The Downs Lab
@thedownslab.bsky.social
The Downs lab at the Institute of Cancer Research in London, studying chromatin biology and genome stability. thedownslab.org
The amazing @lillianwu.bsky.social is now the amazing Dr Lillian Wu 🎉 She passed her viva with flying colours. Massive thanks to her wonderful examiners @esashilab.bsky.social and @viji-draviam.bsky.social
October 30, 2025 at 5:52 PM
The amazing @lillianwu.bsky.social is now the amazing Dr Lillian Wu 🎉 She passed her viva with flying colours. Massive thanks to her wonderful examiners @esashilab.bsky.social and @viji-draviam.bsky.social
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
October 27, 2025 at 7:37 PM
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
Reposted by The Downs Lab
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted by The Downs Lab
#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
September 22, 2025 at 2:22 PM
#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Reposted by The Downs Lab
Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs
September 19, 2025 at 12:32 PM
Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs
Reposted by The Downs Lab
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 4:51 PM
We are hiring! We are looking for a PDRA to study the epigenetics of breast cancer dormancy using chemical biology and genomics approaches. This is a 3-year position and is aimed at chemical biologists or biologists. Please share and apply using the link below 👇👇👇
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Reposted by The Downs Lab
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs
www.cell.com/cell-reports...
www.cell.com/cell-reports...
September 16, 2025 at 3:30 PM
Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by The Downs Lab
Great story from our fantastic neighbour Jörg Mansfeld!
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision Online now:
A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase controls its stability. Loss of C41 oxidation increases p21 stability, impairs proliferation, and promotes senescence after irradiation.
dlvr.it
August 26, 2025 at 10:38 PM
Great story from our fantastic neighbour Jörg Mansfeld!
August 25, 2025 at 2:47 PM
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
July 18, 2025 at 5:39 AM
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
July 4, 2025 at 2:09 PM
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
Reposted by The Downs Lab
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
June 12, 2025 at 12:58 PM
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
www.biorxiv.org
May 27, 2025 at 5:32 PM
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by The Downs Lab
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex
At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.
url.uk.m.mimecastprotect.com
May 21, 2025 at 10:22 AM
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
Please forward to prospective students! Thank you
url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
Reposted by The Downs Lab
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
April 9, 2025 at 8:05 AM
A must for all DNA repair aficionados!
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters
Don’t miss it: dnarepairmeeting-egmond2026.com
Reposted by The Downs Lab
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
tinyurl.com
February 12, 2025 at 2:53 PM
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
Reposted by The Downs Lab
We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025
Senior Research Officer at University of Essex
Searching for an academic job? Explore this Senior Research Officer opening on jobs.ac.uk! Click to view more details and browse other academic jobs.
www.jobs.ac.uk
March 27, 2025 at 9:15 AM
We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and beyond www.jobs.ac.uk/job/DMK060/s.... Application deadline: 21st April 2025
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
Nobel prize-winning technology in cancer care - The Cancer Researcher
Katalin Karikó's work into mRNA vaccines
magazine.eacr.org
March 19, 2025 at 7:43 AM
Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...
Reposted by The Downs Lab
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
March 12, 2025 at 2:51 PM
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
www.nature.com
March 5, 2025 at 2:44 PM
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
Reposted by The Downs Lab
Happy to finally share this paper from our lab! First authors @kezlane.bsky.social @alison-harrod.bsky.social and the team worked so hard on it, I'm proud to be on it too!
PBAF as the protector of centromere and pericentromere integrity🧬🔬
@thedownslab.bsky.social
www.nature.com/articles/s41...
PBAF as the protector of centromere and pericentromere integrity🧬🔬
@thedownslab.bsky.social
www.nature.com/articles/s41...
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
www.nature.com
February 26, 2025 at 11:14 AM
Happy to finally share this paper from our lab! First authors @kezlane.bsky.social @alison-harrod.bsky.social and the team worked so hard on it, I'm proud to be on it too!
PBAF as the protector of centromere and pericentromere integrity🧬🔬
@thedownslab.bsky.social
www.nature.com/articles/s41...
PBAF as the protector of centromere and pericentromere integrity🧬🔬
@thedownslab.bsky.social
www.nature.com/articles/s41...
These are two awesome, talented postdocs! Lucky to have them in the lab 😍
Cheers @kezlane.bsky.social to our co-first author paper on PBRM1 and the centromere being published this week in @naturecomms.bsky.social! @thedownslab.bsky.social @icr.ac.uk
March 5, 2025 at 2:33 PM
These are two awesome, talented postdocs! Lucky to have them in the lab 😍
Congratulations @kezlane.bsky.social and @alison-harrod.bsky.social and thanks to all our fabulous collaborators!
Delighted to share that our paper on the role of PBAF in centromere integrity is out now in @natcomms.bsky.social! It was a long journey but it was made so much easier thanks to my co-first author/coding whiz @alison-harrod.bsky.social, the whole @thedownslab.bsky.social team, & our wonderful boss!
PBRM1 directs PBAF to pericentromeres and protects centromere integrity
Nature Communications - Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is...
rdcu.be
March 5, 2025 at 2:32 PM
Congratulations @kezlane.bsky.social and @alison-harrod.bsky.social and thanks to all our fabulous collaborators!
Reposted by The Downs Lab
We're pleased to announce that Katie Begg is the second recipient of an EACR-Molecular Oncology Editorial Fellowship! Learn more about Katie and this exciting opportunity: magazine.eacr.org/katie-begg-r...
Katie Begg receives EACR-Molecular Oncology Editorial Fellowship - The Cancer Researcher
Katie Begg is the recipient of an EACR-Molecular Oncology Editorial Fellowship, including a placement with the Molecular Oncology journal.
magazine.eacr.org
February 5, 2025 at 10:29 AM
We're pleased to announce that Katie Begg is the second recipient of an EACR-Molecular Oncology Editorial Fellowship! Learn more about Katie and this exciting opportunity: magazine.eacr.org/katie-begg-r...