Jonathan H
@12q13.bsky.social
DP fellow@MDACC; Past AP/CP resident@UTSW and SP fellow@BWH
Reposted by Jonathan H
RAC3910 M60s. Dorsal foot warty lesion. ?VW ?SCC.#Dermpath @iyengarish.bsky.social
November 16, 2025 at 12:34 PM
RAC3910 M60s. Dorsal foot warty lesion. ?VW ?SCC.#Dermpath @iyengarish.bsky.social
Reposted by Jonathan H
I’m thrilled to share our work out now in Nature identifying CREM as a central intracellular checkpoin in #CARNK cells.
📄Link: nature.com/articles/s41...
Our story👇🏼
📄Link: nature.com/articles/s41...
Our story👇🏼
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells - Nature
The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeri...
nature.com
June 5, 2025 at 3:03 AM
I’m thrilled to share our work out now in Nature identifying CREM as a central intracellular checkpoin in #CARNK cells.
📄Link: nature.com/articles/s41...
Our story👇🏼
📄Link: nature.com/articles/s41...
Our story👇🏼
Reposted by Jonathan H
International Melanocytic Slide Club associated with UK National Specialist Skin EQA
Questionaire & 10 Educational Cases: Thin melanocytic lesions.
Please take part & share w colleagues.
Respond by 26th May 2025
Meeting Discussion 2/6/2025
forms.cloud.microsoft/e/vceeXWXwLE...
Questionaire & 10 Educational Cases: Thin melanocytic lesions.
Please take part & share w colleagues.
Respond by 26th May 2025
Meeting Discussion 2/6/2025
forms.cloud.microsoft/e/vceeXWXwLE...
Microsoft Forms
https://forms.cloud.microsoft/e/vceeXWXwLE[forms.cloud.microsoft]
May 13, 2025 at 1:06 PM
International Melanocytic Slide Club associated with UK National Specialist Skin EQA
Questionaire & 10 Educational Cases: Thin melanocytic lesions.
Please take part & share w colleagues.
Respond by 26th May 2025
Meeting Discussion 2/6/2025
forms.cloud.microsoft/e/vceeXWXwLE...
Questionaire & 10 Educational Cases: Thin melanocytic lesions.
Please take part & share w colleagues.
Respond by 26th May 2025
Meeting Discussion 2/6/2025
forms.cloud.microsoft/e/vceeXWXwLE...
Reposted by Jonathan H
Reposted by Jonathan H
Reposted by Jonathan H
Happy Friday #dermpath! 😆🔬
Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉
#MDACCPath #molepath #pathology
Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉
#MDACCPath #molepath #pathology
April 18, 2025 at 10:47 PM
Happy Friday #dermpath! 😆🔬
Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉
#MDACCPath #molepath #pathology
Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉
#MDACCPath #molepath #pathology
Reposted by Jonathan H
He turned out to have myelodysplasia and myelofibrosis. This is a “sclerosing extramedullary hematopoietic tumor”, basically dysplastic EMH presenting as a soft tissue mass. pubmed.ncbi.nlm.nih.gov/10632487/
Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders - PubMed
Sclerosing extramedullary hematopoietic tumor (SEMHT) occasionally may arise in patients with chronic myeloproliferative disorders (CMPDs). Morphologically, these tumors may be mistaken for sarcomas o...
pubmed.ncbi.nlm.nih.gov
April 15, 2025 at 6:07 PM
He turned out to have myelodysplasia and myelofibrosis. This is a “sclerosing extramedullary hematopoietic tumor”, basically dysplastic EMH presenting as a soft tissue mass. pubmed.ncbi.nlm.nih.gov/10632487/
Reposted by Jonathan H
#PathSky Abdominal wall mall mass, 65M. Multinodular with thick fibrous septa. Bland spindled to ovoid cells surrounding prominent vessels. Microcystic, pseudoglandular spaces.
April 2, 2025 at 7:42 PM
#PathSky Abdominal wall mall mass, 65M. Multinodular with thick fibrous septa. Bland spindled to ovoid cells surrounding prominent vessels. Microcystic, pseudoglandular spaces.
Reposted by Jonathan H
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
March 18, 2025 at 6:40 PM
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
Reposted by Jonathan H
IHC: positive for keratins, S100 protein, and brachyury. SMARCB1 retained (normal).
March 14, 2025 at 7:08 PM
IHC: positive for keratins, S100 protein, and brachyury. SMARCB1 retained (normal).
Reposted by Jonathan H
Another unvaccinated child dies from measles, a fully preventable disease, and only the second child to die from measles in the US in the past 22 years
March 6, 2025 at 10:02 PM
Another unvaccinated child dies from measles, a fully preventable disease, and only the second child to die from measles in the US in the past 22 years
Reposted by Jonathan H
RFK Jr. and his movement do not simply ignore the need for vaccination. They also have a habit of dismissing child death and disability.
www.theatlantic.com/health/archi...
www.theatlantic.com/health/archi...
The MAHA Movement’s Trivialization of Measles
The outbreak of disease in Texas is, in fact, unusual.
www.theatlantic.com
February 28, 2025 at 12:14 AM
RFK Jr. and his movement do not simply ignore the need for vaccination. They also have a habit of dismissing child death and disability.
www.theatlantic.com/health/archi...
www.theatlantic.com/health/archi...
Reposted by Jonathan H
RAC9197: This was a patient with Ferguson Smith disease (FSD). Consult case, had been reported as a SCC but on review I thought it was fairly typical for FSD epithelioma. Quite hard to find systematic studies of FSD histology but histo & behaviour is similar to keratoacanthoma it seems.
February 17, 2025 at 6:31 AM
RAC9197: This was a patient with Ferguson Smith disease (FSD). Consult case, had been reported as a SCC but on review I thought it was fairly typical for FSD epithelioma. Quite hard to find systematic studies of FSD histology but histo & behaviour is similar to keratoacanthoma it seems.
Reposted by Jonathan H
Today, send a note to your NIH program officers to thank them for the amazing work they have done to support your research. They have been critical in making this country a leader in life sciences.
Do it now.
Do it now.
February 14, 2025 at 1:42 PM
Today, send a note to your NIH program officers to thank them for the amazing work they have done to support your research. They have been critical in making this country a leader in life sciences.
Do it now.
Do it now.
Reposted by Jonathan H
#PathSky Fatty-appearing thigh mass in a 69M. A solid nodule was present, concerning for dedifferentiation. The solid nodule is lateral in the mass.
February 13, 2025 at 10:51 PM
#PathSky Fatty-appearing thigh mass in a 69M. A solid nodule was present, concerning for dedifferentiation. The solid nodule is lateral in the mass.
Reposted by Jonathan H
#PathSky 43F with a solitary lung mass. Relatively circumscribed, nests and interesting micropapillae of lightly eosinophilic epithelioid cells. Negative for everything except TFE3. Dx?
February 6, 2025 at 9:41 PM
#PathSky 43F with a solitary lung mass. Relatively circumscribed, nests and interesting micropapillae of lightly eosinophilic epithelioid cells. Negative for everything except TFE3. Dx?
Reposted by Jonathan H
#PathSky 76M with a testicular mass. The outside was quite convinced this was a germ cell tumor with ITGCN, but it was resolutely negative for germ cell markers, and a broad panel of other markers. What to do next? NGS? Methylation? NGS + methylation?
January 27, 2025 at 8:18 PM
#PathSky 76M with a testicular mass. The outside was quite convinced this was a germ cell tumor with ITGCN, but it was resolutely negative for germ cell markers, and a broad panel of other markers. What to do next? NGS? Methylation? NGS + methylation?
Reposted by Jonathan H
#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?
January 8, 2025 at 5:13 PM
#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?
Reposted by Jonathan H
Some tumor look-a-likes on this Friday:
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
December 6, 2024 at 5:46 PM
Some tumor look-a-likes on this Friday:
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
Chordoid meningioma and chordoma can share similar features of cords of cells in a myxoid background. Chordoma shows diffuse nuclear Brachyury expression whereas chordoid meningioma is positive for SSTR2 helping to differentiate the two 🧠 #pathsky #neuropath
Reposted by Jonathan H
#PathSky 79M with a superficial neck mass. Wildly pleomorphic, quite cellular- undifferentiated pleomorphic sarcoma, right? There are basically no mitoses though, the cells have abundant granular-glassy cytoplasm, there is a lot of inflammation, and many bizarre cells have nuclear inclusions.
February 5, 2025 at 7:08 PM
#PathSky 79M with a superficial neck mass. Wildly pleomorphic, quite cellular- undifferentiated pleomorphic sarcoma, right? There are basically no mitoses though, the cells have abundant granular-glassy cytoplasm, there is a lot of inflammation, and many bizarre cells have nuclear inclusions.
Reposted by Jonathan H
#PathSky Slowly growing superficial leg mass, 38M. Well-circumscribed, phleboliths, thrombosed vessels, cellular spindle cell areas, cavernous vascular channels. Dx?
February 5, 2025 at 6:57 PM
#PathSky Slowly growing superficial leg mass, 38M. Well-circumscribed, phleboliths, thrombosed vessels, cellular spindle cell areas, cavernous vascular channels. Dx?
Reposted by Jonathan H
Just like Texas rarely sees snow ❄️, every once in a while you will find a primary tumor of the posterior pituitary so keep it in mind during frozen section analysis! Here is a classic example of pituicytoma showing diffuse nuclear positivity for TTF1 #pathsky #neuropath #medsky 🔬 🧠
January 19, 2025 at 8:58 PM
Just like Texas rarely sees snow ❄️, every once in a while you will find a primary tumor of the posterior pituitary so keep it in mind during frozen section analysis! Here is a classic example of pituicytoma showing diffuse nuclear positivity for TTF1 #pathsky #neuropath #medsky 🔬 🧠