Wyatt Yue
@wyattyue.bsky.social
Professor of #structuralbiology at Newcastle University.
Heart says x-ray but mind starts to say EM.
#Drugdiscovery in #rarediseases, esp Inborn errors of metabolism
Yue Lab: https://www.staff.ncl.ac.uk/yuelab/
Heart says x-ray but mind starts to say EM.
#Drugdiscovery in #rarediseases, esp Inborn errors of metabolism
Yue Lab: https://www.staff.ncl.ac.uk/yuelab/
Reposted by Wyatt Yue
Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium
November 5, 2025 at 10:28 AM
Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium
Reposted by Wyatt Yue
Looking forward to the Grand Opening of the Northern Eye Imaging facility on 5th November at the Frederick Douglass Centre, Newcastle. Register now nusbf.ncl.ac.uk/ccpem-tfs-ne... for the latest #structuralbiology and #cryoem in the region, to see the new Tundra cryo-TEM and lots more!
October 21, 2025 at 11:25 AM
Looking forward to the Grand Opening of the Northern Eye Imaging facility on 5th November at the Frederick Douglass Centre, Newcastle. Register now nusbf.ncl.ac.uk/ccpem-tfs-ne... for the latest #structuralbiology and #cryoem in the region, to see the new Tundra cryo-TEM and lots more!
Reposted by Wyatt Yue
Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye:
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
Grand Opening of the Northern eye, a cryo-TEM in Newcastle
Grand Opening of the Northern Eye in Newcastle, a100 kV Tundra cryo-TEM in Newcastle University on Wednesday 5th November 2025
nusbf.ncl.ac.uk
October 21, 2025 at 9:31 AM
Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye:
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
Reposted by Wyatt Yue
The CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th.
nusbf.ncl.ac.uk/ccp4-norther...
nusbf.ncl.ac.uk/ccp4-norther...
nusbf.ncl.ac.uk
October 14, 2025 at 4:58 AM
The CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th.
nusbf.ncl.ac.uk/ccp4-norther...
nusbf.ncl.ac.uk/ccp4-norther...
Reposted by Wyatt Yue
Dorothy Crowfoot Hodgkin, biochemist & trailblazer in crystallography, she established the biomolecular structures of insulin, vitamin B12, & penicillin winning the Nobel in Chemistry in 1964 #WomensHistoryMonth #WomenInStem #WomenInScience
March 24, 2025 at 10:14 AM
Dorothy Crowfoot Hodgkin, biochemist & trailblazer in crystallography, she established the biomolecular structures of insulin, vitamin B12, & penicillin winning the Nobel in Chemistry in 1964 #WomensHistoryMonth #WomenInStem #WomenInScience
Reposted by Wyatt Yue
Nikol Zografou Barredo, PhD Student (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
April 2, 2025 at 8:34 AM
Nikol Zografou Barredo, PhD Student (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky
Reposted by Wyatt Yue
What better way to join Bluesky than post our first professional team photo. We've been busy onboarding everyone over the last few months, so welcome to Giusy, Debakshi, Kako and Gonzalo who have joined James. We're looking forward to helping our users do great cryo-EM.
March 25, 2025 at 1:47 PM
What better way to join Bluesky than post our first professional team photo. We've been busy onboarding everyone over the last few months, so welcome to Giusy, Debakshi, Kako and Gonzalo who have joined James. We're looking forward to helping our users do great cryo-EM.
Reposted by Wyatt Yue
Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
www.nature.com
March 20, 2025 at 10:05 PM
Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...
Reposted by Wyatt Yue
New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
www.nature.com
March 21, 2025 at 9:30 AM
New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Wyatt Yue
We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.
Image processing for cryo-electron microscopy
Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …
meetings.embo.org
March 18, 2025 at 7:06 PM
We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.
**deadline Mar 30th** Passionate about #cryoEM? Interested in #PhD project on allosteric mechanism of a dynamic enzyme implicated in metabolic and neurological disorders? Join @allostericstate.bsky.social and me in NCL on a funded @mosmedcdt.bsky.social studentship.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
March 17, 2025 at 10:28 AM
**deadline Mar 30th** Passionate about #cryoEM? Interested in #PhD project on allosteric mechanism of a dynamic enzyme implicated in metabolic and neurological disorders? Join @allostericstate.bsky.social and me in NCL on a funded @mosmedcdt.bsky.social studentship.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Wyatt Yue
"CACHE Challenge 2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13" is out now on ChemRxiv: dx.doi.org/10.26434/che...
You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.
You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.
CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13
A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target...
dx.doi.org
March 8, 2025 at 5:27 PM
"CACHE Challenge 2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13" is out now on ChemRxiv: dx.doi.org/10.26434/che...
You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.
You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.
**Please repost**Interested in a #PhD project on #cryoEM & enzymatic mechanism? Join @allostericstate.bsky.social and me in Newcastle on a funded @mosmedcdt.bsky.social studentship. Choose project code mos2_04 in Thomas' link below. Or go to: www.findaphd.com/phds/project...
PhD opportunity at @newcastleuni.bsky.social 🚨
Are you passionate about structural biology & enzymes? We have a fully funded @mosmedcdt.bsky.social PhD project with KinderSpital Zürich on studying the allosteric inhibition of human MTHFR.
research.ncl.ac.uk/mosmed/joinu...
#CryoEM #structuralbiology
Are you passionate about structural biology & enzymes? We have a fully funded @mosmedcdt.bsky.social PhD project with KinderSpital Zürich on studying the allosteric inhibition of human MTHFR.
research.ncl.ac.uk/mosmed/joinu...
#CryoEM #structuralbiology
March 6, 2025 at 6:00 PM
**Please repost**Interested in a #PhD project on #cryoEM & enzymatic mechanism? Join @allostericstate.bsky.social and me in Newcastle on a funded @mosmedcdt.bsky.social studentship. Choose project code mos2_04 in Thomas' link below. Or go to: www.findaphd.com/phds/project...
A story of fragment screening to initiate drug discovery
📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother.
Read more in @theguardian.com ⤵️
www.theguardian.com/science/2025...
Read more in @theguardian.com ⤵️
www.theguardian.com/science/2025...
British professor makes ‘thrilling’ breakthrough for cancer that killed his mother
Paul Workman has researched untreatable chordoma for years. Now new technology points towards to a potential drug to beat it
www.theguardian.com
February 16, 2025 at 4:04 PM
A story of fragment screening to initiate drug discovery
Reposted by Wyatt Yue
Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio
www.linkedin.com/posts/chrisd...
www.linkedin.com/posts/chrisd...
Chris De Savi on LinkedIn: #medicine #pharmaceuticals #healthcare | 90 comments
FDA Novel Drug Approvals 2024 #medicine
That is a wrap for 2024! And another year of relentless drug discovery!
There you have it, drug-hunting aficionados,… | 90 comments on LinkedIn
www.linkedin.com
January 3, 2025 at 9:00 AM
Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio
www.linkedin.com/posts/chrisd...
www.linkedin.com/posts/chrisd...
Reposted by Wyatt Yue
Registration for the CCP-EM Spring Symposium 23-25th April 2025 open, see www.ccpem.ac.uk/training/spr...
January 22, 2025 at 10:37 PM
Registration for the CCP-EM Spring Symposium 23-25th April 2025 open, see www.ccpem.ac.uk/training/spr...
Great discovery of a new gene involvement in vitamin B6 metabolism
Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :)
www.nature.com/articles/s41...
#metabolism #CRISPRscreens #mitochondria
www.nature.com/articles/s41...
#metabolism #CRISPRscreens #mitochondria
SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
Nature Communications - Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP...
www.nature.com
January 25, 2025 at 3:15 PM
Great discovery of a new gene involvement in vitamin B6 metabolism
Reposted by Wyatt Yue
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
go.nature.com
January 24, 2025 at 11:52 AM
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X
https://go.nature.com/42tH8Ai
https://go.nature.com/42tH8Ai
Reposted by Wyatt Yue
Anyone ever have any problems with bacmid transpositions continuously not working? I have been struggling to get any positive white colonies using pFastbac plasmids from Twist and even for a plasmid from another lab for a while now.
January 19, 2025 at 4:12 PM
Anyone ever have any problems with bacmid transpositions continuously not working? I have been struggling to get any positive white colonies using pFastbac plasmids from Twist and even for a plasmid from another lab for a while now.
Reposted by Wyatt Yue
Time to look up your favourite (human) protein in the subcellular map.
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
January 15, 2025 at 4:47 PM
Time to look up your favourite (human) protein in the subcellular map.
Reposted by Wyatt Yue
Finally updated the lab website: www.medicinesfromthesea.com
Duncan lab
Duncan lab
www.medicinesfromthesea.com
January 8, 2025 at 12:25 PM
Finally updated the lab website: www.medicinesfromthesea.com
Reposted by Wyatt Yue
Diagnose the diagnosable and don't miss the treatable.
Did you know that approximately 1 in 5 IMDs (18%) are amenable to some form of treatment? Therefore it's imperative to make the diagnosis and keep abreast of developments in the therapy space. onlinelibrary.wiley.com/doi/full/10....
Did you know that approximately 1 in 5 IMDs (18%) are amenable to some form of treatment? Therefore it's imperative to make the diagnosis and keep abreast of developments in the therapy space. onlinelibrary.wiley.com/doi/full/10....
January 8, 2025 at 10:44 AM
Diagnose the diagnosable and don't miss the treatable.
Did you know that approximately 1 in 5 IMDs (18%) are amenable to some form of treatment? Therefore it's imperative to make the diagnosis and keep abreast of developments in the therapy space. onlinelibrary.wiley.com/doi/full/10....
Did you know that approximately 1 in 5 IMDs (18%) are amenable to some form of treatment? Therefore it's imperative to make the diagnosis and keep abreast of developments in the therapy space. onlinelibrary.wiley.com/doi/full/10....