@aeron15.bsky.social
Reposted
I have kind of eclectic taste, so this list is going to be a mere curiosity for most of y'all. I've also not seen or finished some of the bigger US productions that might have squeezed their way onto it otherwise.
But, yeah, here are my 12 favorite shows of 2024.
1/
But, yeah, here are my 12 favorite shows of 2024.
1/
January 3, 2025 at 2:59 AM
I have kind of eclectic taste, so this list is going to be a mere curiosity for most of y'all. I've also not seen or finished some of the bigger US productions that might have squeezed their way onto it otherwise.
But, yeah, here are my 12 favorite shows of 2024.
1/
But, yeah, here are my 12 favorite shows of 2024.
1/
Reposted
🔖New paper from the lab!
'Evolution of 3D Chromatin Folding' | Annual Reviews - go.shr.lc/3B60kZF
'Evolution of 3D Chromatin Folding' | Annual Reviews - go.shr.lc/3B60kZF
November 28, 2024 at 5:44 PM
🔖New paper from the lab!
'Evolution of 3D Chromatin Folding' | Annual Reviews - go.shr.lc/3B60kZF
'Evolution of 3D Chromatin Folding' | Annual Reviews - go.shr.lc/3B60kZF
Reposted
George Orwell
Letter to Victor Gollancz
8 January 1940
Letter to Victor Gollancz
8 January 1940
December 31, 2024 at 12:31 AM
George Orwell
Letter to Victor Gollancz
8 January 1940
Letter to Victor Gollancz
8 January 1940
Reposted
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
Reposted
What were the most inspiring 2024 discoveries in cancer?
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
December 3, 2024 at 3:46 PM
What were the most inspiring 2024 discoveries in cancer?
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
Reposted
🚨 If you haven’t seen it yet…
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
November 23, 2024 at 11:30 PM
🚨 If you haven’t seen it yet…
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition.
Check it out at bioart.niaid.nih.gov
Reposted
The deep goal of bluesky is to decentralize the social internet so that every individual controls their experience of it rather than having it be controlled by 5 random billionaires. Everyone thinks they signed up for a demuskified twitter...we actually signed an exciting and bizarre experiment.
December 3, 2024 at 4:05 PM
The deep goal of bluesky is to decentralize the social internet so that every individual controls their experience of it rather than having it be controlled by 5 random billionaires. Everyone thinks they signed up for a demuskified twitter...we actually signed an exciting and bizarre experiment.
Reposted
Fascinating thread here: apparently, caffeine and ibuprofen both have binding affinity to their target proteins so weak that they might get tossed out of a typical drug discovery project!
What are some examples of weak-binding (approved) drugs?
I think memantine binds NMDAR with an affinity of about 1µM. Are there other such examples?
I think memantine binds NMDAR with an affinity of about 1µM. Are there other such examples?
November 27, 2024 at 2:08 AM
Fascinating thread here: apparently, caffeine and ibuprofen both have binding affinity to their target proteins so weak that they might get tossed out of a typical drug discovery project!
Reposted
Review: The present and future of bispecific antibodies for cancer therapy
The present and future of bispecific antibodies for cancer therapy - Nature Reviews Drug Discovery
Bispecific antibodies (bsAbs) can mediate therapeutic effects beyond those of natural monospecific antibodies. This Review provides an overview of recent developments in the field of bsAbs for cancer ...
www.nature.com
November 27, 2024 at 3:46 AM
Review: The present and future of bispecific antibodies for cancer therapy
Reposted
#NatureReviewsCancer🚨
The #CancerDepMap is an invaluable, publicly available resource for systemically identifying cancer vulnerabilities. In this #Perspective, Bill Hahn & team (@broadinstitute.org) review its impact, uses, limitations & efforts to improve + expand its use.
go.nature.com/4fiZ6sw
The #CancerDepMap is an invaluable, publicly available resource for systemically identifying cancer vulnerabilities. In this #Perspective, Bill Hahn & team (@broadinstitute.org) review its impact, uses, limitations & efforts to improve + expand its use.
go.nature.com/4fiZ6sw
The present and future of the Cancer Dependency Map - Nature Reviews Cancer
The Cancer Dependency Map (DepMap) is a data repository and research platform that can be utilized to systematically identify cancer vulnerabilities. Here Arafeh, Shibue et al. outline the current lim...
go.nature.com
November 27, 2024 at 10:44 AM
#NatureReviewsCancer🚨
The #CancerDepMap is an invaluable, publicly available resource for systemically identifying cancer vulnerabilities. In this #Perspective, Bill Hahn & team (@broadinstitute.org) review its impact, uses, limitations & efforts to improve + expand its use.
go.nature.com/4fiZ6sw
The #CancerDepMap is an invaluable, publicly available resource for systemically identifying cancer vulnerabilities. In this #Perspective, Bill Hahn & team (@broadinstitute.org) review its impact, uses, limitations & efforts to improve + expand its use.
go.nature.com/4fiZ6sw
Reposted
So GCN2 could potentially be a good anti-cancer target in this p53-deficient setting
www.science.org/doi/10.1126/...
#ISR
This also offers explanations about some confusing (opposing) roles of this kinase upon metabolic stress
www.science.org/doi/10.1126/...
#ISR
This also offers explanations about some confusing (opposing) roles of this kinase upon metabolic stress
Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
Targeting a cell stress response is synthetic lethal with loss of p53 in prostate cancer cells.
www.science.org
November 27, 2024 at 11:21 AM
So GCN2 could potentially be a good anti-cancer target in this p53-deficient setting
www.science.org/doi/10.1126/...
#ISR
This also offers explanations about some confusing (opposing) roles of this kinase upon metabolic stress
www.science.org/doi/10.1126/...
#ISR
This also offers explanations about some confusing (opposing) roles of this kinase upon metabolic stress
Reposted
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
November 17, 2024 at 6:48 PM
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...