Jonathan H
@12q13.bsky.social
DP fellow@MDACC; Past AP/CP resident@UTSW and SP fellow@BWH
Oh, I mean it looks very epithelioid, reminding me of those biphasic sarcomas that have epithelioid component
May 15, 2025 at 11:09 PM
Oh, I mean it looks very epithelioid, reminding me of those biphasic sarcomas that have epithelioid component
Almost like the epithelial component in a glandular MPNST or biphasic synovial sarcoma
May 15, 2025 at 2:51 AM
Almost like the epithelial component in a glandular MPNST or biphasic synovial sarcoma
The veggie appears full of ❤️
May 3, 2025 at 4:09 PM
The veggie appears full of ❤️
Reposted by Jonathan H
He turned out to have myelodysplasia and myelofibrosis. This is a “sclerosing extramedullary hematopoietic tumor”, basically dysplastic EMH presenting as a soft tissue mass. pubmed.ncbi.nlm.nih.gov/10632487/
Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders - PubMed
Sclerosing extramedullary hematopoietic tumor (SEMHT) occasionally may arise in patients with chronic myeloproliferative disorders (CMPDs). Morphologically, these tumors may be mistaken for sarcomas o...
pubmed.ncbi.nlm.nih.gov
April 15, 2025 at 6:07 PM
He turned out to have myelodysplasia and myelofibrosis. This is a “sclerosing extramedullary hematopoietic tumor”, basically dysplastic EMH presenting as a soft tissue mass. pubmed.ncbi.nlm.nih.gov/10632487/
Counterpart of vulva's DEVIL. Amazed by the people making those acronyms.
pubmed.ncbi.nlm.nih.gov/39863109/
pubmed.ncbi.nlm.nih.gov/39863109/
TP53 Wild-Type, Human Papillomavirus-Independent Anal Growth/(Intra)Epithelial Lesion (ANGEL): A Potential Precursor of Anal Squamous Cell Carcinoma - PubMed
Human papillomavirus (HPV) underpins ∼90% of squamous cell carcinomas (SCCs) of the anus and perianal region. These tumors usually arise in association with precursor lesions such as anal intraepithel...
pubmed.ncbi.nlm.nih.gov
April 4, 2025 at 11:49 AM
Counterpart of vulva's DEVIL. Amazed by the people making those acronyms.
pubmed.ncbi.nlm.nih.gov/39863109/
pubmed.ncbi.nlm.nih.gov/39863109/
Differentiated SCC in background of lichen sclerosis. Hope it's p53 mutant or null type. Otherwise may fall into the category of "ANGEL"?
April 4, 2025 at 1:30 AM
Differentiated SCC in background of lichen sclerosis. Hope it's p53 mutant or null type. Otherwise may fall into the category of "ANGEL"?
What prompted you to do S100/SOX10? History or else? I do see a few large nuclei without staining for b-cat
March 22, 2025 at 12:25 PM
What prompted you to do S100/SOX10? History or else? I do see a few large nuclei without staining for b-cat
Dan, we all learn from our mistakes. I always admire your diagnostic skills across different subspecialties. Your courage to share your experience even further shows your character.
March 20, 2025 at 4:39 PM
Dan, we all learn from our mistakes. I always admire your diagnostic skills across different subspecialties. Your courage to share your experience even further shows your character.
Reposted by Jonathan H
IHC: positive for keratins, S100 protein, and brachyury. SMARCB1 retained (normal).
March 14, 2025 at 7:08 PM
IHC: positive for keratins, S100 protein, and brachyury. SMARCB1 retained (normal).
It does not look like a collision tumor since those phenotypically distinct cell types are mixed with each other. Lots of people don't believe basosquamous cell carcinoma. This tumor also has convincing glandular differentiation. It will be interesting to see the molecular findings of this tumor.
March 13, 2025 at 5:52 AM
It does not look like a collision tumor since those phenotypically distinct cell types are mixed with each other. Lots of people don't believe basosquamous cell carcinoma. This tumor also has convincing glandular differentiation. It will be interesting to see the molecular findings of this tumor.
Sebaceous carcinoma is on the differential as well
March 11, 2025 at 11:49 AM
Sebaceous carcinoma is on the differential as well
Although well-circumscribed, worrisome for malignancy. It has different cell populations, maybe a hidradenocarcinoma?
March 11, 2025 at 11:48 AM
Although well-circumscribed, worrisome for malignancy. It has different cell populations, maybe a hidradenocarcinoma?
Would have definitely thought this was schwannoma
March 7, 2025 at 8:25 PM
Would have definitely thought this was schwannoma
More like anal area with hemorrhoidal component ...
March 6, 2025 at 2:43 AM
More like anal area with hemorrhoidal component ...
Seems to be legitimate for squamoid eccrine duct carcinoma
March 6, 2025 at 2:42 AM
Seems to be legitimate for squamoid eccrine duct carcinoma