Alex Holehouse
@alexholehouse.bsky.social
Associate Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him.
https://www.holehouselab.com/
https://www.holehouselab.com/
Pinned
Alex Holehouse
@alexholehouse.bsky.social
· May 23
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
Reposted by Alex Holehouse
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Alex Holehouse
How to tackle emerging questions in cellular organisation, adaptation, and robustness? Join #EESPhaseSeparation! 🧬🦠
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
November 13, 2025 at 10:05 AM
How to tackle emerging questions in cellular organisation, adaptation, and robustness? Join #EESPhaseSeparation! 🧬🦠
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
Bringing together scientists from diverse fields to foster new discoveries in condensate biology.
Submit your abstract by 10 Feb: s.embl.org/ees26-08-bl
📅 19 – 22 May 2026
Reposted by Alex Holehouse
The First Annual Virtual WALII Symposium: Exploring Life Without Water is ONE WEEK AWAY! 🗓️💧
Register now to join us on November, 18!
www.walii.science/virtual-symp...
Register now to join us on November, 18!
www.walii.science/virtual-symp...
November 11, 2025 at 7:37 PM
The First Annual Virtual WALII Symposium: Exploring Life Without Water is ONE WEEK AWAY! 🗓️💧
Register now to join us on November, 18!
www.walii.science/virtual-symp...
Register now to join us on November, 18!
www.walii.science/virtual-symp...
The fact that if you search for something on Google with a typo, it suggests a correct spelling (good!), and you select that spelling to search (also good!), but then click on the search bar, it RETAINS THE WRONG SPELLING is among the most bizarre UI/UX decisions I've seen in many years.
November 8, 2025 at 11:27 PM
The fact that if you search for something on Google with a typo, it suggests a correct spelling (good!), and you select that spelling to search (also good!), but then click on the search bar, it RETAINS THE WRONG SPELLING is among the most bizarre UI/UX decisions I've seen in many years.
Reposted by Alex Holehouse
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
October 18, 2025 at 12:05 AM
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
Reposted by Alex Holehouse
Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧
Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social
www.sciencedirect.com/science/arti...
Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social
www.sciencedirect.com/science/arti...
October 16, 2025 at 8:46 AM
Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧
Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social
www.sciencedirect.com/science/arti...
Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Alex Holehouse
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
October 8, 2025 at 8:26 PM
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
Reposted by Alex Holehouse
Musk FRS.
The elimination of USAID is a moral atrocity and all involved made a choice to enable, and then lie about, ending the lives of some of the most vulnerable people in the world.
October 8, 2025 at 2:25 PM
Musk FRS.
Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.
Will stay for the foreseeable future!
Will stay for the foreseeable future!
October 2, 2025 at 4:00 PM
Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.
Will stay for the foreseeable future!
Will stay for the foreseeable future!
Reposted by Alex Holehouse
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
October 2, 2025 at 7:46 AM
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
Last week, Washington University made the perhaps questionable decision to award me tenure.
September 29, 2025 at 12:53 PM
Last week, Washington University made the perhaps questionable decision to award me tenure.
Reposted by Alex Holehouse
Join us for the first inaugural WALII Virtual Symposium on Tuesday, Nov 18, 2025!
Abstract submissions for a contributed talk are NOW OPEN!
Selected speakers will be chosen in Oct. & will present 10-12 min. talks followed by 3-5 min. of Q&A.
Visit: walii.science/virtual-symp...
Abstract submissions for a contributed talk are NOW OPEN!
Selected speakers will be chosen in Oct. & will present 10-12 min. talks followed by 3-5 min. of Q&A.
Visit: walii.science/virtual-symp...
September 23, 2025 at 8:44 PM
Join us for the first inaugural WALII Virtual Symposium on Tuesday, Nov 18, 2025!
Abstract submissions for a contributed talk are NOW OPEN!
Selected speakers will be chosen in Oct. & will present 10-12 min. talks followed by 3-5 min. of Q&A.
Visit: walii.science/virtual-symp...
Abstract submissions for a contributed talk are NOW OPEN!
Selected speakers will be chosen in Oct. & will present 10-12 min. talks followed by 3-5 min. of Q&A.
Visit: walii.science/virtual-symp...
Reposted by Alex Holehouse
Reading today’s big NYT Magazine story made me physically sick
It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research
Not just the US vaccine system—they’re crushing cancer R&D
🎁Link
www.nytimes.com/2025/09/14/m...
It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research
Not just the US vaccine system—they’re crushing cancer R&D
🎁Link
www.nytimes.com/2025/09/14/m...
How the Trump Administration Is Dismantling America’s Cancer-Research System
www.nytimes.com
September 14, 2025 at 1:32 PM
Reading today’s big NYT Magazine story made me physically sick
It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research
Not just the US vaccine system—they’re crushing cancer R&D
🎁Link
www.nytimes.com/2025/09/14/m...
It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research
Not just the US vaccine system—they’re crushing cancer R&D
🎁Link
www.nytimes.com/2025/09/14/m...
Reposted by Alex Holehouse
1/14
Happy (but mostly relieved) to share my dream project with @boudkerlab.bsky.social, now published in @natsmb.nature.com! We used evolution, protein engineering & cryoEM to uncover how ion coupling in glutamate transporters works, and how it evolved.🧵
Free article: go.nature.com/4oRUC1q
Happy (but mostly relieved) to share my dream project with @boudkerlab.bsky.social, now published in @natsmb.nature.com! We used evolution, protein engineering & cryoEM to uncover how ion coupling in glutamate transporters works, and how it evolved.🧵
Free article: go.nature.com/4oRUC1q
Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters - Nature Structural & Molecular Biology
Reddy et al. used ancestral protein reconstruction, cryo-electron microscopy and functional assays to elucidate how a secondary active transporter evolved to harness the energy of sodium gradients to ...
go.nature.com
September 12, 2025 at 12:08 AM
1/14
Happy (but mostly relieved) to share my dream project with @boudkerlab.bsky.social, now published in @natsmb.nature.com! We used evolution, protein engineering & cryoEM to uncover how ion coupling in glutamate transporters works, and how it evolved.🧵
Free article: go.nature.com/4oRUC1q
Happy (but mostly relieved) to share my dream project with @boudkerlab.bsky.social, now published in @natsmb.nature.com! We used evolution, protein engineering & cryoEM to uncover how ion coupling in glutamate transporters works, and how it evolved.🧵
Free article: go.nature.com/4oRUC1q
Reposted by Alex Holehouse
Excited to welcome Rohit Pappu (@rohitpappu68.bsky.social) and Meredith Jackrel this week! Be sure not to miss their talks!
Sign up here if you've not signed up already!
idpseminars.com
Sign up here if you've not signed up already!
idpseminars.com
September 3, 2025 at 3:02 AM
Excited to welcome Rohit Pappu (@rohitpappu68.bsky.social) and Meredith Jackrel this week! Be sure not to miss their talks!
Sign up here if you've not signed up already!
idpseminars.com
Sign up here if you've not signed up already!
idpseminars.com
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
Asst Professor - Molecular Biology - Computational Biochemist
The Department of Molecular Biology (MOLB) and the School of Computing (SoC) at the University of Wyoming seeks candidates for a tenure-track position at the rank of Assistant Professor starting in th...
eeik.fa.us2.oraclecloud.com
August 28, 2025 at 4:16 PM
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
Reposted by Alex Holehouse
🚨🚨IDPSeminars is BACK 🚨🚨
Season 19 (!) gets underway next week with @rohitpappu68.bsky.social and Meredith Jackrel!
Date: Thur. Sept 4th
Time: 1 pm EST [USA] / 7 pm CET [Europe]
If you've previously signed up, you should be good to go, otherwise, please sign up at idpseminars.com
Season 19 (!) gets underway next week with @rohitpappu68.bsky.social and Meredith Jackrel!
Date: Thur. Sept 4th
Time: 1 pm EST [USA] / 7 pm CET [Europe]
If you've previously signed up, you should be good to go, otherwise, please sign up at idpseminars.com
August 27, 2025 at 1:49 PM
🚨🚨IDPSeminars is BACK 🚨🚨
Season 19 (!) gets underway next week with @rohitpappu68.bsky.social and Meredith Jackrel!
Date: Thur. Sept 4th
Time: 1 pm EST [USA] / 7 pm CET [Europe]
If you've previously signed up, you should be good to go, otherwise, please sign up at idpseminars.com
Season 19 (!) gets underway next week with @rohitpappu68.bsky.social and Meredith Jackrel!
Date: Thur. Sept 4th
Time: 1 pm EST [USA] / 7 pm CET [Europe]
If you've previously signed up, you should be good to go, otherwise, please sign up at idpseminars.com
Our 4th generation protocol book has arrived!!
August 26, 2025 at 1:17 PM
Our 4th generation protocol book has arrived!!
...as we cross the grim milestone of adding supplementary fig. S50, I am beginning to wonder where it all went wrong 🫠
August 18, 2025 at 10:43 PM
...as we cross the grim milestone of adding supplementary fig. S50, I am beginning to wonder where it all went wrong 🫠
Reposted by Alex Holehouse
Reposted by Alex Holehouse
PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET, Dr. Sigrid Milles, The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmp-berlin.de Berlin, Germany leibniz-fmp.softgarden.io/job/58144047... #NMRjobs #NMRchat #NMR 🧲
PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) at Leibniz-Forschungsinstitut für Molekulare Pharmakologie
We're looking for: PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) (Part Time) • Berlin, Deutschland
leibniz-fmp.softgarden.io
August 11, 2025 at 4:52 PM
PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET, Dr. Sigrid Milles, The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmp-berlin.de Berlin, Germany leibniz-fmp.softgarden.io/job/58144047... #NMRjobs #NMRchat #NMR 🧲
Although the situation in the world right now is Not Good™, it remains such a preposterous privilege to work with such a wonderful bunch of people. Lab happy hour 25/08/01.
August 2, 2025 at 11:52 PM
Although the situation in the world right now is Not Good™, it remains such a preposterous privilege to work with such a wonderful bunch of people. Lab happy hour 25/08/01.
Reposted by Alex Holehouse
Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling https://www.biorxiv.org/content/10.1101/2025.07.27.667045v1
July 28, 2025 at 3:16 AM
Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling https://www.biorxiv.org/content/10.1101/2025.07.27.667045v1
Reposted by Alex Holehouse
Our SUF4 condensation paper is finally out! cell.com/cell-reports... Thank you to everyone who has scientifically, mentally, and emotionally supported my co-authors and me over the years. Below is a summary of the work-- we hope you enjoy our findings!
Manipulating condensation of thermo-sensitive SUF4 protein tunes flowering time in Arabidopsis thaliana
Meyer et al. present evidence that protein liquid-liquid phase separation may serve
as a physical mechanism for coordinating plant development and flowering time with
environmental seasonality.
cell.com
June 26, 2025 at 12:11 AM
Our SUF4 condensation paper is finally out! cell.com/cell-reports... Thank you to everyone who has scientifically, mentally, and emotionally supported my co-authors and me over the years. Below is a summary of the work-- we hope you enjoy our findings!
Reposted by Alex Holehouse
Very happy (and frankly relieved) to see this paper finally out in peer-reviewed form. (Preprint was posted in August 2021, but this is the world we live in now). rdcu.be/erMk6
Crossover patterning through condensation and coarsening of pro-crossover factors
Nature Cell Biology - Zhang et al. provide evidence that, during meiosis, recombination proteins assemble into active droplets, the coarsening of which partially explains the phenomenon of...
rdcu.be
June 19, 2025 at 2:37 PM
Very happy (and frankly relieved) to see this paper finally out in peer-reviewed form. (Preprint was posted in August 2021, but this is the world we live in now). rdcu.be/erMk6