Abeg Dutta
@abegdutta.bsky.social
Early career researcher interested in epigenetics, LLPS & gene regulation
🔬 🧬.
PhD student at the EMBL Australia Node in Single Molecule Science, UNSW Sydney | IISER Kolkata alumnus | Prev. Master's @ MPI-MG, Berlin.
He/him 🏳️🌈
🔬 🧬.
PhD student at the EMBL Australia Node in Single Molecule Science, UNSW Sydney | IISER Kolkata alumnus | Prev. Master's @ MPI-MG, Berlin.
He/him 🏳️🌈
Reposted by Abeg Dutta
I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉
We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.
We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.
August 25, 2025 at 5:21 PM
I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉
We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.
We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.
Reposted by Abeg Dutta
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
June 16, 2025 at 6:16 PM
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
Reposted by Abeg Dutta
Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳
tinyurl.com/m9s5su7s 1/2
tinyurl.com/m9s5su7s 1/2
June 17, 2025 at 7:33 AM
Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳
tinyurl.com/m9s5su7s 1/2
tinyurl.com/m9s5su7s 1/2
Reposted by Abeg Dutta
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
rdcu.be
June 17, 2025 at 3:26 AM
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
rdcu.be/eq975
Reposted by Abeg Dutta
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.
This is a major win for public health.
This is a major win for public health.
June 16, 2025 at 9:46 PM
BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.
This is a major win for public health.
This is a major win for public health.
Reposted by Abeg Dutta
Happy Pride Month, humans! I invented the rainbow, but you made it beautiful!
June 1, 2025 at 10:11 PM
Happy Pride Month, humans! I invented the rainbow, but you made it beautiful!
Happy to share that I’ve (finally) started my PhD at UNSW Sydney. I’ll be investigating biomolecular condensates and am excited to connect with the Australian life sciences community !
May 28, 2025 at 11:56 AM
Happy to share that I’ve (finally) started my PhD at UNSW Sydney. I’ll be investigating biomolecular condensates and am excited to connect with the Australian life sciences community !
Reposted by Abeg Dutta
I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d
🔗 tinyurl.com/3jkzzy7d
May 2, 2025 at 7:57 PM
I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d
🔗 tinyurl.com/3jkzzy7d
Reposted by Abeg Dutta
From cell lines to full embryos, drug treatments to genetic perturbations, neuron engineering to virtual organoid screens — odds are there’s something in it for you!
Built on flow matching, CellFlow can help guide your next phenotypic screen: biorxiv.org/content/10.1101/2025.04.11.648220v1
Built on flow matching, CellFlow can help guide your next phenotypic screen: biorxiv.org/content/10.1101/2025.04.11.648220v1
April 23, 2025 at 9:26 AM
From cell lines to full embryos, drug treatments to genetic perturbations, neuron engineering to virtual organoid screens — odds are there’s something in it for you!
Built on flow matching, CellFlow can help guide your next phenotypic screen: biorxiv.org/content/10.1101/2025.04.11.648220v1
Built on flow matching, CellFlow can help guide your next phenotypic screen: biorxiv.org/content/10.1101/2025.04.11.648220v1
Reposted by Abeg Dutta
Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
April 21, 2025 at 2:47 PM
Paper Out👇🥳 thanks to ALL authors, Nakatani-san @tamas-schauer.bsky.social @palmrinmoy.bsky.social and bluesky-less
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
RIF1 regulates Replication Timing in mouse embryos & (suprising) findings disentangling effects on transcription and LADs...lots to think about 🙄👍🤔
👉 www.cell.com/developmenta...
Reposted by Abeg Dutta
New Online! Blebbisomes are one bleb away from a functional cell
Blebbisomes are one bleb away from a functional cell
Nature Reviews Molecular Cell Biology, Published online: 09 April 2025; doi:10.1038/s41580-025-00849-wThe authors of a new study characterize blebbisomes, large extracellular vesicles that contain functional mitochondria and other organelles and have significant roles in inter-cellular communication and the tumour microenvironment.
bit.ly
April 9, 2025 at 3:59 PM
New Online! Blebbisomes are one bleb away from a functional cell
Reposted by Abeg Dutta
The reason biologists in your timeline are furious by this PR: the idea that species that diverged millions of years ago have only 20 genetic differences defies the fundamental principles of evolution. Like saying you turned a Honda Civic into a Formula 1 car by changing the oil
It's not a dire wolf. It's a gray wolf clone with 20 dire-wolf gene edits, and with some dire wolf traits. And here's my story! Gift link: www.nytimes.com/2025/04/07/s...
April 8, 2025 at 1:52 PM
The reason biologists in your timeline are furious by this PR: the idea that species that diverged millions of years ago have only 20 genetic differences defies the fundamental principles of evolution. Like saying you turned a Honda Civic into a Formula 1 car by changing the oil
Reposted by Abeg Dutta
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
April 8, 2025 at 1:52 PM
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
Reposted by Abeg Dutta
Very happy to share that our paper on stem cell culture conditions is now out! doi.org/10.1371/jour... We found that modulating mESC culture conditions influences gastruloid elongation and lineage specification, and helps with making the protocol more reproducible in our hands! more below 🧵⬇️ [1/7]
Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation
Aggregating low numbers of mouse embryonic stem cells (mESCs) and inducing Wnt signalling generates ‘gastruloids’, self-organising complex structures that display an anteroposterior organisation of ce...
doi.org
March 28, 2025 at 3:20 PM
Very happy to share that our paper on stem cell culture conditions is now out! doi.org/10.1371/jour... We found that modulating mESC culture conditions influences gastruloid elongation and lineage specification, and helps with making the protocol more reproducible in our hands! more below 🧵⬇️ [1/7]
Reposted by Abeg Dutta
I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
March 6, 2025 at 11:40 AM
I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
Reposted by Abeg Dutta
The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin
Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyce…
www.sciencedirect.com
February 27, 2025 at 7:31 AM
The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Abeg Dutta
Stop doomscrolling for a second and look at this absolute unit that visited me earlier today
February 27, 2025 at 4:46 AM
Stop doomscrolling for a second and look at this absolute unit that visited me earlier today
Reposted by Abeg Dutta
How do so many students get to grad school without a reference manager? I am an unabashed @zotero.org zealot. Students are practically sobbing tears of joy when they find that there is a FREE tool that will organize and label PDFs, allow markup, and insert bibliographies!
February 26, 2025 at 6:34 PM
How do so many students get to grad school without a reference manager? I am an unabashed @zotero.org zealot. Students are practically sobbing tears of joy when they find that there is a FREE tool that will organize and label PDFs, allow markup, and insert bibliographies!
Reposted by Abeg Dutta
OMG it's out! The latest from Gladstone Institute of Cardiovascular Research: Isha Jain's lab, with an outstanding discovery of a small molecule that can mimic hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, an RA in Isha's lab, is first author! www.cell.com/cell/fulltex...
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity
A small molecule that increases oxygen-hemoglobin affinity was shown to prevent and
reverse pathology in a mouse model of mitochondrial disease, thereby enabling a practical
form of hypoxia therapy.
www.cell.com
February 17, 2025 at 6:04 PM
OMG it's out! The latest from Gladstone Institute of Cardiovascular Research: Isha Jain's lab, with an outstanding discovery of a small molecule that can mimic hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, an RA in Isha's lab, is first author! www.cell.com/cell/fulltex...
Reposted by Abeg Dutta
Here is a beach with pebbles to clean your timeline.
February 17, 2025 at 1:30 AM
Here is a beach with pebbles to clean your timeline.
Reposted by Abeg Dutta
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted by Abeg Dutta
When reviewer 2 has no comments.
February 3, 2025 at 2:28 AM
When reviewer 2 has no comments.
Reposted by Abeg Dutta
Superb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive #machinelearning models & interpretation tools that use #scRNAseq + #scATACseq data to better understand how chromatin accessibility relates to gene expression doi.org/10.1038/s414...
Happy 2025 everyone 🎆 !
Happy 2025 everyone 🎆 !
ChromatinHD connects single-cell DNA accessibility and conformation to gene expression through scale-adaptive machine learning - Nature Communications
Functional chromatin changes occur at different scales. Here, the authors introduce ChromatinHD, a method that characterises differential and predictive chromatin accessibility changes in a scale-adap...
doi.org
January 6, 2025 at 2:05 PM
Superb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive #machinelearning models & interpretation tools that use #scRNAseq + #scATACseq data to better understand how chromatin accessibility relates to gene expression doi.org/10.1038/s414...
Happy 2025 everyone 🎆 !
Happy 2025 everyone 🎆 !
Reposted by Abeg Dutta
Great article (in which I am quoted) about biomolecular condensates, the cellular phenomena I work on in my day job! 🧪
www.scientificamerican.com/article/myst...
www.scientificamerican.com/article/myst...
Mysterious Blobs in Cells Are Changing the Way We Understand Life
Tiny specks called biomolecular condensates are leading to a new understanding of the cell
www.scientificamerican.com
January 23, 2025 at 5:30 PM
Great article (in which I am quoted) about biomolecular condensates, the cellular phenomena I work on in my day job! 🧪
www.scientificamerican.com/article/myst...
www.scientificamerican.com/article/myst...