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ZeigerLab
@zeigerlab.bsky.social
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Science from the Zeiger Lab at UCLA. Neural circuits, stroke, movement disorders. zeigerlab.com
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zeigerlab.bsky.social
ZeigerLab @zeigerlab.bsky.social · Aug 2
On the same day we posted this manuscript describing our work on the circuit mechanisms of cognitive impairment in PD, the grant funding the research was suspended. www.biorxiv.org/content/10.1...
Cortical α-synuclein pathology induces cell autonomous neuronal hypoactivity and compensatory circuit changes in a model of early Lewy Body Dementia
Cognitive impairment is a common non-motor symptom of Parkinson's disease (PD) and a defining feature of Dementia with Lewy Bodies (DLB). Although many cognitive domains can be affected, impairments i...
www.biorxiv.org
zeigerlab.bsky.social
It was a great event! Really enjoyed meeting some families excited to learn about science on a Saturday morning.
janellebelle.bsky.social Janel Le Belle @janellebelle.bsky.social · 2d
The UCLA Brain Research Institute & the Brain Injury Research Center held a public “science fair” today in support of CA Senate bill 895 that proposes a new $23 billion bond (just like CIRM before it) for California to fund our own science since our federal science agencies are being destroyed.
People looking at a real human brain People doing a biofeedback test Human brain and brain models Senator Wiener, UC, UAW Announce $23 Billion Bond To Fund Scientific Research While Requiring Drug Discounts For Californians
January 25, 2026 at 8:31 PM
Reposted by ZeigerLab
maxkozlov.bsky.social
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year.

That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027.

A wonky bureaucratic problem with big implications.

A short 🧵
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
www.nature.com
January 22, 2026 at 7:46 PM
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jenna-m-norton.bsky.social
The district court injunction that prevented NIH from capping indirects at 15% was upheld today on appeal!

www.reuters.com/world/trump-...
Trump administration cannot slash NIH research funding, court rules
District Judge Angel Kelley last year blocked the cuts, and on Monday the appeals court agreed.
www.reuters.com
January 6, 2026 at 1:09 AM
zeigerlab.bsky.social
Happy New Year from London. Let’s see how 2026 starts off…maybe we’ll just stay awhile longer….
A view of London Northwest of the Thames from the London Eye.
December 31, 2025 at 10:38 PM
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ubiquity75.xyz
Admin at UC have claimed various reasons why they aren’t fighting in court, but they simply are afraid to take on the Feds, believing antagonism will somehow make a terrible situation worse. Thing is, it can’t be much worse, and you can’t placate a bully.
Commentary: The UC faculty just won a big court victory over Trump. But why didn't UC join their lawsuit?
The UC faculty went to court to fight Trump's funding cutoffs and won. Why has the university system tried to negotiate instead?
www.latimes.com
November 22, 2025 at 2:28 AM
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miriamposner.com
WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)
On official UC letterhead: UNIVERSITY OF CALIFORNIA James B. Milliken President Office of the President 1111 Franklin Street Oakland, CA 94607 universityofcalifornia.edu CAMPUSES Berkeley Davis Irvine UCLA Merced Riverside San Diego San Francisco Santa Barbara Santa Cruz MEDICAL CENTERS Davis Irvine UCLA San Diego San Francisco NATIONAL LABORATORIES Lawrence Berkeley Lawrence Livermore Los Alamos DIVISION OF AGRICULTURE AND NATURAL RESOURCES November 18, 2025 Dear Chancellors: I'm writing with regard to the President's Postdoctoral Fellowship Program (PPFP) and the program's associated faculty hiring incentive. As you know, for more than 40 years, PPFP has provided postdoctoral research fellowships, professional development, and faculty mentoring to scholars in all fields whose research, teaching, and service advance the academic and research missions of the University of California. Since 2003, UC campuses that hire current and former PPFP fellows into ladder-rank positions have been eligible for a hiring incentive funded by the University that provides support for newly hired fellows for five years. Since the creation of the incentive, more than $162 million has been invested by the University to support PPFP faculty hires. This commitment has enabled our campuses to successfully recruit and retain outstanding faculty across a range of disciplines. Given the myriad challenges currently facing UC - including disruptions to billions of dollars in annual federal support, as well as uncertainty around the state budget- reasonable questions were raised in recent months about whether the University could maintain the commitment to current levels of incentive funding. After considering a recommendation to sunset the incentive program due to these significant fiscal constraints, I consulted with all of you as well as faculty and campus academic administrators and systemwide Academic Senate leadership. [continued on next image] After learning more about the history and success of the program and weighing the thoughtful perspectives that have been shared, I have concluded that barring extraordinary financial setbacks, the PPFP faculty hiring incentive program will continue while the University continues to assess the program's structure as well as its long-term financial sustainability. As a result of our continuing consultation and review, there may be consideration of some changes to elements of the program including the total number of incentives supported, a number that has fluctuated significantly over the years, and how the awards are distributed among campuses. In the meantime, the University will continue to fund the PPFP faculty hiring incentive program and campuses may continue to take advantage of these incentives. We will have an opportunity to discuss any potential changes prior to adoption. As we look to the future, I will continue to engage with faculty leaders, program stakeholders, and UC community members about this important program. I especially appreciate the thoughtful perspectives shared in recent weeks by Academic Council Chair Palazoglu and Vice Chair Scott, the Council of Graduate Deans, UC faculty members, and you as our campus leaders. Sincerely, James B. Milliken President
November 18, 2025 at 10:34 PM
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amygleichman.bsky.social
If you’re interested in the roles of glia in stroke and TBI, kick off #SfN2025 with a minisymposium on Saturday afternoon in room 6B!

@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!
Flyer for a social for Glial Interactions at SfN. Monday Nov 17, 9PM-close, The Smoking Gun, 555 Market St. Microscopy images of two astrocytes (top, red/blue) and an oligodendrocyte and myelin sheaths (bottom, white/red).
November 14, 2025 at 8:07 PM
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jaweedkaleem.bsky.social
In a major win for UC faculty groups and unions that sued, a federal judge on Friday blocked the Trump from imposing a $1.2-billion fine on UCLA along with stipulations for deep campus changes in exchange for being eligible for federal grants: www.latimes.com/california/s...
Judge blocks Trump administration push to fine UCLA $1.2 billion for alleged antisemitism
A federal judge late Friday issued a preliminary injunction blocking the Trump administration from imposing a $1.2-billion fine on UCLA for alleged civil rights violations over antisemitism, its recog...
www.latimes.com
November 15, 2025 at 4:12 AM
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pryprk.bsky.social
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
Advances in the genetics and pathology of Lewy body dementia
Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…
www.sciencedirect.com
November 13, 2025 at 12:56 AM
zeigerlab.bsky.social
Anyone out there have any first hand experience with NIH reviews of an R01 with mostly mouse experiments? Curious to know how the guidance emphasizing NAMs is being implemented.
October 31, 2025 at 2:33 AM
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craigedbrown.bsky.social
New finding from the lab. This surprised us since it went against the common assumption that increasing peri-infarct blood flow is best for stroke recovery. Congrats to Kamal and the team!
www.biorxiv.org/content/10.1...
Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption
Focal stroke leads to complex changes in the cerebral microcirculation in surviving brain tissues that strongly influence recovery. Plasminogen activator inhibitor-1 (PAI-1; encoded by Serpine1) is hi...
www.biorxiv.org
October 16, 2025 at 6:03 PM
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amygleichman.bsky.social
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
October 10, 2025 at 11:13 PM
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aliciaizquierdo.bsky.social
🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...
Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex - Nature Communications
Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.
www.nature.com
October 8, 2025 at 12:33 PM
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tdverstynen.bsky.social
Anyone else get anxiety on Sundays just thinking about what you meant to accomplish and what you need to do during the upcoming week?
October 5, 2025 at 12:41 PM
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jaweedkaleem.bsky.social
Here is the formal letter the NIH sent today to UCLA Chancellor Julio Frenk.

“These projects are fully reinstated, and the letter dated July 31, 2025 is rescinded without conditions. Funds will be made available immediately and are no longer suspended, terminated, or restricted.”
September 25, 2025 at 1:47 AM
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martinowk.bsky.social
In the early years of my PhD I remember being asked if we'd ever treat or cure diseases like HIV or Huntington's. I remember saying maybe, but not knowing if I believed. Seeing research pay off as real impact on human lives is - incredible.

www.bbc.com/news/article...

www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 12:41 PM
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jaweedkaleem.bsky.social
BREAKING: A federal judge has ordered Trump to restore $500 million in frozen UCLA NIH grants. The same judge, Rita F. Lin, previously ordered all UCLA NSF grants reinstated. Lin has now nearly entirely reversed Trump's July de-funding of UCLA research: www.latimes.com/california/s...
Federal judge orders Trump to restore $500 million in frozen UCLA medical research grants
A San Francisco-based federal judge on Monday ordered the Trump administration to restore all National Institutes of Health grants to UCLA, roughly $500 million, that the government suspended in July.
www.latimes.com
September 23, 2025 at 1:00 AM
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griz1.bsky.social
We shared research about things affecting us all: addiction, autism, brain injury, dementia, mental illness. This work has been arbitrarily cut or delayed.
Thats a human brain on cafeteria tray. UCLA fair shows off science cuts. @sfn.org @standupforscience.bsky.social www.latimes.com/california/s...
Yes, that’s a human brain on a cafeteria tray. UCLA fair shows off science cuts under Trump
UCLA's researchers go low-tech to plead their case to the public with poster boards and props. The Trump administration has suspended more than $500 million in research grants to the university.
www.latimes.com
September 13, 2025 at 5:35 PM
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tuite002.bsky.social
parkinsonsnewstoday.com/news/advocat...
Advocates urge Congress to boost Parkinson's research funding
Advocates gathered in Washington to urge Congress to expand federal funding for Parkinson’s disease research at NIH.
parkinsonsnewstoday.com
September 17, 2025 at 2:36 AM
zeigerlab.bsky.social
More coverage of suspended science outreach efforts this week at UCLA.

laist.com/news/educati...
UCLA researchers host science fair to showcase work suspended by the Trump administration
On Thursday evening, dozens of researchers hosted a science fair at UCLA to demonstrate the long-term impact of frozen grants.
laist.com
September 14, 2025 at 12:39 AM
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kakape.bsky.social
“Supporters of the proposal said it would effectively create a state version of the National Institutes of Health or the National Science Foundation, two of the nation’s largest institutional funders of scientific and public health research.”
🧪 #giftarticle
California’s $23 Billion Plan to Restore Federal Cuts to Scientific Research
www.nytimes.com
September 13, 2025 at 7:29 PM
zeigerlab.bsky.social
This was a great event I was happy to help organize it. It was so heartening to see so many folks put their time and effort into making it happen. At the same time, it is eye opening to realize how little most folks out in the public, including our own backyard, know about what is going on.
jaweedkaleem.bsky.social Jaweed Kaleem @jaweedkaleem.bsky.social · Sep 12
Going on more than six weeks without $500 million in federal research grants cut under Trump, UCLA faculty and students took their cases public this week in the "Science Fair for Suspended Research" -- including demonstrations with preserved human brains: www.latimes.com/california/s...
Yes, that’s a human brain on a cafeteria tray. UCLA fair shows off science cuts under Trump
UCLA's researchers go low-tech to plead their case to the public with poster boards and props. The Trump administration has suspended more than $500 million in research grants to the university.
www.latimes.com
September 13, 2025 at 2:47 AM
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asnrehab.bsky.social
You can also learn more about this important research in this press release from UCLA: newsroom.ucla.edu/releases/ucl...

#neurorehabilitation #rehabilitation #stroke #drugdiscovery #drugdevelopment #therapeutics #research #science #neurology #neuroscience #UCLA
@ucalgary.bsky.social
UCLA discovers first stroke rehabilitation drug to reestablish brain connections in mice
The drug was able to replicate the movement recovered in physical rehab, the traditional treatment.
newsroom.ucla.edu
September 5, 2025 at 3:37 PM
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asnrehab.bsky.social
After a #stroke, patients typically undergo extensive #rehabilitation and a slow journey to recover the ability to do everyday tasks. However, ASNR Past President Dr. Tom Carmichael is developing a drug to produce the same effects as rehabilitation and could augment or replace rehab after a stroke.
A Pill to Heal the Brain Could Revolutionize Neuroscience
www.nytimes.com
September 5, 2025 at 3:35 PM
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democracyactionnet.bsky.social
join us for our Science Fair for Suspended Research, sponsored by the UCLA Faculty Association and the UCLA Brain Research Institute! We are reaching out to the public to show the life-saving research that is at stake in the Trump admin's attack on UCLA research!
September 3, 2025 at 1:23 AM