Amy Strom
@dnamystrom.bsky.social
Chromatin and cancer and condensates. Lab Head in Discovery Oncology at Genentech.
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Amy Strom
@dnamystrom.bsky.social
· Jun 16
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
Interplay of condensation and chromatin binding underlies BRD4 targeting | Molecular Biology of the Cell
Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific ...
www.molbiolcell.org
September 13, 2025 at 12:20 AM
Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read!
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
www.molbiolcell.org/doi/full/10....
Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social
And huge thank you @ascbiology.bsky.social
Getting Strom Lab set up!
September 11, 2025 at 5:34 AM
Getting Strom Lab set up!
First day at my new job!
I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech.
I'll be searching for new targets to develop cancer treatments.
2nd photo is my newest friend on campus, decoy-ote.
@genentech.bsky.social
I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech.
I'll be searching for new targets to develop cancer treatments.
2nd photo is my newest friend on campus, decoy-ote.
@genentech.bsky.social
August 5, 2025 at 2:34 AM
First day at my new job!
I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech.
I'll be searching for new targets to develop cancer treatments.
2nd photo is my newest friend on campus, decoy-ote.
@genentech.bsky.social
I'm a Lab Head, Principal Scientist in Discovery Oncology at Genentech.
I'll be searching for new targets to develop cancer treatments.
2nd photo is my newest friend on campus, decoy-ote.
@genentech.bsky.social
The latest in my favorite love triangle:
Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics
Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics
Congrats to Jing @jesszhiyuezhao.bsky.social
& @dnamystrom.bsky.social on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR
& @dnamystrom.bsky.social on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR
Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior
Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...
rdcu.be
July 13, 2025 at 4:46 PM
The latest in my favorite love triangle:
Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics
Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics
Cancelling grants that were already competitively won and awarded is the waste and abuse.
www.nytimes.com/2025/07/10/u...
www.nytimes.com/2025/07/10/u...
The Surprising Scientists Hit by Trump’s D.E.I. Cuts
www.nytimes.com
July 10, 2025 at 4:01 PM
Cancelling grants that were already competitively won and awarded is the waste and abuse.
www.nytimes.com/2025/07/10/u...
www.nytimes.com/2025/07/10/u...
I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
July 7, 2025 at 9:25 PM
I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
June 16, 2025 at 6:16 PM
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...