Xu Zhou lab @ BCH & HMS
@xuzhoulab.bsky.social
AP @BostonChildrens @harvardmed AM @broadinstitute
inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists #NewPI
inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists #NewPI
Pinned
Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...
Reposted by Xu Zhou lab @ BCH & HMS
How does acidity affect #ImmuneCells?
The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4.
🥼 Abstract in @cellpress.bsky.social: https://bit.ly/3IZDAhP
✏️ Press release: https://on.bchil.org/48rhZtf
The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4.
🥼 Abstract in @cellpress.bsky.social: https://bit.ly/3IZDAhP
✏️ Press release: https://on.bchil.org/48rhZtf
October 13, 2025 at 4:09 PM
How does acidity affect #ImmuneCells?
The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4.
🥼 Abstract in @cellpress.bsky.social: https://bit.ly/3IZDAhP
✏️ Press release: https://on.bchil.org/48rhZtf
The @xuzhoulab.bsky.social at @bostonchildrens.bsky.social found that a drop in pH can suppress immune responses by disrupting a protein called #BRD4.
🥼 Abstract in @cellpress.bsky.social: https://bit.ly/3IZDAhP
✏️ Press release: https://on.bchil.org/48rhZtf
Super excited to see our recent @cellcellpress.bsky.social paper featured in a Life Metabolism preview! Huge thanks to Christoopher Glass @ucsdmedschool.bsky.social for the thoughtful highlight. 🔗 academic.oup.com/lifemeta/adv...
#inflammation #macrophage #chromatin #pH #biomolecularcondensates
#inflammation #macrophage #chromatin #pH #biomolecularcondensates
September 19, 2025 at 3:31 PM
Super excited to see our recent @cellcellpress.bsky.social paper featured in a Life Metabolism preview! Huge thanks to Christoopher Glass @ucsdmedschool.bsky.social for the thoughtful highlight. 🔗 academic.oup.com/lifemeta/adv...
#inflammation #macrophage #chromatin #pH #biomolecularcondensates
#inflammation #macrophage #chromatin #pH #biomolecularcondensates
Reposted by Xu Zhou lab @ BCH & HMS
TLR4 endocytosis continues to be the centerpiece of TRIF-Interferon signaling. Kasper et al report diverse structures of Bacteroides LPS and their impact on TLR4 endocytosis and signaling. Functional consequences on Treg induction in the gut.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Structure of gut microbial glycolipid modulates host inflammatory response
Structural variations in the number of acyl chains and phosphate groups of gram-negative
microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically
regulated by TL...
www.cell.com
September 19, 2025 at 12:44 PM
TLR4 endocytosis continues to be the centerpiece of TRIF-Interferon signaling. Kasper et al report diverse structures of Bacteroides LPS and their impact on TLR4 endocytosis and signaling. Functional consequences on Treg induction in the gut.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
congratulations to @virusesimmunity.bsky.social @brangwynnelab.bsky.social!
🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.
September 19, 2025 at 3:27 PM
congratulations to @virusesimmunity.bsky.social @brangwynnelab.bsky.social!
Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...
July 22, 2025 at 1:24 PM
Beyond excited to share our #NewPaper in @cellcellpress.bsky.social! Inflamed environments acidify intracellular #pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of #inflammation authors.elsevier.com/sd/article/S...
Been waiting for this from my dear friends: Macrophage derived growth factor promotes epithelial proliferation for repair when lung is under inflammatory damage 🔥🔥🔥 huge congrats to @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social and the team! 🎉👏🏼🍾 @harvard.edu @harvardmed.bsky.social
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 22, 2025 at 1:21 PM
Been waiting for this from my dear friends: Macrophage derived growth factor promotes epithelial proliferation for repair when lung is under inflammatory damage 🔥🔥🔥 huge congrats to @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social and the team! 🎉👏🏼🍾 @harvard.edu @harvardmed.bsky.social
Reposted by Xu Zhou lab @ BCH & HMS
#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
July 17, 2025 at 9:14 PM
#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇
Reposted by Xu Zhou lab @ BCH & HMS
pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here ->
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
Regulation of inflammatory responses by pH-dependent transcriptional condensates
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically
disordered region. Inflammation-associated acidification triggers a pH-dependent switch
in transcriptional...
www.cell.com
July 17, 2025 at 11:08 PM
pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here ->
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social
Thank you for those who have a conscientious!
May 22, 2025 at 8:00 PM
Thank you for those who have a conscientious!
Reposted by Xu Zhou lab @ BCH & HMS
Schumer advocated for budget CR today, essentially giving White House decision making power on AMERICAS budget. Cutting Medicaid, social security, and SCIENCE would be no problem. Call and email your senator now if think this is a horrible idea, especially if you live in New York www.govtrack.us
GovTrack.us
Tracking legislation and votes in the United States Congress.
www.govtrack.us
March 13, 2025 at 11:57 PM
Schumer advocated for budget CR today, essentially giving White House decision making power on AMERICAS budget. Cutting Medicaid, social security, and SCIENCE would be no problem. Call and email your senator now if think this is a horrible idea, especially if you live in New York www.govtrack.us
Reposted by Xu Zhou lab @ BCH & HMS
Amazing article www.sensible-med.com/p/the-nih-is...
The NIH is Being Slashed and Burned, not “Reformed”
A strong and well-argued rebuttal to NIH criticism
www.sensible-med.com
March 4, 2025 at 3:11 AM
Amazing article www.sensible-med.com/p/the-nih-is...
Reposted by Xu Zhou lab @ BCH & HMS
Reposted by Xu Zhou lab @ BCH & HMS
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...
www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 15, 2025 at 1:59 AM
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...
www.nytimes.com/2025/02/14/o...
Reposted by Xu Zhou lab @ BCH & HMS
The perk of a wildly successful research enterprise is knowledge--and medical innovation.
The cost of successful research is the forever argument over credit for discoveries (and revenue).
How about we all invest in research, so we can keep living (and arguing)?
The cost of successful research is the forever argument over credit for discoveries (and revenue).
How about we all invest in research, so we can keep living (and arguing)?
February 9, 2025 at 10:01 PM
The perk of a wildly successful research enterprise is knowledge--and medical innovation.
The cost of successful research is the forever argument over credit for discoveries (and revenue).
How about we all invest in research, so we can keep living (and arguing)?
The cost of successful research is the forever argument over credit for discoveries (and revenue).
How about we all invest in research, so we can keep living (and arguing)?
Reposted by Xu Zhou lab @ BCH & HMS
Reposted by Xu Zhou lab @ BCH & HMS
This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.
All of them.
February 8, 2025 at 4:09 AM
This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research?
All of them.
All of them.
Reposted by Xu Zhou lab @ BCH & HMS
If this is not reversed it is going to destroy the ability of universities to support biomedical research and it will completely shut down private research institutes like the Salk Institute, the Fred Hutchinson Cancer Research Center, Scripps, and many others.
February 8, 2025 at 4:45 AM
If this is not reversed it is going to destroy the ability of universities to support biomedical research and it will completely shut down private research institutes like the Salk Institute, the Fred Hutchinson Cancer Research Center, Scripps, and many others.
Despite all kinds of chaos, nothing beats a hotpot celebration of Lunar New Year with my lab family! Happy the year of snake! Year of slytherin! 🎉🎊🎆🍲
January 29, 2025 at 4:11 PM
Despite all kinds of chaos, nothing beats a hotpot celebration of Lunar New Year with my lab family! Happy the year of snake! Year of slytherin! 🎉🎊🎆🍲
Heroic effort by @prywes.bsky.social tackling one of the most difficult protein! 👏🏼
Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling
A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods
"...engineer RuBisCo..."
And this paper takes us one step closer
www.nature.com/articles/s41...
A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods
"...engineer RuBisCo..."
And this paper takes us one step closer
www.nature.com/articles/s41...
A map of the rubisco biochemical landscape - Nature
A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further e...
www.nature.com
January 22, 2025 at 11:36 PM
Heroic effort by @prywes.bsky.social tackling one of the most difficult protein! 👏🏼
Happy holidays to everyone! Just celebrated 2024 with the amazing group of people who made me want to go to work everyday, full of surprises and excitement! Looking forward to 2025 of Zhou lab #labholiday @bostonchildrens.bsky.social @harvardmed.bsky.social
December 22, 2024 at 1:35 AM
Happy holidays to everyone! Just celebrated 2024 with the amazing group of people who made me want to go to work everyday, full of surprises and excitement! Looking forward to 2025 of Zhou lab #labholiday @bostonchildrens.bsky.social @harvardmed.bsky.social