Alexis Rohou
@alexisrohou.bsky.social
CryoEM and structural biology methods, drug discovery. Also: Celtics, Camus, rocksteady, drum and bass. He, him, his.
Reposted by Alexis Rohou
This bring me back to one of my favorite anecdotes.
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
November 14, 2025 at 3:31 PM
This bring me back to one of my favorite anecdotes.
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
In the early 1980s, a chemical physicist submitted a proposal to NIH that was assigned to NIGMS.
It received a fairly poor score (~60th percentile).
7/13
Reposted by Alexis Rohou
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
November 5, 2025 at 4:23 PM
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
Reposted by Alexis Rohou
Reposted by Alexis Rohou
my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
#hiring #researchassociate #structuralbiology #proteinsciences #cryoem #biochemistry #biophysics #dnarepair #drugdiscovery | Stanislau Yatskevich
We’re hiring a 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐀𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞 (Contractor) to join our 𝐒𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐁𝐢𝐨𝐥𝐨𝐠𝐲 team in 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞𝐬 focused on the molecular mechanisms of DNA repair.
𝐖𝐡𝐲 𝐭𝐡𝐢𝐬 𝐫𝐨𝐥𝐞 𝐦𝐚𝐭𝐭𝐞𝐫𝐬
You’ll help purify and ...
www.linkedin.com
October 31, 2025 at 9:05 PM
my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility
www.linkedin.com/posts/stanis...
Reposted by Alexis Rohou
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Reposted by Alexis Rohou
Interested in Biological Macromolecules?
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...
October 29, 2025 at 8:05 PM
Interested in Biological Macromolecules?
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...
I’ll be there and the cryoEM/cryoET session lineup looks great. See you there?
Interested in Biological Macromolecules?
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...
IUCr2026 has you covered with NINETEEN symposia, including cryoEM/cryoET innovations; membrane proteins; protein design/engineering; drug discovery; 21st century structural enzymology; and more!
Join us in Calgary:
event.fourwaves.com/...
October 29, 2025 at 3:04 AM
I’ll be there and the cryoEM/cryoET session lineup looks great. See you there?
Reposted by Alexis Rohou
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
October 28, 2025 at 6:30 PM
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
Reposted by Alexis Rohou
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
How mRNA Vaccines Can Help Fight Cancer
Turning "cold" tumors "hot"
erictopol.substack.com
October 22, 2025 at 3:19 PM
How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...
Reposted by Alexis Rohou
... and the Angel whispered "finish your current manuscript before starting a new one."
October 22, 2025 at 9:01 AM
... and the Angel whispered "finish your current manuscript before starting a new one."
Very cool! Congratulations @vcushing.bsky.social @bjgreber.bsky.social and the whole team!
New paper out now in Science! Check it out!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
October 16, 2025 at 6:45 PM
Very cool! Congratulations @vcushing.bsky.social @bjgreber.bsky.social and the whole team!
Reposted by Alexis Rohou
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
www.biorxiv.org/content/10.1...
#teamtomo
October 15, 2025 at 6:26 AM
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
www.biorxiv.org/content/10.1...
#teamtomo
Trigger warning.
Just printing out a paper to read. So glad the figures are at the end so I can look at them alongside whatever bit of the text I want to, rather than in-line making me have to flip back to the first in-text callout 😜 @pracheeac.bsky.social
October 15, 2025 at 4:03 AM
Trigger warning.
Reposted by Alexis Rohou
Re-upping:
Excellent assessment of John "Roger Taney" Roberts.
In @harvardmagazine.bsky.social , by Lincoln Caplan.
As careful, legally informed, judicious-minded writer as you're going to find. With an unsparing judgment.
www.harvardmagazine.com/legal/suprem...
Excellent assessment of John "Roger Taney" Roberts.
In @harvardmagazine.bsky.social , by Lincoln Caplan.
As careful, legally informed, judicious-minded writer as you're going to find. With an unsparing judgment.
www.harvardmagazine.com/legal/suprem...
What Trump Means for John Roberts's Legacy | Harvard Magazine
Executive power is on the docket at the Supreme Court.
www.harvardmagazine.com
October 11, 2025 at 4:57 PM
Re-upping:
Excellent assessment of John "Roger Taney" Roberts.
In @harvardmagazine.bsky.social , by Lincoln Caplan.
As careful, legally informed, judicious-minded writer as you're going to find. With an unsparing judgment.
www.harvardmagazine.com/legal/suprem...
Excellent assessment of John "Roger Taney" Roberts.
In @harvardmagazine.bsky.social , by Lincoln Caplan.
As careful, legally informed, judicious-minded writer as you're going to find. With an unsparing judgment.
www.harvardmagazine.com/legal/suprem...
An insightful read. I hadn’t appreciated the links between feudalism and privatization. The author’s evocation of how future historians may look back on our era in that respect felt important, and a fruitful way to think, to me. I’m hopeful the pendulum will swing back towards effective government.
Feudalism Is Our Future
What the next Dark Ages could look like
www.theatlantic.com
October 11, 2025 at 6:56 PM
An insightful read. I hadn’t appreciated the links between feudalism and privatization. The author’s evocation of how future historians may look back on our era in that respect felt important, and a fruitful way to think, to me. I’m hopeful the pendulum will swing back towards effective government.
Reposted by Alexis Rohou
1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
Engineering substrate selectivity in the human sodium/iodide symporter (NIS)
Iodide (I-) uptake mediated by the Na+/I- symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I- is an essential constituent. NIS couples the inward transport of I-...
www.biorxiv.org
October 9, 2025 at 2:43 AM
1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
Reposted by Alexis Rohou
Fwd: Fwd: “I hope this email finds you well”
October 7, 2025 at 8:37 AM
Fwd: Fwd: “I hope this email finds you well”
Reposted by Alexis Rohou
Love this story about one of today's Nobel winners, Mary Brunkow.
(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)
(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)
October 6, 2025 at 1:35 PM
Love this story about one of today's Nobel winners, Mary Brunkow.
(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)
(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)
Reposted by Alexis Rohou
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Medicine Nobel goes to three researchers who identified immune system’s security guards
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease
scim.ag
October 6, 2025 at 1:45 PM
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Reposted by Alexis Rohou
RIP to the legend
October 3, 2025 at 8:37 PM
RIP to the legend
I hadn't realized Robert Oppenheimer was a francophone. A few pearls in there. Last question: "Einstein is often quoted as saying if he had to do it all over again he'd be a plumber... what about you?" Oppenheimer: "I am very glad that the human condition means one never has to answer this question"
1958 : Entretien avec Oppenheimer, le père de la bombe atomique | Archive INA
YouTube video by INA Histoire
www.youtube.com
September 30, 2025 at 3:39 PM
I hadn't realized Robert Oppenheimer was a francophone. A few pearls in there. Last question: "Einstein is often quoted as saying if he had to do it all over again he'd be a plumber... what about you?" Oppenheimer: "I am very glad that the human condition means one never has to answer this question"
The end of an era. An outstanding body of broadcasting work.
Melvyn Bragg steps down from BBC Radio 4's In Our Time after 26 years
The veteran presenter has hosted more than 1,000 epsiodes of the programme over the past 26 years.
www.bbc.com
September 29, 2025 at 5:33 AM
The end of an era. An outstanding body of broadcasting work.