ANDCS
@andcs-asso.bsky.social
Promotes #scientific training programs for #health #students in France, encourages interaction between #MD_PhD trainees and provides them support and networking
Reposted by ANDCS
Astrocytes make up one-quarter of the brain. Nature reports how researchers are learning their value in shaping our behaviour, memory, and health. #Neuroskyence 🧪
The ‘silent’ brain cells that shape our behaviour, memory and health
Astrocytes make up one-quarter of the brain, but researchers are only now realizing their true value.
go.nature.com
December 6, 2025 at 5:29 PM
Astrocytes make up one-quarter of the brain. Nature reports how researchers are learning their value in shaping our behaviour, memory, and health. #Neuroskyence 🧪
Reposted by ANDCS
Nature research paper: Inhibitors supercharge kinase turnover through native proteolytic circuits
go.nature.com/3JWgIk4
go.nature.com/3JWgIk4
Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature
Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.
go.nature.com
December 1, 2025 at 10:42 AM
Nature research paper: Inhibitors supercharge kinase turnover through native proteolytic circuits
go.nature.com/3JWgIk4
go.nature.com/3JWgIk4
Reposted by ANDCS
Nature research paper: Thalamocortical transcriptional gates coordinate memory stabilization
go.nature.com/48CjZy8
go.nature.com/48CjZy8
Thalamocortical transcriptional gates coordinate memory stabilization - Nature
The sequential recruitment of a thalamocortical transcriptional cascade enables memory maintenance over long timescales.
go.nature.com
November 26, 2025 at 5:47 PM
Nature research paper: Thalamocortical transcriptional gates coordinate memory stabilization
go.nature.com/48CjZy8
go.nature.com/48CjZy8
Reposted by ANDCS
The method might one day overcome a key stumbling block faced by gene-editing therapies: the need to design a bespoke treatment for each disease
go.nature.com/4a0QoQ6
go.nature.com/4a0QoQ6
How to fix genetic ‘nonsense’: versatile gene-editing tool could tackle a host of diseases
Synthetic RNA molecules can program cells to ignore DNA mutations that interfere with protein production.
go.nature.com
November 20, 2025 at 9:35 AM
The method might one day overcome a key stumbling block faced by gene-editing therapies: the need to design a bespoke treatment for each disease
go.nature.com/4a0QoQ6
go.nature.com/4a0QoQ6
L’ANDCS est heureuse de vous proposer un évènement inédit : une soirée de découverte de l’Institut Pasteur se déroulant le jeudi 23 novembre !
Voici le formulaire d'inscription :
forms.gle/v8QYsYz7s2q8...
Voici le formulaire d'inscription :
forms.gle/v8QYsYz7s2q8...
November 19, 2025 at 6:54 PM
L’ANDCS est heureuse de vous proposer un évènement inédit : une soirée de découverte de l’Institut Pasteur se déroulant le jeudi 23 novembre !
Voici le formulaire d'inscription :
forms.gle/v8QYsYz7s2q8...
Voici le formulaire d'inscription :
forms.gle/v8QYsYz7s2q8...
Reposted by ANDCS
Nature research paper: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death
go.nature.com/4hSSG5Q
go.nature.com/4hSSG5Q
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature
CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a therapeutic target.
go.nature.com
November 12, 2025 at 7:15 PM
Nature research paper: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death
go.nature.com/4hSSG5Q
go.nature.com/4hSSG5Q
Reposted by ANDCS
Human biomass movement may be up to 40 times greater than that of all land animals combined, according to research in Nature Ecology & Evolution. A second Nature Communications paper finds that wild mammal biomass has more than halved since 1850. go.nature.com/4oID33i go.nature.com/3LhSD7n 🧪
November 10, 2025 at 2:20 AM
Human biomass movement may be up to 40 times greater than that of all land animals combined, according to research in Nature Ecology & Evolution. A second Nature Communications paper finds that wild mammal biomass has more than halved since 1850. go.nature.com/4oID33i go.nature.com/3LhSD7n 🧪
Reposted by ANDCS
In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo
#AHA25
#AHA25
November 9, 2025 at 4:14 PM
In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo
#AHA25
#AHA25
Reposted by ANDCS
Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors, according to a paper in Nature Materials. go.nature.com/4ouOWds 🧪
November 5, 2025 at 5:19 PM
Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors, according to a paper in Nature Materials. go.nature.com/4ouOWds 🧪
Le lundi 17 novembre 2025 à 19h30, à l’ @ibensens.bsky.social, nous aurons le plaisir d’accueillir @lacombekarine.bsky.social
, professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr.
Inscrivez-vous ici : forms.gle/iguhqmQndjw1...
, professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr.
Inscrivez-vous ici : forms.gle/iguhqmQndjw1...
November 4, 2025 at 8:02 PM
Le lundi 17 novembre 2025 à 19h30, à l’ @ibensens.bsky.social, nous aurons le plaisir d’accueillir @lacombekarine.bsky.social
, professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr.
Inscrivez-vous ici : forms.gle/iguhqmQndjw1...
, professeure des universités - practicienne hospitalière (PUPH) en infectiologie à @sorbonne-universite.fr.
Inscrivez-vous ici : forms.gle/iguhqmQndjw1...
Reposted by ANDCS
A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
go.nature.com
October 29, 2025 at 1:50 AM
A paper in Nature reports that mRNA vaccines targeting SARS-CoV-2, COVID-19, also sensitize tumours to immune checkpoint inhibitors. #medsky 🧪
Reposted by ANDCS
Researchers in #ScienceTranslationalMedicine present a new method to generate stable, antigen-specific regulatory #Tcells in large quantities using the body’s own conventional T cell pool, and show the resulting cells can treat IBD and GvHD in mouse models. https://scim.ag/47dDYBm
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
scim.ag
October 27, 2025 at 6:00 PM
Researchers in #ScienceTranslationalMedicine present a new method to generate stable, antigen-specific regulatory #Tcells in large quantities using the body’s own conventional T cell pool, and show the resulting cells can treat IBD and GvHD in mouse models. https://scim.ag/47dDYBm
Reposted by ANDCS
In low-risk patients with severe aortic stenosis, transcatheter and surgical aortic-valve replacement had similar 7-year survival and valve durability outcomes, with no evidence of differences in composite end points. Full PARTNER 3 trial results: nej.md/4nieHfx
#TCT2025 | @crfheart.bsky.social
#TCT2025 | @crfheart.bsky.social
October 27, 2025 at 6:27 PM
In low-risk patients with severe aortic stenosis, transcatheter and surgical aortic-valve replacement had similar 7-year survival and valve durability outcomes, with no evidence of differences in composite end points. Full PARTNER 3 trial results: nej.md/4nieHfx
#TCT2025 | @crfheart.bsky.social
#TCT2025 | @crfheart.bsky.social
Reposted by ANDCS
Nature research paper: Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
go.nature.com/4nlQFQK
go.nature.com/4nlQFQK
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled in the faeces.
go.nature.com
October 23, 2025 at 8:09 AM
Nature research paper: Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
go.nature.com/4nlQFQK
go.nature.com/4nlQFQK
Reposted by ANDCS
Vaccines for #H5N1 based on either mRNA or an adenovirus vector can shield macaques from the virus when delivered via an intramuscular prime and a mucosal boost regimen, according to new experiments in #ScienceTranslationalMedicine. https://scim.ag/47aS1HR
An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques
Mucosal delivery of a rhesus adenovirus–vectored H5N1 influenza vaccine confers protection against lethal challenge in cynomolgus macaques.
scim.ag
October 20, 2025 at 6:00 PM
Vaccines for #H5N1 based on either mRNA or an adenovirus vector can shield macaques from the virus when delivered via an intramuscular prime and a mucosal boost regimen, according to new experiments in #ScienceTranslationalMedicine. https://scim.ag/47aS1HR
Reposted by ANDCS
This ‘fundamental’ work substantially reveals how the cell’s glycocalyx (a dense layer of sugars and proteins on the cell surface) acts as a non-specific barrier, making it harder for viruses to interact with receptors.
buff.ly/YkpiWzD
buff.ly/YkpiWzD
October 20, 2025 at 8:02 PM
This ‘fundamental’ work substantially reveals how the cell’s glycocalyx (a dense layer of sugars and proteins on the cell surface) acts as a non-specific barrier, making it harder for viruses to interact with receptors.
buff.ly/YkpiWzD
buff.ly/YkpiWzD
Reposted by ANDCS
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
October 16, 2025 at 12:55 PM
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
Le jeudi 23 octobre 2025 à 19h30, à l’ @ibensens.bsky.social , nous aurons le plaisir d’accueillir @thomasdavergne.bsky.social , enseignant-chercheur en sciences de la rééducation et de la réadaptation, à l'occasion du premier dîner double cursus de l'année !
Inscrivez-vous ici : urls.fr/RA1rrO
Inscrivez-vous ici : urls.fr/RA1rrO
October 15, 2025 at 7:16 PM
Le jeudi 23 octobre 2025 à 19h30, à l’ @ibensens.bsky.social , nous aurons le plaisir d’accueillir @thomasdavergne.bsky.social , enseignant-chercheur en sciences de la rééducation et de la réadaptation, à l'occasion du premier dîner double cursus de l'année !
Inscrivez-vous ici : urls.fr/RA1rrO
Inscrivez-vous ici : urls.fr/RA1rrO
Reposted by ANDCS
Nature research paper: The astrocytic ensemble acts as a multiday trace to stabilize memory
go.nature.com/4hc7zQp
go.nature.com/4hc7zQp
The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature
Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilization.
go.nature.com
October 15, 2025 at 4:12 PM
Nature research paper: The astrocytic ensemble acts as a multiday trace to stabilize memory
go.nature.com/4hc7zQp
go.nature.com/4hc7zQp
Reposted by ANDCS
Replicating RNA vaccines based on older #H5N1 antigens can shield macaques from lethal infections with contemporary H5N1 strains, according to new work that hints current vaccine stockpiles can still offer cross-protection. #ScienceTranslationalMedicine https://scim.ag/3W1QdMn
A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge
LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.
scim.ag
October 13, 2025 at 6:00 PM
Replicating RNA vaccines based on older #H5N1 antigens can shield macaques from lethal infections with contemporary H5N1 strains, according to new work that hints current vaccine stockpiles can still offer cross-protection. #ScienceTranslationalMedicine https://scim.ag/3W1QdMn
Reposted by ANDCS
Mild stresses on the body, like fasting or cold exposure, can delay ageing. But how?
A new Insight Article explores how oxygen-sensing neurons in C. elegans trigger body-wide stress signals that boost resilience and extend lifespan.
buff.ly/wJIQKfm
A new Insight Article explores how oxygen-sensing neurons in C. elegans trigger body-wide stress signals that boost resilience and extend lifespan.
buff.ly/wJIQKfm
October 12, 2025 at 8:21 AM
Mild stresses on the body, like fasting or cold exposure, can delay ageing. But how?
A new Insight Article explores how oxygen-sensing neurons in C. elegans trigger body-wide stress signals that boost resilience and extend lifespan.
buff.ly/wJIQKfm
A new Insight Article explores how oxygen-sensing neurons in C. elegans trigger body-wide stress signals that boost resilience and extend lifespan.
buff.ly/wJIQKfm
Reposted by ANDCS
Can we exploit past phage infection events (prophages) to decipher the specificity of phage receptor-binding proteins such as depolymerases?🔎 Happy to share our recent work at @natcomms.nature.com 🔽 #microsky #phagesky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases - Nature Communications
Here, the authors exploit the genetic information encoded in Klebsiella prophages to model the interplay between bacteria, prophages, and their depolymerases, using a directed acyclic graph-model and a sequence clustering-based model.
www.nature.com
October 8, 2025 at 8:59 AM
Can we exploit past phage infection events (prophages) to decipher the specificity of phage receptor-binding proteins such as depolymerases?🔎 Happy to share our recent work at @natcomms.nature.com 🔽 #microsky #phagesky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by ANDCS
The newfound ensemble of neurons could lead to therapies to treat persistent pain
go.nature.com/4gZHzrv
go.nature.com/4gZHzrv
Brain area linked to chronic pain discovered — offering hope for treatments
The newfound ensemble of neurons could lead to therapies to treat persistent pain, which affects roughly one of five people globally.
go.nature.com
October 8, 2025 at 5:12 PM
The newfound ensemble of neurons could lead to therapies to treat persistent pain
go.nature.com/4gZHzrv
go.nature.com/4gZHzrv
Reposted by ANDCS
I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...
Hidden networks in the brain
Dendritic nanotubes extend brain connectivity beyond synapses
www.science.org
October 4, 2025 at 7:14 AM
I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...
Reposted by ANDCS
Nature research paper: Connecting chemical and protein sequence space to predict biocatalytic reactions
go.nature.com/4gUrL9t
go.nature.com/4gUrL9t
Connecting chemical and protein sequence space to predict biocatalytic reactions - Nature
A two-phase machine-learning-based tool making use of high-throughput experimentation is introduced to examine the connections between chemical and protein sequence space and predict productive biocatalytic reactions among substrate and enzyme pairs.
go.nature.com
October 3, 2025 at 11:41 AM
Nature research paper: Connecting chemical and protein sequence space to predict biocatalytic reactions
go.nature.com/4gUrL9t
go.nature.com/4gUrL9t