Anu Sharma
@anu-sharma.bsky.social
Ph.D Candidate @Molecular and Cellular Biology, UIUC.
Studying bacteria in fluid flow @Sanfilippo Lab
Studying bacteria in fluid flow @Sanfilippo Lab
Pinned
Anu Sharma
@anu-sharma.bsky.social
· Nov 19
Do you feel stressed?
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Reposted by Anu Sharma
Why would anyone want to be a scientist? There are the pleasures of:
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
August 15, 2025 at 8:30 PM
Why would anyone want to be a scientist? There are the pleasures of:
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
Reposted by Anu Sharma
@anu-sharma.bsky.social
want a twitch? lose itch
to use LB, go with flow
and your cells may grow
#sciku 🧪🧬🔬🧫🦠 #Phages2025
doi.org/10.1016/j.cu...
want a twitch? lose itch
to use LB, go with flow
and your cells may grow
#sciku 🧪🧬🔬🧫🦠 #Phages2025
doi.org/10.1016/j.cu...
Redirecting
doi.org
August 7, 2025 at 4:18 PM
@anu-sharma.bsky.social
want a twitch? lose itch
to use LB, go with flow
and your cells may grow
#sciku 🧪🧬🔬🧫🦠 #Phages2025
doi.org/10.1016/j.cu...
want a twitch? lose itch
to use LB, go with flow
and your cells may grow
#sciku 🧪🧬🔬🧫🦠 #Phages2025
doi.org/10.1016/j.cu...
Reposted by Anu Sharma
@anu-sharma.bsky.social: flow increases H2O2 effectiveness against #pseudomonas 50-fold, combining the two blocks motility and growth
#phages2025 🦠
www.cell.com/current-biol...
#phages2025 🦠
www.cell.com/current-biol...
Combining multiple stressors blocks bacterial migration and growth
Here, Sharma et al. use microfluidics to simultaneously provide a physical stressor
(shear flow) and a chemical stressor (H2O2) to the human pathogen Pseudomonas aeruginosa.
The replenishing power of ...
www.cell.com
August 7, 2025 at 4:11 PM
@anu-sharma.bsky.social: flow increases H2O2 effectiveness against #pseudomonas 50-fold, combining the two blocks motility and growth
#phages2025 🦠
www.cell.com/current-biol...
#phages2025 🦠
www.cell.com/current-biol...
Reposted by Anu Sharma
Reposted by Anu Sharma
(bacterial) cell divisionists take note, unbedingt 👇
#MicroSky
#MicroSky
@felixrl.bsky.social's new review in JBC highlights recent research on how #Staph aureus performs several interrelated processes like peptidoglycan assembly, cell division septum placement, and how the septum is a hub for modifying the PG to decorate the cell surface:
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Staphylococcus aureus as an emerging model to study bacterial cell division
Research on bacterial cell division has traditionally focused on rod-shaped model
organisms such as Escherichia coli and Bacillus subtilis. While these models have
been important in uncovering broadly...
www.jbc.org
June 9, 2025 at 4:42 PM
(bacterial) cell divisionists take note, unbedingt 👇
#MicroSky
#MicroSky
Reposted by Anu Sharma
Our new big review on Pseudomonas aeruginosa. Hope you enjoy reading it. www.nature.com/articles/s41...
Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility - Nature Reviews Microbiology
Pseudomonas aeruginosa is a functionally versatile bacterium, a leading opportunistic human pathogen and a model organism in microbiology. In this Review, Letizia, Diggle and Whiteley discuss P. aerug...
www.nature.com
May 29, 2025 at 1:18 PM
Our new big review on Pseudomonas aeruginosa. Hope you enjoy reading it. www.nature.com/articles/s41...
Reposted by Anu Sharma
In B. subtilis, TerC proteins function in Mn export to support the metalation of exoenzymes. MeeY is also required (directly or indirectly) for production of surfactin, a lipopeptide required for swarming motility! (collab. with Dan Kearns' lab @IU).
#MicroSky
journals.asm.org/doi/10.1128/...
#MicroSky
journals.asm.org/doi/10.1128/...
The TerC family metal chaperone MeeY enables surfactin export in Bacillus subtilis | Journal of Bacteriology
Bacillus subtilis produces surfactin, a powerful detergent-like compound that functions in intercellular communication, surface motility, and as a broad-spectrum antimicrobial agent. Production of surfactin, a cyclic lipopeptide, depends on a non-...
journals.asm.org
April 16, 2025 at 2:13 PM
In B. subtilis, TerC proteins function in Mn export to support the metalation of exoenzymes. MeeY is also required (directly or indirectly) for production of surfactin, a lipopeptide required for swarming motility! (collab. with Dan Kearns' lab @IU).
#MicroSky
journals.asm.org/doi/10.1128/...
#MicroSky
journals.asm.org/doi/10.1128/...
Reposted by Anu Sharma
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 7, 2025 at 1:07 AM
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anu Sharma
A very helpful read on tackling procrastination @naturebiotech.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology
Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write
www.nature.com
March 19, 2025 at 1:41 PM
A very helpful read on tackling procrastination @naturebiotech.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Read this to find out how fluid flow influences antimicrobial delivery! 🧪
Glad to be a part of this work.
Congratulations @ashuppara.bsky.social!
Glad to be a part of this work.
Congratulations @ashuppara.bsky.social!
Some notoriously difficult to treat infections may not be as resistant to antibiotics as has been thought, according to new research from #ILLINOIS using a microfluidic device that more closely duplicates the fluid flow found in the body than standard cultures.
go.mcb.illinois.edu/flow
go.mcb.illinois.edu/flow
March 18, 2025 at 5:20 PM
Read this to find out how fluid flow influences antimicrobial delivery! 🧪
Glad to be a part of this work.
Congratulations @ashuppara.bsky.social!
Glad to be a part of this work.
Congratulations @ashuppara.bsky.social!
Reposted by Anu Sharma
1/10 🧵 Injecting some science in your feed: Happy to share another chapter in our investigation of bacterial surface sensing. We describe the role of CpaL, a minor pilin-like protein, a key player in surface sensing and adhesion in Caulobacter crescentus. #microsky www.biorxiv.org/content/10.1...
Stimulation of the Caulobacter crescentus surface sensing pathway by deletion of a specialized minor pilin-like gene
Bacteria colonize surfaces through complex mechanisms of surface sensing. Pili are dynamic bacterial appendages that play an important role in this process. In Caulobacter crescentus , tension on retr...
www.biorxiv.org
February 19, 2025 at 8:20 AM
1/10 🧵 Injecting some science in your feed: Happy to share another chapter in our investigation of bacterial surface sensing. We describe the role of CpaL, a minor pilin-like protein, a key player in surface sensing and adhesion in Caulobacter crescentus. #microsky www.biorxiv.org/content/10.1...
Reposted by Anu Sharma
How do bacteria experience nutrient stress in nature? In our new preprint, we study how cells respond to nutrient limitation under flow. We find that in flow, cells can grow on concentrations of glucose 1,000 times lower than in batch cell culture. (1/5)
#microsky
www.biorxiv.org/content/10.1...
#microsky
www.biorxiv.org/content/10.1...
December 24, 2024 at 1:41 PM
How do bacteria experience nutrient stress in nature? In our new preprint, we study how cells respond to nutrient limitation under flow. We find that in flow, cells can grow on concentrations of glucose 1,000 times lower than in batch cell culture. (1/5)
#microsky
www.biorxiv.org/content/10.1...
#microsky
www.biorxiv.org/content/10.1...
Reposted by Anu Sharma
New research from the lab of Joe Sanfilippo demonstrates that the amount of hydrogen peroxide required to inhibit bacterial growth is 50x less than previously thought, at amounts naturally present in the human body.
go.mcb.illinois.edu/bacteria
go.mcb.illinois.edu/bacteria
December 12, 2024 at 5:09 PM
New research from the lab of Joe Sanfilippo demonstrates that the amount of hydrogen peroxide required to inhibit bacterial growth is 50x less than previously thought, at amounts naturally present in the human body.
go.mcb.illinois.edu/bacteria
go.mcb.illinois.edu/bacteria
Reposted by Anu Sharma
To honour Abigail A. Salyers (1942-2013), who is considered as the mother of microbiome research, DSMZ researchers named the strain Streptomyces salyersiae (DSM 41770) after her.
#WomenInScience #antibiotics #antibioticresistance #microbiome #microbiology
#WomenInScience #antibiotics #antibioticresistance #microbiome #microbiology
December 5, 2024 at 8:22 AM
To honour Abigail A. Salyers (1942-2013), who is considered as the mother of microbiome research, DSMZ researchers named the strain Streptomyces salyersiae (DSM 41770) after her.
#WomenInScience #antibiotics #antibioticresistance #microbiome #microbiology
#WomenInScience #antibiotics #antibioticresistance #microbiome #microbiology
Must listen!
Too often we spend only two weeks choosing a problem and then many years trying to solve it, but this limits our potential impact. For more listen to this really interesting @nightsciencepod.bsky.social episode!
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...
66 | Michael Fischbach and the scientific decision tree
Podcast Episode · Night Science · 11/25/2024 · 51m
podcasts.apple.com
November 26, 2024 at 6:30 AM
Must listen!
Reposted by Anu Sharma
The first review article from my lab, helmed by @celiasouque.bsky.social, "From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance" is now online and open access at Annual Reviews Microbiology:
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
November 21, 2024 at 3:27 PM
The first review article from my lab, helmed by @celiasouque.bsky.social, "From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance" is now online and open access at Annual Reviews Microbiology:
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Anu Sharma
So excited to see this in press! Congratulations to @anu-sharma.bsky.social for her fantastic work and first published first author paper. Check it out!!!
Do you feel stressed?
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
November 19, 2024 at 8:04 PM
So excited to see this in press! Congratulations to @anu-sharma.bsky.social for her fantastic work and first published first author paper. Check it out!!!
Do you feel stressed?
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
November 19, 2024 at 8:03 PM
Do you feel stressed?
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Reposted by Anu Sharma
Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
November 18, 2024 at 4:38 PM
Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance.
www.nature.com/articles/s44...
www.nature.com/articles/s44...