Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characterize the role of developmental, physiological and molecular perturbations on branching tissue invasion, growth, and maintenance. Yet, the field still lacks a fully open-sourced, quantitative framework to analyze whole-mount mammary tissue images, as a commonly utilized methodology. Here, we present MaGNet (Mammary Gland Network analysis tool), a method that leverages network theory to characterize key features of ductal branching during mammary gland development. Applying this pipeline to mammary gland images captured at three pubertal timepoints, we achieved reproducible quantification of ductal tree expansion across development. In addition, this network analysis pipeline captures ductal expansion induced by pregnancy hormones. By providing open-source tools to the research community, this method may increase reproducibility and broad applicability across diverse organ systems, model organisms, and developmental stages.

Wen et al. reveal that social interaction reduces breast cancer progression by activating ACCGlu→BLAGlu circuits, inhibiting intratumoral sympathetic activity. This neural mechanism enhances antitumor...

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

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Some types of cell are more likely than others to give rise to tumours. A rapid cell cycle is a newly identified predictor of cancer susceptibility.

CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and...

UC Santa Cruz neuroscientists aiming to better understand how specific brain connectivity contributes to perception, thoughts, and behavior are leveraging artificial intelligence to enhance their stud...

Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.

“These cuts aren’t just about UCSC; they’re about Santa Cruz,” writes Needhi Bhalla, Susan Carpenter and Carol Greider in a Guest Commentary. “This crucial NIH support fuels our l…