Lorenzo de la Rica
@ldelarica.bsky.social
Accelerating and supporting high-impact cancer research at a major international funding initiative, for the benefit of cancer patients. Opinions exclusively my own.
Reposted by Lorenzo de la Rica
Incredible science was shared at the #TeamPROSPECT scientific retreat this week bringing together experts in epidemiology, oncology, immunology, computational biology & more. A global effort to understand and reverse the rapid rise of early-onset colorectal cancer.
#CancerResearch #ColorectalCancer
#CancerResearch #ColorectalCancer
October 3, 2025 at 4:01 PM
Incredible science was shared at the #TeamPROSPECT scientific retreat this week bringing together experts in epidemiology, oncology, immunology, computational biology & more. A global effort to understand and reverse the rapid rise of early-onset colorectal cancer.
#CancerResearch #ColorectalCancer
#CancerResearch #ColorectalCancer
Reposted by Lorenzo de la Rica
New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.
Read more: www.cancergrandchallenges.org/news/early-c...
Read more: www.cancergrandchallenges.org/news/early-c...
October 8, 2025 at 3:15 PM
New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.
Read more: www.cancergrandchallenges.org/news/early-c...
Read more: www.cancergrandchallenges.org/news/early-c...
Reposted by Lorenzo de la Rica
Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3
Weird rings of DNA fuel cancers. This scientist leads the effort to target them
Paul Mischel and others are testing therapies for rogue genetic loops that drive tumor evolution and growth
scim.ag
September 12, 2025 at 7:24 PM
Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy. https://scim.ag/4m5x2f3
We are hiring! 🚨
Great opportunity to be at the forefront of cancer research internationally as a @cancergrand.bsky.social Research Portfolio Manager (going to the London office 2 days/week).
Apply by: 1 July 2025
Get in touch📩
More info 👇
cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...
Great opportunity to be at the forefront of cancer research internationally as a @cancergrand.bsky.social Research Portfolio Manager (going to the London office 2 days/week).
Apply by: 1 July 2025
Get in touch📩
More info 👇
cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...
Research Portfolio Manager (Cancer Grand Challenges)
4,000 professionals, 0 days wasted, 1 incredible purpose. Together we are beating cancer. Research Portfolio Manager (Cancer Grand Challenges) Salary: £46,000 - £54,000 depending on experience plus be...
cancerresearchuk.wd3.myworkdayjobs.com
June 25, 2025 at 8:22 AM
We are hiring! 🚨
Great opportunity to be at the forefront of cancer research internationally as a @cancergrand.bsky.social Research Portfolio Manager (going to the London office 2 days/week).
Apply by: 1 July 2025
Get in touch📩
More info 👇
cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...
Great opportunity to be at the forefront of cancer research internationally as a @cancergrand.bsky.social Research Portfolio Manager (going to the London office 2 days/week).
Apply by: 1 July 2025
Get in touch📩
More info 👇
cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...
#ICYMI from team eDyNAmiC: SPACE-seq!
Howard Chang's group at @stanfordmedicine.bsky.social published a new method in @pnas.org allowing spatial multi-omics and lineage tracing, coupled with detection of ecDNA copy number. The team went on to show the utility of SPACE-seq in glioblastoma.
Howard Chang's group at @stanfordmedicine.bsky.social published a new method in @pnas.org allowing spatial multi-omics and lineage tracing, coupled with detection of ecDNA copy number. The team went on to show the utility of SPACE-seq in glioblastoma.
Happy to share our paper describing SPACE-seq - a new approach to spatial multiomics and lineage tracing - out today in @pnas.org! 🧵(1/5)
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
June 9, 2025 at 8:33 AM
#ICYMI from team eDyNAmiC: SPACE-seq!
Howard Chang's group at @stanfordmedicine.bsky.social published a new method in @pnas.org allowing spatial multi-omics and lineage tracing, coupled with detection of ecDNA copy number. The team went on to show the utility of SPACE-seq in glioblastoma.
Howard Chang's group at @stanfordmedicine.bsky.social published a new method in @pnas.org allowing spatial multi-omics and lineage tracing, coupled with detection of ecDNA copy number. The team went on to show the utility of SPACE-seq in glioblastoma.
Last week, Regina Barzilay's group @mit.edu released Boltz-2.
With accuracy rivalling AlphaFold3, the updated model can now predict small molecule-protein binding affinity.
Crucially, Boltz-2 is open source.
Read more: bit.ly/4kY1gki (wonderful article by @rebeccaeccles.bsky.social).
With accuracy rivalling AlphaFold3, the updated model can now predict small molecule-protein binding affinity.
Crucially, Boltz-2 is open source.
Read more: bit.ly/4kY1gki (wonderful article by @rebeccaeccles.bsky.social).
Boltz-2: democratising the future of drug design
Open source structure prediction with binding affinity
bit.ly
June 9, 2025 at 8:30 AM
Last week, Regina Barzilay's group @mit.edu released Boltz-2.
With accuracy rivalling AlphaFold3, the updated model can now predict small molecule-protein binding affinity.
Crucially, Boltz-2 is open source.
Read more: bit.ly/4kY1gki (wonderful article by @rebeccaeccles.bsky.social).
With accuracy rivalling AlphaFold3, the updated model can now predict small molecule-protein binding affinity.
Crucially, Boltz-2 is open source.
Read more: bit.ly/4kY1gki (wonderful article by @rebeccaeccles.bsky.social).
💡 ecDNA Conference
🗓️ 11–13 June 2025
📍 London, UK
🚨 Register by Monday 5th May (3 days left!!)
The full programme for our conference on ecDNA is now confirmed!
You can view all the details and register here:
www.cancergrandchallenges.org/ecDNA-2025
🗓️ 11–13 June 2025
📍 London, UK
🚨 Register by Monday 5th May (3 days left!!)
The full programme for our conference on ecDNA is now confirmed!
You can view all the details and register here:
www.cancergrandchallenges.org/ecDNA-2025
May 2, 2025 at 9:51 PM
💡 ecDNA Conference
🗓️ 11–13 June 2025
📍 London, UK
🚨 Register by Monday 5th May (3 days left!!)
The full programme for our conference on ecDNA is now confirmed!
You can view all the details and register here:
www.cancergrandchallenges.org/ecDNA-2025
🗓️ 11–13 June 2025
📍 London, UK
🚨 Register by Monday 5th May (3 days left!!)
The full programme for our conference on ecDNA is now confirmed!
You can view all the details and register here:
www.cancergrandchallenges.org/ecDNA-2025
Reposted by Lorenzo de la Rica
🚨 New transatlantic research funding! 🚨
We've partnered with the American Cancer Society to co-fund our Biology to Prevention Award, doubling the funding pot for collaborative UK and US prevention research teams.
Join us for a webinar on 21 May to find out how to apply: bit.ly/445v4pO
We've partnered with the American Cancer Society to co-fund our Biology to Prevention Award, doubling the funding pot for collaborative UK and US prevention research teams.
Join us for a webinar on 21 May to find out how to apply: bit.ly/445v4pO
Webinar: Biology to Prevention Award co-funded with American Cancer Society
Join our webinar on 21 May to learn about this new partnership and how to apply for co-funding through the Biology to Prevention Award
bit.ly
May 1, 2025 at 4:30 PM
🚨 New transatlantic research funding! 🚨
We've partnered with the American Cancer Society to co-fund our Biology to Prevention Award, doubling the funding pot for collaborative UK and US prevention research teams.
Join us for a webinar on 21 May to find out how to apply: bit.ly/445v4pO
We've partnered with the American Cancer Society to co-fund our Biology to Prevention Award, doubling the funding pot for collaborative UK and US prevention research teams.
Join us for a webinar on 21 May to find out how to apply: bit.ly/445v4pO
What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!
April 27, 2025 at 4:12 PM
What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!
🌟 Hello from #AACR25 🌟
At @cancergrand.bsky.social, we're uniting the world's brightest minds to tackle cancer's toughest challenges. Applications are now open to take on our newest set of challenges, with awards of up to £20m available.
Come by booth 2327 to learn more 💭
We're about to open!
At @cancergrand.bsky.social, we're uniting the world's brightest minds to tackle cancer's toughest challenges. Applications are now open to take on our newest set of challenges, with awards of up to £20m available.
Come by booth 2327 to learn more 💭
We're about to open!
April 27, 2025 at 2:51 PM
🌟 Hello from #AACR25 🌟
At @cancergrand.bsky.social, we're uniting the world's brightest minds to tackle cancer's toughest challenges. Applications are now open to take on our newest set of challenges, with awards of up to £20m available.
Come by booth 2327 to learn more 💭
We're about to open!
At @cancergrand.bsky.social, we're uniting the world's brightest minds to tackle cancer's toughest challenges. Applications are now open to take on our newest set of challenges, with awards of up to £20m available.
Come by booth 2327 to learn more 💭
We're about to open!
Fantastic science at #AACR25 yesterday! So inspiring to see @cancergrand.bsky.social Challenges like extrachromosomal DNAs #ecDNAs 🧬⭕ (team eDyNAmiC!) and transposable elements 🦘🧬 (key for the Dark Proteome!) highlighted in the 🎓educational sessions. Really cool science being discussed 🔬!
April 27, 2025 at 12:24 PM
Fantastic science at #AACR25 yesterday! So inspiring to see @cancergrand.bsky.social Challenges like extrachromosomal DNAs #ecDNAs 🧬⭕ (team eDyNAmiC!) and transposable elements 🦘🧬 (key for the Dark Proteome!) highlighted in the 🎓educational sessions. Really cool science being discussed 🔬!
#AACR25 has officially started! I presented at the Professional Development Session "Grant Writing Workshop", sharing UK🇬🇧 & European🇪🇺 funding opportunities in #CancerResearch, and spotlighting our 7 #CancerGrandChallenges. @theaacr.bsky.social @cancerresearchuk.org
April 25, 2025 at 9:30 PM
#AACR25 has officially started! I presented at the Professional Development Session "Grant Writing Workshop", sharing UK🇬🇧 & European🇪🇺 funding opportunities in #CancerResearch, and spotlighting our 7 #CancerGrandChallenges. @theaacr.bsky.social @cancerresearchuk.org
Reposted by Lorenzo de la Rica
The 24/25 edition of @cancergrand.bsky.social progress magazine is now live!
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
DFS 0161 CGC Discover mag 2024
A year of scientific creativity
features.cancerresearchuk.org
April 24, 2025 at 12:25 PM
The 24/25 edition of @cancergrand.bsky.social progress magazine is now live!
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
Including:
👉key advances from our funded teams
👉 the biggest themes in cancer research from early-onset cancers to AI and cancer as a systemic disease
👉our 7 new challenges
features.cancerresearchuk.org/cancergrandc...
@cancergrand.bsky.social funded research featured in The Guardian "Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’ "
Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’
Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’
Researchers say mutations more often found in younger patients’ tumours caused by toxin secreted by E coli strains
Childhood exposure to a toxin produced by bacteria in the bowel may be contributing to the rise of colorectal cancer in under-50s around the world, researchers say.
Countries, including some in Europe and Oceania, have witnessed an increase in young adults with bowel cancer in recent decades, with some of the steepest increases reported in England, New Zealand, Puerto Rico and Chile. Continue reading...
www.theguardian.com
April 23, 2025 at 4:20 PM
@cancergrand.bsky.social funded research featured in The Guardian "Childhood toxin exposure ‘may be factor in bowel cancer rise in under-50s’ "
🚨New in @nature.com
@cancergrand.bsky.social Mutographs team identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases.
Read more about the findings, the open questions and the curiosities of colibactin 👇 t.co/FfElyKim68
@cancergrand.bsky.social Mutographs team identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases.
Read more about the findings, the open questions and the curiosities of colibactin 👇 t.co/FfElyKim68
DFS 0161 CGC Discover mag 2024 — Early-onset cancers
A year of scientific creativity
features.cancerresearchuk.org
April 23, 2025 at 4:17 PM
🚨New in @nature.com
@cancergrand.bsky.social Mutographs team identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases.
Read more about the findings, the open questions and the curiosities of colibactin 👇 t.co/FfElyKim68
@cancergrand.bsky.social Mutographs team identified mutational signatures caused by the bacterial genotoxin colibactin are enriched in early onset colorectal cancer cases.
Read more about the findings, the open questions and the curiosities of colibactin 👇 t.co/FfElyKim68
We are finalizing the programme of our #CancerGrandChallenges Conference on #ecDNAs, and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇
www.cancergrandchallenges.org/ecDNA-2025
www.cancergrandchallenges.org/ecDNA-2025
Cancer Grand Challenges Conference: extrachromosomal DNA
Taking place on 11 - 13 June 2025 in London, UK. Registration is now open.
www.cancergrandchallenges.org
April 15, 2025 at 10:14 PM
We are finalizing the programme of our #CancerGrandChallenges Conference on #ecDNAs, and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇
www.cancergrandchallenges.org/ecDNA-2025
www.cancergrandchallenges.org/ecDNA-2025
A big congratulations to #CancerGrandChallenges Scientific Committee member, Karen Vousden for her AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research and to OPTIMISTICC co-team lead Matthew Meyerson on his AACR Award for Outstanding Achievement in Pathology in Cancer Research! 🙌👏🧬 #AACR
Congratulations to the recipients of the 2025 AACR Scientific Achievement Awards and Lectureships. This year’s distinguished class of awardees will be recognized at #AACR25 in Chicago. www.aacr.org/about-the-aa...
April 15, 2025 at 10:08 PM
A big congratulations to #CancerGrandChallenges Scientific Committee member, Karen Vousden for her AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research and to OPTIMISTICC co-team lead Matthew Meyerson on his AACR Award for Outstanding Achievement in Pathology in Cancer Research! 🙌👏🧬 #AACR
Reposted by Lorenzo de la Rica
The #CancerGrandChallenges Mutographs team reveals how tobacco smoke damages DNA to drive different types of head and neck cancer 🧬
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
Scientists unlock secret behind how smoking and drinking alcohol causes cancer
Scientists have revealed exactly how tobacco smoke damages DNA to drive the development of different types of head and neck cancer, a finding that could unlock new treatments and prevention strategies...
www.sanger.ac.uk
April 1, 2025 at 3:26 PM
The #CancerGrandChallenges Mutographs team reveals how tobacco smoke damages DNA to drive different types of head and neck cancer 🧬
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs:
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and Tumor-Immune Microenvironment
Abstract. Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial-temporal diversity and influence on tumor evolution and the immune microenvironment remain l...
aacrjournals.org
March 11, 2025 at 2:39 PM
New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs:
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
Fantastic achievement and recognition to some of our
@cancergrand.bsky.social researchers! Congrats to Josep Tabernero @joseptabernero.bsky.social (vhio.bsky.social) and Paul Mischel (@stanford.edu) on being elected as Fellows of the AACR Academy Class of 2025!
@cancergrand.bsky.social researchers! Congrats to Josep Tabernero @joseptabernero.bsky.social (vhio.bsky.social) and Paul Mischel (@stanford.edu) on being elected as Fellows of the AACR Academy Class of 2025!
The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more: buff.ly/8a8WUn9 #AACRFellows
March 11, 2025 at 2:31 PM
Fantastic achievement and recognition to some of our
@cancergrand.bsky.social researchers! Congrats to Josep Tabernero @joseptabernero.bsky.social (vhio.bsky.social) and Paul Mischel (@stanford.edu) on being elected as Fellows of the AACR Academy Class of 2025!
@cancergrand.bsky.social researchers! Congrats to Josep Tabernero @joseptabernero.bsky.social (vhio.bsky.social) and Paul Mischel (@stanford.edu) on being elected as Fellows of the AACR Academy Class of 2025!
Reposted by Lorenzo de la Rica
March 5, 2025 at 8:09 PM
Reposted by Lorenzo de la Rica
Interesting cancer grand challenges just announced. Funders looking for interdisciplinary & international teams. I'm an outsider, but fascinated that some of them have clear eco-evo cell-population dynamical component.
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
Cancer Grand Challenges Announces Seven New Challenges Representing Some of the Toughest Questions Facing Cancer Research Today
BOSTON, March 05, 2025--Cancer Grand Challenges announces seven new challenges representing some of the toughest questions facing cancer research today.
finance.yahoo.com
March 5, 2025 at 3:58 PM
Interesting cancer grand challenges just announced. Funders looking for interdisciplinary & international teams. I'm an outsider, but fascinated that some of them have clear eco-evo cell-population dynamical component.
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
Reposted by Lorenzo de la Rica
7 new Cancer Grand Challenges announced:
www.cancergrandchallenges.org/new-challenges
@cancergrand.bsky.social
www.cancergrandchallenges.org/new-challenges
@cancergrand.bsky.social
New challenges
Explore the challenges currently open for Expressions of Interest.
www.cancergrandchallenges.org
March 5, 2025 at 3:16 PM
7 new Cancer Grand Challenges announced:
www.cancergrandchallenges.org/new-challenges
@cancergrand.bsky.social
www.cancergrandchallenges.org/new-challenges
@cancergrand.bsky.social
Reposted by Lorenzo de la Rica
In collaboration of CRUK, the NCI and many other funders new sets of cancer grand challenges are announced today
March 5, 2025 at 2:59 PM
In collaboration of CRUK, the NCI and many other funders new sets of cancer grand challenges are announced today