@srinituraga.bsky.social
Pinned
This is cool - using the fly connectome to build a constrained ANN model of the fly visual system:
www.nature.com/articles/s41...
Nice to see connectomics actually getting used for something... 😜
🧠📈 🧪
www.nature.com/articles/s41...
Nice to see connectomics actually getting used for something... 😜
🧠📈 🧪
Connectome-constrained networks predict neural activity across the fly visual system - Nature
A study demonstrates how experimental measurements of only the connectivity of a biological neural network can be used to predict neural responses across the fly visual system at single-neuron resolut...
www.nature.com
Thanks for the shoutout, @tyrellturing.bsky.social!
Reposted
🪰 How do dozens of tiny fly muscles cooperate to move a leg?
We’re excited to share the first 3D, data-driven musculoskeletal model of Drosophila legs based on Hill-type muscles, running in OpenSim and MuJoCo simulation environments.
Preprint: arxiv.org/abs/2509.06426
We’re excited to share the first 3D, data-driven musculoskeletal model of Drosophila legs based on Hill-type muscles, running in OpenSim and MuJoCo simulation environments.
Preprint: arxiv.org/abs/2509.06426
September 12, 2025 at 9:26 PM
🪰 How do dozens of tiny fly muscles cooperate to move a leg?
We’re excited to share the first 3D, data-driven musculoskeletal model of Drosophila legs based on Hill-type muscles, running in OpenSim and MuJoCo simulation environments.
Preprint: arxiv.org/abs/2509.06426
We’re excited to share the first 3D, data-driven musculoskeletal model of Drosophila legs based on Hill-type muscles, running in OpenSim and MuJoCo simulation environments.
Preprint: arxiv.org/abs/2509.06426
Reposted
Thanks Misha for the shout-out!
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
September 8, 2025 at 4:30 PM
Thanks Misha for the shout-out!
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.
Reposted
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
September 8, 2025 at 4:25 PM
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Reposted
Hey spinal/ventral nerve cord folks. we’re organizing this cross species “cords” meeting @hhmijanelia.bsky.social . Hurry up and upload your abstracts. As a trainee these were my favorite meetings (small and focused) where I got the most useful feedback. DM in case of any Qs.
📢 Applications are now open for our cross-disciplinary conference on nerve cord circuits.
🧠 Join experts to probe the organization & function of cord circuits across species.
🏨 Hotel, meals & registration covered.
🗓️ Apply by May 27 @ janelia.news/CRD25
@hhmi.org
@salilbidaye.bsky.social
🧠 Join experts to probe the organization & function of cord circuits across species.
🏨 Hotel, meals & registration covered.
🗓️ Apply by May 27 @ janelia.news/CRD25
@hhmi.org
@salilbidaye.bsky.social
May 16, 2025 at 3:51 PM
Hey spinal/ventral nerve cord folks. we’re organizing this cross species “cords” meeting @hhmijanelia.bsky.social . Hurry up and upload your abstracts. As a trainee these were my favorite meetings (small and focused) where I got the most useful feedback. DM in case of any Qs.
Reposted
Nice article in the transmitter about connectome-enabled brain models, covering @lappalainenjk.bsky.social’s work with @srinituraga.bsky.social and colleagues!!
It took more than a decade to trace the 130,000 connections in a fruit fly's brain. With the map in hand, researchers are turning to the next step in connectomics: building simulations.
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/connectome/c...
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/connectome/c...
Connectomics 2.0: Simulating the brain
With a complete fly connectome in hand, researchers are taking the next step to model how brain circuits fuel function.
www.thetransmitter.org
May 3, 2025 at 1:36 PM
Nice article in the transmitter about connectome-enabled brain models, covering @lappalainenjk.bsky.social’s work with @srinituraga.bsky.social and colleagues!!
Reposted
The MICrONS papers are finally out. Very happy to have been part of this. Joint work of so many labs lead by @andreastolias.bsky.social and Xaq Pitkow. Large scale efforts and data resources like these combined with cutting edge AI methods are great avenues to drive neuroscience forward.
A package of research papers from the MICrONS (Machine Intelligence from Cortical Networks) consortium in Nature and Nature Methods provides a detailed map of mouse brain cell structure and connections, offering insights into how they relate to activity in the mouse brain. 🧪
The MICrONS Project
An unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses. This integrated view of function and structure lays a foundation for discovering the computational bases of cortical circuits.
go.nature.com
April 9, 2025 at 6:37 PM
The MICrONS papers are finally out. Very happy to have been part of this. Joint work of so many labs lead by @andreastolias.bsky.social and Xaq Pitkow. Large scale efforts and data resources like these combined with cutting edge AI methods are great avenues to drive neuroscience forward.
Reposted
🚨iGluSnFR4 is finally out!🚨🧪
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
March 25, 2025 at 12:10 PM
🚨iGluSnFR4 is finally out!🚨🧪
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
Reposted
Igor Siwanowicz of @hhmijanelia.bsky.social captured these photos of pollen grains on the sigma of a morning glory flower. This is part of the early stage in creating a seed, it might also be the reason why you can’t stop sneezing!
March 25, 2025 at 5:36 PM
Igor Siwanowicz of @hhmijanelia.bsky.social captured these photos of pollen grains on the sigma of a morning glory flower. This is part of the early stage in creating a seed, it might also be the reason why you can’t stop sneezing!
Reposted
Thrilled to share the latest paper from the lab! Huge congrats to first author Dr. Celine Drieu and the amazing team of Ziyi Zhu, Sarah Elnozahy, Joy Wang, Aaron Wang, and Kylie Fuller! Lots of fun stuff in the paper so check it out - and let us know what you think :)
Nature research paper: Rapid emergence of latent knowledge in the sensory cortex drives learning
https://go.nature.com/4kBinZH
https://go.nature.com/4kBinZH
Rapid emergence of latent knowledge in the sensory cortex drives learning - Nature
In mice, learning and performance on an auditory task is driven by higher-order signals in the auditory cortex that are no longer required when the mouse has achieved expert-level performance.
go.nature.com
March 21, 2025 at 9:06 PM
Thrilled to share the latest paper from the lab! Huge congrats to first author Dr. Celine Drieu and the amazing team of Ziyi Zhu, Sarah Elnozahy, Joy Wang, Aaron Wang, and Kylie Fuller! Lots of fun stuff in the paper so check it out - and let us know what you think :)
Reposted
🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠
🔗 www.janelia.org/news/new-ima...
🔗 www.janelia.org/news/new-ima...
March 31, 2025 at 12:44 PM
🥼 Janelia researchers led by @boazmohar.bsky.social @nspruston.bsky.social @rhodamine110.bsky.social & @svoboda314.bsky.social @alleninstitute.bsky.social have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠
🔗 www.janelia.org/news/new-ima...
🔗 www.janelia.org/news/new-ima...
Reposted
Can you spot the difference between the cells on the left and right?
Read on for the solution (and a preprint announcement)… 👇
1/6
Read on for the solution (and a preprint announcement)… 👇
1/6
January 15, 2025 at 8:12 PM
Can you spot the difference between the cells on the left and right?
Read on for the solution (and a preprint announcement)… 👇
1/6
Read on for the solution (and a preprint announcement)… 👇
1/6
Reposted
🪰A connectome of the fruit fly visual system & classification of its 53K neurons unlock new possibilities for probing vision in fruit flies hhmi.news/3XyqYCy
🔗Read more about these #openscience tools from our FlyEM Project Team & collaborators, first published as a 2024 #preprint: hhmi.news/4iIsavL
🔗Read more about these #openscience tools from our FlyEM Project Team & collaborators, first published as a 2024 #preprint: hhmi.news/4iIsavL
March 26, 2025 at 4:26 PM
🪰A connectome of the fruit fly visual system & classification of its 53K neurons unlock new possibilities for probing vision in fruit flies hhmi.news/3XyqYCy
🔗Read more about these #openscience tools from our FlyEM Project Team & collaborators, first published as a 2024 #preprint: hhmi.news/4iIsavL
🔗Read more about these #openscience tools from our FlyEM Project Team & collaborators, first published as a 2024 #preprint: hhmi.news/4iIsavL
Reposted
I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Connectome-driven neural inventory of a complete visual system - Nature
A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.
www.nature.com
March 27, 2025 at 10:58 PM
I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Reposted
I am sadly not at #Cosyne2025, but if you are, don't miss @sarahpugly.bsky.social's wild poster on how she used connectome simulations to discover a central pattern generator circuit that controls the fly walking rhythm. A collabo w @bingbrunton.bsky.social.
Poster 2-042. Fri 3/28 (1:15-3:45pm)
Poster 2-042. Fri 3/28 (1:15-3:45pm)
March 27, 2025 at 11:31 PM
I am sadly not at #Cosyne2025, but if you are, don't miss @sarahpugly.bsky.social's wild poster on how she used connectome simulations to discover a central pattern generator circuit that controls the fly walking rhythm. A collabo w @bingbrunton.bsky.social.
Poster 2-042. Fri 3/28 (1:15-3:45pm)
Poster 2-042. Fri 3/28 (1:15-3:45pm)
Reposted
There's a Korean soap opera on Netflix (When the Stars Gossip) which has *Drosophila courtship in space* as a major plot point (Ep 2). They have Michael Reiser & lab's flight arenas (you can see Janelia & MIchael's initials on the panels). Great way to learn about Drosophila courtship!
February 5, 2025 at 1:51 AM
There's a Korean soap opera on Netflix (When the Stars Gossip) which has *Drosophila courtship in space* as a major plot point (Ep 2). They have Michael Reiser & lab's flight arenas (you can see Janelia & MIchael's initials on the panels). Great way to learn about Drosophila courtship!
Reposted
Join us for the CAJAL NeuroAI summer course in Lisbon July 14-Aug 1. We have a great line-up of speakers from a diverse range of topics across NeuroAI. Check out our website for more details and help us spread the word: cajal-training.org/on-site/neur...
Applications are due March 7!
Applications are due March 7!
February 3, 2025 at 10:46 PM
Join us for the CAJAL NeuroAI summer course in Lisbon July 14-Aug 1. We have a great line-up of speakers from a diverse range of topics across NeuroAI. Check out our website for more details and help us spread the word: cajal-training.org/on-site/neur...
Applications are due March 7!
Applications are due March 7!
Reposted
Really excited for this 3 week NeuroAI summer school in Lisbon!
We have course faculty from a range of neuro domains (language, vision, decision making, memory), and neuro levels (low level to cognitive). There will also be a project advised by our exciting lineup of course faculty!
Come join us!
We have course faculty from a range of neuro domains (language, vision, decision making, memory), and neuro levels (low level to cognitive). There will also be a project advised by our exciting lineup of course faculty!
Come join us!
🚀 Applications are OPEN for the CAJAL NeuroAI course!
Learn how AI & deep learning help us model brain activity & behavior. Work with experts, get hands-on training & join a global network!
📅 Apply by March 7
🔗 loom.ly/xg_uRKE
#NeuroAI #DeepLearning #Neuroscience
Learn how AI & deep learning help us model brain activity & behavior. Work with experts, get hands-on training & join a global network!
📅 Apply by March 7
🔗 loom.ly/xg_uRKE
#NeuroAI #DeepLearning #Neuroscience
February 3, 2025 at 6:22 PM
Really excited for this 3 week NeuroAI summer school in Lisbon!
We have course faculty from a range of neuro domains (language, vision, decision making, memory), and neuro levels (low level to cognitive). There will also be a project advised by our exciting lineup of course faculty!
Come join us!
We have course faculty from a range of neuro domains (language, vision, decision making, memory), and neuro levels (low level to cognitive). There will also be a project advised by our exciting lineup of course faculty!
Come join us!
Reposted
We‘re organizing this year’s Cajal NeuroAI summer course at Champalimaud in Lisbon. We have an amazing lineup of speakers across several computational approaches and species. Please repost to spread the word and/or apply!
🚀 Applications are OPEN for the CAJAL NeuroAI course!
Learn how AI & deep learning help us model brain activity & behavior. Work with experts, get hands-on training & join a global network!
📅 Apply by March 7
🔗 loom.ly/xg_uRKE
#NeuroAI #DeepLearning #Neuroscience
Learn how AI & deep learning help us model brain activity & behavior. Work with experts, get hands-on training & join a global network!
📅 Apply by March 7
🔗 loom.ly/xg_uRKE
#NeuroAI #DeepLearning #Neuroscience
February 3, 2025 at 2:33 PM
We‘re organizing this year’s Cajal NeuroAI summer course at Champalimaud in Lisbon. We have an amazing lineup of speakers across several computational approaches and species. Please repost to spread the word and/or apply!
This summer course is going to be awesome! Please repost and tell your students/postdocs/everyone to apply. We have lots of excellent faculty as well as lectures on #connectome modeling by yours truly and Jonathan Pillow.
🚀 Applications are OPEN for the CAJAL NeuroAI course!
Learn how AI & deep learning help us model brain activity & behavior. Work with experts, get hands-on training & join a global network!
📅 Apply by March 7
🔗 loom.ly/xg_uRKE
#NeuroAI #DeepLearning #Neuroscience
Learn how AI & deep learning help us model brain activity & behavior. Work with experts, get hands-on training & join a global network!
📅 Apply by March 7
🔗 loom.ly/xg_uRKE
#NeuroAI #DeepLearning #Neuroscience
February 3, 2025 at 10:05 PM
This summer course is going to be awesome! Please repost and tell your students/postdocs/everyone to apply. We have lots of excellent faculty as well as lectures on #connectome modeling by yours truly and Jonathan Pillow.
Reposted
I enjoy @markdhumphries.bsky.social's annual review every year-- this year particularly excited for the coverage of fly connectomics, and the shout-out to our paper on our task-trained and connectome-constrained model of the fly visual system @lappalainenjk.bsky.social @srinituraga.bsky.social!
Cutting it a bit fine, but here’s my review of the year in neuroscience for 2024
The eighth of these, would you believe? We’ve got dark neurons, tiny monkeys, the most complete brain wiring diagram ever constructed, and much more…
Published on The Spike
Enjoy!
medium.com/the-spike/20...
The eighth of these, would you believe? We’ve got dark neurons, tiny monkeys, the most complete brain wiring diagram ever constructed, and much more…
Published on The Spike
Enjoy!
medium.com/the-spike/20...
2024: A Review of the Year in Neuroscience
Feeling a bit wired
medium.com
January 4, 2025 at 10:17 AM
I enjoy @markdhumphries.bsky.social's annual review every year-- this year particularly excited for the coverage of fly connectomics, and the shout-out to our paper on our task-trained and connectome-constrained model of the fly visual system @lappalainenjk.bsky.social @srinituraga.bsky.social!
Reposted
Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites
Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma…
www.sciencedirect.com
December 20, 2024 at 7:43 PM
Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
www.sciencedirect.com/science/arti...
by the fabulous @lorenabenedetti.bsky.social and friends.
Reposted
Just in time for your holiday reading, Janne’s @lappalainenjk.bsky.social blogpost on his recent work with Srini @srinituraga.bsky.social et al! Happily holidays!
Can we build neural networks whose structure and computational abilities match a real brain? We are not quite there yet, but recent work by @lappalainenjk.bsky.social et al. shows a strategy for getting closer to this goal. Read more on our blog: www.machinelearningforscience.de/en/improving...
How a tiny animal helps us improve brain simulations with AI
Can we build neural networks whose structure and computational abilities match a real brain? We are not quite there yet, but our new paper shows a strategy for getting closer to this goal.
www.machinelearningforscience.de
December 20, 2024 at 11:42 AM
Just in time for your holiday reading, Janne’s @lappalainenjk.bsky.social blogpost on his recent work with Srini @srinituraga.bsky.social et al! Happily holidays!
Thanks for the shoutout, @tyrellturing.bsky.social!
This is cool - using the fly connectome to build a constrained ANN model of the fly visual system:
www.nature.com/articles/s41...
Nice to see connectomics actually getting used for something... 😜
🧠📈 🧪
www.nature.com/articles/s41...
Nice to see connectomics actually getting used for something... 😜
🧠📈 🧪
Connectome-constrained networks predict neural activity across the fly visual system - Nature
A study demonstrates how experimental measurements of only the connectivity of a biological neural network can be used to predict neural responses across the fly visual system at single-neuron resolut...
www.nature.com
December 18, 2024 at 6:45 PM
Thanks for the shoutout, @tyrellturing.bsky.social!
Reposted
We’re #hiring Theory Fellows.
🥼 Our Computation & Theory research area is recruiting early-career scientists to test theories, collaborate across research areas & tackle fundamental questions in biology.
Apply by Jan. 7 ➡️ janelia.link/theoryfellow...
#computationalbiology
🥼 Our Computation & Theory research area is recruiting early-career scientists to test theories, collaborate across research areas & tackle fundamental questions in biology.
Apply by Jan. 7 ➡️ janelia.link/theoryfellow...
#computationalbiology
December 16, 2024 at 5:02 PM
We’re #hiring Theory Fellows.
🥼 Our Computation & Theory research area is recruiting early-career scientists to test theories, collaborate across research areas & tackle fundamental questions in biology.
Apply by Jan. 7 ➡️ janelia.link/theoryfellow...
#computationalbiology
🥼 Our Computation & Theory research area is recruiting early-career scientists to test theories, collaborate across research areas & tackle fundamental questions in biology.
Apply by Jan. 7 ➡️ janelia.link/theoryfellow...
#computationalbiology