Abhi Das
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adas1.bsky.social
Abhi Das
@adas1.bsky.social
130 followers 140 following 17 posts
50:50 physician scientist
Infectious diseases/microbiology/penicillin allergy de-labelling
Fledgling lab studying immune perturbations in paediatric infections at UCL
Posts Replies Media Videos
Reposted by Abhi Das
germhuntermd.bsky.social
Diagnosis and Management of Candida Endophthalmitis and Chorioretinitis

Nate Permpalung, Sarah Sedik, Pete Pappas, @martinhoenigl.bsky.social, @drluiso.bsky.social in @cmijournal.bsky.social

www.clinicalmicrobiologyandinfection.com/article/S119...
Diagnosis and Management of Candida Endophthalmitis and Chorioretinitis
Candida endophthalmitis and chorioretinitis are uncommon but potentially devastating complications of candidemia, associated with significant risks of vision loss and long-term morbidity. Effective ma...
www.clinicalmicrobiologyandinfection.com
June 2, 2025 at 11:20 PM
Reposted by Abhi Das
germhuntermd.bsky.social
Histoplasmosis remains an important cause of AIDS-related deaths in many regions

Histoplasma antigen tests are now cheap, accessible, and can be done at POC

Are such assays ready to be used for routine screening of patients with advanced HIV?

We have thoughts 🤔

🔓 academic.oup.com/cid/advance-...
Histoplasma antigen screening in advanced HIV disease
Ilan S Schwartz, Alessandro C Pasqualotto; Histoplasma antigen screening in advanced HIV disease, Clinical Infectious Diseases, , ciaf238, https://doi.org/
academic.oup.com
May 15, 2025 at 3:21 PM
Reposted by Abhi Das
labwaggoner.bsky.social
Th1 differentiation and function are inhibited in neonates following human metapneumovirus infection
academic.oup.com/jimmunol/adv...
@jimmunol.bsky.social
April 29, 2025 at 6:53 PM
Reposted by Abhi Das
natrevimmunol.nature.com
NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology
A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...
www.nature.com
April 23, 2025 at 1:20 PM
Reposted by Abhi Das
ostunilab.bsky.social
I go around saying that tissue repair and tumorigenesis are two faces of the same coin. @ejvillablanca.bsky.social &co now show that this is not always the case and the two processes can be "unlinked" in the gut! @natureportfolio.bsky.social

www.nature.com/articles/s41...
Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature
Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.
www.nature.com
November 20, 2024 at 7:04 PM
Reposted by Abhi Das
gpollara.bsky.social
Non-sputum, blood fingerprick triage diagnostic tests for pulmonary TB!

Nice work @jaynesutherlandtb.bsky.social. As you state there are still groups to verify this, but looks promising. Look forward to reading in detail.

#IDSky #TBSky
@cidjournal.bsky.social
academic.oup.com/cid/advance-...
Performance of 2 Finger-Stick Blood Tests to Triage Adults With Symptoms of Pulmonary Tuberculosis: A Prospective Multisite Diagnostic Accuracy Study
Two finger-stick blood tests to triage people with symptoms of pulmonary tuberculosis by measuring 3 host proteins (multibiomarker test) or 3 host RNA tran
academic.oup.com
April 19, 2025 at 6:31 PM
Reposted by Abhi Das
labwaggoner.bsky.social
Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
April 17, 2025 at 6:57 PM
Reposted by Abhi Das
labwaggoner.bsky.social
Multi-zonal liver organoids from human pluripotent stem cells @nature.com @cincyresearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 16, 2025 at 4:52 PM
Reposted by Abhi Das
drneilstone.bsky.social
The 14 day paradigm for antibiotics first bloodstream infection is long since dead.

The BALANCE trial is another nail in its coffin

#IDSky

www.nejm.org/doi/full/10....
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
www.nejm.org
March 17, 2025 at 9:43 PM
Reposted by Abhi Das
sebpoule.bsky.social
Tongue 👅 lesion/oedema
Cancer ?
Biopsy said otherwise…
#IDsky
March 14, 2025 at 10:26 PM
Reposted by Abhi Das
eberllab.bsky.social
Are you ready for it?

"Highlights of 2024: γδ T cells and bad blood"

A summary of the emerging regulatory and effector roles of #gdTcells in #sepsis.

And it may also contain a few Taylor Swift references. More than 50 in fact.

Thank you so much @immunolcellbiol.bsky.social for playing along!
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
In this manuscript for the “Highlights of 2024” series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in hum....
onlinelibrary.wiley.com
March 10, 2025 at 12:29 AM
Reposted by Abhi Das
towerslab.bsky.social
Happy to announce that our 2nd paper of 2025 is out! 🎊

This collaboration between our brilliant postdoc @lsnewton.bsky.social and @claragathmann.bsky.social, from Dave Selwood’s chemistry lab, designs and employs PROTACs to degrade CypA and inhibit HIV and HCV.

www.nature.com/articles/s41...
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV - Nature Communications
Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...
www.nature.com
February 14, 2025 at 12:53 PM
Reposted by Abhi Das
labwaggoner.bsky.social
A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment
www.nature.com/articles/s41...
@garrypnolan.bsky.social
@naturecomms.bsky.social
January 31, 2025 at 11:20 PM
Reposted by Abhi Das
labwaggoner.bsky.social
Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
January 31, 2025 at 6:33 PM
Reposted by Abhi Das
pathogenomenick.bsky.social
Our mSCAPE project has been formally announced to the world by @smhopkins.bsky.social at #FOG2025 today: www.gov.uk/government/n... - a really exciting academic-public health collaboration to build a surveillance platform leveraging NHS metagenomic diagnostic data. @meerac.bsky.social
UKHSA launches new metagenomic surveillance for health security
The UK launches mSCAPE, a world-first metagenomics initiative by UKHSA to enhance health security through rapid pathogen detection and surveillance.
www.gov.uk
January 30, 2025 at 4:54 PM
adas1.bsky.social
Well done @drakishl.bsky.social ... A lot of work to do the meta-analysis!
January 29, 2025 at 10:28 PM
Reposted by Abhi Das
idiots-pod.bsky.social
ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL

Absorption takes drug into blood from GI,
Vd spreads drug out to where bug calls home.
And after bacteria are doomed to die,
The drug’s eliminated on the porcelain throne

In the Land of Notion where this table doth lie…

#idSky #microsky #pharmsky #medsky
January 26, 2025 at 7:48 PM
Reposted by Abhi Das
petterbrodin.bsky.social
Thanks for highlighting!
January 20, 2025 at 7:24 PM
adas1.bsky.social
ulfdahle.bsky.social Ulf R. Dahle @ulfdahle.bsky.social · Jan 17
Antimicrobial stewardship programs are clearly different because they need be tailored to target groups. For premature infants it effectively reduce unnecessary antibiotic use, particularly by focusing initiation or shortening treatment duration.
karger.com/neo/article/...
January 18, 2025 at 2:23 PM
Reposted by Abhi Das
germhuntermd.bsky.social
Epidemiology and Prognostic Factors Associated With Mold-Positive Blood Cultures: 10-Year Data From a French Prospective Surveillance Program (2012–2022)

academic.oup.com/cid/advance-...
Visual abstract
January 11, 2025 at 2:51 PM
Reposted by Abhi Das
gpollara.bsky.social
Interesting study on role of PCT in the stewardship of IV antibiotics for children admitted for suspected / confirmed bacterial infections.

Does not appear helpful in reducing time on IV Abx in this setting.
#IDSky #AMR #AMSsky #pediatrics

www.sciencedirect.com/science/arti...
January 9, 2025 at 2:11 PM
Reposted by Abhi Das
gpollara.bsky.social
#AMR is a risk to antibiotic failure & death, but if this happens, do we record it on death certificates? Our centre data = NO!

👉In 1 year, 4% of deaths were AMR-attributed & NONE were recorded on death certificates!👈

Need to quantify this better to increase awareness! #IDSky @jac-amr.bsky.social
Antimicrobial resistance–attributable mortality: a patient-level analysis
AbstractBackground. The impact of antimicrobial resistance (AMR) on death at the patient level is challenging to estimate. We aimed to characterize AMR-att
academic.oup.com
January 8, 2025 at 3:22 PM
Reposted by Abhi Das
labwaggoner.bsky.social
🩸Blood DNA virome, including HHV-6 & anellovirus, associates with risk of lupus, pulmonary alveolar proteinosis, rheumatoid arthritis, and COVID-19
www.nature.com/articles/s41...
January 3, 2025 at 5:59 PM
Reposted by Abhi Das
labwaggoner.bsky.social
Neonatal T cells unleash innate powers to combat congenital cytomegalovirus infection
commentary @simongrassmann.bsky.social @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
@salliepermar.bsky.social
January 2, 2025 at 9:47 PM