Annie Doyle
@anniedoyle.bsky.social
Postdoc in the Skaar Lab at Vanderbilt | PhD in the Ballard Lab from OU Health Sciences
Reposted by Annie Doyle
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:07 PM
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Reposted by Annie Doyle
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Annie Doyle
This.
"I DON'T NEED YOU TO FUCKING REWRITE WHAT I'VE JUST WRITTEN!"
October 28, 2025 at 10:57 PM
This.
Reposted by Annie Doyle
Ready to start MegaMicrobe 2025! Thanks to Owen and Jesse for leading the Skaar Lab booth with the ESKAPE band. 🎸🤘
September 27, 2025 at 2:05 PM
Ready to start MegaMicrobe 2025! Thanks to Owen and Jesse for leading the Skaar Lab booth with the ESKAPE band. 🎸🤘
Reposted by Annie Doyle
The GRFP lives!! (due end of October)
www.nsf.gov/funding/oppo...
www.nsf.gov/funding/oppo...
NSF Graduate Research Fellowship Program (GRFP)
www.nsf.gov
September 8, 2025 at 6:23 PM
The GRFP lives!! (due end of October)
www.nsf.gov/funding/oppo...
www.nsf.gov/funding/oppo...
Reposted by Annie Doyle
Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
July 26, 2025 at 3:08 AM
Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!
Reposted by Annie Doyle
The 500 additional GRFPs NSF awarded were not very evenly distributed across fields, it seems.
www.science.org/content/arti...
www.science.org/content/arti...
June 25, 2025 at 6:16 PM
The 500 additional GRFPs NSF awarded were not very evenly distributed across fields, it seems.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Annie Doyle
New review article from the lab!
"Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms": www.sciencedirect.com/science/arti...
Led by PhD student Nicole Gadda & former-PhD student from the Cotter lab Lilli Lowrey
Access link: authors.elsevier.com/a/1lHuj_,2Ci...
"Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms": www.sciencedirect.com/science/arti...
Led by PhD student Nicole Gadda & former-PhD student from the Cotter lab Lilli Lowrey
Access link: authors.elsevier.com/a/1lHuj_,2Ci...
June 20, 2025 at 5:42 PM
New review article from the lab!
"Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms": www.sciencedirect.com/science/arti...
Led by PhD student Nicole Gadda & former-PhD student from the Cotter lab Lilli Lowrey
Access link: authors.elsevier.com/a/1lHuj_,2Ci...
"Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms": www.sciencedirect.com/science/arti...
Led by PhD student Nicole Gadda & former-PhD student from the Cotter lab Lilli Lowrey
Access link: authors.elsevier.com/a/1lHuj_,2Ci...
Reposted by Annie Doyle
My latest for American Scientist Magazine helps give scientists the tools to fight back against politicized charges that our research is silly or pointless- tools that will work whether you’re asked “why are we funding this” from your asshole uncle at Thanksgiving or an asshole US Senator.
🧪🌎
🧪🌎
“Why Are We Funding This?”
Long-standing myths about “silly science” have contributed to the reckless slashing of government-supported research.
www.americanscientist.org
June 17, 2025 at 9:47 PM
My latest for American Scientist Magazine helps give scientists the tools to fight back against politicized charges that our research is silly or pointless- tools that will work whether you’re asked “why are we funding this” from your asshole uncle at Thanksgiving or an asshole US Senator.
🧪🌎
🧪🌎
Reposted by Annie Doyle
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library
containing hundreds of N-acyl lipids, including conjugates with short-chain fatty
acids. This resource enabled the...
www.cell.com
June 12, 2025 at 5:56 PM
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
Reposted by Annie Doyle
Incredibly honored to be selected as a @bwfund.bsky.social Investigator in the Pathogenesis of Infectious Disease. Thank you to @bwfund.bsky.social for supporting our work - I am thrilled to join this amazing community! And special thank you to my AMAZING team (past & present) for getting us here!
Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease www.bwfund.org/news/announc... #bwfpath
Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund
DURHAM, N.C. – The Burroughs Wellcome Fund proudly announces the 2025 Investigators in the Pathogenesis of Infectious Disease (PATH) award recipients. This year’s cohort represents a diverse group of…
www.bwfund.org
May 23, 2025 at 5:22 PM
Incredibly honored to be selected as a @bwfund.bsky.social Investigator in the Pathogenesis of Infectious Disease. Thank you to @bwfund.bsky.social for supporting our work - I am thrilled to join this amazing community! And special thank you to my AMAZING team (past & present) for getting us here!
Reposted by Annie Doyle
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
May 16, 2025 at 5:07 PM
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
I guess I’m Dr. Doyle now?!
May 2, 2025 at 6:22 PM
I guess I’m Dr. Doyle now?!
Reposted by Annie Doyle
The emergent properties of biofilms: wow!
"As cells divide and a biofilm grows, it doesn’t simply expand outward. What starts as a flat, smooth layer of cells stretches and pulses."
🧪 🧮 ⚛️ #Science
➡️How a Biofilm’s Strange Shape Emerges From Cellular Geometry
www.quantamagazine.org/how-a-biofil...
"As cells divide and a biofilm grows, it doesn’t simply expand outward. What starts as a flat, smooth layer of cells stretches and pulses."
🧪 🧮 ⚛️ #Science
➡️How a Biofilm’s Strange Shape Emerges From Cellular Geometry
www.quantamagazine.org/how-a-biofil...
April 25, 2025 at 3:43 PM
The emergent properties of biofilms: wow!
"As cells divide and a biofilm grows, it doesn’t simply expand outward. What starts as a flat, smooth layer of cells stretches and pulses."
🧪 🧮 ⚛️ #Science
➡️How a Biofilm’s Strange Shape Emerges From Cellular Geometry
www.quantamagazine.org/how-a-biofil...
"As cells divide and a biofilm grows, it doesn’t simply expand outward. What starts as a flat, smooth layer of cells stretches and pulses."
🧪 🧮 ⚛️ #Science
➡️How a Biofilm’s Strange Shape Emerges From Cellular Geometry
www.quantamagazine.org/how-a-biofil...
Reposted by Annie Doyle
ICYMI:
@harvard.edu today filed a 51-page lawsuit against the Trump Administration, Pam Bondi, RFK Jr., and several other defendants for their unconstitutional and unlawful federal funding freeze.
www.harvard.edu/president/ne...
@harvard.edu today filed a 51-page lawsuit against the Trump Administration, Pam Bondi, RFK Jr., and several other defendants for their unconstitutional and unlawful federal funding freeze.
www.harvard.edu/president/ne...
Upholding Our Values, Defending Our University
Dear Members of the Harvard Community,Over the course of the past week, the federal government has taken several actions following Harvard’s refusal to
www.harvard.edu
April 22, 2025 at 12:54 AM
ICYMI:
@harvard.edu today filed a 51-page lawsuit against the Trump Administration, Pam Bondi, RFK Jr., and several other defendants for their unconstitutional and unlawful federal funding freeze.
www.harvard.edu/president/ne...
@harvard.edu today filed a 51-page lawsuit against the Trump Administration, Pam Bondi, RFK Jr., and several other defendants for their unconstitutional and unlawful federal funding freeze.
www.harvard.edu/president/ne...
Reposted by Annie Doyle
Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky
wgntv.com/evanston/nor...
wgntv.com/evanston/nor...
Northwestern University to self-fund research despite Trump administration freeze
While university officials said they’ve still not received official word of such action, they acknowledged receiving about 100 stop-work orders from the federal government on roughly 100 fede…
wgntv.com
April 19, 2025 at 11:17 AM
Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky
wgntv.com/evanston/nor...
wgntv.com/evanston/nor...
Reposted by Annie Doyle
Thirty-eight of 43 experts cut last month from the boards that review the science and research that happens in laboratories at the National Institutes of Health are female, Black or Hispanic, according to an analysis by the chairs of a dozen of the boards.
Women, minorities fired in purge of NIH science review boards
Scientists, with expertise in fields that include mental health, cancer and infectious disease, typically serve five-year terms and were not given a reason for their dismissal.
www.washingtonpost.com
April 16, 2025 at 6:46 PM
Thirty-eight of 43 experts cut last month from the boards that review the science and research that happens in laboratories at the National Institutes of Health are female, Black or Hispanic, according to an analysis by the chairs of a dozen of the boards.
Reposted by Annie Doyle
The Trump administration has drafted a memo to Congress outlining its intent to end nearly all federal funding for public media, which includes NPR and PBS, according to a White House official who spoke to NPR.
Trump plans order to cut funding for NPR and PBS
President Trump and GOP members of Congress have accused the public broadcasters of biased and "woke" programming. The president plans a rescission, which would give Congress 45 days to approve the di...
www.npr.org
April 15, 2025 at 4:55 PM
The Trump administration has drafted a memo to Congress outlining its intent to end nearly all federal funding for public media, which includes NPR and PBS, according to a White House official who spoke to NPR.
Warning: this story has a 100% chance of filling your day with so much joy
The players are women over 50. The oldest this year is 87. They took the field in South Africa for their "World Cup." One team was crowned the winner but all the players consider themselves champions.
Soccer-loving 'grannies' go for the GOOOOAAAALLLL in their version of the World Cup
The players are women over 50. The oldest this year is 87. They took the field in South Africa for their "World Cup." One team was crowned the winner but all the players consider themselves champions.
www.npr.org
April 13, 2025 at 4:32 PM
Warning: this story has a 100% chance of filling your day with so much joy
What an honor it has been to serve the OUHSC community ❤️
April 11, 2025 at 12:00 AM
What an honor it has been to serve the OUHSC community ❤️
Reposted by Annie Doyle
is.... that a capybara for scale
April 7, 2025 at 5:39 PM
is.... that a capybara for scale
Reposted by Annie Doyle
So much joy to see everyone today coming together to celebrate 20 years of the Skaar Lab. Thank you to Eric for the leadership and mentorship over the years! 🥰
April 5, 2025 at 11:00 PM
So much joy to see everyone today coming together to celebrate 20 years of the Skaar Lab. Thank you to Eric for the leadership and mentorship over the years! 🥰
Reposted by Annie Doyle
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 7, 2025 at 1:07 AM
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Annie Doyle
Such a wonderful day celebrating all that has been accomplished by the Skaar lab over the last 20 years! I feel very lucky and proud to be a part of such an incredible group of scientists!
20 years of the Skaar lab!
April 6, 2025 at 12:20 PM
Such a wonderful day celebrating all that has been accomplished by the Skaar lab over the last 20 years! I feel very lucky and proud to be a part of such an incredible group of scientists!
Reposted by Annie Doyle
Our open letter response to the #USCommerceDept and #POTUS
April 3, 2025 at 12:33 AM
Our open letter response to the #USCommerceDept and #POTUS