Alessandro Prigione
@aleprigio.bsky.social
Stem Cell Metabolism lab. We use iPSCs and brain organoids to search for cures for rare mitochondrial neurological diseases. Professor at the Medical Faculty of Heinrich Heine University, Düsseldorf. Editor-in-Chief of Stem Cell Research journal. He/him.
Pinned
Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS) causing psychomotor regression and...
www.medrxiv.org
Exciting news! Our most important work is out as preprint!
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
Reposted by Alessandro Prigione
An atlas of mitochondrial ATP synthase activity across the lifespan #mitochondria
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
An atlas of mitochondrial ATP synthase activity across the lifespan
Mitochondrial dysfunction and declining energy production are hallmarks of aging, yet we lack a comprehensive systems-level view of ATP synthase (Comp…
www.sciencedirect.com
November 3, 2025 at 8:13 AM
An atlas of mitochondrial ATP synthase activity across the lifespan #mitochondria
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Our latest perspective is out in Dis Model Mech (@biologist.bsky.social)!
We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy.
doi.org/10.1242/dmm....
We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy.
doi.org/10.1242/dmm....
Brain organoid models of Huntington's disease shift the focus towards neurodevelopment
Summary: Increasing evidence indicates neurodevelopmental aspects in Huntington's disease. Early interventions promoting healthy brain development and mitochondrial fitness might lead to prevention or...
doi.org
October 29, 2025 at 11:57 AM
Our latest perspective is out in Dis Model Mech (@biologist.bsky.social)!
We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy.
doi.org/10.1242/dmm....
We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy.
doi.org/10.1242/dmm....
Reposted by Alessandro Prigione
Israel has committed genocide in Gaza, UN commission of inquiry says www.bbc.com/news/article...
Israel has committed genocide in Gaza, UN commission of inquiry says
The panel finds that four of the five genocidal acts defined under international law have been carried out against Palestinians during the war.
www.bbc.com
September 16, 2025 at 7:56 AM
Israel has committed genocide in Gaza, UN commission of inquiry says www.bbc.com/news/article...
Reposted by Alessandro Prigione
Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases
go.nature.com/4fYoEwG
go.nature.com/4fYoEwG
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
go.nature.com
September 1, 2025 at 1:29 PM
Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases
go.nature.com/4fYoEwG
go.nature.com/4fYoEwG
Reposted by Alessandro Prigione
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
tinyurl.com
July 23, 2025 at 3:12 PM
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Our latest review is out in STEM CELLS!
We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders.
academic.oup.com/stmcls/advan...
We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders.
academic.oup.com/stmcls/advan...
Neuronal branching in stem cell models of mitochondrial and neurological diseases
Abstract. Neuronal branching, the extension and arborization of neurites, is critical for establishing and maintaining functional neural circuits. Emerging
academic.oup.com
July 23, 2025 at 5:05 PM
Our latest review is out in STEM CELLS!
We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders.
academic.oup.com/stmcls/advan...
We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders.
academic.oup.com/stmcls/advan...
Reposted by Alessandro Prigione
🎙️ Focus Speakers – Alessandro Prigione
👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress.
#euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers
@ua-recherche.bsky.social
👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress.
#euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers
@ua-recherche.bsky.social
June 10, 2025 at 7:55 AM
🎙️ Focus Speakers – Alessandro Prigione
👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress.
#euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers
@ua-recherche.bsky.social
👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress.
#euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers
@ua-recherche.bsky.social
Looking forward to Euromit 2026!!
🎙️ Focus Speakers – Alessandro Prigione
👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress.
#euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers
@ua-recherche.bsky.social
👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing A. Prigione @aleprigio.bsky.social who will be taking the stage at the congress.
#euromit2026 #MitochondrialDisease #mtDNA #mitochondria #angers
@ua-recherche.bsky.social
June 10, 2025 at 9:01 AM
Looking forward to Euromit 2026!!
Reposted by Alessandro Prigione
mtDNA editing!
A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes - Nature Biotechnology
A mitochondrial disease is modeled using engineered base editors in rats.
www.nature.com
June 4, 2025 at 8:11 PM
mtDNA editing!
Exciting news! Our most important work is out as preprint!
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS) causing psychomotor regression and...
www.medrxiv.org
May 19, 2025 at 12:19 PM
Exciting news! Our most important work is out as preprint!
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
Reposted by Alessandro Prigione
Nature research paper: Spatial transcriptomics reveals human cortical layer and area specification
https://go.nature.com/3GUX8Tm
https://go.nature.com/3GUX8Tm
Spatial transcriptomics reveals human cortical layer and area specification - Nature
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.
go.nature.com
May 15, 2025 at 8:47 AM
Nature research paper: Spatial transcriptomics reveals human cortical layer and area specification
https://go.nature.com/3GUX8Tm
https://go.nature.com/3GUX8Tm
Reposted by Alessandro Prigione
Reposted by Alessandro Prigione
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Alessandro Prigione
I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
📢Registration open!📢
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
So proud to see our very own Elisa Motori co-hosting this exciting EMBO Workshop: “Mitochondria in the Nervous System”
Co-sponsored by the CRC1218! Two invited speakers of the CRC1218! Don’t miss out!
🗓 29.09.-02.10.2025
📍Engelberg, CH
👉 meetings.embo.org/event/25-mit...
May 5, 2025 at 2:37 PM
I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
📅 registration closes MAY 30th, so don’t wait to snag your spot!
Stay tuned - more updates about the topics and speakers coming soon! 🎙️
Reposted by Alessandro Prigione
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
www.nature.com
May 2, 2025 at 8:05 PM
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Reposted by Alessandro Prigione
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids
Guo and colleagues developed vascular network-inspired diffusible (VID) scaffolds for engineering midbrain organoids, providing a versatile technology for organoid development and therapeutic innovation.
dlvr.it
May 1, 2025 at 7:09 PM
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids
Reposted by Alessandro Prigione
After decades of research on stem cells and their reprogramming, we're now seeing extensive clinical trial assessment, some with very encouraging results. This is a new @science.org outstanding review of the biology and ongoing research efforts
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Stem cells as role models for reprogramming and repair
Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decade...
www.science.org
May 1, 2025 at 6:19 PM
After decades of research on stem cells and their reprogramming, we're now seeing extensive clinical trial assessment, some with very encouraging results. This is a new @science.org outstanding review of the biology and ongoing research efforts
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alessandro Prigione
Great study by @nataliabaumann.bsky.social @djabaudon.bsky.social & collaborators, showing how regional differences in progenitor metabolism shape brain growth during development
@cp-cell.bsky.social
www.cell.com/cell/abstrac...
@cp-cell.bsky.social
www.cell.com/cell/abstrac...
Regional differences in progenitor metabolism shape brain growth during development
Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient,
forebrain neurogenesis is temporally sustained through spatiotemporal regulation of
progenitor mitochondrial functi...
www.cell.com
May 1, 2025 at 2:11 PM
Great study by @nataliabaumann.bsky.social @djabaudon.bsky.social & collaborators, showing how regional differences in progenitor metabolism shape brain growth during development
@cp-cell.bsky.social
www.cell.com/cell/abstrac...
@cp-cell.bsky.social
www.cell.com/cell/abstrac...
Reposted by Alessandro Prigione
Reposted by Alessandro Prigione
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 4, 2025 at 6:42 PM
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alessandro Prigione
Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open.
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Mitochondria in the Nervous System
The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…
meetings.embo.org
April 4, 2025 at 1:44 PM
Thrilled to announce that the registration for the EMBO workshop „Mitochondria in the Nervous System“ is now open.
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Join us from Sep 29th to Oct 2nd in beautiful Engelberg, Switzerland!
meetings.embo.org/event/25-mit...
Honored to be part of this landmark forum article @cp-cellstemcell.bsky.social outlining a roadmap for genomic safety in human pluripotent stem cell therapies. Thankful to Ivana Barbaric for leadership and to all coauthors for great efforts.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https://a...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https://a...
kwnsfk27.r.eu-west-1.awstrack.me
April 3, 2025 at 7:58 PM
Honored to be part of this landmark forum article @cp-cellstemcell.bsky.social outlining a roadmap for genomic safety in human pluripotent stem cell therapies. Thankful to Ivana Barbaric for leadership and to all coauthors for great efforts.
kwnsfk27.r.eu-west-1.awstrack.me/L0/https://a...
kwnsfk27.r.eu-west-1.awstrack.me/L0/https://a...
Reposted by Alessandro Prigione
"we have been watching with growing concern policy changes in the US...The scale of disruption to science is unprecedented...We are concerned with policies that threaten censorship & removal of public data...To our colleagues in the US, we stand with you" journals.biologists.com/jcs/article/...
Science under siege: protecting scientific progress in turbulent times
As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...
journals.biologists.com
April 1, 2025 at 3:46 PM
"we have been watching with growing concern policy changes in the US...The scale of disruption to science is unprecedented...We are concerned with policies that threaten censorship & removal of public data...To our colleagues in the US, we stand with you" journals.biologists.com/jcs/article/...
Wonderful to see this out!Thanks to all clinicians for sharing their data. By looking at the natural history of Leigh syndrome patients with mitochondrial mutations MT-ATP6 and MT-ATP8 we can learn key aspects to monitor for future clinical trials.
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Natural History of Patients With Mitochondrial ATPase Deficiency Due to Pathogenic Variants of MT-ATP6 and MT-ATP8 | Neurology
Background and ObjectivesThe mitochondrial DNA (mtDNA) genes MT-ATP6 and MT-ATP8 encode for subunits α and 8 (A6L) of the adenosine triphosphate synthase complex.
Pathogenetic variants in MT-ATP6/8 ca...
www.neurology.org
March 21, 2025 at 7:37 AM
Wonderful to see this out!Thanks to all clinicians for sharing their data. By looking at the natural history of Leigh syndrome patients with mitochondrial mutations MT-ATP6 and MT-ATP8 we can learn key aspects to monitor for future clinical trials.
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Reposted by Alessandro Prigione
🌍Euromit 2026 is coming to Angers!🌍
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
February 3, 2025 at 8:46 AM
🌍Euromit 2026 is coming to Angers!🌍
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬