Cristina Muñoz Pinedo
@crismunozp.bsky.social
Scientist by day, defender of lost causes by night. Especially the right to not spend our lives filling online forms.
Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer
Very happy to announce that both my co-PI Ernest Nadal and myself have made it (independently) to the Stanford/Ioannidis 2% c-index ranking!!!
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
L’IDIBELL consolida l’excel·lència científica amb 33 investigadors i investigadores dins la World’s Top 2% Scientists list – IDIBELL
idibell.cat
November 13, 2025 at 11:27 AM
Very happy to announce that both my co-PI Ernest Nadal and myself have made it (independently) to the Stanford/Ioannidis 2% c-index ranking!!!
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
We are already 33 investigators in this list from IDIBELL, the Bellvitge Research Institute. Congrats all!
@idibell.bsky.social
idibell.cat/2025/10/lidi...
The Matthew effect is extremely strong with ERC grants in some countries. They should study this program separately
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
buff.ly/UEtcRd4
November 12, 2025 at 11:15 PM
The Matthew effect is extremely strong with ERC grants in some countries. They should study this program separately
Reposted by Cristina Muñoz Pinedo
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
full text access here rdcu.be/ePcEK
Reposted by Cristina Muñoz Pinedo
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
November 9, 2025 at 6:43 PM
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
and while we're at it, why don't we also stop using MTT, Alamar blue and similar dies to quantify "cell death" in metabolic studies ...
Can we please stop using GAPDH as a "loading control", particularly in metabolic studies??
November 7, 2025 at 11:01 AM
and while we're at it, why don't we also stop using MTT, Alamar blue and similar dies to quantify "cell death" in metabolic studies ...
Good morning everyone!
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
ApoList – October 2025
Crosstalk apoptosis-other forms of cell death Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics Yun Qiu, Juliana A. Hüther, Bianca Wank, Antonia Rath, René Tykwe,…
celldeath.wordpress.com
November 7, 2025 at 10:28 AM
Good morning everyone!
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
Let's start the day reading a compilation of excellent papers about cell death published last month
The ApoList, October 25
Full of pyroptosis, apoptosis, necroptosis, and crosstalk between these forms and ferroptosis
celldeath.wordpress.com/2025/11/07/a...
Reposted by Cristina Muñoz Pinedo
Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
November 5, 2025 at 5:19 PM
Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Barbara Rivera and coworkers
www.embopress.org/doi/full/10....
Reposted by Cristina Muñoz Pinedo
A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
November 4, 2025 at 12:18 PM
A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
Reposted by Cristina Muñoz Pinedo
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Origins of the Lab Mouse
How the mouse found its way from Victorian novelty to a biomedical mainstay.
www.asimov.press
November 3, 2025 at 6:25 PM
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Reposted by Cristina Muñoz Pinedo
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Katharina Leithner and Katharina Schindlmaier just reported the relevance of gluconeogenesis enzymes in macrophages in lung cancer
Glad to have helped!
www.pnas.org/doi/abs/10.1...
Glad to have helped!
www.pnas.org/doi/abs/10.1...
October 30, 2025 at 11:11 PM
Katharina Leithner and Katharina Schindlmaier just reported the relevance of gluconeogenesis enzymes in macrophages in lung cancer
Glad to have helped!
www.pnas.org/doi/abs/10.1...
Glad to have helped!
www.pnas.org/doi/abs/10.1...
Reposted by Cristina Muñoz Pinedo
Wie passen sich Immunzellen an Krebs an? Ein Forschungsteam rund um Katharina Schindlmaier und Katharina Leithner hat gezeigt, dass Makrophagen („Fresszellen“) ihren Stoffwechsel selbst unter Glukosemangel aufrechterhalten können – etwa in nährstoffarmen Tumoren: https://shorturl.at/EpIUZ
October 30, 2025 at 2:35 PM
Wie passen sich Immunzellen an Krebs an? Ein Forschungsteam rund um Katharina Schindlmaier und Katharina Leithner hat gezeigt, dass Makrophagen („Fresszellen“) ihren Stoffwechsel selbst unter Glukosemangel aufrechterhalten können – etwa in nährstoffarmen Tumoren: https://shorturl.at/EpIUZ
Reposted by Cristina Muñoz Pinedo
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
October 28, 2025 at 3:58 AM
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
Reposted by Cristina Muñoz Pinedo
👇📃 Nos han aceptado en la REDOC el primer trabajo de mi tesis! "Dos décadas de financiación competitiva en España: un análisis longitudinal del principal instrumento de financiación de proyectos de investigación del Plan Nacional de I+D+i (2004-2023)" (1/9)
October 27, 2025 at 2:52 PM
👇📃 Nos han aceptado en la REDOC el primer trabajo de mi tesis! "Dos décadas de financiación competitiva en España: un análisis longitudinal del principal instrumento de financiación de proyectos de investigación del Plan Nacional de I+D+i (2004-2023)" (1/9)
We (scientists) think we are smart, but we are unable to get past this screen at editorialmanager.com
October 24, 2025 at 2:14 PM
We (scientists) think we are smart, but we are unable to get past this screen at editorialmanager.com
What are you guys using for uploading RNAseq data while GEO from the US Government is not working?
Arrayexpress, other?
Or are most people just waiting?
Arrayexpress, other?
Or are most people just waiting?
October 23, 2025 at 2:25 PM
What are you guys using for uploading RNAseq data while GEO from the US Government is not working?
Arrayexpress, other?
Or are most people just waiting?
Arrayexpress, other?
Or are most people just waiting?
Reposted by Cristina Muñoz Pinedo
Reviewing this classic article @bmj.com
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
In this article by Robert Yeh and colleagues ( BMJ 2018;363:k5094, doi:10.1136/bmj.k5094), the final sentence of the Methods section should …
doi.org
October 21, 2025 at 5:45 PM
Reviewing this classic article @bmj.com
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial
doi.org/10.1136/bmj....
I still teach it all the time
Metabolism and cancer articles, September 25: the MetaboList
metabolist.wordpress.com/2025/10/13/m...
metabolist.wordpress.com/2025/10/13/m...
MetaboList – September 2025
Lipid metabolism Defined media reveals the essential role of lipid scavenging in supporting cancer cell proliferation Oliver J. Newsom, Eric Zheng, Lucas B. Sullivan. mTOR inhibition reprograms cel…
metabolist.wordpress.com
October 13, 2025 at 9:38 PM
Metabolism and cancer articles, September 25: the MetaboList
metabolist.wordpress.com/2025/10/13/m...
metabolist.wordpress.com/2025/10/13/m...
celldeath.wordpress.com/2025/10/13/a...
Cell death - September 2025
Apoptosis, pyroptosis, necroptosis, ferroptosis
About enough forms of cell death!
Cell death - September 2025
Apoptosis, pyroptosis, necroptosis, ferroptosis
About enough forms of cell death!
ApoList – September 2025
Bcl-2 family proteins Relative importance of the anti-apoptotic versus apoptosis-unrelated functions of MCL-1 in vivo Kerstin Brinkmann, Kate McArthur, Shezlie Malelang, Leonie Gibson, Annli Tee, S…
celldeath.wordpress.com
October 13, 2025 at 8:55 AM
celldeath.wordpress.com/2025/10/13/a...
Cell death - September 2025
Apoptosis, pyroptosis, necroptosis, ferroptosis
About enough forms of cell death!
Cell death - September 2025
Apoptosis, pyroptosis, necroptosis, ferroptosis
About enough forms of cell death!
A perverse incentive for inventing new names for necrotic cell death according to the stimulus is that editors of big journals want those papers.
Nobody wants to discard in their setting that the stimulus induces a known form of death, and the field self-amplifies like a chain peroxidation reaction
Nobody wants to discard in their setting that the stimulus induces a known form of death, and the field self-amplifies like a chain peroxidation reaction
October 12, 2025 at 4:05 PM
A perverse incentive for inventing new names for necrotic cell death according to the stimulus is that editors of big journals want those papers.
Nobody wants to discard in their setting that the stimulus induces a known form of death, and the field self-amplifies like a chain peroxidation reaction
Nobody wants to discard in their setting that the stimulus induces a known form of death, and the field self-amplifies like a chain peroxidation reaction
Reposted by Cristina Muñoz Pinedo
Acidosis orchestrates adaptations of energy metabolism in tumors www.science.org/doi/10.1126/...
Acidosis orchestrates adaptations of energy metabolism in tumors
Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...
www.science.org
October 9, 2025 at 9:39 PM
Acidosis orchestrates adaptations of energy metabolism in tumors www.science.org/doi/10.1126/...
Do you guys ever cry after hitting "submit"
October 7, 2025 at 11:13 AM
Do you guys ever cry after hitting "submit"
Killer mTOR
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS www.pnas.org/doi/10.1073/...
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS www.pnas.org/doi/10.1073/...
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS
All organisms are exposed to various stressors, which can sometimes lead to organismal
death, depending on their intensity. While stress-induced or...
www.pnas.org
October 5, 2025 at 7:39 PM
Killer mTOR
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS www.pnas.org/doi/10.1073/...
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS www.pnas.org/doi/10.1073/...
Excellent review in the FEBS Journal (@febsj.bsky.social)
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l...
febs.onlinelibrary.wiley.com
September 30, 2025 at 3:08 PM
Excellent review in the FEBS Journal (@febsj.bsky.social)
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....
If an alien without epidemiological knowledge was to investigate what causes headache, they would find -by association- that paracetamol and ibuprofen must be the cause
Because their levels are high in people with headache
Because their levels are high in people with headache
September 24, 2025 at 12:35 PM
If an alien without epidemiological knowledge was to investigate what causes headache, they would find -by association- that paracetamol and ibuprofen must be the cause
Because their levels are high in people with headache
Because their levels are high in people with headache