Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.

The Staphylococcus aureus type VIIb secretion system (T7SSb) is a multiprotein secretion system that secretes toxins with antibacterial activity, but which is also required for full virulence in anima...

Tularemia is a zoonotic disease caused by Francisella tularensis. Most human cases are caused by F. tularensis ssp. tularensis (type A) or F. tularensis ssp. holarctica (type B), with the former consi...

Klebsiella pneumoniae is a prominent opportunistic pathogen increasingly associated with multidrug resistance and virulence. One of the main mechanisms of antimicrobial resistance in K. pneumoniae is ...

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In the constantly evolving world of microbiology, new research and discoveries can often be overwhelming. ‘Microbial Primers’ is a series of short articles designed to simplify and illuminate intricat...

Intrastrain genetic and phenotypic diversity within Pseudomonas aeruginosa populations is common in chronic pulmonary infections. While this intrastrain heterogeneity is a hallmark of chronic infection, its consequences for the spatial organization of P. aeruginosa within the airways remain unclear. Here, we demonstrate that the loss of O-specific antigen in a subpopulation of P. aeruginosa significantly alters the spatial architecture of P. aeruginosa, without changing the total population size or composition. Using a combination of tissue clearing and hybridization chain reaction RNA-FISH in a murine lung infection model, we mapped the localization of genetically distinct P. aeruginosa variants in mixed populations in vivo. These findings reveal that genetic diversification within a strain can reshape the infection landscape at the micron scale, highlighting the overlooked role of intrastrain dynamics in shaping the microbiogeography of infections and influencing host-pathogen interactions.

Abstract. Predation is a top-down regulator of ecosystem integrity and a key driver of community structure and evolution in plants and animals. Despite our

R-pyocins are phage tail-like protein complexes produced by Pseudomonas aeruginosa that deliver a single, lethal hit by depolarizing the target cell membrane. Unlike phages, R-pyocins lack capsids and...

Intrastrain genetic and phenotypic diversity within Pseudomonas aeruginosa populations is common in chronic pulmonary infections. While this intrastrain heterogeneity is a hallmark of chronic infectio...

R-pyocins are phage tail-like protein complexes produced by Pseudomonas aeruginosa that deliver a single, lethal hit by depolarizing the target cell membrane. Unlike phages, R-pyocins lack capsids and...

Dihydrodichlorofluorescein derivatives have been employed as reporters of intracellular reactive oxygen species (ROS) in innumerable studies. Their...

Data also shows an average of nearly 400 newly reported cases of antibiotic-resistant infections a week last year

Artificial intelligence (AI) and machine learning (ML) are reshaping microbiology, enabling rapid antibiotic discovery, resistance prediction and clinical diagnostics. For microbiologists, the goal is...

Pseudomonas aeruginosa uses multiple type VI secretion systems (T6SSs) to manipulate eukaryotic cells, kill competing microbes and take up nutrients. Bacterial strains are known to differ in their T6S...

Data reveal how the global challenge to reduce deaths and infections from drug-resistant bacteria is not going according to plan.

Minimum qualifications:PhD, MD, or equivalent in a relevant field of study, plus applicable postdoctoral experience.