Theodore Pak
@tedpak.bsky.social
Assistant Professor @ucirvine.bsky.social. Former fellow @mgh-id.bsky.social, MGH Medicine resident, Sinai MD-PhD, mghwhitebook.app creator. Posts my own. Lab website: tpaklab.org
Clinical trials affected by NIH grant terminations
"Approximately 1 in 30 trials and more than 74 000 trial participants were affected ... Affected trials disproportionately studied infectious diseases, prevention, and behavioral interventions" #MedSky #IDSky jamanetwork.com/journals/jam...
"Approximately 1 in 30 trials and more than 74 000 trial participants were affected ... Affected trials disproportionately studied infectious diseases, prevention, and behavioral interventions" #MedSky #IDSky jamanetwork.com/journals/jam...
Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health
This cross-sectional study summarizes the number of trials with terminated grants from the National Institutes of Health (NIH) and calculates the proportion of affected trials among those with previou...
jamanetwork.com
January 6, 2026 at 7:40 PM
Clinical trials affected by NIH grant terminations
"Approximately 1 in 30 trials and more than 74 000 trial participants were affected ... Affected trials disproportionately studied infectious diseases, prevention, and behavioral interventions" #MedSky #IDSky jamanetwork.com/journals/jam...
"Approximately 1 in 30 trials and more than 74 000 trial participants were affected ... Affected trials disproportionately studied infectious diseases, prevention, and behavioral interventions" #MedSky #IDSky jamanetwork.com/journals/jam...
Reposted by Theodore Pak
What I'm Reading:
Curiosity, a 1B-parameter model built on Epic Cosmos.
It's genuinely interesting: zero-shot outputs rivaled supervised baselines across 78 real-world tasks, and the scaling laws (α=0.52) mirror NLP. Cool to see how information scales across domains.
arxiv.org/abs/2508.12104
1/
Curiosity, a 1B-parameter model built on Epic Cosmos.
It's genuinely interesting: zero-shot outputs rivaled supervised baselines across 78 real-world tasks, and the scaling laws (α=0.52) mirror NLP. Cool to see how information scales across domains.
arxiv.org/abs/2508.12104
1/
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
December 27, 2025 at 3:22 AM
What I'm Reading:
Curiosity, a 1B-parameter model built on Epic Cosmos.
It's genuinely interesting: zero-shot outputs rivaled supervised baselines across 78 real-world tasks, and the scaling laws (α=0.52) mirror NLP. Cool to see how information scales across domains.
arxiv.org/abs/2508.12104
1/
Curiosity, a 1B-parameter model built on Epic Cosmos.
It's genuinely interesting: zero-shot outputs rivaled supervised baselines across 78 real-world tasks, and the scaling laws (α=0.52) mirror NLP. Cool to see how information scales across domains.
arxiv.org/abs/2508.12104
1/
Reposted by Theodore Pak
Rise of anti-science rhetoric has fundamentally changed the relationship between doctors and patients www.statnews.com/2025/12/10/a... by @krutikakuppalli.bsky.social
via @statnews.com
#HHS #FDA #CDC #publichealth #vaccines #science #MedSky
via @statnews.com
#HHS #FDA #CDC #publichealth #vaccines #science #MedSky
Rise of anti-science rhetoric has fundamentally changed the relationship between doctors and patients
“The rise of anti-science and anti-vaccine rhetoric has fundamentally changed the relationship between clinicians and patients.”
www.statnews.com
December 10, 2025 at 4:34 PM
Rise of anti-science rhetoric has fundamentally changed the relationship between doctors and patients www.statnews.com/2025/12/10/a... by @krutikakuppalli.bsky.social
via @statnews.com
#HHS #FDA #CDC #publichealth #vaccines #science #MedSky
via @statnews.com
#HHS #FDA #CDC #publichealth #vaccines #science #MedSky
Reposted by Theodore Pak
A @idsainfo.bsky.social position statement in @cidjournal.bsky.social describing why the society backed out of ATS CAP guidelines.
[In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe”
#IDSky
academic.oup.com/cid/advance-...
[In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe”
#IDSky
academic.oup.com/cid/advance-...
Infectious Diseases Society of America (IDSA) Position Statement: Why IDSA Did Not Endorse the Community-Acquired Pneumonia Guidelines 2025 Update
The Infectious Diseases Society of America (IDSA) did not endorse updated community-acquired pneumonia guidelines because they recommend antibiotics for pa
academic.oup.com
December 8, 2025 at 11:58 PM
A @idsainfo.bsky.social position statement in @cidjournal.bsky.social describing why the society backed out of ATS CAP guidelines.
[In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe”
#IDSky
academic.oup.com/cid/advance-...
[In viral pneumonia] “briefly withholding antibiotics for patients with nonsevere illness to clarify the diagnosis is safe”
#IDSky
academic.oup.com/cid/advance-...
Reposted by Theodore Pak
Today I am very proud to announce the release of the Antibiotic Resistance Microbiology Dataset - Mass General Brigham (ARMD-MGB; physionet.org/content/armd...) , as part of an NIH-funded collaboration led by Jonathan Chen at Stanford. (1/6)
Antibiotic Resistance Microbiology Dataset Mass General Brigham (ARMD-MGB) v1.0.0
ARMD-MGB contains detailed microbiology and clinical metadata for >225,000 patients and >970,000 cultures collected over 10 years
physionet.org
December 5, 2025 at 7:39 AM
Today I am very proud to announce the release of the Antibiotic Resistance Microbiology Dataset - Mass General Brigham (ARMD-MGB; physionet.org/content/armd...) , as part of an NIH-funded collaboration led by Jonathan Chen at Stanford. (1/6)
Reposted by Theodore Pak
To be effective, data science agents need to be able to read plots reliably. @sara-altman.bsky.social and I wrote about some concerning findings on LLMs' ability to interpret plots when the content contradicts their expectations on the @posit.co blog.
posit.co/blog/introdu...
posit.co/blog/introdu...
When plotting, LLMs see what they expect to see - Posit
Data science agents need to accurately read plots even when the content contradicts their expectations. Our testing shows today's LLMs still struggle here.
posit.co
November 13, 2025 at 3:07 PM
To be effective, data science agents need to be able to read plots reliably. @sara-altman.bsky.social and I wrote about some concerning findings on LLMs' ability to interpret plots when the content contradicts their expectations on the @posit.co blog.
posit.co/blog/introdu...
posit.co/blog/introdu...
Reposted by Theodore Pak
Gave my 1st talk in NL: how to make multicenter data analysis with patient data actually work.
tl;dr: common data models (global interoperability) + LLMs (data harmonization, mapping, future-proofing) + federated learning (privacy)
Let me know what you think!
drive.google.com/file/d/1N3yk...
tl;dr: common data models (global interoperability) + LLMs (data harmonization, mapping, future-proofing) + federated learning (privacy)
Let me know what you think!
drive.google.com/file/d/1N3yk...
November 5, 2025 at 11:06 AM
Gave my 1st talk in NL: how to make multicenter data analysis with patient data actually work.
tl;dr: common data models (global interoperability) + LLMs (data harmonization, mapping, future-proofing) + federated learning (privacy)
Let me know what you think!
drive.google.com/file/d/1N3yk...
tl;dr: common data models (global interoperability) + LLMs (data harmonization, mapping, future-proofing) + federated learning (privacy)
Let me know what you think!
drive.google.com/file/d/1N3yk...
Reposted by Theodore Pak
An #LLM extracted signs and symptoms for patients with sepsis with similar accuracy to humans, and identified 7 syndromes differentially correlating with multidrug-resistant infection risk and mortality. ja.ma/47onWVE
October 25, 2025 at 12:00 PM
An #LLM extracted signs and symptoms for patients with sepsis with similar accuracy to humans, and identified 7 syndromes differentially correlating with multidrug-resistant infection risk and mortality. ja.ma/47onWVE
Reposted by Theodore Pak
Maybe AI Knows Something That We Do Not!
🆕💫 Cohort study
LLM accurately extracted presenting signs & symptoms from admission notes that clustered into syndromes differentially correlated with infection sources, MDR infections, and mortality #IDsky
jamanetwork.com/journals/jam...
🆕💫 Cohort study
LLM accurately extracted presenting signs & symptoms from admission notes that clustered into syndromes differentially correlated with infection sources, MDR infections, and mortality #IDsky
jamanetwork.com/journals/jam...
Syndromic Analysis of Sepsis Cohorts Using Large Language Models
This cohort study compares the performance of a large language model against manual medical record review for extracting presenting signs and symptoms data from hospital admission notes and uses these...
jamanetwork.com
October 24, 2025 at 7:23 PM
Maybe AI Knows Something That We Do Not!
🆕💫 Cohort study
LLM accurately extracted presenting signs & symptoms from admission notes that clustered into syndromes differentially correlated with infection sources, MDR infections, and mortality #IDsky
jamanetwork.com/journals/jam...
🆕💫 Cohort study
LLM accurately extracted presenting signs & symptoms from admission notes that clustered into syndromes differentially correlated with infection sources, MDR infections, and mortality #IDsky
jamanetwork.com/journals/jam...
Reposted by Theodore Pak
My new piece in @medpagetoday.com
We Can Stop Deadly Hospital Outbreaks - So Why Aren't We?
Genomic surveillance can prevent outbreaks from spreading, save lives, and costs.
So what’s holding it back from being implemented in hospitals?
#IDSky
www.medpagetoday.com/opinion/seco...
We Can Stop Deadly Hospital Outbreaks - So Why Aren't We?
Genomic surveillance can prevent outbreaks from spreading, save lives, and costs.
So what’s holding it back from being implemented in hospitals?
#IDSky
www.medpagetoday.com/opinion/seco...
Opinion | We Can Stop Deadly Hospital Outbreaks -- So Why Aren't We?
Genomic surveillance can help contain local and nationwide threats
www.medpagetoday.com
October 14, 2025 at 8:12 PM
My new piece in @medpagetoday.com
We Can Stop Deadly Hospital Outbreaks - So Why Aren't We?
Genomic surveillance can prevent outbreaks from spreading, save lives, and costs.
So what’s holding it back from being implemented in hospitals?
#IDSky
www.medpagetoday.com/opinion/seco...
We Can Stop Deadly Hospital Outbreaks - So Why Aren't We?
Genomic surveillance can prevent outbreaks from spreading, save lives, and costs.
So what’s holding it back from being implemented in hospitals?
#IDSky
www.medpagetoday.com/opinion/seco...
It may be silly posting abt research in times like this but I have to share a small bit of joy with fellow ID heads. Our paper modeling the impact of colonization pressure on nosocomial pathogen acquisition just dropped on medRxiv! Only 3.5 years in the making.
www.medrxiv.org/content/10.1...
1/14
www.medrxiv.org/content/10.1...
1/14
Hospital unit colonization pressure and nosocomial acquisition of drug susceptible and drug resistant pathogens
Background Hospitalized patients are at risk for developing hospital acquired infections. Active surveillance for bacterial colonization is effective at preventing infection but is resource-intensive ...
www.medrxiv.org
June 12, 2025 at 11:52 AM
Reposted by Theodore Pak
New preprint from our lab by Rangachar Srinivasa et al:
We WGS 4 major respiratory viruses in 3 hospitals (RSV, influenza, rhinovirus, HMPV) & found silent transmission happening under the radar
Genomics uncovered hidden spread, complex transmission chains #IDSky
📄: www.medrxiv.org/content/10.1...
We WGS 4 major respiratory viruses in 3 hospitals (RSV, influenza, rhinovirus, HMPV) & found silent transmission happening under the radar
Genomics uncovered hidden spread, complex transmission chains #IDSky
📄: www.medrxiv.org/content/10.1...
April 27, 2025 at 8:55 PM
New preprint from our lab by Rangachar Srinivasa et al:
We WGS 4 major respiratory viruses in 3 hospitals (RSV, influenza, rhinovirus, HMPV) & found silent transmission happening under the radar
Genomics uncovered hidden spread, complex transmission chains #IDSky
📄: www.medrxiv.org/content/10.1...
We WGS 4 major respiratory viruses in 3 hospitals (RSV, influenza, rhinovirus, HMPV) & found silent transmission happening under the radar
Genomics uncovered hidden spread, complex transmission chains #IDSky
📄: www.medrxiv.org/content/10.1...
Reposted by Theodore Pak
How many hospitalized patients need care in the ICU? How many of them survive? What interventions do they receive there?
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
Following pandemic-era changes, many ICU outcome measures returned to prior levels.
The rates of mechanical ventilation have declined even further, while vasopressor use remained elevated above 2010s rates.
#MedSky https://ja.ma/42Jl3NO
The rates of mechanical ventilation have declined even further, while vasopressor use remained elevated above 2010s rates.
#MedSky https://ja.ma/42Jl3NO
Life Support and Outcomes Among ICU Patients
This cohort study uses data from US health systems continuously contributing to the Epic Cosmos database from 2014-2023 to characterize changes in intensive care unit (ICU) outcomes (ICU length of stay; use of mechanical ventilation or vasopressors; in-hospital mortality) and use of life support...
ja.ma
April 14, 2025 at 9:41 PM
How many hospitalized patients need care in the ICU? How many of them survive? What interventions do they receive there?
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
These are some of the questions I had two years ago while trying to write the "background" section for my masters thesis. But I couldn't find the answers... they did not exist.
Reposted by Theodore Pak
The amount of green on this level of evidence guiding antifungal treatment duration demonstrates nicely the research knowledge gap in this field!
#IDSky #ClinMicro #AMR @drneilstone.bsky.social
#IDSky #ClinMicro #AMR @drneilstone.bsky.social
March 15, 2025 at 11:19 AM
The amount of green on this level of evidence guiding antifungal treatment duration demonstrates nicely the research knowledge gap in this field!
#IDSky #ClinMicro #AMR @drneilstone.bsky.social
#IDSky #ClinMicro #AMR @drneilstone.bsky.social
Reposted by Theodore Pak
ondering how this year’s measles outbreaks compare to previous years? This chart shows that 2025 (dark purple) is already about 4x higher than this time last year (light purple), which was itself a sharp increase over 2023. The trend is alarming. Prevention—including vaccination—is critical.
March 12, 2025 at 6:29 PM
ondering how this year’s measles outbreaks compare to previous years? This chart shows that 2025 (dark purple) is already about 4x higher than this time last year (light purple), which was itself a sharp increase over 2023. The trend is alarming. Prevention—including vaccination—is critical.
Reposted by Theodore Pak
ID - Return to Basics:
This was the 1st reported case of an adult immunocompetent host who survived measles complicated by ARDS. A 36 yo female ED nurse, unvaccinated, who was exposed to a patient w active measles in October 1989. Ten days later, she developed measles
This was the 1st reported case of an adult immunocompetent host who survived measles complicated by ARDS. A 36 yo female ED nurse, unvaccinated, who was exposed to a patient w active measles in October 1989. Ten days later, she developed measles
January 21, 2025 at 3:06 AM
ID - Return to Basics:
This was the 1st reported case of an adult immunocompetent host who survived measles complicated by ARDS. A 36 yo female ED nurse, unvaccinated, who was exposed to a patient w active measles in October 1989. Ten days later, she developed measles
This was the 1st reported case of an adult immunocompetent host who survived measles complicated by ARDS. A 36 yo female ED nurse, unvaccinated, who was exposed to a patient w active measles in October 1989. Ten days later, she developed measles
Your AI can't see gorillas – A comparison of LLMs' ability to perform exploratory data analysis
chiraaggohel.com/posts/llms-e...
chiraaggohel.com/posts/llms-e...
Your AI can’t see gorillas – Chiraag Gohel
A comparison of LLMs’ ability to perform exploratory data analysis
chiraaggohel.com
February 8, 2025 at 8:08 PM
Your AI can't see gorillas – A comparison of LLMs' ability to perform exploratory data analysis
chiraaggohel.com/posts/llms-e...
chiraaggohel.com/posts/llms-e...
Clever tricks with token sampling can guide a "reasoning" LLM like Deepseek's R1 (and the many new models it is already inspiring) into 'ing longer, and thereby producing more accurate output
There is a lot more juice to squeeze from these kinds of models.
timkellogg.me/blog/2025/02...
There is a lot more juice to squeeze from these kinds of models.
timkellogg.me/blog/2025/02...
S1: The $6 R1 Competitor?
timkellogg.me
February 5, 2025 at 5:30 PM
Clever tricks with token sampling can guide a "reasoning" LLM like Deepseek's R1 (and the many new models it is already inspiring) into 'ing longer, and thereby producing more accurate output
There is a lot more juice to squeeze from these kinds of models.
timkellogg.me/blog/2025/02...
There is a lot more juice to squeeze from these kinds of models.
timkellogg.me/blog/2025/02...
Reposted by Theodore Pak
New paper in JAMA Network Open!
jamanetwork.com/journals/jam...
The IDSA released their guidelines for treatment of uncomplicated UTI back in 2011. We looked at a large claims database formatted into the OMOP common data model to see whether the recommendations still hold
tl;dr They do.
(1/7)
jamanetwork.com/journals/jam...
The IDSA released their guidelines for treatment of uncomplicated UTI back in 2011. We looked at a large claims database formatted into the OMOP common data model to see whether the recommendations still hold
tl;dr They do.
(1/7)
Use of Machine Learning to Assess the Management of Uncomplicated UTI
This cohort study examines the effectiveness and adverse event profile for first-line antibiotics, fluoroquinolones, and oral β-lactams for treating uncomplicated urinary tract infection (UTI) in cont...
jamanetwork.com
February 1, 2025 at 3:28 PM
New paper in JAMA Network Open!
jamanetwork.com/journals/jam...
The IDSA released their guidelines for treatment of uncomplicated UTI back in 2011. We looked at a large claims database formatted into the OMOP common data model to see whether the recommendations still hold
tl;dr They do.
(1/7)
jamanetwork.com/journals/jam...
The IDSA released their guidelines for treatment of uncomplicated UTI back in 2011. We looked at a large claims database formatted into the OMOP common data model to see whether the recommendations still hold
tl;dr They do.
(1/7)
Reposted by Theodore Pak
The removal of #HIV- and #LGBTQ-related resources from the websites of CDC and other health agencies is deeply concerning.
Access to this information is crucial for ID and HIV health care professionals.
Our full statement: https://buff.ly/42AO8LI
Access to this information is crucial for ID and HIV health care professionals.
Our full statement: https://buff.ly/42AO8LI
January 31, 2025 at 10:27 PM
The removal of #HIV- and #LGBTQ-related resources from the websites of CDC and other health agencies is deeply concerning.
Access to this information is crucial for ID and HIV health care professionals.
Our full statement: https://buff.ly/42AO8LI
Access to this information is crucial for ID and HIV health care professionals.
Our full statement: https://buff.ly/42AO8LI
Reposted by Theodore Pak
It is simply not enough for universities to say, “Our grants & research offices are looking into how research will be affected by the latest directive.”
University leaders must actively and very publicly make the case for the kind of work many of us do. The silence on this front is deafening.
University leaders must actively and very publicly make the case for the kind of work many of us do. The silence on this front is deafening.
January 31, 2025 at 3:16 AM
It is simply not enough for universities to say, “Our grants & research offices are looking into how research will be affected by the latest directive.”
University leaders must actively and very publicly make the case for the kind of work many of us do. The silence on this front is deafening.
University leaders must actively and very publicly make the case for the kind of work many of us do. The silence on this front is deafening.
Reposted by Theodore Pak
It appears that the CDC has removed its guidelines for contraception and STIs. www.cdc.gov/contraceptio...
January 31, 2025 at 9:25 PM
It appears that the CDC has removed its guidelines for contraception and STIs. www.cdc.gov/contraceptio...
Reposted by Theodore Pak
The entire website for the NIH Office of Research on Women's Health (ORWH) is very nearly stripped bare. This is so, so devastating. orwh.od.nih.gov/research/fun...
orwh.od.nih.gov
January 31, 2025 at 6:25 PM
The entire website for the NIH Office of Research on Women's Health (ORWH) is very nearly stripped bare. This is so, so devastating. orwh.od.nih.gov/research/fun...
Reposted by Theodore Pak
It's one thing to take down pages talking about diversity in science.
It's another thing entirely to take down research databases that are used for observational studies.
That is exactly what it seems just happened at the CDC.
www.statnews.com/2025/01/31/c... www.statnews.com/2025/01/31/c...
It's another thing entirely to take down research databases that are used for observational studies.
That is exactly what it seems just happened at the CDC.
www.statnews.com/2025/01/31/c... www.statnews.com/2025/01/31/c...
CDC removes data on sexual orientation, gender identity from website
Data from an expansive federal survey on youth behavioral habits, including their sexual orientation and gender identity, have been removed from the website of the CDC.
www.statnews.com
January 31, 2025 at 6:53 PM
It's one thing to take down pages talking about diversity in science.
It's another thing entirely to take down research databases that are used for observational studies.
That is exactly what it seems just happened at the CDC.
www.statnews.com/2025/01/31/c... www.statnews.com/2025/01/31/c...
It's another thing entirely to take down research databases that are used for observational studies.
That is exactly what it seems just happened at the CDC.
www.statnews.com/2025/01/31/c... www.statnews.com/2025/01/31/c...
Reposted by Theodore Pak
🚨If you use public data products from the CDC or other US federal agencies 🚨
Download them NOW
[This is how I’m spending my Friday]
Download them NOW
[This is how I’m spending my Friday]
A colleague asked whether I thought the government would continue the public release of its data products. The data from CDC health monitoring surveys, decades of data on mortality, crime data, climate data of a variety of types that go back for years, etc.
1/
1/
January 31, 2025 at 1:02 PM
🚨If you use public data products from the CDC or other US federal agencies 🚨
Download them NOW
[This is how I’m spending my Friday]
Download them NOW
[This is how I’m spending my Friday]