Chris H. Hill
@chillzaa.bsky.social
Wellcome Sir Henry Dale Fellow and PI at the University of York, UK. He/him 🏳️🌈 Interested in #RNA, #ribosomes, #cryo-EM, #crystallography and #virus gene expression, 🔬🧬
https://www.hill-lab.co.uk
Also piano 🎹🎶
www.youtube.com/@chillzaa
https://www.hill-lab.co.uk
Also piano 🎹🎶
www.youtube.com/@chillzaa
Pinned
Chris H. Hill
@chillzaa.bsky.social
· Nov 13
I'm a structural and molecular biologist and research group leader. We work on mechanisms of pathological translation in viral infection (e.g. IRES initiation, frameshifting, stop codon readthrough). Interested in RNA biology, ribosomes, host-pathogen interactions and regulation of gene expression.
🚨👇One week left to apply for this fully-funded PhD project to study RNA-protein complexes regulating enterovirus genome replication:
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York, listed on FindAPhD.com
www.findaphd.com
November 28, 2025 at 12:41 PM
🚨👇One week left to apply for this fully-funded PhD project to study RNA-protein complexes regulating enterovirus genome replication:
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Chris H. Hill
🚨Attention prospective PhD students🚨
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
chris hill PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in chris hill. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 13, 2025 at 7:54 PM
🚨Attention prospective PhD students🚨
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
🚨Attention prospective PhD students🚨
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
chris hill PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in chris hill. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 13, 2025 at 7:54 PM
🚨Attention prospective PhD students🚨
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES
Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...
www.biorxiv.org
October 7, 2025 at 11:37 AM
Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chris H. Hill
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Ever struggled with low PNK efficiency on a highly structured piece of RNA? Sarah solved this problem by using a DNA scaffold to make the 5' end more accessible, improving the efficiency of end labelling. This enabled us to make smFRET measurements on the SARS-CoV-2 pseudoknot 🧬🔴🟢
🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬
👉 biorxiv.org/content/10.1...
#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
👉 biorxiv.org/content/10.1...
#smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
A DNA scaffold approach facilitates 5′ labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation
Single-molecule Förster resonance energy transfer (smFRET) studies of highly structured RNA molecules are often frustrated by issues with efficient dye conjugation. Here, we develop a DNA scaffold-bas...
biorxiv.org
July 30, 2025 at 10:52 AM
Ever struggled with low PNK efficiency on a highly structured piece of RNA? Sarah solved this problem by using a DNA scaffold to make the 5' end more accessible, improving the efficiency of end labelling. This enabled us to make smFRET measurements on the SARS-CoV-2 pseudoknot 🧬🔴🟢
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 19, 2025 at 3:10 PM
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
I'm thrilled and honoured to receive the 2025 Lister Prize, along with seven other fantastic biomedical scientists 🔬🦠🧬
This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells
This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells
We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...
June 20, 2025 at 9:46 AM
I'm thrilled and honoured to receive the 2025 Lister Prize, along with seven other fantastic biomedical scientists 🔬🦠🧬
This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells
This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells
Reposted by Chris H. Hill
A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography
journals.iucr.org/a/issues/202...
journals.iucr.org/a/issues/202...
George M. Sheldrick (1942–2025)
In memory of George Sheldrick.
journals.iucr.org
May 6, 2025 at 11:34 AM
A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography
journals.iucr.org/a/issues/202...
journals.iucr.org/a/issues/202...
Last day to apply for the CCP4 Structural Biology Summer School 2025! 31 July to 8 August at University of York. The programme will focus on X-ray crystallography but many model-building, refinement and validation aspects also relevant to cryo-EM 💎❄️
ccp4.github.io/summer-schoo...
ccp4.github.io/summer-schoo...
CCP4 Summer School 2025
ccp4.github.io
June 10, 2025 at 10:32 AM
Last day to apply for the CCP4 Structural Biology Summer School 2025! 31 July to 8 August at University of York. The programme will focus on X-ray crystallography but many model-building, refinement and validation aspects also relevant to cryo-EM 💎❄️
ccp4.github.io/summer-schoo...
ccp4.github.io/summer-schoo...
Reposted by Chris H. Hill
Congratulations to Dr Sarah Graham @york.ac.uk #Physicsoflife group for successfully defending her thesis!
Thanks also to Dr Tara Sabir & @agnesnoy.bsky.social for doing the honours as examiners, @bpsiyork.bsky.social for co-supervising & @chillzaa.bsky.social for all the help along the way!
Thanks also to Dr Tara Sabir & @agnesnoy.bsky.social for doing the honours as examiners, @bpsiyork.bsky.social for co-supervising & @chillzaa.bsky.social for all the help along the way!
a cartoon of snoopy jumping with the words yay congratulations below him
ALT: a cartoon of snoopy jumping with the words yay congratulations below him
media.tenor.com
June 2, 2025 at 12:49 PM
Congratulations to Dr Sarah Graham @york.ac.uk #Physicsoflife group for successfully defending her thesis!
Thanks also to Dr Tara Sabir & @agnesnoy.bsky.social for doing the honours as examiners, @bpsiyork.bsky.social for co-supervising & @chillzaa.bsky.social for all the help along the way!
Thanks also to Dr Tara Sabir & @agnesnoy.bsky.social for doing the honours as examiners, @bpsiyork.bsky.social for co-supervising & @chillzaa.bsky.social for all the help along the way!
Reposted by Chris H. Hill
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 7:51 PM
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
a little É(as)tude... 🎹🐣
Happy holidays everyone!
Happy holidays everyone!
April 20, 2025 at 12:42 PM
a little É(as)tude... 🎹🐣
Happy holidays everyone!
Happy holidays everyone!
Reposted by Chris H. Hill
It's here. The lumicks C-Trap is up and running with real samples from Durham, Hull, Newcastle and York consortium. Thanks @ukri.org #BBSRC for funding.
@chillzaa.bsky.social
@chillzaa.bsky.social
April 16, 2025 at 1:09 PM
It's here. The lumicks C-Trap is up and running with real samples from Durham, Hull, Newcastle and York consortium. Thanks @ukri.org #BBSRC for funding.
@chillzaa.bsky.social
@chillzaa.bsky.social
Super excited for the arrival of our brand new Lumicks C-Trap in Biology at York @yorkbioimaging.bsky.social, funded by @ukri.org BBSRC. This state-of-the-art optical tweezers / confocal microscope will enable us to probe the dynamics of structured viral RNAs, one molecule at a time 🔆🧬🔆
April 16, 2025 at 8:38 AM
Super excited for the arrival of our brand new Lumicks C-Trap in Biology at York @yorkbioimaging.bsky.social, funded by @ukri.org BBSRC. This state-of-the-art optical tweezers / confocal microscope will enable us to probe the dynamics of structured viral RNAs, one molecule at a time 🔆🧬🔆
Reposted by Chris H. Hill
Foam film vitrification for cryo-EM https://www.biorxiv.org/content/10.1101/2025.03.10.642366v1
March 12, 2025 at 3:50 PM
Foam film vitrification for cryo-EM https://www.biorxiv.org/content/10.1101/2025.03.10.642366v1
New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
www.nature.com
March 21, 2025 at 9:30 AM
New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
👀📅👇One week left to apply for this fully-funded UK PhD - closing date 3rd February. Come and join my lab in beautiful York to work on protein-RNA interactions in FMDV, then follow up with virology experiments at the world-leading Pirbright Institute🧬 Please share widely!
🚨 I'm delighted to announce a fully-funded PhD studentship (October 2025 entry) in collaboration with the Pirbright Institute.
Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here:
www.findaphd.com/phds/project...
Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here:
www.findaphd.com/phds/project...
Probing the Function of RNA Structural Elements in the FMDV Genome using Biophysical and Genetic Approaches at The Pirbright Institute on FindAPhD.com
PhD Project - Probing the Function of RNA Structural Elements in the FMDV Genome using Biophysical and Genetic Approaches at The Pirbright Institute, listed on FindAPhD.com
www.findaphd.com
January 28, 2025 at 10:14 AM
👀📅👇One week left to apply for this fully-funded UK PhD - closing date 3rd February. Come and join my lab in beautiful York to work on protein-RNA interactions in FMDV, then follow up with virology experiments at the world-leading Pirbright Institute🧬 Please share widely!
🚨 I'm delighted to announce a fully-funded PhD studentship (October 2025 entry) in collaboration with the Pirbright Institute.
Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here:
www.findaphd.com/phds/project...
Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here:
www.findaphd.com/phds/project...
Probing the Function of RNA Structural Elements in the FMDV Genome using Biophysical and Genetic Approaches at The Pirbright Institute on FindAPhD.com
PhD Project - Probing the Function of RNA Structural Elements in the FMDV Genome using Biophysical and Genetic Approaches at The Pirbright Institute, listed on FindAPhD.com
www.findaphd.com
January 20, 2025 at 11:12 AM
🚨 I'm delighted to announce a fully-funded PhD studentship (October 2025 entry) in collaboration with the Pirbright Institute.
Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here:
www.findaphd.com/phds/project...
Are you interested in FMDV genome replication and packaging? Fascinated by structure and RNA-protein interactions? More info here:
www.findaphd.com/phds/project...
🚨⏰One day left to apply for this fully-funded MRC DiMeN PhD to join me, @Steve_Quinn_Lab and Purba Mukherjee at the University of York. Apply here: www.dimen.org.uk/how-to-apply
December 12, 2024 at 1:02 PM
🚨⏰One day left to apply for this fully-funded MRC DiMeN PhD to join me, @Steve_Quinn_Lab and Purba Mukherjee at the University of York. Apply here: www.dimen.org.uk/how-to-apply
Reposted by Chris H. Hill
Reposted by Chris H. Hill
Delighted to be advertising 2 exciting PhD projects 1) lncRNA derived micropeptides & their contribution to brain cancers with James Poulter & Lucy Stead 2) mechanisms of translational regulation by specialised ribosomes. @chillzaa.bsky.social & Ade Whitehouse www.findaphd.com/phds/?Keywor...
aspden PhD Projects, Programmes & Scholarships
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in aspden. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 26, 2024 at 5:05 PM
Delighted to be advertising 2 exciting PhD projects 1) lncRNA derived micropeptides & their contribution to brain cancers with James Poulter & Lucy Stead 2) mechanisms of translational regulation by specialised ribosomes. @chillzaa.bsky.social & Ade Whitehouse www.findaphd.com/phds/?Keywor...
Reposted by Chris H. Hill
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
November 18, 2024 at 3:09 PM
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
Reposted by Chris H. Hill
Hey, that’s me! Please do spread the word about this project and get in touch if you’re interested in finding out more.
XH-🥧 interactions are the best!
XH-🥧 interactions are the best!
Here is a great opportunity to join YSBL (York) and work with @mjplevin.bsky.social and myself! www.findaphd.com/phds/project...
Application of Deep Learning (AI) to the refinement of XH-π interactions in protein atomic structure determination at University of York on FindAPhD.com
PhD Project - Application of Deep Learning (AI) to the refinement of XH-π interactions in protein atomic structure determination at University of York, listed on FindAPhD.com
www.findaphd.com
November 14, 2024 at 6:41 PM
Hey, that’s me! Please do spread the word about this project and get in touch if you’re interested in finding out more.
XH-🥧 interactions are the best!
XH-🥧 interactions are the best!
We have a fully-funded 4 year PhD position in the lab, for October 2025 entry. Both UK and international students are eligible to apply. Please share and get in touch if you're interested 🧬🧪🦠
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding molecular mechanisms of protein-primed genome replication in enteroviruses at University of York, listed on FindAPhD.com
www.findaphd.com
November 13, 2024 at 3:26 PM
We have a fully-funded 4 year PhD position in the lab, for October 2025 entry. Both UK and international students are eligible to apply. Please share and get in touch if you're interested 🧬🧪🦠
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...