Mirko Pegoraro PhD
@3volution.bsky.social
Lecturer in Epigenetics at Liverpool John Moores university. Focus on understanding Evolution via Natural Selection at multiple levels. I am interested in Genetics, Epigenetics and Molecular Biology. 🐝🪰🦟🐜🦠🧬🌈he/him
Web: https://shorturl.at/WF8o3
Web: https://shorturl.at/WF8o3
Reposted by Mirko Pegoraro PhD
Racism is not justified by immigration levels or rising poverty, unemployment or crime.
It is not justified, period.
I see the rising wave of voices & arguments justifying the rising levels of racism as the most sinister political development in 2025 on the British landscape.
It is not justified, period.
I see the rising wave of voices & arguments justifying the rising levels of racism as the most sinister political development in 2025 on the British landscape.
The Home Secretary explaining that the rise in racist violence is, actually, the natural response to higher levels of immigration is a state of affairs that can't exist without the government having largely decided that racist violence is, if not legitimate, at least understandable.
November 22, 2025 at 11:20 AM
Racism is not justified by immigration levels or rising poverty, unemployment or crime.
It is not justified, period.
I see the rising wave of voices & arguments justifying the rising levels of racism as the most sinister political development in 2025 on the British landscape.
It is not justified, period.
I see the rising wave of voices & arguments justifying the rising levels of racism as the most sinister political development in 2025 on the British landscape.
Reposted by Mirko Pegoraro PhD
Would it have killed these journalists to ask MBS about murdering their colleague NICELY?
November 21, 2025 at 8:01 PM
Would it have killed these journalists to ask MBS about murdering their colleague NICELY?
Small moment of pure science 🧬 joy 🤩: I just confirmed that I managed to amplify my methylation target 🎯 🧬 to estimate age at death 💀 in hedgehog 🦔 samples. We are in business.
#epigenetics
#epigenetics
November 20, 2025 at 5:06 PM
Small moment of pure science 🧬 joy 🤩: I just confirmed that I managed to amplify my methylation target 🎯 🧬 to estimate age at death 💀 in hedgehog 🦔 samples. We are in business.
#epigenetics
#epigenetics
Reposted by Mirko Pegoraro PhD
SO HAPPY to share our new paper in @currentbiology.bsky.social! Using volumetric EM, we found daily shifts in synapses, vesicles, and mitochondria that accompany neuronal remodeling, linking structural plasticity to changes in how s-LNv neurons influence their targets
www.cell.com/current-biol...
www.cell.com/current-biol...
Daily ultrastructural remodeling of clock neurons
A cluster of Drosophila clock neurons remodel their axonal arbors daily. Using volumetric
electron microscopy at different times of day, Ispizua, Rodriguez-Caron, and colleagues
reveal ultrastructural...
www.cell.com
November 19, 2025 at 5:03 PM
SO HAPPY to share our new paper in @currentbiology.bsky.social! Using volumetric EM, we found daily shifts in synapses, vesicles, and mitochondria that accompany neuronal remodeling, linking structural plasticity to changes in how s-LNv neurons influence their targets
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Mirko Pegoraro PhD
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
November 13, 2025 at 11:54 AM
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Reposted by Mirko Pegoraro PhD
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Mirko Pegoraro PhD
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
November 19, 2025 at 9:48 AM
Fun week for DNA methylation research! Here is a thread of three cool papers that came out, all with an evolution angle. And a bonus 4th that examines DNAme/PcG interplay (certainly an interest for our lab!) #Epigenetics
Reposted by Mirko Pegoraro PhD
Alex Padilla lays it plain.
November 18, 2025 at 8:37 PM
Alex Padilla lays it plain.
Reposted by Mirko Pegoraro PhD
#Review
Bacteria can “remember” past environments through genetic & biochemical imprints helping them adapt and thrive! 🦠🧠
#MicroSky
www.nature.com/articles/s41...
Bacteria can “remember” past environments through genetic & biochemical imprints helping them adapt and thrive! 🦠🧠
#MicroSky
www.nature.com/articles/s41...
Exploring the concept of bacterial memory - Nature Microbiology
This Perspective discusses the concept, mechanisms and evidence for memory in bacteria at individual and community levels.
www.nature.com
November 18, 2025 at 8:51 AM
#Review
Bacteria can “remember” past environments through genetic & biochemical imprints helping them adapt and thrive! 🦠🧠
#MicroSky
www.nature.com/articles/s41...
Bacteria can “remember” past environments through genetic & biochemical imprints helping them adapt and thrive! 🦠🧠
#MicroSky
www.nature.com/articles/s41...
Reposted by Mirko Pegoraro PhD
🐠 Medaka (Oryzias latipes) ✨ A tiny fish with big developmental insights! 🧬 Medaka is perfect for studying sex determination, germ cell development, pigmentation, and environmental effects on embryos 📸 Image by Philipp Keller #ModelMonday #DevBio #EvoDevo
November 17, 2025 at 7:08 PM
🐠 Medaka (Oryzias latipes) ✨ A tiny fish with big developmental insights! 🧬 Medaka is perfect for studying sex determination, germ cell development, pigmentation, and environmental effects on embryos 📸 Image by Philipp Keller #ModelMonday #DevBio #EvoDevo
Reposted by Mirko Pegoraro PhD
In fact, unlike a *mechanical* motor, we can disrupt the genes controlling the delicate workings & the bacteria will evolve back to the functional form *surprisingly quickly*.
Or maybe that's how mechanical motors work too, but 'Big Auto Repair' don't want you to know that.
Or maybe that's how mechanical motors work too, but 'Big Auto Repair' don't want you to know that.
The rapid evolution of flagellar ion selectivity in experimental populations of E. coli
This study shows that bacteria can rapidly adapt to changes in their environment to preserve their ability to swim.
www.science.org
November 17, 2025 at 10:31 PM
In fact, unlike a *mechanical* motor, we can disrupt the genes controlling the delicate workings & the bacteria will evolve back to the functional form *surprisingly quickly*.
Or maybe that's how mechanical motors work too, but 'Big Auto Repair' don't want you to know that.
Or maybe that's how mechanical motors work too, but 'Big Auto Repair' don't want you to know that.
Reposted by Mirko Pegoraro PhD
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
November 17, 2025 at 10:31 PM
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
Reposted by Mirko Pegoraro PhD
Pass the phone… to the 40,000 Young Greens! 📲 💚
We now have the largest youth and student movement in UK politics - AND the biggest Young Greens group in Europe 🥳
This is the generation that’s done waiting. Join us. ⤵️
We now have the largest youth and student movement in UK politics - AND the biggest Young Greens group in Europe 🥳
This is the generation that’s done waiting. Join us. ⤵️
November 18, 2025 at 8:01 AM
Pass the phone… to the 40,000 Young Greens! 📲 💚
We now have the largest youth and student movement in UK politics - AND the biggest Young Greens group in Europe 🥳
This is the generation that’s done waiting. Join us. ⤵️
We now have the largest youth and student movement in UK politics - AND the biggest Young Greens group in Europe 🥳
This is the generation that’s done waiting. Join us. ⤵️
Reposted by Mirko Pegoraro PhD
ICIJ's latest investigation The #CoinLaundry is a collaboration of 113 journalists from 38 media partners in 35 countries that exposes how cryptocurrency companies have empowered a shadow economy that lavishly profits from crime.
Here are our findings:
Here are our findings:
November 17, 2025 at 3:08 PM
ICIJ's latest investigation The #CoinLaundry is a collaboration of 113 journalists from 38 media partners in 35 countries that exposes how cryptocurrency companies have empowered a shadow economy that lavishly profits from crime.
Here are our findings:
Here are our findings:
Reposted by Mirko Pegoraro PhD
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
www.nature.com
November 17, 2025 at 12:12 PM
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mirko Pegoraro PhD
This is brilliant!
🧪“The Monster Slash”
By @ellecordova.bsky.social on IG
She performs a song about the cuts to the government agencies that impact our daily lives.
🧪“The Monster Slash”
By @ellecordova.bsky.social on IG
She performs a song about the cuts to the government agencies that impact our daily lives.
November 18, 2025 at 2:02 AM
This is brilliant!
🧪“The Monster Slash”
By @ellecordova.bsky.social on IG
She performs a song about the cuts to the government agencies that impact our daily lives.
🧪“The Monster Slash”
By @ellecordova.bsky.social on IG
She performs a song about the cuts to the government agencies that impact our daily lives.
Reposted by Mirko Pegoraro PhD
A Government of cowards.
Rather than tackle inequality - they've gone for pensioners, disabled people and now it's people fleeing war and persecution.
They can't get away with this.
Join.greenparty.org.uk
Rather than tackle inequality - they've gone for pensioners, disabled people and now it's people fleeing war and persecution.
They can't get away with this.
Join.greenparty.org.uk
November 17, 2025 at 11:16 PM
A Government of cowards.
Rather than tackle inequality - they've gone for pensioners, disabled people and now it's people fleeing war and persecution.
They can't get away with this.
Join.greenparty.org.uk
Rather than tackle inequality - they've gone for pensioners, disabled people and now it's people fleeing war and persecution.
They can't get away with this.
Join.greenparty.org.uk
Reposted by Mirko Pegoraro PhD
Join us! 🧬🪰🎉🔬
We are currently advertising two #PhD projects to study the #evolution, #development and #genomics of sexual traits in stalk-eyed flies.
Deadline for applying is Wednesday, January 7, 2026. Get in touch for more info!
We are currently advertising two #PhD projects to study the #evolution, #development and #genomics of sexual traits in stalk-eyed flies.
Deadline for applying is Wednesday, January 7, 2026. Get in touch for more info!
November 17, 2025 at 3:58 PM
Join us! 🧬🪰🎉🔬
We are currently advertising two #PhD projects to study the #evolution, #development and #genomics of sexual traits in stalk-eyed flies.
Deadline for applying is Wednesday, January 7, 2026. Get in touch for more info!
We are currently advertising two #PhD projects to study the #evolution, #development and #genomics of sexual traits in stalk-eyed flies.
Deadline for applying is Wednesday, January 7, 2026. Get in touch for more info!
Reposted by Mirko Pegoraro PhD
Cruel. Callous. Cowardly.
The public are seeing this Labour government for exactly who they are.
We all have a responsibility to make them pay at the ballot box.
Reject the hate. Reject them.
This is not who we are. Let's make hope normal again.
Join.greenparty.org.uk
The public are seeing this Labour government for exactly who they are.
We all have a responsibility to make them pay at the ballot box.
Reject the hate. Reject them.
This is not who we are. Let's make hope normal again.
Join.greenparty.org.uk
November 17, 2025 at 5:19 PM
Cruel. Callous. Cowardly.
The public are seeing this Labour government for exactly who they are.
We all have a responsibility to make them pay at the ballot box.
Reject the hate. Reject them.
This is not who we are. Let's make hope normal again.
Join.greenparty.org.uk
The public are seeing this Labour government for exactly who they are.
We all have a responsibility to make them pay at the ballot box.
Reject the hate. Reject them.
This is not who we are. Let's make hope normal again.
Join.greenparty.org.uk
Reposted by Mirko Pegoraro PhD
ICE-style raids on Britain's streets: that's all Labour's brutal asylum reforms will achieve | Stella Creasy
ICE-style raids on Britain's streets: that's all Labour's brutal asylum reforms will achieve | Stella Creasy
If we want to ‘stop the boats’, we need to stop the BS when it comes to what creates refugees, and how to respond to them, says Labour MP Stella Creasy
www.theguardian.com
November 17, 2025 at 1:37 PM
ICE-style raids on Britain's streets: that's all Labour's brutal asylum reforms will achieve | Stella Creasy
Reposted by Mirko Pegoraro PhD
"Postdoc in the job market"
November 16, 2025 at 7:52 PM
"Postdoc in the job market"
Reposted by Mirko Pegoraro PhD
Everything about the current 'debate' around this is dismal, not just morally but because it is so stupid. For example:
It conflates asylum-seeking and illegal immigration (and sometimes with migration generally)
It shows no understanding of why there is AS
www.theguardian.com/uk-news/2025... 1/3
It conflates asylum-seeking and illegal immigration (and sometimes with migration generally)
It shows no understanding of why there is AS
www.theguardian.com/uk-news/2025... 1/3
Asylum system in UK ‘out of control’ and dividing country, home secretary says
Shabana Mahmood to unveil new proposals modelled on Denmark’s controversial system
www.theguardian.com
November 16, 2025 at 6:49 PM
Everything about the current 'debate' around this is dismal, not just morally but because it is so stupid. For example:
It conflates asylum-seeking and illegal immigration (and sometimes with migration generally)
It shows no understanding of why there is AS
www.theguardian.com/uk-news/2025... 1/3
It conflates asylum-seeking and illegal immigration (and sometimes with migration generally)
It shows no understanding of why there is AS
www.theguardian.com/uk-news/2025... 1/3
Reposted by Mirko Pegoraro PhD
This is a very comprehensive review for those of you who are interested in vaccines and the use of mRNA in vaccines.
Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications - Virology Journal
Messenger RNA (mRNA) vaccines have emerged as a transformative platform in modern vaccinology. mRNA vaccine is a powerful alternative to traditional vaccines due to their high potency, safety, and eff...
virologyj.biomedcentral.com
November 16, 2025 at 7:52 PM
This is a very comprehensive review for those of you who are interested in vaccines and the use of mRNA in vaccines.
Reposted by Mirko Pegoraro PhD
Like it or not this technology is here to stay and if you don’t use it you’ll fall behind in your industry
November 16, 2025 at 11:49 PM
Like it or not this technology is here to stay and if you don’t use it you’ll fall behind in your industry
Reposted by Mirko Pegoraro PhD
Labour concocts more ugly measures to punish asylum seekers and the right immediately demands worse… howling to leave the ECHR.
This scapegoating of migrants must stop. It is failure - morally and practically.
“Either we all have human rights or none of us do.”
app.independent.co.uk/edition/uk.c...
This scapegoating of migrants must stop. It is failure - morally and practically.
“Either we all have human rights or none of us do.”
app.independent.co.uk/edition/uk.c...
November 17, 2025 at 7:46 AM
Labour concocts more ugly measures to punish asylum seekers and the right immediately demands worse… howling to leave the ECHR.
This scapegoating of migrants must stop. It is failure - morally and practically.
“Either we all have human rights or none of us do.”
app.independent.co.uk/edition/uk.c...
This scapegoating of migrants must stop. It is failure - morally and practically.
“Either we all have human rights or none of us do.”
app.independent.co.uk/edition/uk.c...