Ryan M. Pearson, PhD.
@ryanmpearson.bsky.social
Associate Professor of Pharmaceutical Sciences - University of Maryland, Baltimore @PharmSciUMB. Immune Engineering, Past Chair @CRS_FG_Immuno and @AAPSNano.
Pinned
News Center » UMSOP Faculty Awarded $3.4 Million NIH Grant to Develop Innovative Nanoparticle Immunotherapy for Sepsis
news.pharmacy.umaryland.edu
I'm thrilled to share that our lab has been awarded an R01 from NIH NIAID to continue our research to develop new nanoparticle-based immunotherapies for treating sepsis! news.pharmacy.umaryland.edu/umsop-facult...
Reposted by Ryan M. Pearson, PhD.
#Throwback 🧪
COMMENT | A brief guide to studying extracellular vesicle function in the context of metabolism
C Crewe et al
COMMENT | A brief guide to studying extracellular vesicle function in the context of metabolism
C Crewe et al
A brief guide to studying extracellular vesicle function in the context of metabolism - Nature Metabolism
Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.
bit.ly
November 16, 2025 at 7:01 PM
#Throwback 🧪
COMMENT | A brief guide to studying extracellular vesicle function in the context of metabolism
C Crewe et al
COMMENT | A brief guide to studying extracellular vesicle function in the context of metabolism
C Crewe et al
The University of Maryland School of Pharmacy (UMSOP) in Baltimore is recruiting new students for PhD and MS programs. Come join us and apply today! www.pharmacy.umaryland.edu/academics/ps...
November 7, 2025 at 2:41 PM
The University of Maryland School of Pharmacy (UMSOP) in Baltimore is recruiting new students for PhD and MS programs. Come join us and apply today! www.pharmacy.umaryland.edu/academics/ps...
Reposted by Ryan M. Pearson, PhD.
Myelin damage in multiple sclerosis can be detected up to seven years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis, according to a paper in Nature Medicine. go.nature.com/4qqq47L #medsky 🧪
November 1, 2025 at 1:50 AM
Myelin damage in multiple sclerosis can be detected up to seven years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis, according to a paper in Nature Medicine. go.nature.com/4qqq47L #medsky 🧪
Reposted by Ryan M. Pearson, PhD.
RESEARCH | S Benhmammouch, L Yvan-Charvet et al. (Univ Côte d’Azur)
Glutamine uptake and utilization regulates macrophage function in atherosclerosis 🧪
Glutamine uptake and utilization regulates macrophage function in atherosclerosis 🧪
Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis - Nature Metabolism
The authors provide a comprehensive characterization of how glutamine uptake and utilization regulate macrophage function in atherosclerosis.
bit.ly
October 19, 2025 at 6:48 PM
RESEARCH | S Benhmammouch, L Yvan-Charvet et al. (Univ Côte d’Azur)
Glutamine uptake and utilization regulates macrophage function in atherosclerosis 🧪
Glutamine uptake and utilization regulates macrophage function in atherosclerosis 🧪
Reposted by Ryan M. Pearson, PhD.
#Throwback 🧪
COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
KS Lee, X Su & T Huan
COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
KS Lee, X Su & T Huan
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.
bit.ly
October 19, 2025 at 7:01 PM
#Throwback 🧪
COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
KS Lee, X Su & T Huan
COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
KS Lee, X Su & T Huan
Reposted by Ryan M. Pearson, PhD.
#Throwback 🧪
PERSPECTIVE | On the pathogenesis of obesity: causal models and missing pieces of the puzzle
F Magkos, @kevinh-phd.bsky.social , @johnspeakman4.bsky.social , A Astrup et al
www.nature.com/articles/s42...
PERSPECTIVE | On the pathogenesis of obesity: causal models and missing pieces of the puzzle
F Magkos, @kevinh-phd.bsky.social , @johnspeakman4.bsky.social , A Astrup et al
www.nature.com/articles/s42...
On the pathogenesis of obesity: causal models and missing pieces of the puzzle - Nature Metabolism
This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis and by defining terms that are at the core of this discussion.
www.nature.com
October 6, 2025 at 3:09 PM
#Throwback 🧪
PERSPECTIVE | On the pathogenesis of obesity: causal models and missing pieces of the puzzle
F Magkos, @kevinh-phd.bsky.social , @johnspeakman4.bsky.social , A Astrup et al
www.nature.com/articles/s42...
PERSPECTIVE | On the pathogenesis of obesity: causal models and missing pieces of the puzzle
F Magkos, @kevinh-phd.bsky.social , @johnspeakman4.bsky.social , A Astrup et al
www.nature.com/articles/s42...
Reposted by Ryan M. Pearson, PhD.
A study in Nature Metabolism shows that the dietary fiber inulin modifies the gut #microbiome to better process fructose, helping prevent metabolic dysfunctions and emphasizing the role of dietary fiber. go.nature.com/4gKCvHe 🧪
October 4, 2025 at 1:29 AM
A study in Nature Metabolism shows that the dietary fiber inulin modifies the gut #microbiome to better process fructose, helping prevent metabolic dysfunctions and emphasizing the role of dietary fiber. go.nature.com/4gKCvHe 🧪
Reposted by Ryan M. Pearson, PhD.
Reposted by Ryan M. Pearson, PhD.
Artificial intelligence-assisted academic writing: recommendations for ethical use
advancesinsimulation.biomedcentral.com/articles/10....
advancesinsimulation.biomedcentral.com/articles/10....
October 1, 2025 at 8:09 AM
Artificial intelligence-assisted academic writing: recommendations for ethical use
advancesinsimulation.biomedcentral.com/articles/10....
advancesinsimulation.biomedcentral.com/articles/10....
Reposted by Ryan M. Pearson, PhD.
Reposted by Ryan M. Pearson, PhD.
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 22, 2025 at 9:20 AM
Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
Reposted by Ryan M. Pearson, PhD.
The immune response
September 13, 2025 at 4:31 PM
The immune response
Reposted by Ryan M. Pearson, PhD.
'Here, we identify the immunometabolic crosstalk that generates homocysitaconate, a metabolite formed by homocysteine & itaconate adduction catalyzed by S-adenosyl-L-homocysteine hydrolase. Homocysitaconate increases 152-fold during #inflammation and exhibits anti-inflammatory effects.'
#Immunology
#Immunology
Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation
Lin et al. discover homocysitaconate, an anti-inflammatory metabolite formed during
inflammation via AHCY-catalyzed adduction of homocysteine and itaconate. Homocysitaconate
is recognized by MARS, ind...
www.cell.com
August 27, 2025 at 11:54 PM
'Here, we identify the immunometabolic crosstalk that generates homocysitaconate, a metabolite formed by homocysteine & itaconate adduction catalyzed by S-adenosyl-L-homocysteine hydrolase. Homocysitaconate increases 152-fold during #inflammation and exhibits anti-inflammatory effects.'
#Immunology
#Immunology
Reposted by Ryan M. Pearson, PhD.
Join us for #IMES2025!
🚨 Abstract deadline for trainees and early career PI's is coming soon! Due: Aug. 15, 2025
Submit for a chance to present oral talks and for awards!💲
👉Learn more/submit: tinyurl.com/DIMES2025
🚨 Abstract deadline for trainees and early career PI's is coming soon! Due: Aug. 15, 2025
Submit for a chance to present oral talks and for awards!💲
👉Learn more/submit: tinyurl.com/DIMES2025
August 8, 2025 at 11:46 PM
Join us for #IMES2025!
🚨 Abstract deadline for trainees and early career PI's is coming soon! Due: Aug. 15, 2025
Submit for a chance to present oral talks and for awards!💲
👉Learn more/submit: tinyurl.com/DIMES2025
🚨 Abstract deadline for trainees and early career PI's is coming soon! Due: Aug. 15, 2025
Submit for a chance to present oral talks and for awards!💲
👉Learn more/submit: tinyurl.com/DIMES2025
Reposted by Ryan M. Pearson, PhD.
We're recruiting a lab technician to assist with our ongoing liquid biopsy projects. Please encourage those with relevant experience to apply. Feel free to contact me with questions! tinyurl.com/prattlabtech
August 4, 2025 at 5:52 PM
We're recruiting a lab technician to assist with our ongoing liquid biopsy projects. Please encourage those with relevant experience to apply. Feel free to contact me with questions! tinyurl.com/prattlabtech
Reposted by Ryan M. Pearson, PhD.
COMMENT | 🧪
@colbyvorland.bsky.social , L Golzarri-Arroyo & DB Allison (Indiana Uni)
This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses.
www.nature.com/articles/s42...
@colbyvorland.bsky.social , L Golzarri-Arroyo & DB Allison (Indiana Uni)
This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses.
www.nature.com/articles/s42...
A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism
Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. He...
www.nature.com
July 29, 2025 at 2:28 PM
COMMENT | 🧪
@colbyvorland.bsky.social , L Golzarri-Arroyo & DB Allison (Indiana Uni)
This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses.
www.nature.com/articles/s42...
@colbyvorland.bsky.social , L Golzarri-Arroyo & DB Allison (Indiana Uni)
This comment discusses how clustering and nesting (C&N) arise in #preclinical studies, as well as valid designs and analyses.
www.nature.com/articles/s42...
Reposted by Ryan M. Pearson, PhD.
RESEARCH | MH Tschöp, TD Müller et al
@www.helmholtz-munich.de
Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms.
🧪
www.nature.com/articles/s42...
@www.helmholtz-munich.de
Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms.
🧪
www.nature.com/articles/s42...
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism
This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...
www.nature.com
July 22, 2025 at 3:30 PM
RESEARCH | MH Tschöp, TD Müller et al
@www.helmholtz-munich.de
Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms.
🧪
www.nature.com/articles/s42...
@www.helmholtz-munich.de
Part 2: This study and a co-pub delve into how both #GIPreceptor #agonists and #antagonists trigger weight loss through different mechanisms.
🧪
www.nature.com/articles/s42...
Reposted by Ryan M. Pearson, PhD.
Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo!
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
July 16, 2025 at 11:59 AM
Excited to be co-chairing a fantastic Immuno Delivery session at the CRS this Wednesday alongside Helena Florindo!
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
We have an outstanding lineup of speakers :
✨ Ayelet David
✨ Vincent J. Venditto
✨ Paul Sagoe
✨ Milan paul
✨ Ana Baião
✨ David Peeler
✨ Madhan Mohan Chandra Sekhar Jaggarapu
Reposted by Ryan M. Pearson, PhD.
A paper in Nature Nanotechnology presents a method using arrays of silicon nanoneedles to generate molecular replicas of living tissue, enabling mapping for glioma characterization and classification. The method allows for the monitoring of the response of the tumours to chemotherapy. #medsky 🧪
Nanoneedles enable spatiotemporal lipidomics of living tissues - Nature Nanotechnology
Arrays of silicon nanoneedles are used to generate molecular replicas of live brain tissue for longitudinal spatial lipidomic classification via desorption electrospray ionization mass spectrometry imaging of gliomas and to monitor the responses of the tumours to chemotherapy.
go.nature.com
June 22, 2025 at 1:33 PM
A paper in Nature Nanotechnology presents a method using arrays of silicon nanoneedles to generate molecular replicas of living tissue, enabling mapping for glioma characterization and classification. The method allows for the monitoring of the response of the tumours to chemotherapy. #medsky 🧪
Reposted by Ryan M. Pearson, PhD.
#Fumarate update
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
June 21, 2025 at 7:47 PM
#Fumarate update
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
Reposted by Ryan M. Pearson, PhD.
I'm thrilled to share that our lab has been awarded an R01 from NIH NIAID to continue our research to develop new nanoparticle-based immunotherapies for treating sepsis! news.pharmacy.umaryland.edu/umsop-facult...
News Center » UMSOP Faculty Awarded $3.4 Million NIH Grant to Develop Innovative Nanoparticle Immunotherapy for Sepsis
news.pharmacy.umaryland.edu
June 13, 2025 at 7:36 PM
I'm thrilled to share that our lab has been awarded an R01 from NIH NIAID to continue our research to develop new nanoparticle-based immunotherapies for treating sepsis! news.pharmacy.umaryland.edu/umsop-facult...
Reposted by Ryan M. Pearson, PhD.
Dr. Daniela Frasca et al highlight the interesting role of metabolism in #aging by comparing age and obesity in humans. They note that aging and obesity are conditions which can lead to dysregulated immune responses. Learn more: ow.ly/MeGI50W6fLn
Similarities in B Cell Defects between Aging and Obesity
Abstract. The aging population is increasing worldwide, and there is also an increase in the aging population living with overweight and obesity, due to ch
ow.ly
June 12, 2025 at 1:05 PM
Dr. Daniela Frasca et al highlight the interesting role of metabolism in #aging by comparing age and obesity in humans. They note that aging and obesity are conditions which can lead to dysregulated immune responses. Learn more: ow.ly/MeGI50W6fLn
Reposted by Ryan M. Pearson, PhD.
A Tutorial in Nature Protocols provides guidelines for the use of machine learning models to mine genomes and proteomes for the discovery of antimicrobial peptides. 🔒
Tutorial: guidelines for the use of machine learning methods to mine genomes and proteomes for antibiotic discovery - Nature Protocols
In this Tutorial, we provide guidelines for the use of ML models to mine genomes and proteomes for the discovery of antimicrobial peptides, discussing the various stages of the ML workflow, recent advances in ML models and how to experimentally validate the computational predictions.
go.nature.com
June 11, 2025 at 10:34 PM
A Tutorial in Nature Protocols provides guidelines for the use of machine learning models to mine genomes and proteomes for the discovery of antimicrobial peptides. 🔒
Reposted by Ryan M. Pearson, PhD.
NEWS&VIEWS | Peter Arner ( @ki.se )
Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.
Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.
Signalling from adipose tissue to the brain is not just about leptin - Nature Metabolism
A Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.
bit.ly
June 10, 2025 at 3:39 PM
NEWS&VIEWS | Peter Arner ( @ki.se )
Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.
Under acute stress, adipose tissue lipolysis causes release of GDF15 from local macrophages, which binds to GFRAL in the brain, evoking anxiety.