so much fun working on this project with Venkat, King, Ivy, and team! Read on to learn about the retention elements critical for the tethering of extrachromosomal DNA to mitotic chromosomes in cancer cells.
Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetic elements promote retention of extrachromosomal DNA in cancer cells - Nature
A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing ...
www.nature.com
November 19, 2025 at 8:04 PM
so much fun working on this project with Venkat, King, Ivy, and team! Read on to learn about the retention elements critical for the tethering of extrachromosomal DNA to mitotic chromosomes in cancer cells.
Reposted by Aditi Gnanasekar
Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...
November 14, 2025 at 5:08 PM
Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...
Reposted by Aditi Gnanasekar
Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3
Weird rings of DNA fuel cancers. This scientist leads the effort to target them
Paul Mischel and others are testing therapies for rogue genetic loops that drive tumor evolution and growth
scim.ag
September 12, 2025 at 7:24 PM
Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3
Reposted by Aditi Gnanasekar
Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.
Benjamin Cravatt awarded Tetrahedron Prize for Creativity - Scripps Research Magazine
Benjamin Cravatt, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, will receive the 2025 Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry. Established in ...
magazine.scripps.edu
August 13, 2025 at 12:13 AM
Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.
Beautiful study by Vishnu who found elevated levels of oxidative damage in patients with ME/CFS, an understudied disease that lacks definitive diagnostic tests and effective treatments despite its enormous prevalence and incredible severity. Read more here www.pnas.org/doi/10.1073/...
Oxidative stress is a shared characteristic of ME/CFS and Long COVID | PNAS
Over 65 million individuals worldwide are estimated to have Long COVID (LC), a complex
multisystemic condition marked by fatigue, post-exertional m...
www.pnas.org
August 12, 2025 at 3:39 AM
Beautiful study by Vishnu who found elevated levels of oxidative damage in patients with ME/CFS, an understudied disease that lacks definitive diagnostic tests and effective treatments despite its enormous prevalence and incredible severity. Read more here www.pnas.org/doi/10.1073/...
Reposted by Aditi Gnanasekar
What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!
April 27, 2025 at 4:12 PM
What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!
Reposted by Aditi Gnanasekar
EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs https://www.biorxiv.org/content/10.1101/2025.04.01.646515v1
April 3, 2025 at 3:51 PM
EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs https://www.biorxiv.org/content/10.1101/2025.04.01.646515v1
Reposted by Aditi Gnanasekar
Exclusive: An ambitious California Democrat wants the state to create its own National Institutes of Health and vaccine program, saying California can’t rely on the Trump administration to support research and science.
Fearing Trump cuts, California Democrat proposes creating state’s own NIH
The ambitious state lawmaker argues moves by Elon Musk and Robert F. Kennedy Jr. show the Golden State must “step up” as a global leader.
www.politico.com
March 27, 2025 at 1:54 PM
Exclusive: An ambitious California Democrat wants the state to create its own National Institutes of Health and vaccine program, saying California can’t rely on the Trump administration to support research and science.
Reposted by Aditi Gnanasekar
3 points of progress vs pancreatic cancer!
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
March 1, 2025 at 3:26 PM
3 points of progress vs pancreatic cancer!
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
1. Neoantigen vaccines
www.nature.com/articles/s41...
2. KRAS drugs
www.wsj.com/health/healt...
3. Early diagnosis www.science.org/doi/10.1126/...
Reposted by Aditi Gnanasekar
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Aditi Gnanasekar
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
www.nature.com
November 18, 2024 at 5:37 PM
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aditi Gnanasekar
High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths.
It's free, open-access.
erictopol.substack.com/p/cancer-sci...
It's free, open-access.
erictopol.substack.com/p/cancer-sci...
Cancer Science in On a Tear
New insights on evolution, resistance, and therapies
erictopol.substack.com
November 10, 2024 at 6:51 PM
High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths.
It's free, open-access.
erictopol.substack.com/p/cancer-sci...
It's free, open-access.
erictopol.substack.com/p/cancer-sci...
Reposted by Aditi Gnanasekar
This week in Nature - four papers probe the relationship between ecDNA & cancer
* an atlas of ecDNA in cancer
* ecDNA inheritance in cancer during cell division
* a potential way to leverage ecDNA for treatment
* ecDNA role in tumour evolution & therapy resistance
www.nature.com/nature/volum...
* an atlas of ecDNA in cancer
* ecDNA inheritance in cancer during cell division
* a potential way to leverage ecDNA for treatment
* ecDNA role in tumour evolution & therapy resistance
www.nature.com/nature/volum...
Nature - Outside influence
The cover shows circular extrachromosomal DNA (ecDNA) sitting next to a chromosome. ecDNA has a significant effect on the outcome of cancer treatment —...
www.nature.com
November 19, 2024 at 8:54 PM
This week in Nature - four papers probe the relationship between ecDNA & cancer
* an atlas of ecDNA in cancer
* ecDNA inheritance in cancer during cell division
* a potential way to leverage ecDNA for treatment
* ecDNA role in tumour evolution & therapy resistance
www.nature.com/nature/volum...
* an atlas of ecDNA in cancer
* ecDNA inheritance in cancer during cell division
* a potential way to leverage ecDNA for treatment
* ecDNA role in tumour evolution & therapy resistance
www.nature.com/nature/volum...