Brian Sheridan Lab
Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008
academic.oup.com/hmg/advance-...
academic.oup.com/hmg/advance-...
Macrophages: sentinels, warriors, and healers
Abstract. Macrophages are versatile innate immune cells that act as sentinels, warriors, and healers in virtually every tissue. This review synthesizes cur
academic.oup.com
June 7, 2025 at 6:12 PM
Our latest review on macrophages Macrophages: sentinels, warriors, and healers url:https://academic.oup.com/hmg/article-abstract/doi/10.1093/hmg/ddaf087/8158008
academic.oup.com/hmg/advance-...
academic.oup.com/hmg/advance-...
Listen to our newest Immunology faculty @priyadevarajan.bsky.social discussing her new lab @stonybrookmedicine.bsky.social and the benefit of @societymucosalimm.bsky.social mentorship program to her career development!
Start your week off with the latest episode of the Mucosal Immunology Podcast @societymucosalimm.bsky.social featuring @priyadevarajan.bsky.social with @marionbrunck.bsky.social @ashu-mangalam.bsky.social and more: open.spotify.com/episode/3dJF...
Immunity to respiratory viruses
Mucosal Immunology Podcast · Episode
open.spotify.com
May 27, 2025 at 3:08 PM
Listen to our newest Immunology faculty @priyadevarajan.bsky.social discussing her new lab @stonybrookmedicine.bsky.social and the benefit of @societymucosalimm.bsky.social mentorship program to her career development!
Reposted by Brian Sheridan Lab
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
May 26, 2025 at 4:32 AM
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
Reposted by Brian Sheridan Lab
Proud of Harvard for pushing back, exercising some creativity, and, maybe, helping folks get some needed education.
Harvard is making many of their online government courses FREE.
I just signed up for "Citizen Politics in America".
They even asked me my Gender.
pll.harvard.edu/subject/gove...
Harvard is making many of their online government courses FREE.
I just signed up for "Citizen Politics in America".
They even asked me my Gender.
pll.harvard.edu/subject/gove...
Government | Harvard University
Browse the latest Government courses from Harvard University.
pll.harvard.edu
May 24, 2025 at 11:25 AM
Proud of Harvard for pushing back, exercising some creativity, and, maybe, helping folks get some needed education.
Harvard is making many of their online government courses FREE.
I just signed up for "Citizen Politics in America".
They even asked me my Gender.
pll.harvard.edu/subject/gove...
Harvard is making many of their online government courses FREE.
I just signed up for "Citizen Politics in America".
They even asked me my Gender.
pll.harvard.edu/subject/gove...
Metabolic reprogramming of IL-17 producing gd T cells promotes de novo lipogenesis under psoriasis conditions
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
#gdTcells @natmetabolism.nature.com
#gdTcells @natmetabolism.nature.com
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions - Nature Metabolism
Kao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.
www.nature.com
May 14, 2025 at 3:43 PM
Metabolic reprogramming of IL-17 producing gd T cells promotes de novo lipogenesis under psoriasis conditions
Reposted by Brian Sheridan Lab
NEW: We (mostly @noamross.net) launched a website to shine a brighter light on terminated NIH and NSF grants.
grant-watch.us
It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon.
Check it out and let us know what else you'd like to see.
grant-watch.us
It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon.
Check it out and let us know what else you'd like to see.
Grant Watch
grant-watch.us
April 30, 2025 at 4:19 AM
NEW: We (mostly @noamross.net) launched a website to shine a brighter light on terminated NIH and NSF grants.
grant-watch.us
It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon.
Check it out and let us know what else you'd like to see.
grant-watch.us
It links to our NIH & NSF trackers, grant info submission forms, and other info. We'll also add new analyses soon.
Check it out and let us know what else you'd like to see.
Reposted by Brian Sheridan Lab
Check out this cool new study from a colleague at @stonybrookmedicine.bsky.social. Congrats to Charles and his team! Mtb-reactive CD8a expressing NK cells in humans!
CD8α marks a Mycobacterium tuberculosis-reactive human NK cell population with high activation potential
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 30, 2025 at 12:30 AM
Check out this cool new study from a colleague at @stonybrookmedicine.bsky.social. Congrats to Charles and his team! Mtb-reactive CD8a expressing NK cells in humans!
Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now in@cp-immunity.bsky.social #macrophages
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
April 26, 2025 at 7:33 PM
Another great study from the @khannakm.bsky.social lab! Disease tolerance to limit Pathology in mucosal tissues
Check out this fantastic story from @ikinglab.bsky.social group! There's always something cool going on in the mucosa
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
www.sciencedirect.com
April 26, 2025 at 7:29 PM
Check out this fantastic story from @ikinglab.bsky.social group! There's always something cool going on in the mucosa
Reposted by Brian Sheridan Lab
I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
www.science.org
April 23, 2025 at 12:57 PM
I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.
Reposted by Brian Sheridan Lab
From South America to the global stage!
Meet Dr. Eduardo Villablanca and Gustavo Monasterio Ocares as they share how SMI has supported their efforts to increase opportunities for mucosal immunologists in South America.
Watch here: www.socmucimm.org/about/smi-or...
#MucosalImmunology
Meet Dr. Eduardo Villablanca and Gustavo Monasterio Ocares as they share how SMI has supported their efforts to increase opportunities for mucosal immunologists in South America.
Watch here: www.socmucimm.org/about/smi-or...
#MucosalImmunology
April 18, 2025 at 8:04 PM
From South America to the global stage!
Meet Dr. Eduardo Villablanca and Gustavo Monasterio Ocares as they share how SMI has supported their efforts to increase opportunities for mucosal immunologists in South America.
Watch here: www.socmucimm.org/about/smi-or...
#MucosalImmunology
Meet Dr. Eduardo Villablanca and Gustavo Monasterio Ocares as they share how SMI has supported their efforts to increase opportunities for mucosal immunologists in South America.
Watch here: www.socmucimm.org/about/smi-or...
#MucosalImmunology
Reposted by Brian Sheridan Lab
This chart seems to suggest that something is going wrong in the United States, specifically.
(www.ft.com/content/7568... )
(www.ft.com/content/7568... )
March 11, 2025 at 9:01 PM
This chart seems to suggest that something is going wrong in the United States, specifically.
(www.ft.com/content/7568... )
(www.ft.com/content/7568... )
Reposted by Brian Sheridan Lab
Postdoctoral students, graduate students and other junior scientists in large research groups are more likely to drop out of academia than are their peers in smaller groups, says a study of more than one million early-career researchers.
https://go.nature.com/3F8sZyV
https://go.nature.com/3F8sZyV
How a PhD student’s lab size affects their chance of future academic success
Trainees in big research groups tend to go on to greater academic success than their small-group counterparts ― but are more likely to quit academia altogether.
go.nature.com
March 7, 2025 at 5:57 PM
Postdoctoral students, graduate students and other junior scientists in large research groups are more likely to drop out of academia than are their peers in smaller groups, says a study of more than one million early-career researchers.
https://go.nature.com/3F8sZyV
https://go.nature.com/3F8sZyV
Reposted by Brian Sheridan Lab
2 DAYS until we STAND UP FOR SCIENCE!
More information on local sites available at www.standupforscience2025.org ☀️
#standupforscience2025
More information on local sites available at www.standupforscience2025.org ☀️
#standupforscience2025
March 5, 2025 at 2:08 PM
2 DAYS until we STAND UP FOR SCIENCE!
More information on local sites available at www.standupforscience2025.org ☀️
#standupforscience2025
More information on local sites available at www.standupforscience2025.org ☀️
#standupforscience2025
Reposted by Brian Sheridan Lab
We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country.
This Friday, where will you be?
standupforscience2025.org
This Friday, where will you be?
standupforscience2025.org
March 2, 2025 at 4:27 PM
We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country.
This Friday, where will you be?
standupforscience2025.org
This Friday, where will you be?
standupforscience2025.org
Reposted by Brian Sheridan Lab
Make it make sense!
February 27, 2025 at 11:22 PM
Make it make sense!
Reposted by Brian Sheridan Lab
I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
www.theatlantic.com
February 27, 2025 at 4:13 PM
I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...