Thejas Satheesh
@thejas52.bsky.social
PhD student at Cees Dekker lab, TUD
BS-MS, Mahipal Ganji lab, IISc
SMCs | NAPs | genome organization | DNA repair 🧬
BS-MS, Mahipal Ganji lab, IISc
SMCs | NAPs | genome organization | DNA repair 🧬
Pinned
Thejas Satheesh
@thejas52.bsky.social
· Jan 7
Really excited to share our latest preprint in collaboration with Sandeep Choubey's lab at IMSc. Mycobacterium tuberculosis Nucleoid Associated protein Lsr2 and DNA undergo sequence-dependent co-condensation. Check it out here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sequence-dependent co-condensation of Lsr2 with DNA elucidates the mechanism of genome compaction in Mycobacterium tuberculosis
The xenogeneic silencer protein Lsr2 from Mycobacterium tuberculosis plays a critical role in its survival and pathogenesis. Lsr2 is a nucleoid-associated protein that interacts with DNA in vivo and r...
www.biorxiv.org
Really nice to see this out online! This was part of my research in Mahipal’s lab at IISc. It’s been incredibly interesting solving the Lsr 2 puzzle with him. The project progressed very smoothly in collaboration with Sandeep Choubey's lab at IMSc.
Reposted by Thejas Satheesh
I am thrilled with the news that our ERC Synergy proposal GeneMotors was granted!!
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
📣 Meet the new ERC Synergy Grant awardees!
Sixty-six research teams have been selected for funding, bringing together 239 scientists. Congratulations to all!
➡️ buff.ly/PSn3bi9
#EUfunded #HorizonEurope #ERCSyG
Sixty-six research teams have been selected for funding, bringing together 239 scientists. Congratulations to all!
➡️ buff.ly/PSn3bi9
#EUfunded #HorizonEurope #ERCSyG
November 6, 2025 at 11:57 AM
I am thrilled with the news that our ERC Synergy proposal GeneMotors was granted!!
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
This prestigious grant allows Leonid Mirny (MIT), Wendy Bickmore (Edinburgh), Benjamin Rowland (NKI) and me to study the DNA-looping SMC motors proteins that control our chromosomes in the next 6 years
Reposted by Thejas Satheesh
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
November 5, 2025 at 12:57 PM
Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.
Reposted by Thejas Satheesh
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Thejas Satheesh
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
Reposted by Thejas Satheesh
Time flies .. it is today 25 years ago that we published our studies that revealed that bacterial H-NS is a DNA bridging protein:
academic.oup.com/nar/article/... @narjournal.bsky.social
academic.oup.com/nar/article/... @narjournal.bsky.social
H-NS mediated compaction of DNA visualised by atomic force microscopy
Abstract. The Escherichia coli H-NS protein is a nucleoid-associated protein involved in gene regulation and DNA compaction. To get more insight into the m
academic.oup.com
September 15, 2025 at 8:20 AM
Time flies .. it is today 25 years ago that we published our studies that revealed that bacterial H-NS is a DNA bridging protein:
academic.oup.com/nar/article/... @narjournal.bsky.social
academic.oup.com/nar/article/... @narjournal.bsky.social
Reposted by Thejas Satheesh
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Reposted by Thejas Satheesh
WORK!
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
August 13, 2025 at 1:30 PM
WORK!
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects:
- Nanopore protein sequencing
- Archaeal CDV cell division
- Microfluidics for synthetic cells
- Nuclear Pore Complex
- Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-us/
RT=👍
Reposted by Thejas Satheesh
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 2, 2025 at 3:01 PM
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Reposted by Thejas Satheesh
3 more weeks to apply!
🧬 Fully funded PhD opportunity! 🧬
We are looking for a curious and motivated candidate to join our new team in Utrecht. Our goal is to develop biomimetic mechanisms for protein folding using DNA origami.
More info:
🔗 www.uu.nl/en/organisat...
🗓️ Deadline: 15.08
🧬 Fully funded PhD opportunity! 🧬
We are looking for a curious and motivated candidate to join our new team in Utrecht. Our goal is to develop biomimetic mechanisms for protein folding using DNA origami.
More info:
🔗 www.uu.nl/en/organisat...
🗓️ Deadline: 15.08
July 25, 2025 at 11:21 AM
3 more weeks to apply!
🧬 Fully funded PhD opportunity! 🧬
We are looking for a curious and motivated candidate to join our new team in Utrecht. Our goal is to develop biomimetic mechanisms for protein folding using DNA origami.
More info:
🔗 www.uu.nl/en/organisat...
🗓️ Deadline: 15.08
🧬 Fully funded PhD opportunity! 🧬
We are looking for a curious and motivated candidate to join our new team in Utrecht. Our goal is to develop biomimetic mechanisms for protein folding using DNA origami.
More info:
🔗 www.uu.nl/en/organisat...
🗓️ Deadline: 15.08
Reposted by Thejas Satheesh
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
schmid.chemie.unibas.ch
July 31, 2025 at 2:34 PM
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
#nanopores #smFRET #biomolecular #dynamics #singleMolecules
We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.
Please share broadly, thank you!🤝
schmid.chemie.unibas.ch
Reposted by Thejas Satheesh
Since December 2020, I’ve been building visualize-it.github.io as part of my science communication and outreach efforts. It features 45 interactive visualizations from math, physics, computer science, and complex systems.
If you find it interesting, please repost it!
#science #scicomm #education
If you find it interesting, please repost it!
#science #scicomm #education
July 19, 2025 at 11:10 AM
Since December 2020, I’ve been building visualize-it.github.io as part of my science communication and outreach efforts. It features 45 interactive visualizations from math, physics, computer science, and complex systems.
If you find it interesting, please repost it!
#science #scicomm #education
If you find it interesting, please repost it!
#science #scicomm #education
Reposted by Thejas Satheesh
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Thejas Satheesh
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
June 25, 2025 at 6:59 AM
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
Reposted by Thejas Satheesh
Latest #CDlab paper out now in Nucleus: www.tandfonline.com/doi/epdf/10....
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
June 5, 2025 at 7:35 AM
Latest #CDlab paper out now in Nucleus: www.tandfonline.com/doi/epdf/10....
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
Reposted by Thejas Satheesh
(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
May 15, 2025 at 12:37 PM
(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
Reposted by Thejas Satheesh
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 9, 2025 at 8:00 AM
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Reposted by Thejas Satheesh
Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩
We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨
We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution
We are excited to present our latest work published in @natcomms.nature.com
www.nature.com/articles/s41...
We are excited to present our latest work published in @natcomms.nature.com
www.nature.com/articles/s41...
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution - Nature Communications
Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...
www.nature.com
May 7, 2025 at 2:56 PM
Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩
We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨
We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨
Reposted by Thejas Satheesh
(1/n) New preprint from @claricehongky.bsky.social
Fan Fang Varshini Ramanathan in collab w Jie Liu.
Q: How do we get ultra-high-res 3D genome maps?
A: New deep learning model, Cleopatra.
Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.
Fan Fang Varshini Ramanathan in collab w Jie Liu.
Q: How do we get ultra-high-res 3D genome maps?
A: New deep learning model, Cleopatra.
Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.
May 7, 2025 at 8:53 PM
(1/n) New preprint from @claricehongky.bsky.social
Fan Fang Varshini Ramanathan in collab w Jie Liu.
Q: How do we get ultra-high-res 3D genome maps?
A: New deep learning model, Cleopatra.
Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.
Fan Fang Varshini Ramanathan in collab w Jie Liu.
Q: How do we get ultra-high-res 3D genome maps?
A: New deep learning model, Cleopatra.
Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.
Reposted by Thejas Satheesh
Latest #CDlab paper on @biorxivpreprint.bsky.social:
Lipid flip flop regulates the shape of growing and dividing synthetic cells
www.biorxiv.org/content/10.1...
Here, postdoc Rafa Lira studied GUV growth by SUV fusions to show that lipid flip flop is key for low curvature stress and symmetric buds
Lipid flip flop regulates the shape of growing and dividing synthetic cells
www.biorxiv.org/content/10.1...
Here, postdoc Rafa Lira studied GUV growth by SUV fusions to show that lipid flip flop is key for low curvature stress and symmetric buds
April 28, 2025 at 9:46 AM
Latest #CDlab paper on @biorxivpreprint.bsky.social:
Lipid flip flop regulates the shape of growing and dividing synthetic cells
www.biorxiv.org/content/10.1...
Here, postdoc Rafa Lira studied GUV growth by SUV fusions to show that lipid flip flop is key for low curvature stress and symmetric buds
Lipid flip flop regulates the shape of growing and dividing synthetic cells
www.biorxiv.org/content/10.1...
Here, postdoc Rafa Lira studied GUV growth by SUV fusions to show that lipid flip flop is key for low curvature stress and symmetric buds
Reposted by Thejas Satheesh
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 7:45 AM
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Reposted by Thejas Satheesh
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
The 2026 Biochemical Society Award for Significant Breakthrough or Achievement is presented to Cees Dekker @ceesdekker.bsky.social! Celebrating his ground-breaking contributions to nanotechnology, Cees has pioneered research on solid-state nanopores and nanopore-based DNA sequencing.
April 8, 2025 at 8:30 AM
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
Reposted by Thejas Satheesh
You can download my protein structure-inspired artwork from pdb webpage:
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
March 15, 2025 at 11:42 AM
You can download my protein structure-inspired artwork from pdb webpage:
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
pdb101.rcsb.org/sci-art/bezs...
@rcsbpdb.bsky.social
@pdbeurope.bsky.social
#sciart
Reposted by Thejas Satheesh
Latest #CDlab paper online in @labonachip.rsc.org: pubs.rsc.org/en/content/a...
Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
March 3, 2025 at 9:13 AM
Latest #CDlab paper online in @labonachip.rsc.org: pubs.rsc.org/en/content/a...
Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
Reposted by Thejas Satheesh
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
February 10, 2025 at 8:21 AM
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Reposted by Thejas Satheesh
Latest #CDlab paper now at @biorxivpreprint.bsky.social: www.biorxiv.org/content/10.1...
In this paper, we identify two amino acid motifs on CTCF that impede cohesin-mediated DNA loop extrusion - important as CTCF and cohesin are crucial to the structure and regulation of our chromosomes.
In this paper, we identify two amino acid motifs on CTCF that impede cohesin-mediated DNA loop extrusion - important as CTCF and cohesin are crucial to the structure and regulation of our chromosomes.
January 27, 2025 at 9:02 AM
Latest #CDlab paper now at @biorxivpreprint.bsky.social: www.biorxiv.org/content/10.1...
In this paper, we identify two amino acid motifs on CTCF that impede cohesin-mediated DNA loop extrusion - important as CTCF and cohesin are crucial to the structure and regulation of our chromosomes.
In this paper, we identify two amino acid motifs on CTCF that impede cohesin-mediated DNA loop extrusion - important as CTCF and cohesin are crucial to the structure and regulation of our chromosomes.