Alex Radzisheuskaya
@a-radzisheuskaya.bsky.social
Scientist, group leader @icrlondon.bsky.social
https://www.radzisheuskayalab.com
https://www.radzisheuskayalab.com
Reposted by Alex Radzisheuskaya
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.
dlvr.it
August 26, 2025 at 7:17 PM
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
Reposted by Alex Radzisheuskaya
Great story from our fantastic neighbour Jörg Mansfeld!
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.
dlvr.it
August 26, 2025 at 10:38 PM
Great story from our fantastic neighbour Jörg Mansfeld!
Registration is still open for Transcription and Chromatin UK 2025. Join our growing research community in Manchester this September!
August 13, 2025 at 10:52 AM
Registration is still open for Transcription and Chromatin UK 2025. Join our growing research community in Manchester this September!
Reposted by Alex Radzisheuskaya
🚨Transcription and Chromatin UK abstract deadline is TODAY🚨 Join us in Manchester and showcase your best science. Register for earlybird rates and submit your abstract here bit.ly/4eUl4mz
Transcription and Chromatin UK 2025
bit.ly
July 17, 2025 at 10:45 AM
🚨Transcription and Chromatin UK abstract deadline is TODAY🚨 Join us in Manchester and showcase your best science. Register for earlybird rates and submit your abstract here bit.ly/4eUl4mz
Join us for the 2025 version of Transcription and Chromatin UK, this time in Manchester! Submit your abstract by July 17th.
Registration for Transcription and Chromatin UK is OPEN! Taking place from September 17 to 19, 2025, this conference will showcase cutting-edge research and is a ‘must-attend’ event for the UK transcription and chromatin community & both at home and abroad.
Pl register ow.ly/7QQb50W9Alo & share
Pl register ow.ly/7QQb50W9Alo & share
June 26, 2025 at 9:07 PM
Join us for the 2025 version of Transcription and Chromatin UK, this time in Manchester! Submit your abstract by July 17th.
Reposted by Alex Radzisheuskaya
Belarus has released the husband of opposition leader Sviatlana Tsikhanouskaya — Sergei Tsikhanouski — along with several other prisoners, during Kellogg’s visit to the country.
Tsikhanouski ran for president in Belarus’s 2020 election. He was arrested and sentenced to 18 years in prison.
Tsikhanouski ran for president in Belarus’s 2020 election. He was arrested and sentenced to 18 years in prison.
June 21, 2025 at 2:18 PM
Belarus has released the husband of opposition leader Sviatlana Tsikhanouskaya — Sergei Tsikhanouski — along with several other prisoners, during Kellogg’s visit to the country.
Tsikhanouski ran for president in Belarus’s 2020 election. He was arrested and sentenced to 18 years in prison.
Tsikhanouski ran for president in Belarus’s 2020 election. He was arrested and sentenced to 18 years in prison.
Reposted by Alex Radzisheuskaya
Now I've had a chance to read Andrea Sella's article in @chemistryworld.com on why he returned his Royal Society Faraday Medal. I recommend that you read it too. It's inspiring, though inevitably also disturbing, in these troubled times.
www.chemistryworld.com/opinion/why-...
www.chemistryworld.com/opinion/why-...
Why I returned the Faraday prize to the Royal Society
Andrea Sella explains how inaction over Elon Musk's membership motivated him to act
www.chemistryworld.com
June 13, 2025 at 8:40 PM
Now I've had a chance to read Andrea Sella's article in @chemistryworld.com on why he returned his Royal Society Faraday Medal. I recommend that you read it too. It's inspiring, though inevitably also disturbing, in these troubled times.
www.chemistryworld.com/opinion/why-...
www.chemistryworld.com/opinion/why-...
Reposted by Alex Radzisheuskaya
Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
Looking for a Postdoc? A PDRA position is available in the LSI Exeter with Prof Brian Hendrich from September 2025. Do you have experience in mammalian stem cell culture and a solid understanding of molecular & biochemical lab techniques? Apply! Job Ref: Q05546 jobs.exeter.ac.uk/hrpr_webrecr...
Powered by MHR
jobs.exeter.ac.uk
June 11, 2025 at 10:10 AM
Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
So proud of Dan for winning the poster prize — and it was his very first poster! What a great start!
Congratulations to poster prize winners Daniel Price and Maximilian H. Fitz-James and @manthan5277.bsky.social . Sponsored by @gensocuk.bsky.social and cosponsored by the @biochemsoc.bsky.social
June 6, 2025 at 8:06 PM
So proud of Dan for winning the poster prize — and it was his very first poster! What a great start!
Reposted by Alex Radzisheuskaya
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
www.biorxiv.org
May 27, 2025 at 5:32 PM
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alex Radzisheuskaya
I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
Quick Check Needed
qmul-jobs.tal.net
April 4, 2025 at 4:04 PM
I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.
The Transcription and Chromatin UK Meeting is back for 2025! Don't miss out — register your interest: www.biochemistry.org/events-and-t... @biochemsoc.bsky.social
Transcription and Chromatin UK 2025
Transcription and Chromatin UK brings together the rich transcription and epigenetics community in the UK and leading experts from abroad, and will feature all aspects of transcription and chromatin r...
www.biochemistry.org
April 1, 2025 at 11:36 AM
The Transcription and Chromatin UK Meeting is back for 2025! Don't miss out — register your interest: www.biochemistry.org/events-and-t... @biochemsoc.bsky.social
Reposted by Alex Radzisheuskaya
Here I react to the shameful encounter between American leaders and media and the Ukrainian president. No doubt there were more, but I saw five failures on our side: of hospitality, decency, democracy, strategy, and independence. Please watch and share.
snyder.substack.com/p/five-failu...
snyder.substack.com/p/five-failu...
Five Failures in the Oval Office (video)
America hurt itself badly today.
snyder.substack.com
February 28, 2025 at 10:15 PM
Here I react to the shameful encounter between American leaders and media and the Ukrainian president. No doubt there were more, but I saw five failures on our side: of hospitality, decency, democracy, strategy, and independence. Please watch and share.
snyder.substack.com/p/five-failu...
snyder.substack.com/p/five-failu...
Reposted by Alex Radzisheuskaya
Decent people thank Ukraine.
February 28, 2025 at 8:40 PM
Decent people thank Ukraine.
Reposted by Alex Radzisheuskaya
Tally just ticked past 1900 signatures. Please keep spreading the word about the letter & asking people to sign. It's important to make the Royal Society aware (at their meeting on 03 March) just how much the scientific community wants them to speak up for their values. forms.gle/SfsDemyS8QhP...
February 14, 2025 at 6:39 PM
Tally just ticked past 1900 signatures. Please keep spreading the word about the letter & asking people to sign. It's important to make the Royal Society aware (at their meeting on 03 March) just how much the scientific community wants them to speak up for their values. forms.gle/SfsDemyS8QhP...
Reposted by Alex Radzisheuskaya
My lab is #hiring!
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
Research Fellow at University of Birmingham
Discover an exciting academic career path as a Research Fellow at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
www.jobs.ac.uk
January 31, 2025 at 10:01 AM
My lab is #hiring!
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
Reposted by Alex Radzisheuskaya
We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!
It's a great team and a wonderful place to work!
Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research
View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea .
Salary : Commencement on the salary range is subject to comparable skills and exp...
jobs.icr.ac.uk
December 13, 2024 at 6:37 PM
We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!
It's a great team and a wonderful place to work!
Reposted by Alex Radzisheuskaya
Follow the Institute of Cancer Research on our new Bluesky account. Moving from X -
@icrlondon.bsky.social
@icrlondon.bsky.social
November 14, 2024 at 8:05 AM
Follow the Institute of Cancer Research on our new Bluesky account. Moving from X -
@icrlondon.bsky.social
@icrlondon.bsky.social