Despite progress in spectral matching techniques for mass spectrometry, current methods often struggle to resolve fine-grained structural dissimilarities. Here, the authors present LLM4MS, an approach based on large language models to generate discriminative spectral embeddings for improved compound identification.

Rethinking Alzheimer’s disease through the lens of myelin

The FeMS+ directory of underrepresented scientists is a resource for conferences, professional societies and journals in mass spectrometry and related fields to build diverse and inclusive panels o…

The Galleri test looks for fragments of DNA that have broken off a tumour and are circulating in the blood.

While our understanding of Alzheimer’s disease is far from complete, the latest therapies, and others in more than 100 clinical trials, offer new hope

La presidenta de la Fundación Pasqual Maragall explica que su padre, el exalcalde de Barcelona diagnosticado hace 18 años de la enfermedad, “está muy tranquilo y sigue una vida muy rutinaria”

Nature Methods - Spatiotemporal lipidomics in living tissue

There's something about the female brain that makes it more susceptible to Alzheimer's disease.

Glucuronidation is the major phase II biotransformation reaction that facilitates the clearance of exogenous compounds from the human body. Glucuronidated metabolites have been investigated in urine samples at a broad scale; however, their characterization in other human biospecimens is underexplored. Our study has now performed a comprehensive profiling of glucuronides in plasma, fecal, and cerebrospinal fluid (CSF) of humans. We performed a mass spectrometry-based analysis that combines enzymatic hydrolysis with a β-glucuronidase to selectively cleave the glucuronic acid moiety, a developed in-house glucuronide identification pipeline, and enzymatic synthesis of standard metabolites. In total, we identified 32 glucuronidated metabolites across the three sample types in both negative and positive mass spectrometry ionization modes using advanced MS/MS fragmentation analysis. We have utilized a straightforward enzymatic synthesis of glucuronidated metabolites for annotation at the highest confidence level. Among the identified conjugates, we detected glucuronides of different compound classes including drugs, bile acid derivatives, steroid conjugates, and phenolic compounds. Unexpectedly, we validated the glucuronides of acetaminophen and propofol in CSF samples, the latter representing a novel observation that highlights the importance of investigating phase II metabolites in uncommon sample types. Graphical Abstract

INTRODUCTION Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) are tauopathies with gray matter (GM) myelin changes that are challenging to assess with standard imaging. New method...

INTRODUCTION Alzheimer's disease (AD) is a devastating neurological disease that disproportionately affects women. This study aimed to investigate sex-specific single lipids associated with AD. ME.....