Abhishek Chatterjee
@achemsynbio.bsky.social
Professor @BostonCollege
Chemical Biology, Synthetic Biology, Directed Evolution, Expanding the genetic code https://sites.google.com/a/bc.edu/thechatterjeelab/home
https://scholar.google.com/citations?user=zeSNxNcAAAAJ&hl=en
Chemical Biology, Synthetic Biology, Directed Evolution, Expanding the genetic code https://sites.google.com/a/bc.edu/thechatterjeelab/home
https://scholar.google.com/citations?user=zeSNxNcAAAAJ&hl=en
Pinned
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
Nice work from the Deliz Liang lab @lab-adl.bsky.social on genetically encoding diverse His analogs
They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...
November 6, 2025 at 3:11 PM
Nice work from the Deliz Liang lab @lab-adl.bsky.social on genetically encoding diverse His analogs
Reposted by Abhishek Chatterjee
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Abhishek Chatterjee
Our latest work seeks to answer a longstanding question: why is discovering new protein binders seemingly unpredictable – and can we better quantify and understand the de novo binder discover process? 1/12
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mapping the diverse topologies of protein-protein interaction fitness landscapes
De novo binder discovery is unpredictable and inefficient due to a lack of quantitative understanding of protein-protein interaction (PPI) sequence-function landscapes. Here, we use our PANCS-Binder t...
www.biorxiv.org
October 15, 2025 at 5:19 PM
Our latest work seeks to answer a longstanding question: why is discovering new protein binders seemingly unpredictable – and can we better quantify and understand the de novo binder discover process? 1/12
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics
Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...
rdcu.be
October 2, 2025 at 2:10 PM
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5
Reposted by Abhishek Chatterjee
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Abhishek Chatterjee
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Cornell University, Chemistry and Chemical Biology
Job #AJO30338, WDR-00054776 Assistant Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New York, US
academicjobsonline.org
August 25, 2025 at 8:30 PM
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Thrilled to see this in print! Co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yields novel backbone modifications. One step closer to novel genetically encoded biopolymers!
✨New in Nat Chem Biol: Site-selective protein editing by backbone extension acyl rearrangements
bit.ly/4oKQ251
Congrats @roeleah.bsky.social, Izzi, Carly, Taylor, Bhavana, @nxhamlish.bsky.social, Arjun, Diondra, Zhongqi, @achemsynbio.bsky.social, Matt, Scott, Alanna, and collaborators!
#NSFfunded
bit.ly/4oKQ251
Congrats @roeleah.bsky.social, Izzi, Carly, Taylor, Bhavana, @nxhamlish.bsky.social, Arjun, Diondra, Zhongqi, @achemsynbio.bsky.social, Matt, Scott, Alanna, and collaborators!
#NSFfunded
Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...
www.nature.com
August 21, 2025 at 10:24 PM
Thrilled to see this in print! Co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yields novel backbone modifications. One step closer to novel genetically encoded biopolymers!
Continuous evolution in E. coli using an orthogonal replisome www.science.org/doi/10.1126/...
An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli
Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions....
www.science.org
August 8, 2025 at 11:36 PM
Continuous evolution in E. coli using an orthogonal replisome www.science.org/doi/10.1126/...
Cool technology from the @chembiobryan.bsky.social lab for high-throughput discovery of protein binders
PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 6, 2025 at 11:10 PM
Cool technology from the @chembiobryan.bsky.social lab for high-throughput discovery of protein binders
Reposted by Abhishek Chatterjee
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
Reposted by Abhishek Chatterjee
The further a researcher or inventor moves from their previous work, the less cited their latest work will be
https://go.nature.com/44VjEW9
https://go.nature.com/44VjEW9
Shifting research focus comes with the risk of reduced impact
An analysis of millions of scientific papers and patents shows that the further a researcher or inventor moves from their previous work, the less cited their latest work will be.
go.nature.com
May 30, 2025 at 1:14 PM
The further a researcher or inventor moves from their previous work, the less cited their latest work will be
https://go.nature.com/44VjEW9
https://go.nature.com/44VjEW9
Reposted by Abhishek Chatterjee
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by Abhishek Chatterjee
I am a big believe of doing your own research and checking facts and sources.
BUT THE BIG PROBLEM IS THAT A POST FROM SOME DUDE ON THE INTERNET SHOULD NOT BE WEIGHTED THE SAME AS INFORMATION FROM SOMEONE WHO HAS SPENT DECADES STUDYING AN ISSUE.
BUT THE BIG PROBLEM IS THAT A POST FROM SOME DUDE ON THE INTERNET SHOULD NOT BE WEIGHTED THE SAME AS INFORMATION FROM SOMEONE WHO HAS SPENT DECADES STUDYING AN ISSUE.
May 23, 2025 at 2:23 PM
I am a big believe of doing your own research and checking facts and sources.
BUT THE BIG PROBLEM IS THAT A POST FROM SOME DUDE ON THE INTERNET SHOULD NOT BE WEIGHTED THE SAME AS INFORMATION FROM SOMEONE WHO HAS SPENT DECADES STUDYING AN ISSUE.
BUT THE BIG PROBLEM IS THAT A POST FROM SOME DUDE ON THE INTERNET SHOULD NOT BE WEIGHTED THE SAME AS INFORMATION FROM SOMEONE WHO HAS SPENT DECADES STUDYING AN ISSUE.
Reposted by Abhishek Chatterjee
Chemists Stuart Schreiber of Harvard University and Arena BioWorks and Peter Schultz of @scripps.edu will split the 2025 Welch Award in Chemistry for their work in the field of chemical biology. cen.acs.org/people/award... #chemsky🧪
2025 Welch Award honors chemical biologists
Recipients Schreiber and Schultz will each receive $500K prize for work on chemical probes, unnatural amino acids, and new therapeutics
cen.acs.org
May 22, 2025 at 7:51 PM
Chemists Stuart Schreiber of Harvard University and Arena BioWorks and Peter Schultz of @scripps.edu will split the 2025 Welch Award in Chemistry for their work in the field of chemical biology. cen.acs.org/people/award... #chemsky🧪
Reposted by Abhishek Chatterjee
They're terminating OPT.
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Skilled immigration on the chopping block? Effects of eliminating "Optional Practical Training" in the US
The White House has taken numerous steps to sharply reduce the number of immigrant workers, with or without legal status, in the US economy. These policies, so far, typically target immigrants with le...
www.piie.com
May 21, 2025 at 9:04 PM
They're terminating OPT.
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.
6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Reposted by Abhishek Chatterjee
Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases. www.cell.com/cell-chemica...
MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA
tRNA chemical modifications play critical roles in biology and diseases. Tepe et al.
report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from
HEK293T and breast cancer-rel...
www.cell.com
May 16, 2025 at 3:58 AM
Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases. www.cell.com/cell-chemica...
Reposted by Abhishek Chatterjee
HAPPY 75th, NSF!
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
May 10, 2025 at 8:19 PM
HAPPY 75th, NSF!
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
Reposted by Abhishek Chatterjee
🧪 Though a doubling of NSF's budget might seem far-fetched, that's exactly what Congress said what's needed to maintain national competitiveness in science & tech.
From the bipartisan CHIPS and Science Act of 2022:
From the bipartisan CHIPS and Science Act of 2022:
May 4, 2025 at 3:04 AM
🧪 Though a doubling of NSF's budget might seem far-fetched, that's exactly what Congress said what's needed to maintain national competitiveness in science & tech.
From the bipartisan CHIPS and Science Act of 2022:
From the bipartisan CHIPS and Science Act of 2022:
Reposted by Abhishek Chatterjee
Escherichia coli with a 57-codon genetic code https://www.biorxiv.org/content/10.1101/2025.05.02.651837v1
May 2, 2025 at 9:09 PM
Escherichia coli with a 57-codon genetic code https://www.biorxiv.org/content/10.1101/2025.05.02.651837v1
Reposted by Abhishek Chatterjee
BREAKING: Reports that Trump would try to cut NIH's budget by 40% have come true.
The request released moments ago would:
- Cut $18 BILLION to NIH's $47b budget
- Eliminate NIMHD, NCCIH, FIC
- Collapse ICs into five 'focus areas'
There's also a long screed about NIH's deficiencies.
The request released moments ago would:
- Cut $18 BILLION to NIH's $47b budget
- Eliminate NIMHD, NCCIH, FIC
- Collapse ICs into five 'focus areas'
There's also a long screed about NIH's deficiencies.
May 2, 2025 at 2:50 PM
BREAKING: Reports that Trump would try to cut NIH's budget by 40% have come true.
The request released moments ago would:
- Cut $18 BILLION to NIH's $47b budget
- Eliminate NIMHD, NCCIH, FIC
- Collapse ICs into five 'focus areas'
There's also a long screed about NIH's deficiencies.
The request released moments ago would:
- Cut $18 BILLION to NIH's $47b budget
- Eliminate NIMHD, NCCIH, FIC
- Collapse ICs into five 'focus areas'
There's also a long screed about NIH's deficiencies.
Reposted by Abhishek Chatterjee
Badass Surgeon Puts On Fingerless Latex Gloves Before Operating
April 28, 2025 at 4:00 PM
Badass Surgeon Puts On Fingerless Latex Gloves Before Operating
Reposted by Abhishek Chatterjee
So excited for the annual student-organized Chemistry-Biology Interface symposium today! Amazing lineup including @hsulab.bsky.social @achemsynbio.bsky.social, Sloan Devlin (Harvard), & Nick Agard (Genentech) + stellar Cornell student and faculty speakers. Looking forward to some great science!
April 26, 2025 at 11:27 AM
So excited for the annual student-organized Chemistry-Biology Interface symposium today! Amazing lineup including @hsulab.bsky.social @achemsynbio.bsky.social, Sloan Devlin (Harvard), & Nick Agard (Genentech) + stellar Cornell student and faculty speakers. Looking forward to some great science!
Reposted by Abhishek Chatterjee
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
chemsymposia.com
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
chemsymposia.com
April 11, 2025 at 4:35 PM
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
chemsymposia.com
Reposted by Abhishek Chatterjee
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
www.training.nih.gov
April 10, 2025 at 1:22 AM
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...