Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

www.science.org/content/arti...

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

We identify evidence of off-target probe binding in the 10x Genomics #Xenium v1 Human Breast Gene Expression Panel, compromising the accuracy of resulting #singlecell #spatialtranscriptomics profiles

See our preprint for more details: www.biorxiv.org/content/10.1...

#AcademicSky

🧵👇 1/n

We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪

www.nature.com/articles/d41...

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!

key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity

many are "negative regulators" & misexpressed in cancer

www.sciencedirect.com/science/arti...

McGill’s MSc & PhD in Human Genetics Program is accepting applications for Fall 2025 from Canadian citizens & permanent residents (Deadline: May 31). International students are encouraged to apply for Winter 2026 (Deadline: Oct 15).
Join our vibrant research community!
www.mcgill.ca/humangenetic...

New in @naturecomms.bsky.social: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration www.nature.com/articles/s41...

Congratulations to @soniagr.bsky.social, rytenlab.com team, et al for this project re-analyzing #GTEx human gene expression data uniformly re-processed with #recount3

It was a pleasure working with Sonia G & Mina Ryten

doi.org/10.1038/s414...

@bioconductor.bsky.social @lieberinstitute.bsky.social

New research from IGI Investigator Dave Savage and first author Noam Prywes details the landscape of possible Rubisco variants, suggesting ways to make the world's most abundant enzyme better at its job. 🌱

Read more: ow.ly/t2JO50ULh10

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

Excited to share our latest preprint on scE2G – a new model to link enhancers to target genes using single-cell data – with state-of-the-art performance across multiple perturbation benchmarks.

biorxiv.org/cgi/content/...

Read more below!

1/12

A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...

NIH faces sweeping reforms, including downsizing and increased oversight, sparking fears of political influence and a shift in priorities. The scientific community must act now to protect the integrity and future of the nation’s biomedical research enterprise.

www.nature.com/articles/d41...