The beloved south London club has announced it will shut next year as redevelopment of the site goes ahead. Founder Adrian Jones, DJs and promoters look back

Small study suggests uniQure drug could be first successful treatment for devastating brain disorder

Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

Trump’s dictator-like behaviour is so brazen, so blatant, that paradoxically, we discount it. But now it’s time to call it what it is, says Guardian columnist Jonathan Freedland

Scientists say ‘shocking’ discovery shows rapid cuts in carbon emissions are needed to avoid catastrophic fallout The collapse of a critical Atlantic current can no longer be considered a low-likelihood event, a study has concluded, making deep cuts to fossil fuel emissions even more urgent to avoid the catastrophic impact. The Atlantic meridional overturning circulation (Amoc) is a major part of the global climate system. It brings sun-warmed tropical water to Europe and the Arctic, where it cools and sinks to form a deep return current. The Amoc was already known to be at its weakest in 1,600 years as a result of the climate crisis. Continue reading...

When millions of once-loyal supporters become disillusioned with a party, there can only be one result: electoral disaster, says Guardian columnist Nesrine Malik

Faced with ‘catastrophic financial doom’ in a difficult industry, the Sunderland outfit explain why imitating Jim Morrison is their way to survive

Inner speech is robustly represented in the motor cortex and can be decoded in real time to restore communication to people with paralysis. Unintentional decoding of private inner speech can be preven...

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation a...

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...

Like so many others, I moved from London to Portugal’s capital for the sun, lifestyle – and the tax break. But as tensions rise with struggling locals, many of us are beginning to wonder whether we’re doing more harm than good …

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...