Sounak Sahu
@sounaksahu.bsky.social
Assistant Professor @NYU Langone Health #WeAreHiring #NewPI
https://www.sahulab.com/
https://www.sahulab.com/
Reposted by Sounak Sahu
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
urldefense.com
November 5, 2025 at 9:07 PM
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbymmubqq @ISSCR.org
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 4, 2025 at 2:53 AM
There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbymmubqq @ISSCR.org
Reposted by Sounak Sahu
🔥🚨 Our new paper is finally out in @narjournal.bsky.social!
academic.oup.com/nar/article/53/17/gkaf804/8248607
We built the first comprehensive atlas of dynamic allelic expression in the mouse mammary gland across adulthood, tracking genes across virgin, #pregnancy, #lactation & #involution.
🧵
academic.oup.com/nar/article/53/17/gkaf804/8248607
We built the first comprehensive atlas of dynamic allelic expression in the mouse mammary gland across adulthood, tracking genes across virgin, #pregnancy, #lactation & #involution.
🧵
Dynamic allelic expression in mouse mammary glands across the adult developmental cycle
Abstract. The mammary gland, which primarily develops postnatally, undergoes significant changes during pregnancy and lactation to facilitate milk producti
academic.oup.com
September 10, 2025 at 9:14 AM
🔥🚨 Our new paper is finally out in @narjournal.bsky.social!
academic.oup.com/nar/article/53/17/gkaf804/8248607
We built the first comprehensive atlas of dynamic allelic expression in the mouse mammary gland across adulthood, tracking genes across virgin, #pregnancy, #lactation & #involution.
🧵
academic.oup.com/nar/article/53/17/gkaf804/8248607
We built the first comprehensive atlas of dynamic allelic expression in the mouse mammary gland across adulthood, tracking genes across virgin, #pregnancy, #lactation & #involution.
🧵
Reposted by Sounak Sahu
In the INAVO120 trial, inavolisib+palbociclib-fulvestrant improved PFS in PIK3CA-mutated, HR+HER2- advanced breast cancer vs placebo+palbociclib-fulvestrant. PMID:40454641, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2501796 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1056/NEJMoa2501796
No description available
doi.org
November 3, 2025 at 1:10 AM
We are hiring a research associate in using stem cells and organoid for breast cancer modeling. Please apply jobs.nyulangone.org/job/22446992...
Know more about our ongoing work www.sahulab.com
Know more about our ongoing work www.sahulab.com
Research Associate
Start your career journey at NYU Langone Health, where cutting-edge research meets compassionate, patient-centered care.
jobs.nyulangone.org
November 3, 2025 at 2:20 AM
We are hiring a research associate in using stem cells and organoid for breast cancer modeling. Please apply jobs.nyulangone.org/job/22446992...
Know more about our ongoing work www.sahulab.com
Know more about our ongoing work www.sahulab.com
Thrilled to announce that I’m joining New York University (NYU) Langone Health as an Assistant Professor. We are diving into the world of embryonic stem cells and organoids to unravel how normal development goes right and how it goes wrong in cancer. med.nyu.edu/faculty/soun...
September 2, 2025 at 12:18 AM
Thrilled to announce that I’m joining New York University (NYU) Langone Health as an Assistant Professor. We are diving into the world of embryonic stem cells and organoids to unravel how normal development goes right and how it goes wrong in cancer. med.nyu.edu/faculty/soun...
Reposted by Sounak Sahu
1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants.
🔗 www.nature.com/articles/s41...
🧵
🔗 www.nature.com/articles/s41...
🧵
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification - Nature Communications
BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to pro...
www.nature.com
May 26, 2025 at 6:56 AM
1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants.
🔗 www.nature.com/articles/s41...
🧵
🔗 www.nature.com/articles/s41...
🧵
Reposted by Sounak Sahu
Reposted by Sounak Sahu
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer
Open Access
www.nature.com/articles/s43...
Open Access
www.nature.com/articles/s43...
November 26, 2024 at 7:48 AM
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer
Open Access
www.nature.com/articles/s43...
Open Access
www.nature.com/articles/s43...
Excited to share our latest study in
@nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...
@nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...
Saturation genome editing-based clinical classification of BRCA2 variants - Nature
CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and...
www.nature.com
January 9, 2025 at 1:52 AM
Excited to share our latest study in
@nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...
@nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...
Reposted by Sounak Sahu
“During pregnancy, several organs are rewired to support the health of the mother and the offspring. A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation.”
#ReproSky 🧪
www.nature.com/articles/d41...
#ReproSky 🧪
www.nature.com/articles/d41...
Gut lining in pregnant and lactating mice expands to ensure offspring health
The RANK–RANKL pathway promotes intestinal epithelial expansion in pregnancy and lactation to meet increased nutritional demands.
www.nature.com
January 1, 2025 at 11:42 PM
“During pregnancy, several organs are rewired to support the health of the mother and the offspring. A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation.”
#ReproSky 🧪
www.nature.com/articles/d41...
#ReproSky 🧪
www.nature.com/articles/d41...
Reposted by Sounak Sahu
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
November 29, 2024 at 4:17 PM
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
Reposted by Sounak Sahu
Exciting to see the collection of HCA papers out this week in Nature. Honored to be in the mix with our collaboration with @mhaniffa.bsky.social and Sarah Teichmann on a fetal skin atlas. Bravo to Hudaa, Elena, and Bayanne et al, for pulling this study together. A tremendous effort! rdcu.be/d02Yx
A prenatal skin atlas reveals immune regulation of human skin morphogenesis
Nature - A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including...
rdcu.be
November 21, 2024 at 6:34 PM
Exciting to see the collection of HCA papers out this week in Nature. Honored to be in the mix with our collaboration with @mhaniffa.bsky.social and Sarah Teichmann on a fetal skin atlas. Bravo to Hudaa, Elena, and Bayanne et al, for pulling this study together. A tremendous effort! rdcu.be/d02Yx