Alex Holehouse
@alexholehouse.bsky.social
Associate Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him.
https://www.holehouselab.com/
https://www.holehouselab.com/
Thanks Martin! Also I'm so sorry I owe you note one but TWO emails!!
October 2, 2025 at 3:56 PM
Thanks Martin! Also I'm so sorry I owe you note one but TWO emails!!
Thanks Natalie - hugely appreciated... Caipirinhas soon!!!!🍹🍹🍹
October 2, 2025 at 3:55 PM
Thanks Natalie - hugely appreciated... Caipirinhas soon!!!!🍹🍹🍹
Thanks Michelle! Hope you're doing well!!
October 2, 2025 at 3:54 PM
Thanks Michelle! Hope you're doing well!!
Thanks Professor Lohman!!
October 2, 2025 at 3:53 PM
Thanks Professor Lohman!!
He is 😂. Never misses a day, works late, and is in early. Perfect colleague.
October 2, 2025 at 3:53 PM
He is 😂. Never misses a day, works late, and is in early. Perfect colleague.
Thanks Gabriel!! Also, that paper I mentioned in Ascona, looking at surface chemistry of proteins in desiccation, came out like, 30 minutes ago (literally)!
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Protein surface chemistry encodes an adaptive tolerance to desiccation
Desiccated cells lose over 85% of their water content and experience widespread biomolecular
dysfunction. Romero-Pérez et al. show that the yeast proteome contains a subset of
proteins that are desicc...
www.cell.com
October 2, 2025 at 3:52 PM
Thanks Gabriel!! Also, that paper I mentioned in Ascona, looking at surface chemistry of proteins in desiccation, came out like, 30 minutes ago (literally)!
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Thanks Charlotte!
October 2, 2025 at 3:50 PM
Thanks Charlotte!
The ultimate endpoint is an acronym where none of the letters in the acronym are in any of the words. This is the final boss. We are trying.
October 2, 2025 at 3:49 PM
The ultimate endpoint is an acronym where none of the letters in the acronym are in any of the words. This is the final boss. We are trying.
Hahaha thank Marcin - feels like a long time ago we were sat in first year undergraduate tutorials (because, I suppose, it was a long time ago 😭). REALLY hope we get to catch up in person again soon!!
October 2, 2025 at 3:48 PM
Hahaha thank Marcin - feels like a long time ago we were sat in first year undergraduate tutorials (because, I suppose, it was a long time ago 😭). REALLY hope we get to catch up in person again soon!!
Thanks Kaushik! Much appreciated!
October 2, 2025 at 3:48 PM
Thanks Kaushik! Much appreciated!