Arnau Vich
@arnauvich.bsky.social
Human gut microbiome researcher
Postdoc at KU Leuven / VIB (BE)
Previously UMCG (NL)
Postdoc at KU Leuven / VIB (BE)
Previously UMCG (NL)
Reposted by Arnau Vich
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Arnau Vich
Highlighting another recent paper from the lab in Science Advances on engineering a gut probiotic to modulate GLP-1 levels and ameliorating colitis. Led by Leonie Brockmann & @carlottaronda.bsky.social . @columbiasysbio.bsky.social @columbiauniversity.bsky.social 🧬🦠💊
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Engineered probiotic restores GLP-1 signaling to ameliorate fiber-deficiency exacerbated colitis
Engineered probiotic delivers bacterial peptide that enhances GLP-1 and restores barrier integrity in diet-modulated colitis.
www.science.org
November 21, 2025 at 1:32 AM
Highlighting another recent paper from the lab in Science Advances on engineering a gut probiotic to modulate GLP-1 levels and ameliorating colitis. Led by Leonie Brockmann & @carlottaronda.bsky.social . @columbiasysbio.bsky.social @columbiauniversity.bsky.social 🧬🦠💊
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Arnau Vich
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
Reposted by Arnau Vich
Back-to-back recognition! 💪🏼 A huge shoutout to Arnau @arnauvich.bsky.social and Jeroen Raes for once again making @clarivate.com global #HighlyCited2025 list! 🌍✨ @viblifesciences.bsky.social @vibmicrobes.bsky.social clarivate.com/highly-cited...
Clarivate Highly Cited Researchers 2025
The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...
clarivate.com
November 14, 2025 at 8:11 AM
Back-to-back recognition! 💪🏼 A huge shoutout to Arnau @arnauvich.bsky.social and Jeroen Raes for once again making @clarivate.com global #HighlyCited2025 list! 🌍✨ @viblifesciences.bsky.social @vibmicrobes.bsky.social clarivate.com/highly-cited...
Reposted by Arnau Vich
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...
rdcu.be
October 24, 2025 at 4:20 PM
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Reposted by Arnau Vich
Another great day at #UEGWeek 2025! 🎉Congratulations to our colleague Jorge Vazquez Castellanos for presenting his exciting work on microbial dysbiosis, inflammation, and the gut–brain axis in IBS at the United European Gastroenterology Week in Berlin🇩🇪 @myueg.bsky.social @vibmicrobes.bsky.social
October 7, 2025 at 10:01 AM
Another great day at #UEGWeek 2025! 🎉Congratulations to our colleague Jorge Vazquez Castellanos for presenting his exciting work on microbial dysbiosis, inflammation, and the gut–brain axis in IBS at the United European Gastroenterology Week in Berlin🇩🇪 @myueg.bsky.social @vibmicrobes.bsky.social
Reposted by Arnau Vich
Huge congratulations to our colleague @arnauvich.bsky.social for presenting his research on FODMAP restriction and gut microbiota in IBS patients at United European Gastroenterology Week 2025 in Berlin🇩🇪👏! #UEGWeek @myueg.bsky.social @vibmicrobes.bsky.social
October 6, 2025 at 11:54 AM
Huge congratulations to our colleague @arnauvich.bsky.social for presenting his research on FODMAP restriction and gut microbiota in IBS patients at United European Gastroenterology Week 2025 in Berlin🇩🇪👏! #UEGWeek @myueg.bsky.social @vibmicrobes.bsky.social
Reposted by Arnau Vich
The most interesting report of the week (IMHO) 🧵
New @nature.com
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.
nature.com
August 7, 2025 at 11:29 PM
The most interesting report of the week (IMHO) 🧵
Reposted by Arnau Vich
Reposted by Arnau Vich
Super happy to share our latest preprint in #liverdisease & #gut microbiota mechanisms.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changes
Background: Alcohol overuse disrupts liver function and alters microbial gut communities, with alcohol-related liver disease (ALD) accounting for half of all liver-related deaths worldwide. Bile acids...
www.medrxiv.org
July 24, 2025 at 5:02 PM
Super happy to share our latest preprint in #liverdisease & #gut microbiota mechanisms.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Arnau Vich
Thrilled to share that our manuscript on strain-level gut microbiome variation across diverse populations and human phenotypes is out today in @cellpress.bsky.social
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
www.sciencedirect.com/science/arti...
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
www.sciencedirect.com/science/arti...
Global genetic structure of human gut microbiome species is related to geographic location and host health
The human gut harbors thousands of microbial species, each exhibiting significant inter-individual genetic variability. Although many studies have ass…
www.sciencedirect.com
April 30, 2025 at 4:15 PM
Thrilled to share that our manuscript on strain-level gut microbiome variation across diverse populations and human phenotypes is out today in @cellpress.bsky.social
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
www.sciencedirect.com/science/arti...
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
www.sciencedirect.com/science/arti...
Reposted by Arnau Vich
🦠🧬🖥️ New Bakta DB v6.0 released!
After a year, it was time for a Bakta database update - and it's a huge one:
- IPS: 330.9M
- PSC: 135.3M
- PSCC: 37M
doi.org/10.5281/zeno...
👇 1/6
After a year, it was time for a Bakta database update - and it's a huge one:
- IPS: 330.9M
- PSC: 135.3M
- PSCC: 37M
doi.org/10.5281/zeno...
👇 1/6
Bakta database
This data repository contains the mandatory DB for Bakta. It is available in two versions: the default (db.tar.gz or) and a lightweight alternative (db-light.tar.gz). Bakta is a tool for the rapid & s...
doi.org
March 6, 2025 at 8:59 AM
🦠🧬🖥️ New Bakta DB v6.0 released!
After a year, it was time for a Bakta database update - and it's a huge one:
- IPS: 330.9M
- PSC: 135.3M
- PSCC: 37M
doi.org/10.5281/zeno...
👇 1/6
After a year, it was time for a Bakta database update - and it's a huge one:
- IPS: 330.9M
- PSC: 135.3M
- PSCC: 37M
doi.org/10.5281/zeno...
👇 1/6
Reposted by Arnau Vich
Citation: www.sciencedirect.com/science/arti...
A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance
Clostridioides difficile, a major cause of antibiotic-associated diarrhea, is suppressed by the gut microbiome, but the precise mechanisms are not ful…
www.sciencedirect.com
March 6, 2025 at 11:02 AM
Citation: www.sciencedirect.com/science/arti...
Reposted by Arnau Vich
Nature research paper: Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses
https://go.nature.com/3XmyOPD
https://go.nature.com/3XmyOPD
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regulated by nutrient-sensing mechanisms and bacterial viability.
go.nature.com
February 27, 2025 at 4:04 PM
Nature research paper: Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses
https://go.nature.com/3XmyOPD
https://go.nature.com/3XmyOPD
Reposted by Arnau Vich
Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
February 21, 2025 at 8:42 PM
Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
Reposted by Arnau Vich
A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Planning and describing a microbiome data analysis - Nature Microbiology
We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.
www.nature.com
February 21, 2025 at 2:48 PM
A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social
www.nature.com/articles/s41...
Reposted by Arnau Vich
We're hiring a postdoc!🚨
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Postdoctoral position in bioinformatics of the human gut microbiome - VIB
About the Lab
Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its clinical applications
jobs.vib.be
February 20, 2025 at 7:53 AM
We're hiring a postdoc!🚨
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Reposted by Arnau Vich
Excited to share our MicrobiomeBenchmarkData preprint, addressing compositional data analysis for microbiome DA. This Bioconductor package features 3 datasets with biological ground truths. Spoiler: simple methods like LEfSe, Wilcoxon, RNA-seq methods performed well www.biorxiv.org/content/10.1...
Commonly used compositional data analysis implementations are not advantageous in microbial differential abundance analyses benchmarked against biological ground truth
Previous benchmarking of differential abundance (DA) analysis methods in microbiome studies have employed synthetic data, simulations, and "real data" examples, but to the best of our knowledge, none ...
www.biorxiv.org
February 19, 2025 at 11:53 AM
Excited to share our MicrobiomeBenchmarkData preprint, addressing compositional data analysis for microbiome DA. This Bioconductor package features 3 datasets with biological ground truths. Spoiler: simple methods like LEfSe, Wilcoxon, RNA-seq methods performed well www.biorxiv.org/content/10.1...
Reposted by Arnau Vich
A big congratulations to our incredible team at RaesLab! We’re excited to share that two of our colleagues, Arnau @arnauvich.bsky.social and Jeroen, have been honored on the global #HighlyCited2024 researchers list by @Clarivate🤩🙌🏼 @viblifesciences.bsky.social
clarivate.com/highly-cited...
clarivate.com/highly-cited...
Highly Cited Researchers | Clarivate
The Highly Cited Researchers 2024 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...
clarivate.com
November 21, 2024 at 1:32 PM
A big congratulations to our incredible team at RaesLab! We’re excited to share that two of our colleagues, Arnau @arnauvich.bsky.social and Jeroen, have been honored on the global #HighlyCited2024 researchers list by @Clarivate🤩🙌🏼 @viblifesciences.bsky.social
clarivate.com/highly-cited...
clarivate.com/highly-cited...
Although I'm not a big fan of individual recognitions in science- collaboration and teamwork are the real driving forces- I'm honored to be recognised as #HighlyCited2024 by Clarivate. Grateful to all colleagues, mentors and collaborators who made this happen.
November 20, 2024 at 3:15 PM
Although I'm not a big fan of individual recognitions in science- collaboration and teamwork are the real driving forces- I'm honored to be recognised as #HighlyCited2024 by Clarivate. Grateful to all colleagues, mentors and collaborators who made this happen.