The Journal of Immunology
@jimmunol.bsky.social
The Journal of Immunology is an official journal of The American Association of Immunologists, journals.aai.org/jimmunol
Editor-in-Chief: Gail A. Bishop, Ph.D.
Editor-in-Chief: Gail A. Bishop, Ph.D.
Reposted by The Journal of Immunology
#ICYMI: From Dr. Kristin Hogquist at the Center for Immunology-UMN focuses on interferon (IFN) production within the thymus and its effects on thymic APCs and developing thymocyte while also examining the importance of T-cell tolerance to IFN. The Journal of Immunology: https://ow.ly/UEMw50VEIEx
December 29, 2025 at 8:00 PM
#ICYMI: From Dr. Kristin Hogquist at the Center for Immunology-UMN focuses on interferon (IFN) production within the thymus and its effects on thymic APCs and developing thymocyte while also examining the importance of T-cell tolerance to IFN. The Journal of Immunology: https://ow.ly/UEMw50VEIEx
Researchers developed optimized detection and inference of names in scRNA-seq data (scODIN) to enhance the understanding of immune cell heterogeneity and immune regulation. Read more to see the broad implications for immunology and personalized medicine: ow.ly/InOb50XS9k2.
Optimized detection and inference of immune cell type names in single-cell RNA sequencing data
Abstract. Accurate identification of immune cell subsets in single-cell RNA sequencing (scRNA-seq) data is critical for understanding immune responses in a
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January 5, 2026 at 7:57 PM
Researchers developed optimized detection and inference of names in scRNA-seq data (scODIN) to enhance the understanding of immune cell heterogeneity and immune regulation. Read more to see the broad implications for immunology and personalized medicine: ow.ly/InOb50XS9k2.
Female Malat1-/- mice demonstrated altered Th2 cytokine expression, evidenced by a reduction in IL-10+ Th2 cells in both lung and spleen, while male Malat1-/- mice did not, revealing Malat1 as a novel determinant of immune sexual dimorphism. Read more: ow.ly/RgN050XQCz8.
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
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December 31, 2025 at 2:28 PM
Female Malat1-/- mice demonstrated altered Th2 cytokine expression, evidenced by a reduction in IL-10+ Th2 cells in both lung and spleen, while male Malat1-/- mice did not, revealing Malat1 as a novel determinant of immune sexual dimorphism. Read more: ow.ly/RgN050XQCz8.
Awesome @altmetric.com trending research from The Journal of Immunology & @immunohorizons.bsky.social is featured in this year's #immunologywrapped! From the "Impact of sleep deprivation on monocyte subclasses and function" to "TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni".
🧬 2025 was a MOOD. From Hawaii to Capitol Hill, AAI has been busy advancing the field! Check out our #ImmunologyWrapped to see our highlights in research, advocacy, and community.
Which 2025 #Immunology moment was your favorite? ⬇️
https://ow.ly/ulsv50XMEsf
Which 2025 #Immunology moment was your favorite? ⬇️
https://ow.ly/ulsv50XMEsf
December 19, 2025 at 7:44 PM
Awesome @altmetric.com trending research from The Journal of Immunology & @immunohorizons.bsky.social is featured in this year's #immunologywrapped! From the "Impact of sleep deprivation on monocyte subclasses and function" to "TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni".
Researchers evaluated SB834Fc, an IL-2 mutated variant, for its anti-tumor properties. Their results support SB834Fc as a candidate to develop a new IL-2 based cancer #immunotherapy with less toxicity than other IL-2 treatments. Read more online: ow.ly/7Axz50XIyeG.
Enhanced affinity for the IL-2 receptor β subunit potently increases antitumor efficacy of IL-2 across various tumor models by reshaping the tumor microenvironment
Abstract. The main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of reg
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December 17, 2025 at 6:05 PM
Researchers evaluated SB834Fc, an IL-2 mutated variant, for its anti-tumor properties. Their results support SB834Fc as a candidate to develop a new IL-2 based cancer #immunotherapy with less toxicity than other IL-2 treatments. Read more online: ow.ly/7Axz50XIyeG.
Reposted by The Journal of Immunology
Happy #InternationalVeterinaryMedicineDay! See how diverse species are advancing research in our special collection in The Journal of Immunology, "Beyond the Mouse: Nontraditional Animal Models." Discover more: https://ow.ly/i5Vk50XGp5K.
December 9, 2025 at 5:01 PM
Happy #InternationalVeterinaryMedicineDay! See how diverse species are advancing research in our special collection in The Journal of Immunology, "Beyond the Mouse: Nontraditional Animal Models." Discover more: https://ow.ly/i5Vk50XGp5K.
Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.
Associated transcription factors of allergic rhinitis: SP1 aggravates nasal epithelial barrier damage
Abstract. Allergic rhinitis (AR) is a respiratory airway disorder characterized by inflammation and barrier dysfunction. The transcription factor specifici
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December 9, 2025 at 4:03 PM
Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.
Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.
MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma
Abstract. Hepatocellular carcinoma (HCC) stands as one of the most prevalent and fatal malignancies globally, posing a persistent challenge in its treatmen
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December 8, 2025 at 7:37 PM
Researchers found that MEF2D blocks T-cell–mediated antitumor immunity by regulating the expression of CD70 and activating the CD70-CD27 signaling axis. Manipulating this pathway may improve the efficacy of liver cancer immunotherapy. Learn more: ow.ly/nh8n50XFUxU.
📥 Submit your abstracts for IMMUNOLOGY2026™ by Dec 16 and ensure that your original abstract is published in The Journal of Immunology as a supplement: immunology2026.aai.org/abstracts/
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
🔬 The second abstract period for #IMMUNOLOGY2026™ is now OPEN!
Submit your research December 2–16 and share your findings with the top minds in #immunology. Join us in Boston, MA, April 15–19, 2026.
🔗 immunology2026.aai.org/abstracts
#AAI2026
Submit your research December 2–16 and share your findings with the top minds in #immunology. Join us in Boston, MA, April 15–19, 2026.
🔗 immunology2026.aai.org/abstracts
#AAI2026
December 5, 2025 at 7:14 PM
📥 Submit your abstracts for IMMUNOLOGY2026™ by Dec 16 and ensure that your original abstract is published in The Journal of Immunology as a supplement: immunology2026.aai.org/abstracts/
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
📖 Explore last year's IMMUNOLOGY2025™ abstracts now: academic.oup.com/jimmunol/iss...
This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.
December 3, 2025 at 2:55 PM
This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.
The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
Volume 214 Issue 11 | The Journal of Immunology | Oxford Academic
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
ow.ly
December 1, 2025 at 4:20 PM
The latest issue of The JI is now online! Read cutting edge research, brief reviews, and more.
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
🔗 ow.ly/RMa250XA7Ce
#ReadTheJI #Immunology
This #CuttingEdge article reports that neutralizing FLT3L may effectively treat Sjögren’s and other FLT3L-associated autoimmune diseases. Read all about in The JI: ow.ly/u3lj50XyhWR.
November 26, 2025 at 5:27 PM
This #CuttingEdge article reports that neutralizing FLT3L may effectively treat Sjögren’s and other FLT3L-associated autoimmune diseases. Read all about in The JI: ow.ly/u3lj50XyhWR.
Data suggest that S. mansoni may have evolved to manipulate TRPV1+ neuron activation as a countermeasure to limit IL-17-mediated inflammation, facilitating systemic dissemination and chronic parasitism. Read more: ow.ly/3zz250XxJKa .
November 25, 2025 at 7:21 PM
Data suggest that S. mansoni may have evolved to manipulate TRPV1+ neuron activation as a countermeasure to limit IL-17-mediated inflammation, facilitating systemic dissemination and chronic parasitism. Read more: ow.ly/3zz250XxJKa .
New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.
Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections
The Editors have selected this article as a highlight of the issue.
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November 21, 2025 at 7:53 PM
New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
Eomesodermin defines uterine NK cells crucial for pregnancy success in mice
Abstract. Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we
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November 17, 2025 at 4:44 PM
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
November 7, 2025 at 3:05 PM
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.
Role of companion dogs in cancer immunotherapy development
Abstract. Rodent models for evaluating new cancer immunotherapies often fail to fully recapitulate the complexity of immune interactions that occur in canc
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November 6, 2025 at 7:00 PM
Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.
Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.
🔗 ow.ly/EQ3r50Xmt9l.
🔗 ow.ly/EQ3r50Xmt9l.
Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax
Abstract. Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic
ow.ly
November 5, 2025 at 5:30 PM
Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.
🔗 ow.ly/EQ3r50Xmt9l.
🔗 ow.ly/EQ3r50Xmt9l.
As part of the special collection on non-traditional animal models, researchers discuss how understanding immunity in a range of large animals can expand awareness of immunological processes critical for the maintenance of human health. Learn more: ow.ly/bCtV50Xmt0s.
Contributions of large and agricultural animal models to immunology
Abstract. While studies with laboratory rodent models have defined molecular and cellular components of the human immune system, experiments in these small
ow.ly
November 4, 2025 at 3:02 PM
As part of the special collection on non-traditional animal models, researchers discuss how understanding immunity in a range of large animals can expand awareness of immunological processes critical for the maintenance of human health. Learn more: ow.ly/bCtV50Xmt0s.
#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.
📘 ow.ly/189i50Xl7h4
📘 ow.ly/189i50Xl7h4
Zombie Ants, Spider Bait, and a Sneaky Burrowing Worm: The 6 Spookiest Science Discoveries of the Past Year
The natural world is full of discoveries that feel straight out of a Tim Burton fever dream.
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October 31, 2025 at 5:26 PM
#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.
📘 ow.ly/189i50Xl7h4
📘 ow.ly/189i50Xl7h4
A treat for you this Halloween: the October edition of The Journal of Immunology is online! Featuring a special collection titled. “Beyond the Mouse: Nontraditional Animal Models in Immunology” you don’t want to miss this one. Explore it all: ow.ly/jmK850Xj1K0
Volume 214 Issue 10 | The Journal of Immunology | Oxford Academic
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
ow.ly
October 31, 2025 at 1:49 PM
A treat for you this Halloween: the October edition of The Journal of Immunology is online! Featuring a special collection titled. “Beyond the Mouse: Nontraditional Animal Models in Immunology” you don’t want to miss this one. Explore it all: ow.ly/jmK850Xj1K0
Mortality from Pneumocystis #pneumonia (PCP) continues to increase among non-HIV patients. A new study looks at the role of withdrawing glucocorticoid in disease progression to better understand disease progression. Read more in The JI: ow.ly/EXrx50Xj1CR.
Glucocorticoid-induced Pneumocystis pneumonia mice developed immune reconstitution inflammatory syndrome after glucocorticoid withdrawal
Abstract. Mortality from Pneumocystis pneumonia (PCP) continues to increase among non-human immunodeficiency virus (HIV) patients. Previous studies have re
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October 31, 2025 at 1:48 PM
Mortality from Pneumocystis #pneumonia (PCP) continues to increase among non-HIV patients. A new study looks at the role of withdrawing glucocorticoid in disease progression to better understand disease progression. Read more in The JI: ow.ly/EXrx50Xj1CR.
This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5
October 28, 2025 at 1:45 PM
This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5
Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.
October 23, 2025 at 12:56 PM
Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.
Don't delay! Submit your abstract for IMMUNOLOGY2026™ before 6 pm today.
Today is the deadline for Regular Abstract Submissions for IMMUNOLOGY2026™ at 6 PM ET. If you feel that you will miss today's deadline, we will open a second Regular Abstract submission period from Dec 2–16, 2025. It's also the final day to apply for a Travel Award. ow.ly/LB8P50XggzQ.
October 22, 2025 at 6:04 PM
Don't delay! Submit your abstract for IMMUNOLOGY2026™ before 6 pm today.