Alba Hykollari
@albahykolla.bsky.social
Reposted by Alba Hykollari
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
www.science.org
November 12, 2025 at 9:57 PM
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
Reposted by Alba Hykollari
May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu
November 10, 2025 at 4:39 PM
May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu
Reposted by Alba Hykollari
My student's paper on enzymatic remodelling to generate anionic glycan arrays has just been published online in @jbiolchem! Various recombinant glycosyl- or sulphotransferases were employed to prepare glycan motifs tested with various lectins. #glycotime
www.jbc.org/article/S002...
www.jbc.org/article/S002...
November 5, 2025 at 3:20 PM
My student's paper on enzymatic remodelling to generate anionic glycan arrays has just been published online in @jbiolchem! Various recombinant glycosyl- or sulphotransferases were employed to prepare glycan motifs tested with various lectins. #glycotime
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Reposted by Alba Hykollari
Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper!
The manuscript is available here: www.mcponline.org/article/S153...
The manuscript is available here: www.mcponline.org/article/S153...
October 16, 2025 at 6:05 PM
Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper!
The manuscript is available here: www.mcponline.org/article/S153...
The manuscript is available here: www.mcponline.org/article/S153...
Reposted by Alba Hykollari
A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪
This first of its kind procedure could improve access to donor organs because the donor blood type would no longer matter
go.nature.com/3IToaM3
go.nature.com/3IToaM3
First human transplant of kidney modified to have ‘universal’ blood type
Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.
go.nature.com
October 3, 2025 at 1:43 PM
A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪
Reposted by Alba Hykollari
Calling all glycoimmunologists! Whether you have exciting new data, a publication on the horizon or wish to discover more about the latest developments, our International Glycoimmunology Online Symposium is the place to be! Register now and join us on 1 December 🧪: buff.ly/qEafofC
September 24, 2025 at 12:04 PM
Calling all glycoimmunologists! Whether you have exciting new data, a publication on the horizon or wish to discover more about the latest developments, our International Glycoimmunology Online Symposium is the place to be! Register now and join us on 1 December 🧪: buff.ly/qEafofC
Reposted by Alba Hykollari
📢 Join us for the next GlySpace Alliance Webinar!
🗓️ Tuesday, September 16, 2025 | 10 AM ET
🎙️ @dbojar.bsky.social presents: “Structure, Function and Everything in Between: Glyco-AI goes 3D”
🔗 Info: wiki.glygen.org/GlySpace_All...
#glycotime #bioinformatics #cfde
🗓️ Tuesday, September 16, 2025 | 10 AM ET
🎙️ @dbojar.bsky.social presents: “Structure, Function and Everything in Between: Glyco-AI goes 3D”
🔗 Info: wiki.glygen.org/GlySpace_All...
#glycotime #bioinformatics #cfde
September 3, 2025 at 6:29 PM
📢 Join us for the next GlySpace Alliance Webinar!
🗓️ Tuesday, September 16, 2025 | 10 AM ET
🎙️ @dbojar.bsky.social presents: “Structure, Function and Everything in Between: Glyco-AI goes 3D”
🔗 Info: wiki.glygen.org/GlySpace_All...
#glycotime #bioinformatics #cfde
🗓️ Tuesday, September 16, 2025 | 10 AM ET
🎙️ @dbojar.bsky.social presents: “Structure, Function and Everything in Between: Glyco-AI goes 3D”
🔗 Info: wiki.glygen.org/GlySpace_All...
#glycotime #bioinformatics #cfde
Reposted by Alba Hykollari
A cryptic pocket allosterically modulates oligosaccharide binding to DC-SIGN www.biorxiv.org/content/10.1101/2025.08.19.671048v1 #cryoem
August 24, 2025 at 9:04 AM
Reposted by Alba Hykollari
Glycoengineering of nematode antigens using insect cells: a promising approach for producing bioactive vaccine antigens of the barber’s pole worm Haemonchus contortu#glycotimem#Glycobiologygy
Glycoengineering of nematode antigens using insect cells: a promising approach for producing bioactive vaccine antigens of the barber’s pole worm Haemonchus contortus
Abstract. The H11 antigens, located on the intestinal microvilli of Haemonchus contortus, comprise a group of homologous aminopeptidases essential for the
academic.oup.com
August 10, 2025 at 2:39 PM
Glycoengineering of nematode antigens using insect cells: a promising approach for producing bioactive vaccine antigens of the barber’s pole worm Haemonchus contortu#glycotimem#Glycobiologygy
Reposted by Alba Hykollari
Today Salzburg Festival
Premiere of Eötvös‘ Three Sisters (Три сeстры́) with three countertenors in the main roles. Two hours of sometimes dramatic and unusually orchestrated music to accompany the drama on the stage.
Premiere of Eötvös‘ Three Sisters (Три сeстры́) with three countertenors in the main roles. Two hours of sometimes dramatic and unusually orchestrated music to accompany the drama on the stage.
August 8, 2025 at 7:07 PM
Today Salzburg Festival
Premiere of Eötvös‘ Three Sisters (Три сeстры́) with three countertenors in the main roles. Two hours of sometimes dramatic and unusually orchestrated music to accompany the drama on the stage.
Premiere of Eötvös‘ Three Sisters (Три сeстры́) with three countertenors in the main roles. Two hours of sometimes dramatic and unusually orchestrated music to accompany the drama on the stage.
Reposted by Alba Hykollari
New from Elsevier, a way to skip reading what the authors wrote and instead have an LLM tell you what it thinks are important/relevant details.
Many times I've encountered a throwaway sentence in a paper that starts a whole set of rewarding experiments. This approach ensures that doesn't happen.
Many times I've encountered a throwaway sentence in a paper that starts a whole set of rewarding experiments. This approach ensures that doesn't happen.
August 4, 2025 at 2:03 PM
New from Elsevier, a way to skip reading what the authors wrote and instead have an LLM tell you what it thinks are important/relevant details.
Many times I've encountered a throwaway sentence in a paper that starts a whole set of rewarding experiments. This approach ensures that doesn't happen.
Many times I've encountered a throwaway sentence in a paper that starts a whole set of rewarding experiments. This approach ensures that doesn't happen.
Reposted by Alba Hykollari
Using #Caenorhabditis genes to reengineer insect cells to better mimic nematode glycosylation
academic.oup.com/glycob/advan...
academic.oup.com/glycob/advan...
Glycoengineering of nematode antigens using insect cells: a promising approach for producing bioactive vaccine antigens of the barber’s pole worm Haemonchus contortus
Abstract. The H11 antigens, located on the intestinal microvilli of Haemonchus contortus, comprise a group of homologous aminopeptidases essential for the
academic.oup.com
August 5, 2025 at 6:06 AM
Using #Caenorhabditis genes to reengineer insect cells to better mimic nematode glycosylation
academic.oup.com/glycob/advan...
academic.oup.com/glycob/advan...
Reposted by Alba Hykollari
My university can take part in the new OeAW call *APART-USA*. The university can therefore appoint *one scholarship holder* as well as nominate *a reserve candidate*. Deadline to send a letter of interest is 5th August! Candidates must be postdocs in the US.
stipendien.oeaw.ac.at/stipendien/a...
stipendien.oeaw.ac.at/stipendien/a...
APART-USA
Stipendien & Preise der Österreichischen Akademie der Wissenschaften
stipendien.oeaw.ac.at
July 16, 2025 at 6:35 AM
My university can take part in the new OeAW call *APART-USA*. The university can therefore appoint *one scholarship holder* as well as nominate *a reserve candidate*. Deadline to send a letter of interest is 5th August! Candidates must be postdocs in the US.
stipendien.oeaw.ac.at/stipendien/a...
stipendien.oeaw.ac.at/stipendien/a...
Reposted by Alba Hykollari
Glycoproteomics of a lobster: My explanation would be that a Man2GlcNAc2Fuc2 is on the Asn, not that there's some adventurous O-glycan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 1, 2025 at 9:42 PM
Glycoproteomics of a lobster: My explanation would be that a Man2GlcNAc2Fuc2 is on the Asn, not that there's some adventurous O-glycan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alba Hykollari
Latest nematode glycomic research: Excretory-secretory products of the fish-borne parasite Anisakis simplex L3 larvae possess allergens and unusual N-glycan modifications
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excretory-secretory products of the fish-borne parasite Anisakis simplex L3 larvae possess allergens and unusual glycan modifications
Anisakis simplex is a parasitic aquatic nematode, which may cause mild-to-severe gastrointestinal allergic reactions (Anisakiasis) with clinical symptoms, such as rhinitis and urticaria in humans who ...
www.biorxiv.org
June 29, 2025 at 4:58 PM
Latest nematode glycomic research: Excretory-secretory products of the fish-borne parasite Anisakis simplex L3 larvae possess allergens and unusual N-glycan modifications
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alba Hykollari
Detection of antibodies against the African parasite Trypanosoma brucei using synthetic glycosylphosphatidylinositol oligosaccharide fragments
#glycotime #GlycoconjugateJournal
#glycotime #GlycoconjugateJournal
Detection of antibodies against the African parasite Trypanosoma brucei using synthetic glycosylphosphatidylinositol oligosaccharide fragments
Trypanosoma brucei (T. brucei) parasites cause two major infectious diseases in Africa: African trypanosomiasis in humans (HAT) and Nagana in animals. Desp
link.springer.com
June 24, 2025 at 4:45 PM
Detection of antibodies against the African parasite Trypanosoma brucei using synthetic glycosylphosphatidylinositol oligosaccharide fragments
#glycotime #GlycoconjugateJournal
#glycotime #GlycoconjugateJournal
Reposted by Alba Hykollari
The 34th edition of JGM takes place in Lille, France, co-organized by the French Institute of Structural and Functional Glycobiology (UGSF, University of Lille – CNRS) and the Belgian Center for Medical Biotechnology (University of Gent – VIB). 12-14/10/2025
jointglycomeeting.univ-lille.fr
jointglycomeeting.univ-lille.fr
Accueil - Joint Glycobiology Meeting de l'Université de Lille
jointglycomeeting.univ-lille.fr
June 19, 2025 at 12:58 PM
The 34th edition of JGM takes place in Lille, France, co-organized by the French Institute of Structural and Functional Glycobiology (UGSF, University of Lille – CNRS) and the Belgian Center for Medical Biotechnology (University of Gent – VIB). 12-14/10/2025
jointglycomeeting.univ-lille.fr
jointglycomeeting.univ-lille.fr
Reposted by Alba Hykollari
I guess we need more unusual glycan standards, e.g., with GlcA or PC, to increase coverage of, e.g., insect structures! The 83% for MMF seems high for Sf9-produced Spike, unless the BEI stuff is very different from Novavax.
June 11, 2025 at 9:10 PM
I guess we need more unusual glycan standards, e.g., with GlcA or PC, to increase coverage of, e.g., insect structures! The 83% for MMF seems high for Sf9-produced Spike, unless the BEI stuff is very different from Novavax.
Reposted by Alba Hykollari
We checked with untargeted SUGA to be sure (negative mode only), but only saw the more simple structures compared to what you’ve reported.
There’s a chance there was further processing involved of the spike protein by the manufacturer (like ion exchange) which may have depleted charged modifications
There’s a chance there was further processing involved of the spike protein by the manufacturer (like ion exchange) which may have depleted charged modifications
June 11, 2025 at 9:52 PM
We checked with untargeted SUGA to be sure (negative mode only), but only saw the more simple structures compared to what you’ve reported.
There’s a chance there was further processing involved of the spike protein by the manufacturer (like ion exchange) which may have depleted charged modifications
There’s a chance there was further processing involved of the spike protein by the manufacturer (like ion exchange) which may have depleted charged modifications
Reposted by Alba Hykollari
Excited to share aspects of our recently preprinted work, as well as our fresh R&D at the European Glycoscience Community Webinar series.
There's 15 minutes set aside for discussion, so I'm most looking forward to that.
Please find the zoom link below:
unibas.zoom.us/webinar/regi...
There's 15 minutes set aside for discussion, so I'm most looking forward to that.
Please find the zoom link below:
unibas.zoom.us/webinar/regi...
June 11, 2025 at 1:26 PM
Excited to share aspects of our recently preprinted work, as well as our fresh R&D at the European Glycoscience Community Webinar series.
There's 15 minutes set aside for discussion, so I'm most looking forward to that.
Please find the zoom link below:
unibas.zoom.us/webinar/regi...
There's 15 minutes set aside for discussion, so I'm most looking forward to that.
Please find the zoom link below:
unibas.zoom.us/webinar/regi...